Articles tagged with Prefrontal Cortex
Researchers found that higher eye-blink rates in 3-6 year-olds are associated with improved cognitive flexibility and activation in the right dorsolateral prefrontal cortex. The study suggests that spontaneous eye-blink rate could be a non-invasive indicator for tracking executive function and brain development in early childhood.
A study found that just 10 minutes of very slow running improves mood and executive function, activating the prefrontal cortex. This suggests that even low-intensity exercise can have cognitive benefits.
Mount Sinai scientists reveal how the brain represents leader and follower roles through prefrontal cortex activity, and create an AI that decodes hidden goals behind teamwork. The study shows that leadership is an asymmetric yet bidirectional partnership, and that followers play a crucial role in maintaining cooperation.
Neuroscientists have identified flexible modules in the prefrontal cortex that can be reused to perform various tasks. The discovery supports the theory of compositionality, where cognitive building blocks can be flexibly combined to generate new behaviors.
Researchers identified a protective subtype of microglia that expands as Alzheimer's disease progresses, playing a key role in clearing harmful material from the brain. The study provides insights into how the brain's immune cells change across the lifespan and throughout Alzheimer's disease, paving the way for therapies that strengthe...
A study in mice found that the prefrontal cortex can block flexible thinking, but silencing this region allows for faster learning of a new strategy. This discovery may provide insights into human neurodiversity and cognitive disorders.
Researchers found that patients with Parkinson's disease showing little to no Lewy bodies despite long-standing, clinically advanced disease. The study provides new insight into the relationship between clinical symptoms and neuropathological progression.
Researchers at UCLA Health have identified a brain region called the ventromedial prefrontal cortex (vmPFC) that regulates memory integration. The vmPFC acts as a quality control checkpoint, preventing memories from getting mixed up when they are significantly different or far apart in time.
A longitudinal study identified distinct brain-wave patterns emerging from age 9 that can forecast a child's vulnerability to anxiety or depression by age 13. The predictive markers reveal divergent neurodevelopmental trajectories linked to the right and left sides of the brain, respectively.
Researchers discovered that KD025 restored neural connections and improved memory and visual recognition in mice with schizophrenia-associated gene variants. The drug also reduced ROCK2 overactivity without causing serious side effects common to current medications.
Researchers identified a key brain pathway in rats that helps them decide whether to approach stressed pups or avoid stressed adult peers. The insular cortex and prefrontal cortex work together to process social information, with the pathway playing a crucial role in making these decisions.
Researchers found that the rostral prefrontal cortex acts as a bridge between the default mode network and executive control network, enabling a gradual functional transition. The study suggests that creativity relies on a measurable balance between these networks.
Researchers at the University of Houston found that distraction disrupts memory consolidation primarily due to demands on central executive processing. To improve short-term memory, focus attention on a task for a few seconds before switching, and avoid multitasking.
Researchers identify the ventromedial prefrontal cortex (vmPFC) as the brain region associated with moral inconsistency. Studies show that individuals with less vmPFC activity are more likely to be morally inconsistent, indicating a failure to integrate moral knowledge into daily behavior.
Researchers found differences in how brain regions work together during certain cognitive tasks in individuals with obsessive-compulsive disorder (OCD). The findings may lead to new treatment targets for OCD, especially when involving transcranial magnetic stimulation (TMS).
Researchers at Karolinska Institutet created the first activity-based maps of the prefrontal cortex, revealing a hierarchy of information flow rather than tissue structure. This challenges traditional definitions of brain regions and has major implications for understanding brain organisation overall.
Scientists discovered that the brain sorts emotionally significant stimuli into three independent channels: salience, valence, and value. This allows the brain to evaluate information efficiently and guide decisions.
Researchers at UVA Health System discover how traumatic brain injury increases Alzheimer's risk and find a potential prevention strategy using a hollowed-out virus to deliver repair supplies. The approach could help limit neurodegeneration and potentially prevent other neurological diseases.
Researchers identify abnormal sugar modifications linked to depressive behaviors, offering potential diagnostic and therapeutic targets. Chronic stress disrupts sugar chains in the prefrontal cortex, triggering depression.
Researchers analyzed neuroimaging data from over 650 individuals aged 8 to 21, discovering a key organizational shift in the dorsal prefrontal cortex. The study found that this refinement of brain architecture is driven by specific changes in the medial part of the prefrontal cortex.
A new study found that tolcapone increases activity in the prefrontal cortex during self-control tasks, associated with better behavioral control and reduced alcohol consumption. The findings suggest that medications increasing prefrontal dopamine could be a promising lead for treating alcohol use disorder.
The study reveals highly refined axon targeting and arborization in primates, with distinct PFC neuron subtypes projecting to different brain regions. This finding suggests a modular network of intra-PFC connections providing a structural basis for working memory.
A new study published in PLOS Biology found that non-invasive brain stimulation can improve maths learning outcomes for individuals with weaker brain connectivity between the dorsolateral prefrontal cortex and the posterior parietal cortex. The treatment also showed positive effects on GABA levels, a brain chemical involved in learning.
Older adults show increased locus coeruleus activity when processing hard-to-read facial expressions, which strengthens a neural pathway supporting mental well-being and resilience. This adaptive mechanism could help older individuals cope with cognitive decline or younger people with anxiety or depression.
Research finds that mild physical activity affects brainstem dopaminergic and noradrenergic neurons, leading to improved executive function. Blink frequency increases in individuals showing cognitive benefits from exercise.
A USC study found that high levels of iron in the brain contribute to cell damage and oxidative stress, accelerating Alzheimer’s symptoms in individuals with Down syndrome. This connection could lead to targeted treatments and improved outcomes for those at risk.
Researchers have identified the medial prefrontal cortex (mPFC) as the basis of emotional inference in animals and humans. In a study published in Nature, Xiaowei Gu and Joshua Johansen found that rats can learn inferred emotions by associating a neutral stimulus with an unpleasant experience.
A new study found that damage to the medial prefrontal cortex (mPFC) makes people more likely to be influenced by other people's impulsive decisions. The researchers also discovered that this type of brain damage is linked to increased impulsivity, even before being influenced by someone else.
A randomized clinical trial of transcranial pulsed current stimulation found significant improvements in social functioning and sleep in children with autism spectrum disorder. The treatment, which targeted the prefrontal-cerebellar region, was well-tolerated and showed promise as a viable alternative to pharmaceutical interventions.
A study found that brain activity can predict a person's political affiliation with 80% accuracy when making food purchases. Researchers used fMRI to measure brain activity in Republicans and Democrats, finding distinct neural patterns for each group.
Researchers have identified specific brain structures that regulate political passion, finding damage to the prefrontal cortex increases intensity and amygdala decrease it. The study suggests emotion plays a role in shaping expressed political beliefs rather than determining ideology.
A new study sheds light on how age-related changes affect financial skills, finding that verbal representations and language processing play a crucial role. Individuals with better language skills and higher household income are more likely to excel in financial tasks.
A study published in the Journal of Neuroscience examines how different parts of the prefrontal cortex guide decisions to persist or quit. Participants with damage to specific regions waited less overall, particularly when persistence was optimal, highlighting the brain's role in evaluating subjective value and adapting to real-time fe...
A study published in JAMA Psychiatry found that targeting the prefrontal cortex with cognitive remediation and transcranial direct current stimulation can effectively slow cognitive decline in older adults at risk of cognitive decline. The treatment was particularly beneficial for those with remitted major depressive disorder and mild ...
Researchers found that fear memories start as broad associative memories, but become more specific over time. Individuals with high anxiety may struggle with integrating episodic memories, leading to persistent fear linked to cues.
Researchers have developed a novel platform for testing radiation therapy effects on brain cells, providing insights into how the brain reacts to cancer treatment. The study aims to improve treatment strategies by understanding the impact of radiation on neural circuits, ultimately leading to personalized care for patients.
Research on macaque monkeys reveals that neurons in the frontal cortex respond differently to real and filmed partners during turn-taking exercises. This finding suggests that these neurons may be involved in spatial perspective-taking, a cognitive operation that enables individuals to mentally rotate themselves into others' positions.
Researchers found a significant reduction in serine racemase protein levels in the medial prefrontal cortex and hippocampal subfields of aged rats compared to young rats, suggesting a role in age-associated decline of NMDA receptor function. No sex differences were observed in serine racemase expression.
Researchers at IIT have identified a brain network that enables the recognition of others' emotions, which could lead to more effective treatments for neurodevelopmental conditions. The discovery provides insight into how the brain processes social functions and may help develop targeted therapies.
This Neuron special issue highlights recent findings on consciousness research, including neural theories, sleep, anesthesia, coma recovery, and prefrontal cortex roles. It showcases how these areas contribute to our understanding of the complex topic.
Beta bursts regulate neuron activity to implement cognitive control, enabling flexible but controlled patterns of neural activity for intentional thought. Studying these bursts could aid in diagnosing and treating cognitive disorders, including ADHD, schizophrenia, and Alzheimer's disease.
Researchers used fMRI and predictive modeling to decode emotional dimensions of spontaneous thoughts, revealing the involvement of default mode, ventral attention, and frontoparietal networks. The study's findings hold promise for daydream decoding and potential applications in mental health.
The study found that the cerebellum uses information about errors to refine movement and contributes to cognitive functions. The posterior lateral region of the cerebellum is interconnected with the prefrontal cortex and helps shape cognition.
A study published in Nature tracked neural activity of freely moving macaques using wireless eye tracking and neural monitoring. The research found that the visual cortex plays an active role in social behavior by providing signals to the prefrontal cortex, enabling the decision to cooperate.
A NTU Singapore study found that ageing alters brain cells' communication, leading to weakening connections and poorer memory in middle-aged mice. The research suggests strengthening these connections through memory training may delay age-related working memory decline.
Researchers found that brain waves are slower in deep cortical layers and faster in superficial layers, with gamma waves dominating the topmost layers. These oscillations may play a fundamental role in brain function and contribute to disorders such as attention deficit hyperactivity disorder.
New research found that rapid-acting antidepressants modulate affective biases associated with learning and memory. The study proposes a neuropsychological mechanism explaining both immediate and sustained effects of these drugs.
Researchers investigated the neural mechanisms of verbal working memory processing in healthy aging adults using magnetoencephalography. Age-related increases in theta activity were detected during encoding, and alpha and beta oscillations were stronger in older participants during maintenance and retrieval phases.
Researchers found that combined use of alcohol and THC affects the prefrontal cortex, impairing synaptic plasticity in rats. The effects were more pronounced in females and were likely due to changes in gamma-aminobutyric acid signaling.
A new study suggests that hormonal birth control used by adolescents may influence the development of their brain, leading to altered risk assessment. The researchers found increased myelination and decreased immune cells in the brains of treated rats, while also exhibiting signs of impulsivity in behavior tests.
Researchers at Imperial College London found that specific brain cells in the prefrontal cortex trigger mice to prepare for bed when tired, a behavior likely shared with humans. This hard-wired survival feature suggests that humans should prioritize sleep hygiene to maintain good health.
A study published in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging found that greater activation in the right inferior frontal gyrus predicts better recovery from early PTSD symptoms. This breakthrough suggests a potential role for cortical/cognitive regions in regulating fear and PTSD development.
A Penn State-led research team discovered that somatostatin signaling acts to dampen communication among cell types in the prefrontal cortex, promoting exploratory and risk-taking-like behavior. The findings suggest that somatostatin fine-tunes circuits to promote certain behaviors, including decision making.
A study found that teenage smokers have less grey matter in their left frontal lobe, associated with decision-making and rule-breaking. This loss of grey matter may lead to increased impulsivity and a desire for smoking, as well as weaken control over nicotine use.
A recent study published in Nature Communications identified an important brain circuit for socially subjective reward valuation, finding that temporarily disconnecting the medial prefrontal cortex from the lateral hypothalamus reduces susceptibility to others' rewards but not individual expectations. This research has significant impl...
Scientists have identified a region of the brain where sustained visual images are retained during perception. This finding may help doctors determine whether coma patients are still aware of their surroundings and could lead to treatments for disorders of consciousness.
A team of scientists identified the dorsal medial prefrontal cortex as a key region in predicting rumination, which is linked to depression. The study's findings suggest that dynamic connectivity between brain regions can be used to decode rumination patterns.
Scientists found that drinking coffee increases connectivity in higher visual networks and executive control regions of the brain, leading to improved alertness and cognitive performance. In contrast, taking only caffeine did not replicate these effects, suggesting that the experience of drinking coffee plays a crucial role.
Researchers have discovered that inhibitory neurons can transmit information over long distances in the prefrontal cortex, allowing for adaptive changes in behavior. This synchronization of gamma oscillations is associated with the realization of new rules and enables cognitive flexibility.
Higher testosterone levels during adolescence enhance emotion control, but decrease in young adulthood; the study suggests a shift in testosterone's role across developmental periods. The findings may be related to mood disorders that arise during adolescence.