Articles tagged with Tissue Cultures
The Hippenmeyer group has developed a stable mouse stem cell line and created a robust and reproducible mouse cortical organoid protocol. By comparing developmental stages of the mouse brain with those of the organoids using single-cell sequencing, they found similar cell populations and molecular programs.
Researchers created a platform to study chronic pancreatitis pathogenesis and identify potential treatments by generating patient-derived organoids. The organoids revealed consistent dysfunction in the CFTR protein, which may be a future effective therapeutic target.
A study published in Cancer Cell identified a six-gene signature in microscopic colorectal cancer liver metastases that may help predict recurrence after treatment. The findings suggest these tiny tumor deposits could serve as a tissue-based marker of residual cancer cells, recurrence risk and chemotherapy resistance.
Researchers have developed a new tool to screen genes involved in human development at unprecedented scale and speed. The method, using organoids from human pluripotent stem cells, revealed new insights into human brain development, including the role of ZIC2, SOX11, and ZNF521 genes.
A new device inspired by fish's lateral line senses the pulse of lab-grown heart tissue, enabling real-time monitoring of hundreds of tests. This breakthrough could revolutionize drug screening and personalized medicine with more accurate human tissue simulations.
Researchers at the University of Zurich have developed epigenetic drugs that can reprogram perivascular fat cells to reduce inflammation and improve blood vessel health. By targeting specific gene-expression regulators, these drugs aim to prevent vascular damage in people with obesity and metabolic disease.
Researchers at Institute of Science Tokyo have developed a novel culture system to produce stable, scalable, and low-cost clinical-grade intestinal organoids from patient biopsy samples. The innovative approach uses clinical-grade collagen and synthetic peptides to enhance growth and improve scalability.
A new study replicated patient- and sex-specific hallmarks of Inflammatory Bowel Disease (IBD) in a human organ chip, identifying stromal fibroblasts as key drivers of inflammation, fibrosis, and enhanced cancer risk. The model also recapitulated the impact of pregnancy hormones on IBD severity in female patients.
Researchers review organoid-related regulations and progress in IND approval, highlighting the prospects and limitations of organoid models. Organoids are poised to reshape drug research and development with their high clinical relevance, shorter experimental cycles, and lower costs.
Researchers at the University of Toronto have developed a new method to mature lab-grown heart cells, which exhibits greater structural organization and improved ability to contract. This advance could help create more reliable models for studying heart disease and testing new drugs.
Researchers have created a 3D experimental system to study the response of low-grade gliomas to drugs, providing a more realistic environment for testing treatments. The system uses organoids from pluripotent stem cells to replicate glioma development and characteristics.
Researchers at King's College London have developed a new brain organoid system that reduces variability and allows for longer-term recordings of neural activity. The approach enables the simultaneous study of multiple parallel cultures, providing a better understanding of how drugs or gene variants affect neural networks.
Researchers at UC Santa Cruz successfully train brain organoids to balance a virtual pole, demonstrating adaptive learning capabilities. This breakthrough has implications for understanding neurological conditions and developing new tools for studying brain function.
Researchers found that early brain firings occur in structured patterns without external experiences, suggesting a genetically encoded blueprint. This discovery can help better understand neurodevelopmental disorders and the impact of toxins on the developing brain.
AcCELLerate has partnered with ATCC to provide customized Master, Working, and assay-ready instaCELL banks for research clients. Researchers will gain access to high-quality, authenticated cell lines with increased assay reproducibility.
Researchers developed a new human brain tissue platform called miBrains, integrating all major brain cell types and modeling brain structures, cellular interactions, activity, and pathological features. The models can be customized through gene editing and are derived from individual patients' genomes.
Recent advances in biofabrication and biomedical electronics have led to the development of biohybrid-engineered tissue (BHET) platforms, turning passive constructs into intelligent systems. These platforms show promise in diverse applications, including brain organoids and cardiac tissues, blurring the line between biology and machine.
A new framework outlines crucial validity standards for stem cell technology to study devastating brain disorders, aiming to translate laboratory discoveries into effective treatments. The framework addresses the critical gap in translating genetic discovery to clinical application.
Researchers at Harvard University's Wyss Institute have successfully created human microglia cells in a dish, using induced pluripotent stem cells, within four days. This breakthrough enables new avenues for brain disease-focused research and potential therapeutic perspectives.
Scientists have created a comprehensive bat organoid model to study zoonotic viruses, enabling early detection and drug testing for future outbreaks. The platform, comprising diverse bat species and organs, has led to breakthroughs in understanding virus behavior, isolation, and treatment.
Scientists successfully grow chimpanzee naive-type pluripotent stem cells, revealing key mechanisms for self-renewal and differentiation. The study's findings shed light on the evolutionary conservation of these properties, offering a powerful tool for investigating early developmental processes.
A new type of bioengineered blood vessel demonstrated superior infection resistance and better limb preservation compared to conventional synthetic grafts. The technology has the potential to reduce amputation numbers significantly, as it can be implanted immediately and is more resistant to infection than traditional options.
Researchers at ETH Zurich have found an antidepressant, vortioxetine, effective against glioblastomas, a particularly aggressive brain tumor with no cure. The drug's ability to cross the blood-brain barrier and trigger a signalling cascade makes it promising for treating this deadly tumour.
Researchers developed Stain SAN, a novel domain adaptation technique to correct color differences in stained histopathology images. The method improves consistency and comparability of data, leading to better performance in machine-learning-based classifiers.
Researchers have designed a novel 3D hydrogel culture system that accurately mimics the mammalian lung environment, allowing for the study of tuberculosis bacteria infection and therapeutics. The system successfully tracks infection progression and demonstrates the efficacy of pyrazinamide in clearing out TB bacteria.
Researchers have developed a cell culture system that differentiates human pluripotent stem cells to amniotic and surface ectoderm, which are essential for human embryo development. The study found that the degree of cell crowding influences cell identity decision.
Researchers studied the effects of resveratrol on circadian clock gene expression in young and older human adipose-derived progenitor cells. They found increased levels of some components in older-APCs compared to young-APCs, but also observed gained rhythmicity of some components after resveratrol treatment.
A study by Waseda University explores the effects of different vascularization strategies on brain organoids, improving cell differentiation and transcriptome profiles. Vascularized cerebral organoids exhibit a gene expression profile closer to fetal human brains than non-vascularized ones.
Researchers found a significant increase in extracellular vesicles released by aged keratinocytes, which were also enriched with specific microRNAs. These EVs impaired young keratinocyte proliferation and organogenesis, mimicking aged skin defects.
A new method for studying cancer cells' behavior on soft and stiff tissue environments has been developed, revealing crucial survival cues for cell growth. The study challenges the long-held assumption that cells prefer stiffer surfaces, opening up new possibilities for research in cancer biology and tissue engineering.
A team of Chinese and UK researchers has identified superoxide dismutase 1 (SOD1) as a potential target for reversing drug resistance in ovarian cancer. By using nanoparticles to deliver siRNA that reduces SOD1 levels, the study showed reduced growth and decreased resistance to cisplatin in female mice.
Scientists have developed an innovative method to create 'peri-gastruloids,' human embryo-like structures with extraembryonic tissues, including yolk sac and placenta. This breakthrough allows researchers to study early human development stages, mimicking the formation of vital organs.
Researchers have developed a new manufacturing pipeline to simplify and advance high-value manufacturing of tissue-compatible organs, reducing costs and increasing efficiency. This breakthrough aims to address the dire need for artificially engineered organs and tissue grafts, potentially saving thousands of lives in the UK.
Scientists have developed an innovative platform using engineered human tissue to study how pathogens carried by mosquitoes impact and infect human cells. This breakthrough holds promise for studying other disease vectors like ticks, which spread Lyme disease.
A team led by Professor Timo Betz has developed a 3D cell culture chamber to grow muscle and other tissue using high-resolution microscopy. The new system will enable scientists to mimic the mechanical situations that confront various living tissues in serious conditions, reducing animal testing and costs.
Vogel and Benn's study replicates tissue growth in vitro, revealing the importance of ECM interactions. Myofibroblasts play a key role in wound healing and cancer progression, but their transformation into fibroblasts is influenced by ECM composition and structure.
Researchers at Tufts University have successfully produced bulk fat tissue in a lab that has a similar texture and makeup to natural animal fat. The aggregated fat cells can be fine-tuned to resemble real-life fat within meat, offering a key step towards mass production of cultured meat.
Researchers have successfully produced lab-grown fat tissue with a similar texture and make-up to naturally occurring fats from animals. The breakthrough could enable large-scale production of cultured meat with a more realistic texture and flavor.
Researchers at Max Planck Institute and Heidelberg University have developed a technology to assemble matter in 3D using sound waves. They successfully printed microparticles, gel beads, and biological cells into three-dimensional shapes, paving the way for novel 3D cell culture techniques.
Researchers highlight recent progress in organotypic models, which offer a balance between the accessibility and control of in vitro context. These models have been used to study various aging-related phenotypes, including skin, gut, and skeletal muscle, providing valuable insights into the underlying mechanisms.
Researchers from Tokyo Medical and Dental University developed a new approach to grow human intestinal mini-organs in the lab. They used cell culture plates and bioreactors to create robust and healthy intestine-like tissues that can be transplanted into mice, demonstrating the potential for regenerative medicine applications.
The SpaceX Dragon spacecraft will launch onboard a Falcon 9 rocket with critical research and supplies for the International Space Station. ISS National Laboratory-sponsored projects aim to bring value through space-based research and technology development.
A new method developed by the University of Vienna has provided deeper insights into glycolipids located on stem cell surfaces. The approach enables comprehensive analysis of gangliosides, a class of fatty sweet molecules whose composition changes during stem cell differentiation.
Researchers discover that oxytocin stimulates stem cells to migrate and develop into cardiomyocytes in zebrafish and human cell cultures. This could lead to the regeneration of damaged hearts after a heart attack. The study found that oxytocin also activates EpiPCs, which can replenish lost cardiomyocytes.
A team of researchers created an in vitro human model of environmental enteric dysfunction (EED) using the Human Organ Chip technology. The EED Chips recapitulate features of EED found in biopsies from human patients, including inflammation and intestinal barrier dysfunction. The study sheds light on the complex interplay between malnu...
Researchers from the University of Tokyo have created a controllable robotic finger covered with living skin tissue that can heal itself. The development could lead to new possibilities in advanced manufacturing industries, such as automation and cosmetics, reducing costs, time, and complexity of research.
Researchers at Karolinska Institutet have successfully repurposed a cancer drug to target neuroinflammatory diseases like multiple sclerosis. A novel drug carrier was developed to deliver the treatment specifically to microglia, reducing inflammation and disease progression.
A new study found that microgravity analog culture profoundly affects the microbial infection process in 3-D human tissue models. This is critical for ensuring astronaut health on extended space missions and sheds light on mysterious processes of infection on Earth.
A team of researchers has successfully treated damaged pig hearts with cardiac progenitor cells, demonstrating the formation of new cardiac tissue and improved cardiac function. The treatment could potentially be used to treat patients with serious heart failure, particularly older patients with coexisting conditions.
Scientists have identified a retinoic acid-dependent hemogenic endothelial progenitor from human pluripotent stem cells, enabling the development of transcriptionally similar cells in tissue culture. This breakthrough method brings researchers closer to developing blood-forming stem cells for transfusions and cancer treatments.
Researchers at UC Riverside have discovered that curcumin promotes vascular endothelial growth factor (VEGF) secretion, helping to grow engineered blood vessels and tissues. The study uses magnetic hydrogels coated with curcumin-coated nanoparticles, which gradually release the compound without injuring cells.
A recent study analyzed the genomes, methylomes, and transcriptomes of calli and sweet orange calli cultured in vitro for 30 years. The results show dynamic somaclonal variation patterns during dedifferentiation and reprogramming, affecting somatic embryogenesis. The findings offer a deeper understanding of in vitro variation and its a...
Researchers at KTH Royal Institute of Technology created a 3D model of living brain cancer using cavitation molding technique. The model closely replicates human tissue and maintains cell viability, making it suitable for drug screening.
A simple change in the way donor cells are processed can maximize a single cell's production of extracellular vesicles, which are small nanoparticles naturally secreted by cells. The finding offers new avenues for research around cellular therapies, where transplanted cells are used to help the body heal or work better.
Researchers at UConn Health have discovered that eliminating senescent cells in human fat tissue can alleviate signs of diabetes and improve insulin sensitivity. The study suggests that clearing away these dysfunctional cells could lead to game-changing new treatments for Type 2 diabetes.
Researchers developed two model systems to study peritoneal metastases from colorectal cancer patients. Biomarkers were identified, including severe mutations of the BRCA2 gene, which predict therapy response. These findings offer new hope for treating advanced cases.
A team of researchers has identified a cellular mechanism that enables embryonic stem cells to maintain their state as stem cells. The study, published in Cell Reports, reveals the genetic ingredients required for ESCs to decide whether to divide or differentiate.
Researchers have established an organoid biobank to search for genes essential for SARS-CoV-2 replication and spread. The study identified TMPRSS2 as a potential therapeutic target for the coronavirus, with specific inhibitors recently developed.
Researchers used functional genomics to identify key genes involved in inducing callus from immature maize embryos, overcoming a major roadblock in plant breeding. The study found that nearly 30% of predicted A188 genes were structurally different from other maize lines, accounting for high protein divergence and phenotypic variations.
Martha Somerman received the AADR Jack Hein Public Service Award for her exemplary work promoting oral health research to a wide constituency. She has over 150 peer-review publications and contributed to 20 books or book chapters.