Articles tagged with Psoriasis
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Researchers discovered that a gene called ZNF750, active in skin cells, is essential for supporting Langerhans cells and building the body's first line of immune defense. The study found that ZNF750 controls the production of IL-34, a molecule released by skin cells that acts as a survival signal for Langerhans cells.
A study reports on the underdiagnosis of 'topical steroid withdrawal syndrome' (TSW), a condition triggered by sudden or tapered use of steroid creams for inflammatory skin conditions. TSW can lead to severe symptoms, including skin reddening, burning, itching, and systemic problems like insomnia and depression.
Researchers have identified a potential biomarker for targeted psoriasis therapy by discovering the link between fat metabolism and skin inflammation. FABP5 drives ferroptosis, amplifying inflammatory processes in the skin, which can be blocked to improve skin changes associated with psoriasis.
Two first-in-class antibodies, C01 and C04, have been developed to inhibit inflammation in autoimmune diseases by blocking the high-affinity IgG receptor FcγRI. The antibodies were discovered using a unique immunization method and exhibit higher affinity for FcγRI than human IgG.
Scientists have discovered that immune cells shed their glycocalyx layer to move into tissues, changing the understanding of inflammatory skin diseases like psoriasis. This finding may lead to new approaches in developing drugs targeting immune cell movement and treating infections and inflammatory diseases.
Longitudinal research found that severe stress caused by family structure changes like divorce or separation during infancy triples the risk of developing psoriasis. The study, published in Journal of Investigative Dermatology, emphasizes the need to protect young children from stressful life factors.
New research finds that GLP-1 receptor agonists (GLP-1RAs) significantly reduce the risk of death and major cardiovascular events in psoriasis patients. GLP-1RAs also show promise in reducing alcohol and substance abuse, with a 65% lower risk of alcohol abuse.
A recent study has found that people with psoriasis are at a significantly higher risk of developing AMD, including both exudative and non-exudative forms. The study suggests that biologic therapies may offer protective benefits for individuals with psoriasis.
Scientists have developed a monoclonal antibody to combat life-threatening inflammatory diseases like sepsis and ARDS. The antibody shows promise in blocking the immune system's hyperactive response and restoring healthy function without unwanted side effects.
A research team at Nanjing University of Chinese Medicine discovered that plant-derived extracellular vesicles can deliver miRNAs across kingdoms to treat psoriasis. The researchers isolated perilla leaf-derived extracellular vesicle-like particles, which demonstrated potent antioxidant and anti-inflammatory activity.
Researchers found that central body fat, especially around the abdomen, is a stronger link to psoriasis risk than total body fat. This association remained consistent regardless of genetic predisposition, suggesting abdominal fat as an independent risk factor.
Researchers found that residual inflammation in psoriasis patients is linked to obesity, metabolic dysfunction, and increased systemic inflammation. This study suggests that despite good skin response to biologics, patients may still exhibit broader health implications, such as cardiovascular disease and fatty liver disease.
Researchers at the University of Birmingham have identified a three-amino acid sequence that reduces psoriasis severity, comparable to steroid cream. The study found that topical application resulted in a clear reduction in disease and was confirmed using Psoriasis Area and Severity Index scoring.
A new study from the University of Bath reveals that delays in diagnosing and treating psoriatic arthritis often result in irreparable damage to joints. Early diagnosis and effective treatment can prevent this damage and improve physical function and quality of life for patients with PsA.
New guidelines support safe and efficient use of JAK inhibitors for treating chronic inflammatory diseases like rheumatoid arthritis, psoriasis, and Crohn's disease. The updated consensus statement considers safety concerns, including cardiovascular disease and cancer risk, to ensure individualized treatment decisions.
Researchers have identified a new starting point for therapy by targeting SSAT enzyme in psoriasis, restoring regulatory T cell function and breaking inflammation cycle. This approach could lead to a promising alternative treatment option with fewer side effects.
A study by King's College London found that a diet high in plant-based foods and low in saturated fats may help reduce psoriasis severity. Individuals with lower adherence to the DASH dietary pattern were more likely to report higher psoriasis severity, while those consuming more fruits, nuts, and legumes had less severe symptoms.
Researchers from Aarhus University have developed a method to track disease progression in patients with autoimmune diseases. The new method identifies large immuno-active complexes and can be measured in parallel, increasing capacity and reducing the need for training new staff or investing in equipment.
A new compound, MRS7787, has been shown to treat psoriasis in an animal model with anti-inflammatory effects. The therapy is activated by blue light and opens new avenues for multimodal treatment, especially for treatment-resistant cases.
Researchers at Case Western Reserve University have identified a protein called NF-kB c-Rel as intensifying psoriasis symptoms when activated by immune signals. The study found that c-Rel plays a major role in psoriasis inflammation and that its absence alleviates skin inflammation.
Researchers at Uppsala University found that people with psoriasis have invisible inflammation in their small intestine, which can lead to gastrointestinal problems and an increased risk of developing Crohn's disease. Half of the study participants had a leaky gut, allowing bacteria and harmful substances to leak through the intestinal...
A recent study published in Helion found that individuals who experienced childhood abuse, neglect, or domestic abuse were at a significantly higher risk of developing rheumatoid arthritis and psoriasis. The study used a database of over 16 million Electronic Health Records to analyze the incidence rates of these diseases over a 26-yea...
Researchers found a significant association between ultraprocessed food intake and active psoriasis status. High consumption of these foods was shown to have a proinflammatory effect separate from high BMI.
Developed by University of Copenhagen researchers, a new nanofiber patch reduces psoriasis treatment frequency to once a day, improving comfort for patients. The patch releases two active ingredients at different rates, addressing the need for multiple products in psoriasis treatment.
A team of researchers, including Binghamton University's Ahyeon Koh, is working on an innovative project to treat inflammatory bowel diseases like Crohn's and ulcerative colitis. The goal is to create a 'cell factory' in the body that can produce pharmaceuticals to alleviate symptoms.
A study found MALDI-TOF mass spectrometry to be highly sensitive and specific for diagnosing onychomycosis in patients with nail psoriasis, distinguishing it from nail psoriasis without infection. The technique's accuracy was comparable to conventional methods, making it a promising tool for clinical diagnosis.
Researchers at UC San Diego School of Medicine identified ZNF750 as a key player in controlling inflammation, shedding light on susceptibility to inflammatory skin diseases. The study paves the way for more effective therapies and broader insights into molecular biology of skin cells.
Researchers have provided compelling evidence that perceived stress can directly trigger the relapse of psoriatic skin lesions. The study used a humanized mouse model to show that sonic stress led to a relapse in all psoriasis lesions within 14 days, accompanied by increased inflammation and immune activation.
A new study suggests the hormone hepcidin may trigger psoriasis by causing iron overload in the skin. This excess iron amplifies the damaging effects of UV sunlight, leading to hyperproliferative chronic diseases like psoriasis. A potential treatment targeting hepcidin could improve treatment options for millions.
A randomized clinical trial found home-based phototherapy to be as effective as office-based treatment for plaque and guttate psoriasis, while reducing patient burden. The study suggests that this approach could become a viable option for everyday clinical practice.
A large-scale study investigated the relationship between childhood obesity and immune-mediated skin diseases (IMSDs), such as atopic dermatitis and psoriasis. The study found that obese children were more likely to develop these conditions, with changes in body weight affecting their risk of developing these diseases.
Researchers have identified a crucial molecular signaling pathway in maintaining the skin barrier, which could lead to new treatments for inflammatory skin diseases. The study's findings also suggest that this pathway may contribute to certain types of cancer.
A large register-based study found that young adults with low stress resilience are more likely to develop psoriasis later in life. The study, based on data from over 1.6 million Swedish men, showed a significant link between stress resilience and the risk of developing severe cases of psoriasis.
A new study finds that the interleukin-17 pathway activates hypoxia-inducible factor 1-alpha in psoriasis, leading to increased sugar breakdown and lactate production. Blocking this pathway with an experimental drug may offer a new treatment option for inflammatory skin diseases.
A new Northwestern Medicine study reveals that 73% of children with skin diseases face stigma and bullying, leading to impaired relationships and mental health issues such as depression and anxiety. The study suggests that clinicians should aggressively treat skin disorders in children and consider referral to evaluation and counseling.
A study from the University of Gothenburg found that patient images are severely lacking in scientific articles on atopic dermatitis. This lack of visual aids hinders patients' ability to make informed decisions about their care, as they struggle to understand complex medical terminology and figures. The absence of images also affects ...
A team of researchers from the Australian National University has identified a gene mutation responsible for causing psoriasis, which can also lead to psoriatic arthritis. The discovery could improve diagnosis and treatment for patients with these conditions, reducing stigma in the community.
Researchers developed a scoring system to distinguish between two serious skin diseases with similar symptoms. The study analyzed data from 117 patients and found the scoring system could help medical professionals quickly diagnose and choose appropriate treatment.
Researchers have discovered two genetic variants associated with generalized pustular psoriasis (GPP), a rare and serious condition characterized by widespread skin lesions and inflammation. These variants, found in the MEFV gene, may hold promise for new diagnostic and therapeutic approaches to GPP.
A study published in Lancet eClinical Health found pregnancy outcomes for pregnant individuals with autoimmune disease vary greatly depending on the specific condition and individual factors. Research highlights the importance of considering comorbidities when discussing autoimmune disease and pregnancy.
Women with autoimmune disease are 30% more likely to experience perinatal depression, while those with perinatal depression have a 30% higher risk of developing an autoimmune disease. The strongest association is seen with multiple sclerosis.
Researchers discovered distinct mechanisms controlling different types of immune cells and found a way to selectively eliminate 'problematic' cells driving autoimmune disorders. This breakthrough offers precise targets for potential treatment strategies, potentially revolutionizing the way we treat skin conditions.
A systematic review found that only 203 images of 60 patients were included in 152 studies on psoriasis treatment outcomes over 20 years. The low image sharing rate complicates patient understanding and highlights the need for more clinical images.
Researchers sequenced skin samples from people with psoriasis and found minimal differences in mutation types between affected and unaffected skin tissue. Driver mutations were identified, but their impact on the development of psoriasis is unclear.
A large study published in Journal of Investigative Dermatology found that patients with severe psoriasis have a high prevalence of coronary microvascular dysfunction, which is associated with increased cardiovascular risk. Psoriasis severity and duration, as well as the presence of psoriatic arthritis, are independently linked to redu...
A new tool called PRESTO identifies patients with psoriasis at high risk of developing psoriatic arthritis. The tool uses a mathematical model to estimate a patient's risk based on factors such as age, sex, family history, and disease severity.
A large study found a significant link between vitamin D levels and psoriasis severity, with lower levels associated with greater severity. The research suggests that a vitamin D-rich diet or oral supplementation may provide benefits for individuals with psoriasis.
Researchers mapped inflammation features in skin cells, revealing their role in spreading to joints and triggering conditions like diabetes and heart disease. The study's findings may help explain how small skin inflammation can affect the entire body.
Researchers at Salk Institute discover that mechanical and chemical itch sensations are encoded by different brain pathways, which act together to drive chronic itch. The study reveals key molecules regulating these pathways and opens avenues for new therapies.
A study by University of Gothenburg researchers found a significant association between methotrexate use and an increased risk of basal cell carcinoma, squamous cell carcinoma, and cutaneous malignant melanoma. The study suggests that higher doses of methotrexate may increase the risk of SCC and BCC, while no dose-response relationship...
A common fatty acid found in the Western diet contributes to increased temperature and pain sensitivity in psoriatic lesions. The findings could lead to improved pain treatments for psoriasis patients.
Scientists from Trinity College Dublin discovered that Interleukin-37 activates the immune system, contrary to earlier theories. This finding has significant implications for understanding and treating autoimmune disorders and inflammation.
A study found that in people with significant kidney disease, psoriasis does not increase the risk of heart attack. After controlling for other risk factors, researchers found no association between psoriasis and heart attacks in patients with end-stage renal disease.
A UC Riverside-led study found that acute THS exposure initiates mechanisms of inflammatory skin disease and elevates urinary biomarkers of oxidative harm. The researchers discovered elevated molecular biomarkers in blood associated with early-stage activation of contact dermatitis, psoriasis, and other skin conditions.
Researchers explored how differences in skin composition affect susceptibility to diseases like psoriasis and atopic dermatitis. The study found that body site determines skin structure and function, with specific lipids and proteins playing a crucial role in disease diagnosis.
A new study published in the Journal of the American Heart Association found that individuals with autoimmune diseases are at a higher risk of complications after a heart attack. The research emphasizes the importance of controlling cardiovascular disease risk factors and developing personalized treatment plans for this population.
Researchers found that lidocaine injections reduced Psoriasis Area and Severity Index scores by 35-70% and maintained improvements for at least 24 weeks. The study suggests targeting sensory nerves as a potential therapeutic strategy for psoriasis treatment.
A survey study published in JAMA Dermatology found that Asian patients with psoriasis spend significantly less face-to-face time with dermatologists compared to patients of other races and ethnicities. The study highlights the need for improved healthcare access and cultural competence in dermatology care.
Researchers at Medical University of Vienna discovered that inhibiting the S100A9 systemically can reduce psoriasis severity, paving the way for a paradigm shift in treatment. The study also highlights the importance of modulating neutrophil infiltration and its impact on skin and joint disease.
Research at Kyoto University found that estradiol suppresses severe skin inflammation in females compared to males, revealing its therapeutic potential. The hormone regulates immune cells and reduces IL-17A and IL-1β cytokines production.