Articles tagged with Clinical Neuroscience
New research reveals that the immune system has a potent weapon against the brain parasite Toxoplasma gondii: an enzyme called caspase-8. This discovery offers new insights into how our bodies control the parasite and may lead to better treatments for patients with compromised immune systems.
A study highlights how social media is transforming neurosurgical education, collaboration, and case consultations globally. Platforms like Neurosurgery Cocktail have democratized neurosurgical knowledge, supporting high-level discourse among experts.
A new study found that maternal psychological distress experienced at 1 year postpartum has a stronger association with neurodevelopmental delay in toddlers compared to prenatal distress. The researchers also discovered that experiencing distress during both pregnancy and postpartum periods further amplifies the risk of delays.
The EBRAINS Summit 2025 will bring together experts to assess how neuroscience can drive medical progress, digital innovation, and responsible data use. Preliminary results from the EPINOV clinical trial, integrating virtual brain technology for epilepsy surgery planning, will be presented.
A new review emphasizes the importance of smell health, highlighting its role in nutrition, cognitive function, and psychological resilience. Researchers call for a global campaign to promote smell health through education, awareness, and targeted public health policies.
A new report warns that AI can worsen health disparities in brain disease diagnoses if proper safeguards are not implemented. Researchers call for diverse perspectives, AI education, and strong governance to ensure equitable implementation.
A new study shows a significant increase in the use of computed tomography (CT) scans of the head in emergency departments across the US from 2007 to 2022. The study found that Black people were 10% less likely to receive a head CT scan than white people, and those on Medicaid insurance were 18% less likely.
A recent study found that changes in a single gene can cause mental illnesses, with the GRIN2A gene identified as a key culprit. Variants of this gene are associated with schizophrenia and other mental disorders, which can manifest in childhood or adolescence rather than adulthood.
Researchers discovered that pancreatic tumors form pseudosynapses, exploiting the body's nervous system to drive tumor growth. Calcium waves triggered by glutamate binding promote metastasis and cancer progression.
Researchers created BraDiPho, a 3D atlas of brain connections, combining clinical neuroscience, artificial intelligence, and neuroanatomy. The tool facilitates precise identification of white matter connections, opening up new therapeutic perspectives for neurological diseases.
A new contactless optical-tracking registration method has been developed to simplify robot-guided SEEG surgery, reducing positioning errors and procedure time. The study demonstrates the accuracy and ease of use of this technique, making it a promising innovation in neurosurgery.
A team of researchers from Rice University and the Houston Methodist Research Institute will study how the brain responds to neural implants. They aim to develop more stable and longer-lasting brain-computer interfaces and neuroprosthetics, which could treat neurological disorders such as Parkinson’s disease, epilepsy, and stroke.
Scientists discovered that eIF1A and eIF5B suppress toxic protein synthesis implicated in frontotemporal dementia and amyotrophic lateral sclerosis. The study sheds light on the mechanisms behind RAN translation, a process linked to neurodegenerative disorders.
A small study found that five volunteers with late-onset Alzheimer's disease showed significant improvements in cognitive tests and decreased biomarker tau proteins after two years of receiving 40Hz light and sound stimulation. This suggests that the therapy may slow cognitive decline and have direct biological impacts on Alzheimer's p...
A new clinical trial is investigating the use of advanced brain monitoring to improve epilepsy diagnosis and management. The trial involves multiple sites across Europe, including Ireland, where patients will undergo long-term outpatient monitoring using a subcutaneous EEG system.
A new study found that child neurologists often lack knowledge and education on motor difficulties in children with autism. Motor impairments are common in autistic children, affecting their development, language skills, and social interactions. The study recommends more training for medical students and residents to recognize and addr...
Researchers have identified four distinct profiles of Nonverbal Learning Disability, each with different strengths and challenges. The study suggests that current diagnostic criteria may be too broad, highlighting the importance of individualized approaches to care for children with NVLD.
Researchers created a new tool using local ancestry inference (LAI) to provide more accurate insights into genetic differences. The tool reveals that many rare variants are common in specific ancestry segments, leading to more accurate diagnoses and reclassifications of genetic variants.
Professor John O'Brien's research focuses on understanding the impact of electrical synapses and gap junction plasticity on the retina and other neurological functions. The study aims to identify proteins that control electrical synapse strength, shedding light on their role in human disorders such as autism and seizures.
Salk scientists pinpoint gracile nucleus as brain area responsible for differentiating between painful and non-painful touch, with dysfunction leading to chronic pain. Altered neuronal activity in the dorsal column nuclei drives mechanical allodynia, causing the brain to misinterpret innocuous light touch as painful.
Frontal lobe seizures can cause impaired consciousness when they spread to wider areas of the brain, according to a new study published in Neurology. This understanding may help scientists develop treatments that restore consciousness during seizures.
Despite long-held assumptions, a new study reveals that the brain's somatosensory cortex holds a stable 'body map' even after limb loss. The findings have significant implications for treating phantom limb pain and restoring sensation in prosthetic limbs via brain-computer interfaces.
A recent study by researchers at the University of Missouri has made a groundbreaking discovery using patient's own cartilage cells to aid in healing after hip surgery. The research team successfully cultured and expanded cartilage cells, or chondrocytes, in the lab, paving the way for future clinical applications.
The largest neuroscience event will convene in San Diego from November 15-19, featuring over 10,000 presentations on various topics. Registered journalists will gain access to cutting-edge research, expert interviews, and press-only events.
A NUS-led global study reveals that 30-minute functional MRI scans deliver up to 22% in cost savings while retaining or improving prediction accuracy. This finding could reshape how researchers design neuroscience and mental health studies, especially for hard-to-recruit populations.
Researchers identified four clinically and biologically distinct subtypes of autism, each with distinct developmental, medical, behavioral, and psychiatric traits. The study linked subtypes to genetic profiles and developmental trajectories, offering new insights into the biology underlying autism.
This special collection aims to bring together cutting-edge research on cognitive aging, exploring its cellular and molecular underpinnings, as well as psychosocial and environmental factors. The collection seeks to foster a holistic understanding of how cognitive function changes with age.
Researchers from Karolinska Institutet have identified proliferating neural progenitors in the adult human hippocampus, confirming ongoing neuron formation. This discovery has implications for understanding brain changes during life and developing regenerative treatments for neurodegenerative and psychiatric disorders.
A recent study has discovered a connection between brain damage and an increased likelihood of committing crimes. The research, led by Harvard Medical School and the University of Colorado Anschutz Medical Campus, found that damage to the right uncinate fasciculus was linked to criminal behavior.
Researchers used advanced neuroimaging and the Julich-Brain Atlas to identify specific brain networks linked to psychopathy, finding reduced volumes in multiple regions including basal ganglia, thalamus, and cortex. This study advances research on neuropsychobiological correlates of aggression.
The new centre will investigate neural dynamics, developing novel interventions and devices to improve symptom relief and quality of life for people with brain disorders. It aims to harness neural dynamics for people with conditions like Parkinson’s disease or epilepsy.
Researchers suggest that brains reach a critical state to learn, remember, and think, which can be measured using fMRI technology. This framework offers a new perspective on neurological diseases like Alzheimer's, which disrupt the brain's ability to maintain criticality.
A novel study in Biological Psychiatry highlights the layered and complex interactions between clinical symptoms and neurobiological sources of variation in depression. The research found that multiple brain profiles may manifest as the same clinical symptoms, supporting the presence of both one-to-one and many-to-one heterogeneity.
Professor Benedetti's research explores the intersection of genetics, environmental factors, and treatment response in mood disorders. His work has led to breakthroughs in chronotherapeutics and immuno-psychiatry, revealing crucial insights into immune-inflammatory mechanisms and gene variants influencing brain function.
Researchers used a new fMRI analysis method to measure cerebrovascular reactivity in 53 adults aged 51-83. They found an unexpected improvement in brain health in postmenopausal female participants, primarily in areas related to movement and memory.
A $2.4 million grant will fund the development of an optical imaging technology to image nerve endings in cancer patients with chemotherapy-induced peripheral neuropathy. The goal is to identify potential biomarkers for the disease, enabling early detection and prevention.
A recent epigenetic study identified RABGGTB as a promising biomarker for autism spectrum disorder, revealing extensive DNA methylation abnormalities in key brain regions. The findings suggest that studying this gene could unlock new doors to understanding ASD and lead to future diagnostic breakthroughs.
Researchers develop specialized enzymes to selectively increase or decrease specific mutation loads in mitochondria, allowing precise study of disease manifestation. This technology holds promise for treating patients with mitochondrial diseases by reducing mutant mtDNA load.
Research found that negative expectations have a stronger and longer-lasting impact on pain perception than positive ones. The study showed that nocebo effects, where participants expect a negative outcome, were more powerful and persistent than placebo effects, with implications for patient-practitioner communication.
Lana Ruvolo Grasser, a Wayne State University assistant professor, has been selected as an Early Career Policy Ambassador (ECPA) by the Society for Neuroscience. She will engage in advocacy initiatives and learn effective strategies to advocate for scientific research and its funding.
Cognitive neuroscientists are using VR to develop innovative ways to assess cognitive decline, particularly in identifying age-related differences in spatial memory navigation. The study found significant impacts on memory performance due to the build-up of Alzheimer's proteins in the brain.
The Open Brain Institute launches a groundbreaking platform to simulate and study digital brains, empowering researchers to explore brain complexity and diseases. With its virtual neuroscience laboratories, the OBI enables global collaboration and access to cutting-edge virtual labs.
Studies have consistently shown that 40Hz gamma stimulation can improve cognitive function and reduce Alzheimer's pathology in mice. In human clinical trials, participants exposed to 40Hz light and sound experienced significant slowing of brain atrophy and improvements on some cognitive measures compared to untreated controls.
A new telerehabilitation care service for stroke patients is being offered in Cameron County, Texas, as part of a randomized clinical trial. The program uses software delivered through a website to provide personalized rehabilitation regimens and community health worker home visits.
A study published in Annals of Neurology found that severe early-life adversity accelerates brain aging and amplifies neurodegenerative processes in women. Researchers analyzed biomarkers, brain scans, and cognitive tests to determine the link between childhood trauma and later dementia risk.
A recent study published in JAMA Network Open found that heavy cannabis users exhibited reduced brain activity during working memory tasks, associated with worse performance. Abstaining from cannabis before cognitive tasks may help improve performance.
Researchers use real-time neuroimaging and neurofeedback to modify brain activity patterns, enabling faster learning and treatment of psychiatric disorders. The study demonstrates the ability to inscribe new patterns into the brain without physical manipulation.
A new study will evaluate the benefits and risks of endovascular thrombectomy for patients presenting beyond 24 hours. The trial aims to provide deterministic evidence of clinical benefit due to addition of endovascular thrombectomy to standard medical care.
A new approach profiles gene activity in the living brain, providing insights into neurological conditions like epilepsy. The study enhances understanding of seizure networks, potentially improving surgical interventions.
A study found that 4.6% of Nigerian participants with COVID-19 experienced neurologic symptoms, with some still experiencing symptoms two years after their initial episode. Researchers plan to treat these patients using similar techniques used in the US, aiming to alleviate their suffering.
Research led by Silvia Cappello reveals that extracellular vesicles play a crucial role in the development of the brain, facilitating communication between different cell types. The study found that these vesicles can transport specific molecular signals to the nucleus of recipient cells, inducing rapid transcriptional changes and infl...
A multi-university research team led by University of Virginia engineering professor Gustavo K. Rohde has developed a system that can accurately spot genetic markers of autism in brain images. The system uses generative computer modeling technique called transport-based morphometry, which reveals brain structure patterns that predict v...
Researchers analyzed genetic samples from individuals with undiagnosed illnesses and found that mutations in the DENND5A gene disrupt brain cell division, leading to developmental delays. The discovery provides answers for families affected by this rare condition and may lead to potential treatments.
A new study by researchers at MIT and MGH found that even low stimulation currents could sometimes still cause electrographic seizures in awake mice, with a rate of 2.2 percent of tests experiencing seizures. The study cautions against the use of brain stimulation-based therapies without proper monitoring.
A roundtable discussion explores the integration of positive psychology and autism, highlighting its potential to amplify strengths and improve interpersonal dynamics. The study suggests that appreciating character strengths can have a significant impact on daily life.
Researchers at WVU created a motion-compatible brain scanner that allows patients to move around during imaging. The Ambulatory Motion-enabling PET (AMPET) scanner can help study human behaviors, balance, and emotions, and may be used to monitor brain activity for PTSD treatment and mindfulness meditation.
A novel radiotracer, C05-05, enables multi-scale imaging of α-synuclein depositions in living patients with Parkinson's disease and dementia with Lewy bodies. The tracer shows high binding affinity and selectivity to α-synuclein, providing a powerful tool for understanding its role in neurodegeneration.
Researchers from Children's Hospital of Philadelphia found that two assessments, Leiter-3 and Vineland Adaptive Behavior Scale, can help measure cognitive function in children with Aicardi Goutières Syndrome. The study revealed that a subset of patients scored within a normal IQ range, paving the way for future clinical trial design.
FutureNeuro, a leading SFI Research Centre, is expanding its research programme with a focus on diagnostics, therapeutics, and digital health. The centre aims to develop precision diagnostics, future treatments, and systems using real-time health data.
Researchers found that older adults tend to conserve energy by modifying their movements under certain circumstances. The findings suggest that the effort costs of reaching are a determining factor in slowing movement with age. This research may lead to new tools for diagnosing diseases, including Parkinson's and multiple sclerosis.