Articles tagged with Mitochondria
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Research found that widespread contaminants like mercury and certain PFAS compounds affect the function of mitochondria in wild seabirds, potentially undermining fitness. The study measured pollutant levels and mitochondrial function in Scopoli's shearwaters and connected diet to exposure through stable isotopes.
Cirrhotic cardiomyopathy involves structural, inflammatory, and metabolic pathologies. Inflammation and mitochondrial dysfunction promote cardiac damage, and the liver-heart axis highlights the impact of cirrhosis severity on cardiac health.
Researchers develop experimental drugs that encourage mitochondria in cells to work harder and burn more calories. The findings offer a framework for designing safe and effective weight-loss treatments with potential benefits for metabolic health and neurodegenerative diseases.
Researchers used long-read sequencing to analyze the nuclear genome of Amorphochlora amoebiformis, revealing an extremely high proportion of introns (74%) compared to other eukaryotic genomes. The study provides important insights into the evolutionary dynamics and potential functional roles of introns in eukaryotic genomes.
Proton therapy has been shown to provide a significant survival benefit for patients with head and neck cancers. In another study, researchers have identified a promising target for treating pancreatic cancer by inhibiting the mitochondrial enzyme GFER. Additionally, diagnostic breast MRI may be unnecessary for some patients with early...
Researchers at MD Anderson Cancer Center have found that inhibiting GFER, a mitochondrial enzyme, in combination with immune checkpoint blockade improves antitumor response in preclinical models. This two-pronged approach holds promise for patients with pancreatic cancer.
Research suggests that mitochondria, the powerhouses of cells, play a crucial role in linking psychological processes to physiological changes in the brain. Alterations in mitochondrial function have been linked to various mental health disorders and physical health outcomes.
Research shows that high glucose levels cause mitochondria to move towards the periphery of pancreatic beta cells. This movement is linked to insulin secretion and may play a role in regulating blood sugar levels. The study found that inhibiting microtubules disrupted this process, suggesting a key role for these structures in mitochon...
Researchers discover GFAP's crucial role in regulating mitochondrial fusion and fission, a dynamic process that meets cells' energy needs. The study sheds light on Alexander disease, a genetic disorder caused by GFAP mutations, providing potential new avenues for therapies.
A study conducted at the University of California, Riverside, has uncovered a link between soybean oil consumption and obesity in mice. The research found that a genetically engineered group of mice on a high-fat diet rich in soybean oil did not gain weight, suggesting that the liver protein HNF4α plays a crucial role in fat metabolism.
A team of researchers from Texas A&M University has developed a new method to give damaged cells new mitochondria, restoring energy output and cell health. The technique uses nanoflowers to boost stem cells, which then transfer their surplus mitochondria to injured neighbors.
A new type of DNA damage, glutathionylated DNA adducts, accumulates at high levels in mitochondrial DNA, affecting energy production and stress response. The discovery sheds light on how cells sense and respond to stress, with potential implications for diseases like cancer and diabetes.
The review highlights the complex relationship between mitochondria and tumorigenesis, exploring molecular mechanisms underlying this association. Mitochondrial dysfunction is linked to various cancers, and targeting mitochondria represents an ideal anti-tumor therapeutic approach.
High-resolution label-free imaging reveals stable organelle dynamics and spatial organization, overcoming phototoxicity and halo artifacts. ExAPC microscopy captures biomolecular condensate-like structures and cellular responses to drugs.
Researchers at University of Utah Health have found that AKI is triggered by ceramides, which cause serious injury by damaging kidney mitochondria. Using a backup drug candidate, the team was able to preserve mitochondrial integrity and prevent kidney injury in mice.
Research highlights the importance of mitochondria-endoplasmic reticulum cross-talk in colorectal cancer, regulating Ca2+ homeostasis and lipid metabolism. Novel therapeutic strategies targeting this crosstalk may suppress CRC progression and improve patient outcomes.
A research team discovered that leucine prevents the degradation of specific mitochondrial proteins, enabling efficient energy production. This mechanism allows cells to adapt to increased energy demands during periods of nutrient abundance.
Researchers at St. Jude Children's Research Hospital found that metabolism guides the activation states of regulatory T cells, which dampen inflammation. The study reveals a link between mitochondrial function and lysosome activity in controlling these immune cells.
Researchers at UC Riverside discovered that two toxic chemicals can form when propylene glycol is heated, harming human lung cells. The chemicals, methylglyoxal and acetaldehyde, disrupt cell functions and cause damage even at low levels.
Researchers at Redoxoma found that mitochondrial potassium channels regulate heat production in brown adipose tissue, a process critical for regulating energy expenditure and promoting metabolic health. Closing the channel is necessary for maximum thermogenesis.
Researchers at UTA discovered that mitochondria can protect a cell from dying by taking in calcium, regulating complex cell death. The findings offer insights into brain development and disease, potentially leading to targeted treatments.
The congress brings together experts to explore mitochondria's role in cellular dynamics, metabolic control, and therapeutic targets. Key findings include the emergence of mitochondria as biological sensors and decision-makers, translating environmental signals into cellular fate.
The development of a new pH probe, SITE-pHorin, offers precise organellar pH imaging in living cells. By harnessing quantum-entanglement interactions, the probe boasts unparalleled sensitivity and resolves long-standing controversies over mitochondrial and lysosomal pH.
The 17th World Congress on Targeting Mitochondria will gather world's leading experts from biotechnology, pharma and academia to discuss health, longevity and precision medicine. Over 150 academic and institutional partners and 30 industrial and investment organizations are participating.
Researchers found that a protein linked to Alzheimer's disease also strengthens the immune system, offering insights into innovative treatments for cancer, aging and neurodegenerative diseases. The protein, amyloid beta, plays a dual role in the body by damaging brain cells while boosting T-cells' energy production.
www.mitogether.com centralizes knowledge on genetic mitochondrial diseases affecting 1 in 4,300 people in Europe, with innovative therapies emerging. The platform facilitates information searches for monitoring, care, research, and clinical trials.
Researchers from Trinity College Dublin discovered that nanoplastics can interfere with brain energy production by disrupting the electron transport chain in mitochondria. This finding may have implications for understanding neurodegenerative diseases and learning/memory issues.
Mitochondrial dysfunction is linked to various diseases, including neurodegenerative disorders and cancers. Mitochondria can be transferred between cells via tunneling nanotubes, restoring cellular respiratory function. Understanding mechanotransduction pathways involving mitochondria is essential for developing effective therapies.
Research by University of Pittsburgh scientists discovered that damaging telomeres can lead to dysfunctional T cell function. To combat this, they developed a targeted antioxidant approach that rescued T cell function, opening the door for novel therapies in cancer immunotherapies.
Researchers from The University of Osaka discovered that macrophages can directly engulf and digest damaged mitochondria through a process called microautophagy. This process allows lysosome-like compartments in macrophages to take in broken cell components directly, bypassing the need for digestion.
A clinical trial led by Tohoku University has found that lubiprostone can prevent the decline of renal function in patients with chronic kidney disease. The study evaluated the effects of lubiprostone on kidney function and found that it improves mitochondrial function, which exerts a renoprotective effect.
Researchers found that mitochondrial antioxidant glutathione enables tumors to break away from the primary tumor, travel through the body, and take root in new tissues. Elevated SLC25A39 expression was strongly correlated with poorer overall survival in breast cancer patients.
Researchers discover flower-shaped nanoparticles that restore mitochondrial health, offering hope for new treatments targeting the roots of neurodegenerative diseases. The study found nanoflowers can protect and heal brain cells by promoting healthy mitochondria.
Recent research elucidates PDE4DIP's role in driving Left Ventricular Non-Compaction (LVNC) development through regulating cell polarity, cytoskeleton, and energy metabolism. The study identifies PDE4DIP as a pathogenic gene contributing to LVNC progression.
Researchers discovered that mitochondrial dysfunction triggers a sophisticated metabolic response in brown fat cells, rewiring key enzymes to produce D-2HG. This metabolite modifies the cell nucleus, changing gene expression and nuclear structure, promoting adaptation and altering cellular identity.
Researchers discovered that cancer cells have a defensive mechanism to repair DNA damage and survive physical stress by activating mitochondria to pump in extra ATP. This finding could lead to new therapeutic approaches by targeting the mechanism's underlying scaffold.
Phytochemicals have shown promising effects against leishmaniasis, disrupting mitochondrial function and inducing apoptosis in Leishmania parasites. The study highlights the potential of these compounds to modulate host immune responses and target parasite enzymes.
Researchers discovered a way to boost T cells' ability to fight cancer by rewiring their energy metabolism. By blocking Ant2 protein, they created a state of heightened readiness and potency in T cells, leading to greater stamina, faster replication, and sharper targeting of cancerous threats.
Researchers at Vanderbilt University have generated a high-resolution metabolic map of how cells process glucose, revealing a hidden world where organelles and molecular complexes collaborate. The study provides insights into an organizational framework that can be used to study disruptions in diseases like diabetes, obesity, and cancer.
Researchers developed a new imaging approach combining two-photon microscopy and advanced algorithms to improve resolution and reduce noise. This allowed them to clearly see details smaller than 250 nanometers, enabling real-time observations of mitochondrial behavior in live animals.
An international team has uncovered a new mechanism by which mitochondria and peroxisomes work together to defend against oxidative stress, maintaining cellular health. This discovery challenges the long-standing idea that cellular defense is confined within individual compartments.
Researchers have discovered an oral drug called MA-5 that can improve both heart and muscle problems in patients with Barth syndrome, a rare genetic disorder. The drug boosts cellular energy production by up to 50% and protects cells from oxidative stress-induced death, addressing the underlying cause of the disease.
Mitochondria are responsible for producing cellular energy and maintaining homeostasis, but dysfunction has been implicated in neurodegenerative disorders, cardiovascular diseases, metabolic disorders, cancer, and aging. Targeted therapies are being explored to restore mitochondrial function and reduce oxidative stress.
Researchers aim to replenish the heart's energy reserves by increasing mitochondrial biogenesis, potentially leading to improved recovery rates and longer lives after a heart attack. The project combines synthetic biology tools with animal models and human heart tissue testing.
Researchers have successfully edited harmful mitochondrial DNA mutations in liver and skin cells using a genetic tool called a base editor. The study, published in PLOS Biology, offers promising results for treating mitochondrial diseases and aging-related conditions.
Researchers discovered that aggressive melanomas overactivate mitochondrial pathways, which can be targeted by antibiotics and energy-production inhibitors. The findings suggest a new therapeutic vulnerability in melanoma cells, highlighting the safety and specificity of these treatment approaches.
A Rice University-led research team is working on a new approach to treat acute myeloid leukemia (AML) by targeting the energy-producing mitochondria of cancer cells. By disrupting mitochondrial function, the researchers aim to selectively kill AML cells while leaving healthy blood cells unharmed.
Researchers found that accumulated mitochondrial DNA mutations do not impair respiratory function in mice, contradicting the 'mitochondrial theory of aging'. This study suggests a reevaluation of the relationship between mtDNA mutations and premature aging symptoms.
Researchers have uncovered the mechanism by which ATP enters the endoplasmic reticulum, a process crucial for cellular function. The study reveals SLC35B1 as the key transporter protein, providing a promising target for therapeutic intervention.
Researchers found that aging impairs CAR-T cell function and antitumor activity due to lower NAD levels. Rejuvenating aged cells with NAD-boosting compounds improves their effectiveness.
Researchers at Thomas Jefferson University found that VDAC2, a mitochondrial protein, can make liver cancer cells more vulnerable to existing treatments targeting BAK-dependent cell death. The study suggests that combining pre-clinical drugs targeting BAK could shrink tumors in mice with high levels of VDAC2.
Researchers at Stockholm University and UK DRI have identified a common disease signature across all ALS-causing mutations in motor neurons, revealing early mitochondrial dysfunction. This discovery opens up new avenues for early treatment methods, targeting the energy factories of nerve cells before other signs of disease appear.
Estrogen-related receptors play a crucial role in regulating muscle cell metabolism and energy production. Researchers discovered that these receptors can increase mitochondrial numbers and enhance energetic output when muscles need more energy, making them a promising therapeutic target for metabolic disorders.
Researchers used generative AI to design diverse mitochondrial targeting sequences, achieving a 50-100% success rate in yeast, plant cells, and mammalian cells. The AI-generated sequences showed improved targeting abilities compared to existing ones, with potential applications in metabolic engineering and therapeutics.
Researchers at Pennington Biomedical found that mitochondrial fragmentation can bypass defects in mitophagy to sustain skeletal muscle quality control in patients with Type 2 Diabetes. This adaptation helps maintain mitochondrial function despite impaired mitophagy.
Researchers discovered compromised NAD+ metabolism in WS cells and found that boosting NAD+ levels using nicotinamide riboside decreased senescence in both stem cells and primary fibroblasts. The study suggests targeting NAD+ metabolism for age-related and genetic diseases.
A novel mechanism linking fetal anemia to disrupted intracellular iron distribution has been identified due to impaired mitochondrial protein synthesis. Mitochondrial tRNA modification enzyme Mto1 plays a crucial role in efficient protein synthesis and maintaining proper iron homeostasis.
Scientists have discovered a mechanism that protects and repairs mitochondrial DNA, preventing diseases like Parkinson's and Alzheimer's. A protein complex known as retromer and lysosomes eliminate damaged genetic material, maintaining cellular health.
Researchers developed a stem cell-based system to mass-produce high-quality human mitochondria, overcoming a bottleneck in mitochondrial transplantation. The 'mito-condition' culture medium significantly enhances energy output and facilitates cartilage regeneration in osteoarthritis models.
Compound K exhibits anti-aging properties by enhancing skin barrier function, preventing photoaging, and regulating autophagy. It also protects against mitochondrial dysfunction and promotes tight junctions between keratinocytes.