Articles tagged with Hyperglycemia
Cancer cells' ability to evade the immune system is linked to changes in their surrounding environment, including nearby nutrients and conditions. Researchers discovered that altering these factors can thin the cancer cell's protective sugar coating, allowing the immune system to recognize and eliminate them.
A ketogenic diet reduced high blood sugar and improved aerobic capacity in mice with hyperglycemia. The diet caused remodeling of their muscles, making them more oxidative and reactive to aerobic exercise. Researchers believe that combining the keto diet with exercise may be key to achieving optimal health benefits.
Researchers from The University of Osaka found that blood sugar migration to saliva in individuals with type 2 diabetes causes an imbalance in the oral microbiome, leading to cavity development. Improved glycemic control reduces this imbalance and the risk of tooth decay.
A new study from UC San Diego found that clinical pharmacists can play a crucial role in helping people with cancer and diabetes better manage their blood sugar. The study showed that patients referred to a diabetes management and education clinic led by pharmacists saw meaningful improvements in blood sugar levels over time.
A recent study published in Diabetes Care found that persistently high blood sugar and insulin resistance significantly increased the risk of worsening functional and structural heart damage during adolescence to young adulthood. The study showed a five-fold increase in prediabetes prevalence among adolescents, with females being dispr...
A new study by UNLV researchers finds that diabetes weakens the anterior cingulate cortex, suppressing reward perception and memory signals, leading to mild cognitive impairment. The connection between high blood sugar levels and Alzheimer's disease may be linked to altered hippocampal theta synchrony.
The INHALE-3 extension study found that a regimen of inhaled technosphere insulin and insulin degludec reduced post-meal hyperglycemia in adults with type 1 diabetes. The treatment showed significant improvements in mean time in range, with 43% of participants expressing interest in continuing the regimen.
A new study found that birds have lower cancer rates despite high blood sugar levels, challenging existing assumptions. The research suggests that some species have evolved natural biological defenses against cancer, which could inspire new approaches to prevention and treatment in humans.
A large-scale comparative study reveals that some birds have evolved mechanisms to resist protein glycation, a process causing cellular damage from high blood sugar levels. This challenges conventional wisdom on metabolism and ageing in birds.
Researchers from Brazil's Center for Research on Redox Processes in Biomedicine found that high blood sugar can cause thrombosis by altering endothelial function and promoting platelet adhesion. They identified a specific molecular mechanism involving protein disulfide isomerase A1 as a key regulator of this process.
A study published in Cardiovascular Diabetology found that higher blood glucose levels at admission significantly increase the risk of a poor functional prognosis or death within three months of an ischemic stroke. The study revealed that even a 10% increase in glucose levels raises the risk by 7%, and mortality risk by 88%.
A recent study from the Women's Health Initiative found that both obesity and metabolic syndrome increase breast cancer risk, but in distinct ways for different subtypes. The research highlights the importance of controlling waist circumference and metabolic conditions to reduce breast cancer risk.
The Global Burden of Diseases study reveals a 49.4% increase in global disability-adjusted life years (DALYs) attributable to metabolism-related risk factors between 2000 and 2021. High blood pressure, high blood sugar, and high BMI are key contributors to poor health and early death.
Researchers have discovered a repurposed cancer drug that can convert acinar cells into insulin-producing cells, which could provide a new avenue for treating diabetes. The treatment partially improved hyperglycemia and persisted without additional treatment in diabetic mice and non-human primates.
Research reveals that FoxO6 upregulates ApoC3, leading to increased lipid accumulation and liver damage in aged rats on a high-fat diet. The study suggests that targeting this pathway may offer therapeutic strategies against hepatic steatosis.
A pilot study found that personalized dietary advice based on genetic information reduced blood glucose levels more effectively than standard coaching. The study suggests genetically-informed diets could be an effective intervention for preventing type 2 diabetes.
A Northwestern University study found that nearly two-thirds of patients discontinue or change their medication within a year, highlighting the need for better understanding of barriers to treatment adherence. The high discontinuation rate for GLP-1 RAs may be due to gastrointestinal side effects.
Researchers developed a low-cost anti-inflammatory hydrogel containing annexin A1 that accelerated complete skin wound healing in mice with induced type 1 diabetes. The hydrogel modulated the wound microenvironment and favored tissue regeneration, reducing inflammation and improving blood vessel formation.
A study found that 80.3% of patients with metastatic breast cancer who received standard care treatment with alpelisib developed hyperglycemia, with 40.2% experiencing serious hyperglycemia. Lifestyle interventions and medication may help improve blood sugar levels and reduce the risk of needing to discontinue the drug.
Researchers at UC Berkeley discovered that deep-sleep brain waves can regulate the body's sensitivity to insulin, improving blood sugar control. The study found that synchronized brain waves during deep sleep predict next-day glucose control, even after controlling for other factors.
Children and teenagers with diabetes frequently employ inaccurate CGM alarm settings, which may lead to reduced usefulness of these devices. Research highlights the importance of following recommended alarm best practices to ensure patients receive real-time glycemic data while minimizing alarm fatigue.
A novel treatment involving ACE2-producing probiotic Lactobacillus paracasei may prevent or reverse diabetic retinopathy in Type 1 diabetes patients. The study found that human subjects with retinopathy had a dysregulated systemic RAS and profound gut permeability defects, which were reversed by the probiotic treatment.
A new study uses machine learning to predict poor glycemic control in patients with type 2 diabetes, identifying key factors such as prior glucose levels and anti-diabetic medicines. The findings suggest that data routinely collected for diabetes monitoring can reliably identify patients at risk of hyperglycemia.
Researchers discovered that MODY3 patients experience hypersecretion of insulin from β cells due to more efficient membrane depolarization. This phenomenon precedes pancreatic β cell failure and can be targeted for prevention or delay with treatments, such as diets or drugs.
Over three decades, glycemic control stagnated among US adults with diabetes, exacerbating racial and ethnic disparities. Improved insulin access may optimize glycemic control and reduce disparities in this population.
A new study suggests that human retinal endothelial cells have a protective system against hyperglycemia, which delays the onset of diabetic retinopathy. Prolonged exposure to high glucose actually promotes cell recovery and resistance to damage.
Researchers found that knocking out TXNIP in alpha cells improves diabetes-associated hyperglycemia and hyperglucagonemia. This discovery suggests a new potential treatment for Type 1 diabetes.
A Brazilian study analyzed risk factors for heart attacks and found that high blood sugar had the most significant impact on mortality. Reducing smoking prevented most deaths from cardiovascular disease, while lowering diabetes incidence could have saved up to 5,000 lives over a decade.
A meta-analysis of over 30,000 UK adults found that a higher pre-pandemic BMI was associated with a greater risk of COVID-19 infection and long COVID. The study suggests that obesity-related mechanisms may be responsible for the excess risks, rather than high blood sugar levels.
A study from Linköping University shows that individuals with type 1 diabetes should keep their mean long-term sugar level below 53 mmol/mol (7.0%) to avoid serious damage. The risk of eye- and kidney complications increases as the level increases.
People with diabetes face higher risk of hospitalization during extreme heat events due to dehydration and blood glucose imbalance. Research reveals a link between extreme heat and emergency hospitalizations for hypo- and hyperglycemia-related conditions.
A recent study published in PLOS Medicine found that having a parent with type 1 diabetes may be linked to lower school performance in children. The research involved over 622,000 Danish children and suggested a negative association between parental type 1 diabetes and cognitive development.
A new study suggests that glucose-lowering medications can restore aerobic exercise capacity in people with high blood sugar. The research, published in the journal Diabetes, found that combining a medication like canagliflozin with exercise training may improve exercise response in individuals with diabetes.
A team from UNIGE demonstrates that stem cells giving rise to beta cells cease to exist after birth, and defines the 'identity card' of other hormone-producing cells. This discovery has significant implications for developing cell-based therapies to treat diabetes.
A new study from Brigham and Women's Hospital identified the activation of PIEZO1 as a key trigger for thrombosis in patients with type 2 diabetes. Inhibiting PIEZO1 prevented clot formation, suggesting its potential as a therapeutic target for preventing thrombosis.
Researchers found that COVID-19 patients with high blood sugar levels were more likely to develop severe lung dysfunction, require mechanical ventilation, and die. The study also suggests that SARS-CoV-2 may disrupt fat cells' production of adiponectin, a hormone regulating blood sugar levels.
A study published in Communications Biology reveals that chronic hyperglycemia in diabetes impairs working memory performance by altering the connection between key brain regions. Researchers found that areas critical for forming and retrieving memories were over-connected, leading to errors in remembering correct information.
Researchers developed an experimental device to improve blood sugar control in HI patients. The bihormonal bionic pancreas (BHBP) helps maintain stable glucose levels without human error in calculating doses.
A synthetic hinge concept developed by Indiana University School of Medicine Professor Michael A. Weiss and his team could lead to a breakthrough in 'smart' insulin therapy. The invention exploits a natural mechanism that allows the insulin to adjust its activity based on blood glucose levels, which could transform diabetes care.
Researchers found that people with low blood sugar events had a 75% greater risk of developing dementia, while those with high blood sugar events had more than twice the risk. People experiencing both types of events faced the greatest risk, with an incidence rate of 98.5 cases for every 1,000 person-years
Hospitalized COVID-19 patients with high blood sugar are more likely to require aggressive therapies and experience kidney injury, according to a new study. Patients with diabetes have a higher risk of ICU admission and in-hospital death when their blood glucose levels exceed certain thresholds.
A new study finds that hearing loss and high blood sugar are associated with poor cognitive performance among middle-aged and older Latinos. The research, published in JAMA Otolaryngology-Head & Neck Surgery, suggests that evidence-based interventions, such as hearing aid use, may help mitigate this risk.
Researchers developed an algorithm to monitor high blood sugar in COVID-19 patients, reducing secondary infections and kidney issues. The tool identifies risk categories based on hyperglycemia severity, insulin resistance and inflammatory markers.
A non-fasting blood test, hemoglobin A1c (HbA1c), can accurately identify youth at risk for type 2 diabetes and heart disease. The study suggests using HbA1c more frequently to screen youth for diabetes and related health risks.
Scientists at Joslin Diabetes Center discovered that increased blood sugar levels can impair aerobic fitness and muscle adaptation in mice and humans. Despite this, regular aerobic exercise is still recommended for maintaining health, especially when combined with dietary changes.
A study found that abnormally high blood sugar in COVID-19 patients without a previous diabetes diagnosis increases the risk of death and severe complications. The study also showed that men are at a higher risk of dying than women, and that patients with more severe pneumonia have a higher risk of death.
A new NIH-funded study suggests that standard treatment of blood sugar levels after acute ischemic stroke is more effective than aggressive methods in improving patient outcomes. The study found that intensive glucose management increased the risk of hypoglycemia and required higher levels of care.
A large clinical study found that intensive glucose management after stroke did not improve functional outcomes and increased the risk of low blood sugar. The results provide a clear answer to the long-held debate on blood sugar control after stroke.
Research suggests that maternal hyperglycemia is a primary teratogen in all forms of diabetes, causing birth defects through dysregulation of epigenetic processes and oxidative stress. The study highlights the importance of understanding the gene-environment interactions involved in fetal heart development.
A new study found that whole grain breads, once thought healthier, may not have a significant impact on blood sugar levels. The researchers discovered that an individual's unique microbiome plays a crucial role in how their body responds to different types of bread.
A recent study found that high blood sugar following leg surgery is common and associated with poorer outcomes, including increased infection rates, hospital stays, and mortality. Patients without diabetes were also at a higher risk of complications, highlighting the importance of glucose management in surgical interventions.
Hyperglycemia triggers platelet production through the RAGE pathway, increasing atherosclerosis risk in diabetes. A study found that blocking RAGE receptor signaling reduced platelet production and atherogenesis.
A study of over 3,000 families affected by mid-20th Century China's widespread starvation found that prenatal famine exposure was associated with significantly higher odds of hyperglycemia and type 2 diabetes in both the mother and her children. The risk persisted even when only one parent had been exposed to famine.
A novel cellular membrane protein called TSPAN2 has been identified as a key player in beta-cell apoptosis. The study suggests that targeting TSPAN2 could become a new treatment strategy for type 2 diabetes.
A study published in the Journal of the American Osteopathic Association found that a common blood test can detect hidden diabetes in hospitalized patients with hyperglycemia. The HbA1C test was used to diagnose diabetes in 31 patients, and 77% had results consistent with diabetes diagnosis.
Researchers found that high blood sugar molecules can weaken the body's natural defenses against infections. Dicarbonyls, breakdown products of glucose, interfere with antimicrobial peptides that fight inflammation and infection. This discovery could contribute to developing new treatments for people with uncontrolled diabetes.
Researchers found that chronic high blood sugar disrupts mitochondria activity by altering levels of O-GlcNAc transferase and removal enzymes. This leads to less efficient energy production, increased heat and damaging molecules, and further elevates blood sugar.
A newly discovered protein called HKDC1 may be a genetic predictor for gestational hyperglycemia and its long-term health effects. The enzyme appears during pregnancy in women with less of the gene, which could lead to a predictive test and potential therapeutic targets.
Researchers at Wayne State University are investigating grape skin extract as a potential treatment for type 2 diabetes. The study aims to understand the novel inhibitory activity of GSE on postprandial hyperglycemia, with hopes of developing a safe and targeted nutritional intervention.
Researchers found that patients with a GCK mutation had a low prevalence of microvascular and macrovascular complications, despite decades of isolated hyperglycemia. The study included 99 carriers of the mutation, 91 control relatives, and 83 individuals with young-onset type 2 diabetes.