Articles tagged with Clinical Neuroscience
Researchers used real human brain tissue samples to test the underlying mechanisms of deep brain stimulation. They found that brain cells became more synchronized in communicating, similar to memory formation, while altering gene expression across different types of brain cells.
Researchers have identified a blood marker that can track the hidden progression of multiple sclerosis (MS), even in the absence of relapses. Elevated levels of glial fibrillary acidic protein (GFAP) are associated with disability progression, while changes in GFAP during treatment predict later risk of progression.
A new $3.3 million study aims to investigate how people perceive cognitive changes as they age, with a focus on identifying predictive markers for dementia. The 'worried well' - individuals with cognitive complaints but normal test results - may hold clues to early disease detection.
Scientists at UVA have developed a new method to target glioblastoma, the most common and deadly brain cancer, by delivering microRNAs through the brain's natural barrier. The approach shows promise in slowing tumor growth and extending survival in animal models.
Researchers used sEEG to examine white matter electrophysiological dynamics during working memory. Load modulates tract-specific power and cross-frequency connectivity, with distinct patterns across different brain regions.
The new collaboration will provide hands-on training at Bristol Myers Squibb and fund translational neuroscience research at WashU, focusing on neurological, neuromuscular, neuroinflammatory, and psychiatric conditions. The program aims to accelerate breakthrough discoveries toward meaningful therapies for patients.
A new review proposes a roadmap for developing cognitive brain-computer interfaces to treat cognitive disorders, integrating BCI research and clinical neuromodulation. The emerging field aims to detect dysfunctional brain states and respond with adaptive neurostimulation.
Researchers discovered that brain regions switch between shared and independent timing, allowing for flexibility in coordination. This finding provides a new framework for understanding how brain regions communicate and enables the development of brain-inspired artificial intelligence and robotic control systems.
A team of researchers, led by Sergey Stavisky, has developed an AI-based speech neuroprosthesis that can translate brain signals into speech with high fidelity. The device has enabled a man with amyotrophic lateral sclerosis (ALS) to generate fluent sentences and sustain full-time employment.
A novel salvage surgical approach combining internal neurolysis and targeted glycerol injection has provided durable pain relief for a patient with severe, treatment-resistant MS-TN. The procedure was successful in preserving sensation and reducing medication use.
A team of surgeons used robot-assisted stereotactic surgery to treat a patient with multiple deep brain abscesses, achieving complete resolution and rapid neurological recovery. The minimally invasive strategy reduced surgical trauma and accelerated healing.
A new $250,000 grant will support the development of a novel therapeutic approach for sepsis-associated neurocognitive dysfunction. The treatment aims to protect the brain from inflammation-related damage during and after sepsis, potentially preventing or slowing neurodegeneration and cognitive decline.
The Neuroscape Technology for Aging Health - Digital Approaches (TAH-DA) longitudinal study aims to identify biometric predictors of cognitive decline over a year. Participants will use Samsung wearable technology and digital interventions to assess brain health.
Research presented at the European Academy of Neurology Congress 2026 found that women with Parkinson's disease had significantly greater amyloid plaque burden and neuritic plaque density compared to men. The study suggests that women may be more susceptible to Alzheimer's-related changes in the brain.
A new study finds that multiple sclerosis has a substantial impact on social life and work, with 51% of people reporting an effect. The study highlights the need for comprehensive care addressing not only physical health but also daily functioning, employment, and overall wellbeing.
A study found that sleep deprivation leads to increased markers of brain cell connections, including synaptic vesicle glycoprotein 2A (SV2A), in areas such as the hippocampus. This suggests that sleep plays a crucial role in restoring cellular balance and may be important for maintaining neural health.
A team of researchers from IMB-CNM-CSIC and ICN2 has developed a graphene-based neural interface that can record and decode brain activity simultaneously. The device overcomes current limitations of unidirectional function, enabling bidirectional communication with the brain.
The new section in JMIR Neurotechnology focuses on the responsible and ethical use of neurotechnology. Submissions welcome for original research, case series, theoretical viewpoints, and data-driven analyses on ethics and policy in neurotechnology.
Researchers at Texas Children's Hospital identified a set of dysfunctional genes and specific cell types that are vulnerable to genetic changes in female mice modeling Rett syndrome before symptoms appear. They found that even healthy cells with normal MECP2 gene had changes in gene activity due to neighboring defective cells.
A new study from Northwestern University developed a customized video game to help chronic stroke survivors regain lost arm function. After six weeks of therapy, participants showed significant improvement in arm function and daily activities, with scores improving up to 7.8 times that of the control group.
A new model predicts retinal degeneration in diabetics based on 71 plasma proteins. The Pro-DRN model can help doctors identify patients at risk earlier, potentially preventing neurodegeneration and vision loss.
Scientists have created a miniature circuit that mimics the brain and spinal cord connection, showing that previously thought irreversible nerve damage can be reversed. The researchers found that blocking specific genes in mature neurons restored axon regrowth ability.
A study published in Chinese Neurosurgical Journal reports KRAS gene overexpression associated with brain arteriovenous malformation (bAVM) pathogenesis. The research found altered gene expression profiles linked to cell adhesion, signaling, and mitochondrial function, suggesting KRAS-driven molecular alterations play a role in bAVM de...
A Capital Medical University study reveals that intraoperative signal changes can predict vision loss during brain tumor surgery. Researchers found that a specific signal component, N75-P100, is strongly associated with postoperative visual outcomes.
A novel antibody, NG101, accelerates the regeneration of damaged spinal cord tissue by neutralizing a protein that blocks nerve fiber growth. This therapy enables new nerve fibers to form functional connections, allowing patients to become more independent and potentially recover arm and hand function.
Genomic Press launches Brain Health, a new peer-reviewed journal dedicated to the science of lifelong brain resilience, featuring research on glial plasticity and recovery from depression. The inaugural issue explores the intersection of fields including cognitive reserve, sleep, aging biology, nutritional psychiatry, and social sciences.
Researchers discovered that strokes cause a chain reaction within the brain, leading to neuronal cell death. They found that blocking collagen production can prevent this damage and even restore motor function in paralyzed monkeys. The new drug KDS12025 reduces hydrogen peroxide levels and prevents the entire process from being triggered.
A new study from Center for BrainHealth researchers found that declining slow-wave activity during sleep explains why anxiety rises in older adults. Participants who generated fewer slow waves woke up more anxious the next morning, while those with stronger slow-wave sleep did not show the same pattern.
The EBRAINS Roadmap Symposium will bring together the global neuroscience community to shape the EBRAINS 10-Year-Roadmap. A total of 159 submissions from 134 unique contributors across 25 countries have been received, reflecting the momentum of Europe's digital neuroscience landscape.
The 2026 cohort of Leon Levy Scholars in Neuroscience will pursue research projects addressing neurological disorders and developing new treatments. The program provides scientific and professional career development opportunities, including mentorship and networking.
Researchers developed a nasal spray that reversibly reduces brain inflammation, restores cellular power plants, and improves memory. The treatment bypasses the brain's protective shield through intranasal delivery, suppressing chronic inflammation and promoting successful brain aging.
A secondary analysis of the ANGEL-ASPECT trial found EVT to be beneficial for patients with anterior-circulation LVO and a large ischemic core and absent-to-moderate white matter lesions. In contrast, those with severe WMLs showed less pronounced benefits, suggesting uncertainty about EVT's efficacy in this subgroup.
Researchers have mapped a brain circuit specific to chronic pain, suggesting a promising route to treatment. Silencing this circuit eased chronic pain while preserving acute pain responses in mice. The discovery raises the possibility of developing drugs that target this circuit to ease chronic pain without impacting acute pain.
A new survey by Autism BrainNet reveals a significant disconnect between Americans' strong support for autism research and their limited understanding of postmortem brain donation. The survey found that 70% of respondents had never heard of brain donation, despite 92% agreeing its importance in advancing research.
A clinical trial by University of Auckland researchers found that high-intensity therapy for patients begun within two weeks of a stroke did not improve hand and arm recovery. Despite the extra therapy, neither group did better than a cohort who received standard care alone.
A clinical trial found that high-intensity therapy for patients begun within two weeks of a stroke did not improve hand and arm recovery beyond standard care. Despite having access to extra therapy, neither group did better than a cohort who received standard care alone.
Research suggests that persistent pain drives progressive changes in the hippocampus, a brain region involved in emotional regulation. This can shape whether people develop depression or remain emotionally resilient. The study's findings challenge the idea that depression is an inevitable consequence of long-term pain.
Dr. Cazares co-founded Colors of the Brain and advocated for GRE removal to support students from underprivileged backgrounds. He aims to bring neuroscience to underserved communities through portable, affordable, and non-invasive methods.
Researchers developed a modified high-resolution MRI technique to differentiate intra-dural from extra-dural PAs, providing a refined risk assessment for subarachnoid hemorrhage. The study found that Type S aneurysms had a higher rupture risk and required individualized imaging assessment.
A prospective multicenter study found Woven EndoBridge therapy safe and effective for unruptured wide-necked bifurcation aneurysms in Chinese patients. The therapy promotes durable aneurysm occlusion with minimal risks.
Researchers at the University of Queensland have made a breakthrough in understanding the cellular changes that occur in depression. They found that cells in people with depression produce more energy molecules when resting, but have a reduced ability to increase energy production under stress. This study offers a new potential approac...
Patients with neurological diseases face profound questions about identity, purpose, and meaning, but neurologists often lack training and tools to address these concerns. A new paper offers practical strategies for incorporating spiritual assessment into routine neurological care.
Researchers found that veterans with prior concussions showed slower and less accurate eye movements, along with reduced performance on attention-based tasks. These subtle brain changes can be measured more than a decade after the original injury.
A new study from CU Anschutz links chronic back pain to heightened brain responses to everyday sounds and finds that Pain Reprocessing Therapy can improve sensory amplification. The research found specific brain changes associated with sound hypersensitivity, which can be treated with psychological therapy.
The Society for Brain Health is a new collaborative body dedicated to enhancing cognitive capacity, longevity, and proactive health optimization through cutting-edge research and tools. Its founding members include prominent neuroscientists and experts in the field of brain health.
Researchers at Amsterdam UMC found that a second pregnancy changes the female brain in unique ways, altering brain networks involved in attention and sensory cues. The study also linked structural brain changes to maternal mental health, providing new insights into postpartum depression.
Epicurrents is an open-source web browser application that enables users to view various clinical neurophysiology recordings directly in a web browser. It supports easy, secure, and cost-effective remote teaching and can be used for both educational purposes and scientific research.
Chronic alcohol consumption alters endocannabinoid gene expression in reward- and decision-related brain regions, offering insights into addiction biology. This study reveals changes in CB1 and CB2 receptor genes, as well as GPR55 and FAAH enzymes, potentially leading to targeted therapeutic strategies.
The Korea University-Yale University Joint Forum aimed to discuss expanding cooperation in neuroscience and training physician scientists. Key findings include agreements for annualizing the joint forum and discussing research topics for future forums.
The FENS Forum 2026 will be Europe's largest neuroscience congress, covering areas of basic to translational research. Journalists can register for free and attend symposia and poster sessions.
Researchers used MRI analysis to measure glymphatic system activity, finding changes related to IIH stage and pressure levels. The findings suggest a noninvasive test could diagnose IIH more reliably, improving treatment options for patients with symptoms including headaches and vision loss.
Cancer cells tap into the nervous system's power grid by forming synaptic contacts with nerve cells, promoting tumor growth and spread. Venkataramani's research aims to repurpose the drug perampanel for glioblastoma treatment and develop gene therapy approaches to disconnect tumors from the nervous system.
A new study at York University found autistic adults who are right-handed demonstrate a reduced specialization of hand use and more distinctive movement patterns. Autistic participants used their right hand less often for grasping and followed highly unique, idiosyncratic paths.
Researchers at the University of Virginia Health System have discovered how the keto diet protects against epilepsy seizures by regulating brain cell activity. The team found that a specific cellular receptor, HCAR2, plays a crucial role in reducing seizures, and may be targeted for new treatments.
New research reveals that the immune system has a potent weapon against the brain parasite Toxoplasma gondii: an enzyme called caspase-8. This discovery offers new insights into how our bodies control the parasite and may lead to better treatments for patients with compromised immune systems.
A study highlights how social media is transforming neurosurgical education, collaboration, and case consultations globally. Platforms like Neurosurgery Cocktail have democratized neurosurgical knowledge, supporting high-level discourse among experts.
A new study found that maternal psychological distress experienced at 1 year postpartum has a stronger association with neurodevelopmental delay in toddlers compared to prenatal distress. The researchers also discovered that experiencing distress during both pregnancy and postpartum periods further amplifies the risk of delays.
The EBRAINS Summit 2025 will bring together experts to assess how neuroscience can drive medical progress, digital innovation, and responsible data use. Preliminary results from the EPINOV clinical trial, integrating virtual brain technology for epilepsy surgery planning, will be presented.
A new review emphasizes the importance of smell health, highlighting its role in nutrition, cognitive function, and psychological resilience. Researchers call for a global campaign to promote smell health through education, awareness, and targeted public health policies.
A new report warns that AI can worsen health disparities in brain disease diagnoses if proper safeguards are not implemented. Researchers call for diverse perspectives, AI education, and strong governance to ensure equitable implementation.