Articles tagged with Cancer Genetics
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The updated guidelines provide a unified framework for evaluating residual viable tumor, necrosis, and regression after presurgical treatment. The new criteria demonstrate high reproducibility across different tumor types and pathologists, providing a foundation for standardized data collection and improved patient care.
Cancer researchers have identified a key mechanism by which cancer cells protect themselves from the immune system. The study found that MYC protein can bind to RNA molecules, eliminating alarm signals that would activate the immune defense.
Researchers from The University of Osaka discovered that loss of heterochromatin can trigger genetic changes leading to chromosomal rearrangements and diseases like cancer. Accumulation of R-loops at pericentromeric repeats was found to be a key mechanism in this process.
Researchers identified specific microbial patterns associated with tumor location, genetic features, and patient outcomes. A new Microbial Risk Score (MRS) offers a practical way to translate complex microbiome data into prognostic insight.
A recent study published in Gut journal revealed that Streptococcus anginosus produces methionine metabolites, which significantly contribute to the development of gastric cancer. The research opens new paths for microbiota-targeted prevention strategies.
Early gastric cancer cells become self-sufficient by producing WNT7B, creating a self-sustaining loop and activating WNT signaling internally. This mechanism is triggered by MAPK signaling activation and has been validated in genetically engineered mouse models and human patient-derived organoids.
A recent review suggests that Clostridioides difficile infection may promote the development of gastrointestinal tumors, including colorectal cancer. The bacterium's toxins can cause damage to the epithelial cytoskeleton and induce inflammation, leading to chronic colitis and increased risk of CRC.
A blood test may help doctors identify which patients with colon cancer can benefit from anti-inflammatory medication and chemotherapy after surgery. The test measures circulating tumor DNA levels, and high-risk patients who test positive see improved survival rates when taking celecoxib with chemotherapy.
A NIH-led study identified key factors driving tumor evolution and influence outcomes in lung cancer, revealing a previously unknown origin of aggressive tumors associated with the ID2 mutational signature linked to LINE-1 reactivation. Major driver gene mutations also influenced tumor evolutionary trajectories.
The MUTE-Seq method detects rare cancer mutations at exceptionally low frequencies, enriching circulating tumor DNA and improving detection accuracy. It increases variant allele frequencies by tens of times, enabling detection of mutations present at 0.005% or lower.
Researchers at MD Anderson have made significant discoveries in the treatment of rare bile duct cancers, with zanidatamab showing promising results. Additionally, a study identified RASH3D19 as a target to overcome treatment resistance in KRAS-mutant cancers.
Researchers at UC Riverside and City of Hope have developed a novel Pin1 degrading compound that suppresses pancreatic cancer peritoneal metastases. The treatment targets not only cancer cells but also tumor-supporting cells, potentially overcoming treatment resistance.
Scientists uncover a previously unknown function of the enzyme NUDT5, which acts as a molecular scaffold to control purine synthesis and DNA replication. This discovery sheds light on why some patients respond better to long-used cancer drugs.
Up to 17 million people in the US, approximately 5%, carry genetic mutations associated with cancer risk. The study highlights the importance of routine cancer screenings and suggests expanding genetic testing beyond high-risk groups.
A new Alliance trial is exploring the effectiveness of a combination of targeted therapy and immunotherapy for patients with advanced adrenocortical carcinoma, a rare and aggressive cancer. The study aims to improve disease control and quality of life for patients with limited treatment options.
Researchers found that smoking and biological sex shape how normal cells evolve in healthy bladder tissue, with certain mutations gaining an advantage to expand into clones. This study offers new insights into cancer risk and prevention by providing a way to understand tissue evolution and identify early warning signs.
The NCCN Guidelines Navigator now covers treatment for over a dozen cancer types, including hereditary risk assessment, providing seamless navigation and search capabilities. The new format aims to improve treatment decision-making based on the latest evidence and expert-consensus.
The 2025 NFCR Global Summit will convene world-renowned experts in cancer research, entrepreneurship, and patient care. Keynote speakers include Monica Bertagnolli, Webster K. Cavenee, Lisa Coussens, Ronald DePinho, and Tony Hunter.
Head and neck cancer's intricate connection between energy metabolism and immune regulation holds potential for effective therapies. Tumor cells' metabolic reprogramming fuels growth and supports invasion, while altering glucose transporters and lipid metabolism promotes immune evasion.
Natural compounds normalize tumor vasculature, inhibiting pathological angiogenesis and reducing tumor growth. These agents complement conventional therapies, reduce toxicity, and enhance delivery of chemotherapeutic drugs.
Researchers have developed innovative strategies combining oncolytic viruses with immunotherapies to overcome limitations of OV monotherapy. These synergistic treatments amplify the body's natural defenses, creating a powerful dual attack against cancer cells while minimizing adverse effects.
The in vivo approach eliminates laboratory manipulation, leveraging viral and nonviral vectors for genetic modification of T cells. This method preserves T cell functionality, enhancing therapeutic efficacy compared to in vitro-produced CAR T cells.
The Molecular Analysis for Precision Oncology Congress 2025 (MAP) brings together leading experts to explore the latest cancer research advances. Key topics include AI-integrated diagnostics and therapy, as well as immunotherapy and emerging developments in aging and cellular senescence.
Researchers identified three distinct molecular subtypes of follicular lymphoma, offering insights into personalized treatment plans. The subtypes C1, C2, and C3 differ in their genetic profiles and tumor microenvironments, guiding the use of specific therapies.
Chitinase-3-like protein 1 (CHI3L1) is recognized for its unique ability to influence multiple pathophysiological processes, despite lacking enzymatic activity. Elevated levels of CHI3L1 correlate with fibrosis severity and demonstrate superior diagnostic efficacy compared to conventional markers.
Researchers at WashU Medicine found that clonal hematopoiesis, a condition caused by mutated blood stem cells, is more common among individuals with inherited mutations that increase cancer risk. Those with inherited mutations had a higher risk of developing blood cancer if their stem cell clones acquired additional harmful mutations.
SOX2 is crucial in tumor growth, spread, and resistance to therapy, influencing cell proliferation, apoptosis resistance, and EMT. Elevated SOX2 levels are associated with poor prognosis and enable cancer cells to adapt to therapeutic pressure.
Advances in NGS have revealed non-coding regions' role in gene regulation and disease etiology. Targeting non-coding elements implicated in disease may lead to tailored therapies.
This review article explores the complexities of tumor angiogenesis and endothelial cell origins, highlighting the diverse sources and mechanisms of endothelial cell development in tumors. The study outlines the dysregulation and heterogeneity of tumor blood vessels, complicating the development of effective therapies.
Research reveals that gut microbiota imbalances can contribute to cardiac dysfunction, inflammation, and metabolic disturbances in heart failure. Dietary interventions, probiotics, and fecal microbiota transplantation may offer innovative approaches for managing heart failure.
Researchers explore the potential of boosting mitochondrial biogenesis to alleviate acute kidney injury by targeting energy metabolism, stress resistance, and cell survival. Promising compounds like resveratrol and ZLN005 enhance mitochondrial function while minimizing toxicity.
The study reveals how genetic mutations in fucosyltransferases contribute to disease susceptibility, leading to inflammatory responses, barrier dysfunction, and increased cancer risk. Aberrant fucosylation is linked to conditions such as liver cirrhosis, hepatocellular carcinoma, pancreatic cancer progression, and gastric cancer.
ADAMTS2 plays a pivotal role in collagen maturation and is associated with Ehlers-Danlos syndrome, angiogenesis, lymphangiogenesis, neurodevelopment, immune regulation, and cardiovascular diseases. Its multifunctional nature positions it as a potential therapeutic target for treating genetic disorders, cancer, and cardiovascular diseases.
Researchers are exploring targeting ferroptosis, a regulated cell death process driven by iron accumulation and lipid peroxidation, as a novel strategy to overcome the challenge of cancer stem cells. This approach has shown promise in selectively inducing cell death in CSCs while sparing normal cells.
SETD2 plays a crucial role in regulating immune cell function, influencing tumorigenesis, development, differentiation, and function of immune cells. Targeting SETD2 could modulate immune cell functions, offering novel treatments for autoimmune diseases, inflammatory conditions, and hematological malignancies.
A new analysis suggests that preventive mastectomy is a cost-effective way to reduce the likelihood of developing breast cancer compared to breast screening and medication. Women aged 30 or above with a lifetime breast cancer risk of 35% or more may benefit from this treatment option.
A study published in iScience found that cells in breast tissues of women with African ancestry send cues promoting breast cancer growth. Researchers discovered that PZP cells activate epithelial cells, allowing them to invade surrounding tissue.
The National Institute of Standards and Technology (NIST) has released detailed genetic data about a pancreatic cancer cell, fostering progress in cancer research. The data can be used to research tumors, improve diagnostic tests, and develop new cancer treatments.
This issue of Acta Pharmaceutica Sinica B features research on intestinal aging, single-cell RNA sequencing, and cancer treatment. Articles explore therapeutic strategies for reducing frailty, inhibiting colorectal tumorigenesis, and developing preclinical candidates for acute liver injury.
A new study identifies EMP1 as a pivotal molecule driving pancreatic cancer progression and poor prognosis. EMP1 expression was shown to promote cell proliferation, migration, and invasion through the PI3K/AKT signaling pathway.
Researchers identify XPR1 as critical factor in promoting ovarian cancer aggressiveness through autophagy regulation and MHC-I expression. The study suggests targeting XPR1 alongside autophagy inhibition to improve immunotherapy outcomes in ovarian cancer.
Researchers explored clinical implications of loss-of-function IKBKG/NEMO mutations in the NF-κB signaling pathway. The study revealed diverse clinical manifestations associated with these mutations, including skin abnormalities, dental anomalies, and infections.
A recent study published in Genes & Diseases reveals the relationship between immune cell characteristics, blood metabolites, and urolithiasis. The research highlights how genetically predicted blood metabolites mediate the association between specific immune cell profiles and urinary stone formation.
Pyruvate alleviates ulcerative colitis symptoms by targeting cPLA2, suppressing TNFα/NFκB signaling and reducing inflammation. Pyruvate preserves intestinal mucosal barrier integrity and normalizes tight junction proteins.
Researchers have discovered that the down-regulation of YWHAB in ovarian cancer peritoneal metastasis cells promotes YAP signaling, enhancing chemotherapy resistance and maintaining stem-like characteristics. Targeting the YWHAB-YAP pathway may lead to innovative therapeutic strategies.
A landmark study found that the tumour immune microenvironment plays a critical role in the progression of nasopharyngeal carcinoma, paving the way for precision oncology approaches. The study discovered distinct molecular differences between NPC subtypes, which influence disease progression and treatment responsiveness.
A new study reveals that SETD1B plays a critical role in supporting the growth of aggressive acute myeloid leukemia (AML) cells, particularly in those with FLT3-ITD mutations. By targeting SETD1B, researchers believe it may be possible to develop more effective treatments.
Recent findings reveal TET1's dual role in disease progression, inhibiting malignant cell growth in certain cancers while driving oncogenic pathways in others. Abnormal TET1 activity disrupts epigenetic mechanisms, contributing to neurological disorders, metabolic diseases, and autoimmune conditions.
The review highlights the significance of fusion genes across various cancers, including hematological malignancies, lung cancer, thyroid cancer, and prostate cancer. Fusion genes disrupt normal cellular processes, leading to uncontrolled proliferation and metastatic potential.
The review highlights the indispensable value of model organisms in understanding disease pathogenesis, revealing conserved genetic pathways across species. This knowledge accelerates the identification of candidate disease genes and the testing of therapeutic strategies for rare genetic disorders.
Researchers uncover the crucial role of dermal T cell immunity in regulating hair follicle regeneration and addressing immune-mediated alopecia. The intricate relationship between T cells and hair follicle regeneration is driven by key regulatory signaling pathways that dictate the activity of epithelial stem cells.
LINE-1 elements, retrotransposons actively transcribed in zygotes, facilitate chromatin architecture opening and interact with epigenetic regulators to maintain genome stability. Understanding LINE-1 regulation could lead to novel therapeutic strategies in reproductive medicine and age-related disorders.
The tumor microenvironment in osteosarcoma plays a critical role in disease progression and treatment resistance. Targeting the interplay between cancer cells, immune components, stromal elements, and extracellular matrix is crucial for developing effective treatments.
Ribosome biogenesis is crucial for liver regeneration, hepatitis C virus infection, nonalcoholic fatty liver disease, liver fibrosis, cirrhosis, and hepatocellular carcinoma. Targeted therapies targeting ribosome biogenesis may offer new treatment options for chronic liver diseases and liver cancer.
PDX models accurately mimic human tumors, offering a powerful preclinical platform for testing novel therapies. These models have demonstrated significant promise in various types of cancer research.
A new study explains how the gene CDK12 drives high-grade serous tubo-ovarian carcinoma, a rare and aggressive form of ovarian cancer. Researchers discovered that inactivating CDK12 triggers an immune cell response and identified a partner gene, CDK13, as a target for a degrader or inhibitor.
Researchers have discovered a novel cell-clearance pathway linked to diseases such as Chediak-Higashi Syndrome, which affects immune system function. The study used CRISPR/Cas9 gene-editing technology and live imaging to characterize this pathway and identify key genes involved.
A study found significant gaps in testing for genetic cancer risk among patients with womb cancer, with less than half eligible receiving a blood test for Lynch syndrome. This can lead to delayed diagnosis and increased cancer risk, affecting not only the individual but also their family members.
The Dresden research team developed an autonomous AI agent for precision medicine that can process multimodal data and have reasoning capabilities. The AI agent reached correct clinical conclusions in 91% of cases and accurately cited relevant oncology guidelines in over 75% of its responses.
The ESMO Gynaecological Cancers Congress 2025 will convene in Vienna, Austria, from June 19-21, featuring novel data on immunotherapy combinations and emerging treatment strategies for rare gynaecological cancers. The congress will also explore innovative approaches using antibody-drug conjugates.