A study found that further testing in renal cell carcinoma with an overexpression of gene TRIM63 could uncover a mutation otherwise undetected, leading to more treatment options. In cases where tumors were positive for TRIM63 on a biomarker level but FISH negative, 70% ended up having MiTF gene rearrangement.
The Association for Molecular Pathology recognized Dr. Laposata's contributions to clinical laboratory practice and his role in challenging the FDA's rule on laboratory-developed test regulation. The award preserves diagnostic innovation, ensures patient access, and avoids escalating healthcare costs.
Researchers developed an AI tool that detects intestinal parasites in stool samples with greater sensitivity than human observers, even those with years of experience. The system uses a deep-learning model to identify parasites in wet mounts of stool, improving the likelihood of detecting pathogenic parasites.
Researchers have discovered a novel compound that degrades key proteins found in prostate cancer cells, blocking oncogenic androgen receptor signaling. The study found that levels of H2BNTac, p300 and CBP are elevated in prostate cancer compared to normal tissue.
Engineers at the University of Pittsburgh have created a soft material with a nerve net that mimics how simple living systems coordinate motion. The material responds to chemical reactions, producing mechanical movement without electronics or motors.
A new multi-omics tool, GoT-Multi, has enabled researchers to gain insights into how cancers evolve towards greater aggressiveness and therapy resistance. The tool can analyze diverse types of pathology samples and quickly process large numbers of cells, revealing new details about cancer progression.
The Association for Molecular Pathology has created a standardized biomarker report template to simplify complex molecular profiling data presentation to oncologists and healthcare providers. The template includes guidelines for clear formatting, therapeutic guidance, and references to clinical practice guidelines.
Paul N. Staats, MD, has been appointed Chair of the University of Maryland School of Medicine's Department of Pathology, overseeing clinical services to multiple hospitals and laboratories. He will drive partnerships and expand outpatient laboratory services.
Researchers at CARS create detailed maps of chemical reactivity, discovering regions of unexpected outcomes and reconstructing intricate reaction networks. This new understanding enables control over the formation of different major products from a set of starting materials.
A research team developed a pipeline using pre-trained large language models to unify radiology and pathology reports, achieving high accuracy in tumor presence and stability. The system also predicted survival outcomes without additional training, distinguishing high-risk from low-risk groups.
This review summarizes progress in dynamic biomacromolecular modifications, regulatory mechanisms, and chemical interventions. It highlights newly emerging chemical tools and technologies for precise labeling, detection, and functional regulation of dynamic modifications.
A study found that living in areas with high air pollution concentrations accelerates cognitive decline and worsens Alzheimer's disease by increasing the buildup of toxic proteins in the brain. Exposure to fine particulate matter, such as PM2.5, was associated with increased risk of severe amyloid and tau pathology.
Researchers at Wayne State University are developing novel therapies to treat ocular chemical injuries using host-derived metabolites. The project aims to reduce inflammation, promote corneal nerve regeneration, and enhance wound healing, with potential for clinically translatable treatments that can preserve vision.
A new reporting checklist introduces key methodological details to improve reproducibility and transparency in AI-based automated image analysis. The guidelines will support clear communication of methods and reduce cognitive bias, promoting the translation of AI tools into routine pathology workflows.
The book explores lesser-known plant diseases that influenced human events, drawing from scientific insight and compelling narrative. Written for specialists and curious readers, it offers a new lens on plant pathology and environmental history.
This review systematically maps miRNA-mediated dysregulation of the AGE/RAGE pathway in MetS, revealing widespread but understudied miRNA dysregulation across adipose tissue, liver, and immune cells. Prioritizing poorly studied receptors and multi-pathology miRNAs could accelerate targeted therapies for MetS.
Elaine R. Mardis, Alexis B. Carter, and Dara L. Aisner receive AMP's top honors for groundbreaking work in cancer genomics and molecular diagnostics. Drs. Mardis and Carter will deliver keynote lectures at the AMP Annual Meeting & Expo.
Mayo Clinic has deployed NVIDIA Blackwell infrastructure to accelerate pathomics, drug discovery, and precision medicine using generative AI. The new infrastructure enables faster pathology slide analysis and foundation model development, reducing work time from four weeks to one week.
A 70-billion-parameter large language model called ChemELLM has been developed for chemical engineering applications. It was trained on a specialized dataset and demonstrated superior performance in various tasks compared to mainstream models.
Researchers developed an AI model that accurately predicts genetic mutations from routine pathology slides, reducing the need for rapid genetic testing by over 40% in lung adenocarcinoma patients. This innovation streamlines clinical decision-making and accelerates access to targeted therapies.
Forensic pathologists play a crucial role in monitoring public health threats, advancing disease research, and providing support to families who have lost loved ones. They operate independently of law enforcement and courts, performing final diagnostic evaluations and providing objective facts for the justice system.
A new study found that amylin administration exacerbates tauopathy by impairing lysosomal mechanisms in a hybrid diabetes model. The research highlights the intricate relationship between diabetes and Alzheimer's disease, suggesting that amylin plays a key role in the pancreas-brain axis.
The Association for Molecular Pathology publishes guidelines for detecting homologous recombination deficiency (HRD) in cancer. The report includes recommendations for clinical laboratories, addressing technical aspects of genomic instability and HRD analysis.
The Association for Molecular Pathology (AMP) has announced the election results for 2026-2027 leadership positions, including President-Elect Yassmine M.N. Akkari and Secretary-Treasurer Jonathan A. Nowak. The newly elected leaders will drive AMP's mission to advance molecular diagnostics.
A proof-of-concept study shows that chimeric antigen receptors (CARs) can distinguish between tau tangles and various forms of toxic amyloid plaques, two key contributors to Alzheimer's disease pathology. The technology has the potential to deliver therapeutic drugs directly to affected areas of the brain with reduced side effects.
A new study reveals that protein sequences associated with microbial communities in the human gut have uniquely low stoichiometric water content and undergo counterintuitive chemical shifts during inflammation. Microbial communities inhabit distinct chemical environments throughout the human body, influencing microbial evolution.
Dennis Jones, a BU researcher, has received the Cotran Early Career Investigator Award for his work on cancer research and vascular biology. He aims to improve T cell entry into tumors by developing approaches to enhance blood vessel function.
Researchers have successfully synthesized high-performance materials using high pressure, including superhard and superconducting materials. The article highlights the potential of high-pressure chemistry for discovering new materials and phases, despite challenges remaining in terms of experimental costs and equipment operation.
While digital and artificial intelligence-based pathology (DAIP) offers improved diagnostic accuracy and equity, its implementation is hindered by financial constraints, technical challenges, and legal/ethical concerns. A balanced assessment of the benefits and pitfalls must be conducted before adopting DAIP.
A review in Cancer Biology & Medicine explores the potential of AI to decode complex biological data for personalized cancer care. By integrating genomics, medical imaging, and pathology, AI excels at processing vast quantities of genomic and multi-omic data.
Researchers have developed an AI-driven model that can accurately diagnose various subtypes of pediatric sarcoma using only routine pathology images. The model correctly distinguished between nine sarcoma subtypes, demonstrating its potential to provide quick and accurate cancer diagnoses in under-resourced settings.
A new low-energy chemical recycling method using boron and gallium can convert common silicone waste into useful chlorosilanes with high efficiency and yield. This approach offers a promising new chemical pathway toward circularity in silicone materials, addressing both resource sustainability and emissions reductions.
A new microscopy technique, SIMIP, combines structured illumination with mid-infrared photothermal detection to achieve high-speed chemical imaging with superior resolution. The method outperforms conventional methods in terms of spatial resolution and chemical contrast.
A new framework helps clinicians choose phrases that more accurately reflect the likelihood of certain pathologies in X-rays, improving the reliability of critical clinical information. The approach treats certainty phrases as probability distributions, capturing nuances of what each word means.
The Association for Molecular Pathology (AMP) has won a court ruling that vacates the FDA's rule on laboratory-developed test procedure regulation. This decision will avoid adding billions of dollars in healthcare costs and protect access to high-quality care for hundreds of millions of Americans.
Chemical water-assisted electrolysis is a promising solution for producing clean hydrogen without CO2 emissions. The technology produces hydrogen at low voltage by substituting the water oxidation reaction with various chemical oxidation reactions.
Researchers at WashU Medicine have found that rejuvenating the network of vessels outside the brain can improve memory in old mice. The study lays the groundwork for developing therapies to overcome the challenges faced by conventional medications, which struggle to reach the brain due to the blood-brain barrier.
A recent Gut journal study defines Vasomics as a novel research discipline utilizing multimodal imaging techniques and computational pathology to analyze the pathophysiology of liver diseases. The study categorizes existing hepatic vascular phenotypes into five major types, providing new insights into potential therapeutic targets.
A review article reveals CD2AP's crucial role in amyloid metabolism, tau pathology, synaptic function, and neuroinflammation in Alzheimer's disease. CD2AP deficiency accelerates plaque formation, while its loss in neurons leads to reduced spine density and impaired synaptic plasticity.
Researchers developed a simple, inexpensive tool using robotics and artificial intelligence to analyze dried salt solutions from images. The method increases the accuracy of chemical analysis in scenarios where large samples are difficult to obtain, making it valuable for space exploration, law enforcement, and hospital use.
A team of researchers led by Tufts University's Charles Sykes has discovered a new process for producing ethylene oxide, which is widely used in plastics, textiles, and disinfectants. The new method reduces CO2 emissions and eliminates the need for toxic chlorine.
Researchers at Washington University in St. Louis are developing a new way to detect sulfur mustard, a highly toxic chemical warfare agent, using nucleic acid molecular recognition and dendrimers.
A new study explores how chemical mixtures transform under shifting environmental conditions, shedding light on prebiotic processes that may have led to life. The research finds that environmental factors played a key role in shaping the molecular complexity needed for life to emerge.
A team developed a semiconductor sensor to visualize biomolecule dynamics in solutions, achieving milliseconds time resolution and micron spatial resolution. The sensor captures movement of neurotransmitters and ions, enabling the detection of chemical signals in microscopic regions.
Researchers at UC Davis created nanoislands with trapped platinum clusters, demonstrating improved hydrogenation catalytic activity and stability. The confinement of metal clusters on a tiny island of cerium oxide supports the production of stable catalysts for the chemical industry.
Southwest Research Institute's Risk Evaluation & Medical Decision Efficacy (REMEDY) tool supports agile medical decisions on countermeasures for chemical and biological threats. The REMEDY mission risk evaluations quantify risks and benefits of medical countermeasures, enabling operational planners to make informed decisions.
The 'MarginCall' project aims to create a fully integrated system for real-time, highly accurate assessments of surgical margins during cancer surgeries, reducing the likelihood of cancerous cells being left behind. This approach promises to be faster and more cost-effective than existing techniques.
Mayo Clinic's Digital Pathology platform is transforming pathology by leveraging large datasets and AI models for faster, more accurate diagnoses. The partnership with NVIDIA and Aignostics aims to improve patient care and accelerate medical breakthroughs.
Researchers develop a novel method to simplify chemical modification of ketones and esters, unlocking their potential for faster and more sustainable chemical production. This breakthrough has implications for pharmaceutical innovation, materials science, agrochemicals, and everyday items.
A study found that standard medical reports are often difficult for patients to understand, leading to increased worry. In contrast, patient-centered pathology reports provide clear and concise information, improving patient comprehension and reducing anxiety.
Most study participants struggled to understand standard prostate cancer pathology reports, but found patient-centered reports easier to comprehend. PCPRs reduced perceived worry in low-risk conditions compared to traditional reports, suggesting their inclusion could enhance patient care.
Alzheimer's disease is characterized by amyloid plaques and neurofibrillary tangles, with genetic predispositions and aging contributing to its development. Early intervention and biomarkers are crucial for diagnosis and treatment.
A team of researchers at TIFR Hyderabad has devised a strategy to enhance control over the separation of chemical isomers using a nanoporous metal-organic framework. This approach enables fine-tuning of molecular interactions and diffusion processes, allowing for more efficient and sustainable separation methods.
Researchers have discovered a specific type of body fat linked to abnormal proteins in the brain that are hallmarks of Alzheimer's disease. Higher levels of visceral fat were found to be associated with increased amyloid accumulation and higher PET levels of hallmark pathologic proteins.
Case Western Reserve University has received a $1.5 million grant to study vaginal bacterial infections, which are linked to preterm birth, gynecological malignancies, and sexually transmitted diseases. The researchers aim to identify effective treatments and prevent recurrences.
Researchers at WashU Medicine engineered a probiotic that delivers immunotherapy directly to the gut, shrinking tumors in mice. The probiotic uses a yeast-based system to produce immune checkpoint inhibitors, potentially treating hard-to-reach cancers.
The University of Chicago's MOSAIC Center aims to visualize chemical reactions in real-time at the single-atom level, enabling breakthroughs in catalysis, energy storage, and material development. The center harnesses cutting-edge technologies like Graphene Liquid Cells to unlock secrets about reaction mechanisms.
The Association for Molecular Pathology has published a joint consensus report on SARS-CoV-2 genomic surveillance, outlining key considerations for next-generation sequencing methods. The report provides guidance on pre-analytical, analytical, and post-analytical aspects of NGS-based surveillance programs.
Researchers at Tel Aviv University discovered a variant of TMEM16F protein that enhances the spread of Parkinson's pathology, potentially leading to new treatments. The study found that cells with the mutation secrete more pathological α-synuclein, which can form Lewy bodies and damage brain cells.
Researchers identified a protein in mammals that welcomes arteriviruses into host cells to start an infection. The team also found that an existing monoclonal antibody protects cells from viral infection, providing potential therapeutic strategy.