Articles tagged with Skeletal Muscle
Researchers suggest new criteria for diagnosing sarcopenia, a syndrome characterized by loss of muscle mass and force, with lower cutoff points leading to improved prediction of mortality risk. The study found that raising handgrip strength thresholds can detect the onset of sarcopenia earlier and more accurately.
Researchers identified protein levels that were higher or lower than normal in tissues from individuals at different stages of type 2 diabetes. The study found a correlation between metabolic pathway disturbances and disease progression, suggesting new potential causal mechanisms for the disease.
A study of 15 transgender women found they exceeded the cardiopulmonary capacity and muscle strength of their cisgender peers even after years of hormone therapy. However, their performance was lower than that of cisgender men. The findings could inform policy on transgender women's sports participation.
A new study in mice has mapped the cells, genes, and pathways that respond to exercise and diet, offering potential targets for drugs that mimic exercise's benefits. Exercise was found to push these systems in the opposite direction of high-fat diets.
Researchers are using in vitro skeletal muscle models to study Type 2 diabetes and its treatment. These models enable the exploration of disease characteristics and discovery of new medicines tailored to individual patients' muscles.
Researchers from Tokyo Metropolitan University have developed a method to directly measure the strength of skeletal muscle myotubes by analyzing wrinkles formed on an elastic substrate when stimulated with electric pulses. This new technique is more sensitive than existing measures and has great potential for accelerating drug discover...
Researchers found that adults with low blood urate levels are more likely to have low skeletal muscle mass and strength. This association is also linked to a higher risk of early death, particularly due to weight loss and adverse body composition.
A study published in eLife found that high-intensity interval training increases the production of proteins essential for energy metabolism and muscle contractions, as well as alters key metabolic proteins through acetylation. These changes may contribute to improved metabolic health.
A new clinical study published in Cell Reports Medicine found that daily intake of postbiotic Urolithin A improved muscle strength by 12% in middle-aged adults. The supplement supported the cells' ability to renew their powerplants, the mitochondria, during the aging process.
Researchers have identified a new mechanism involving the oxidation of cysteines in titin protein that modulates cardiac stiffness and dynamics. This discovery sheds light on how the heart adapts to various situations and responds to oxidative balance disorders.
A retrospective study found that higher coronary artery calcium score, higher pulmonary artery-to-aorta ratio, and lower thoracic skeletal muscle index independently predicted worse overall survival. The PA-to-aorta ratio was the most important predictor of overall survival.
Researchers identified peripheral tissues as source of blood amyloid beta, which regulates blood glucose levels and suppresses insulin secretion. The study suggests a possible mechanism linking type 2 diabetes to Alzheimer's disease development.
A clinical trial at UC Davis Health showed that cellular therapy offers promise for patients with late-stage Duchenne muscular dystrophy, stopping deterioration of upper limb and heart functions. The therapy appears to be safe and effective in improving skeletal muscle and cardiac function.
Researchers uncover the pleiotropic functions of hnRNPK in regulating skeletal muscle cell differentiation, including inhibition of myoblast differentiation and suppression of genes involved in endoplasmic reticulum stress. The study suggests that targeting hnRNPK could be a potential therapeutic strategy for treating human disorders.
A study suggests that targeting necroptosis in muscle fibers using an inhibitor can lessen myositis-induced muscle weakness and cell death, promoting muscle regeneration. This approach shows promise for treating polymyositis with potentially fewer infectious complications than current immunosuppressive therapies.
A pooled data analysis found that between 30 and 60 minutes of muscle strengthening activity per week is associated with a 10-17% lower risk of death from any cause. The J-shaped curve showed no conclusive evidence that more than an hour of this activity reduces the risk further.
Researchers at HKUST discovered a protein called CPEB1 that drives skeletal muscle stem cell activation to repair damaged muscle. The study reveals discordance between SC proteome and transcriptome during activation, showing post-transcriptional regulation.
The study of MUNC long non-coding RNA reveals the importance of experimentally determining its structure to identify functional domains. The researchers found that two structural domains, including six common 'hairpins,' were crucial for regulating gene expression and muscle cell differentiation.
Researchers from the Max Planck Institute have obtained the first high-resolution 3D image of the muscle protein nebulin using electron cryo-tomography. The structure reveals that each nebulin repeat binds with an actin subunit, acting as a ruler to dictate filament length and interacting with neighboring actin subunits to stabilize it.
Researchers at the Buck Institute discovered a naturally occurring metabolite, 25-hydroxycholesteral, that significantly reduces senescent cells in multiple cell types and improves muscle mass in aged mice. The molecule targets CRYAB, a small heat shock protein associated with age-related diseases like myopathies.
An international team led by the University of Ottawa has published findings on the importance of the enzyme GCN5 in maintaining muscle integrity. The study discovered that GCN5 plays a crucial role in boosting the expression of key structural proteins, notably dystrophin.
Researchers at the University of Victoria have developed a novel broad-spectrum antidote for neuromuscular blockers, consisting of double calixarenes that bind to blocker rods with high selectivity. The 'double chalices' do not block acetylcholine and other physiologically important amines.
The study found that exercise induces expression of long noncoding RNA CYTOR, which enhances myogenic differentiation and improves muscle morphology and function in aged muscles. CYTOR also re-configures chromatin accessibility at binding sites of other genes, shedding light on its mechanisms.
A team of international scientists has shown that skeletal muscle cells from people with type 2 diabetes have a different circadian rhythm, leading to altered mitochondrial metabolism. The study suggests that considering cellular rhythms when prescribing treatments for type 2 diabetes could optimize their effectiveness.
The MUSC Hollings Cancer Center researchers are exploring the role of macroenvironment in pancreatic cancer-induced cachexia to address this debilitating condition. The team aims to provide new biological insight, which will be coordinated by four cores within the program project grant.
A new study found that a healthy gut microbiome is essential for skeletal muscles to grow after exercise. Researchers used mice with antibiotics to disrupt the microbiome, showing reduced muscle growth compared to healthy mice. The findings support previous studies linking the gut microbiome to muscle health.
Scientists at the University of Copenhagen have discovered that exercise can alter the structure of our DNA, specifically the enhancers that regulate gene expression. This epigenetic rewiring may be responsible for the beneficial effects of physical activity on human health.
Lauren Katz, a postdoctoral researcher at UNC Chapel Hill, received the IADR Osteology Foundation New Investigator Award for her work on craniofacial skeletal muscle regenerative potential. Her goal is to develop therapeutic options for patients with congenital and acquired craniofacial defects.
Sea otters have a higher basal metabolic rate than predicted for their size, with skeletal muscle being the primary source of this hypermetabolism. This process, known as thermogenic mitochondrial leak, allows them to maintain a normal body temperature in cold water environments.
Researchers found that oligo DNA promotes muscle differentiation and reduces inflammation in myoblasts, exacerbating diabetes. This discovery holds potential for developing a therapeutic agent to treat muscle wasting associated with various diseases.
Rice University bioengineers have created electrospun scaffolds from decellularized skeletal muscle that mimic native tissue and direct the growth of myotubes. The tunable scaffolds promote muscle regeneration with minimal crosslinking agents, offering a promising solution for reconstructive surgeries.
A new study found that the anti-aging compound NMN improved insulin sensitivity in skeletal muscle of postmenopausal women with prediabetes. However, it did not lower blood glucose or blood pressure, and more research is needed to determine its clinical benefits.
Researchers studied stress signals in skeletal muscle and found they prevent misfolded protein aggregates in the brain and retina. Tailoring this signaling may help combat neurodegenerative conditions like age-related dementia and Alzheimer's disease.
Skeletal muscle plays a key role in regulating body glucose levels and affects fat storage and metabolism. A new study found that Kruppel-like factor 15 (KLF15) is crucial for skeletal muscle fat uptake and utilization, leading to obesity and metabolic disease.
Researchers found that infection with Porphyromonas gingivalis causes skeletal muscle metabolic dysfunction, leading to insulin resistance and metabolic syndrome. The study also discovered a link between periodontal bacteria and altered gut microbiome, which contributes to the development of metabolic syndrome.
The University of Cincinnati researcher is studying the role of a muscle protein in the development of distal arthrogryposis, a rare skeletal muscle disorder. The protein in question, myosin binding protein-C, has been found to be essential for muscle formation, function, and regulation in both heart and skeletal muscles.
Researchers discovered that rapamycin preserves muscle function by stabilizing neuromuscular junctions, a key factor in maintaining healthy muscles during aging. A molecular signature of sarcopenia was also identified, highlighting mTORC1 as the primary contributor to age-related muscle wasting.
A new study published in the Journal of Nutrition suggests that vitamin C consumption is linked to higher skeletal muscle mass in older adults. The research, which analyzed data from over 13,000 participants, found that those with the highest amounts of vitamin C had the greatest estimated skeletal muscle mass.
The study found that macrophages play a critical role in muscle inflammation, fibrosis, and regeneration. Researchers believe that therapeutic manipulations of these cells hold promise for promoting muscle injury repair and improving outcomes for individuals with muscular dystrophy.
Researchers from SUTD and NTU developed insightful analyses of in vitro skeletal muscle tissue models, reviewing state-of-the-art bioengineering approaches for mimicking skeletal muscle tissues. Despite progress, challenges remain in replicating native muscle functionality, including proper innervation and vascularization.
Research highlights age-related muscle loss as a contributing factor to diabetes in the elderly. Men with lower lean body mass are more prone to developing diabetes, but not women.
Research found that mice with gut microbes had stronger skeletal muscles and improved energy production compared to germ-free mice. Transplanting gut microbes partially restored muscle function in germline mice, opening new avenues for interventions targeting age-related skeletal muscle loss.
Researchers found that pericyte transplantation can facilitate full regrowth of muscle fibers in skeletal muscle following limb immobilization. Pericytes play a crucial role in regulating muscle mass, particularly in the context of recovery from disuse atrophy.
Researchers found that exercising in the morning resulted in higher utilization of carbohydrates and ketone bodies, as well as the breakdown of fats and amino acids. The study suggests that timing of exercise is a critical factor for metabolic benefits, contradicting previous assumptions that focused on food intake timing.
Elevation of blood sugar levels triggers muscle atrophy by increasing KLF15 protein abundance, slowing down its degradation via WWP1. This leads to diabetes-induced skeletal muscle mass decline.
A UCI-led study reveals that fasting affects circadian clocks in the liver and skeletal muscle, rewiring metabolism for improved health. Fasting-driven cellular responses prime the genome for new gene expression patterns, suggesting optimal timed fasting could benefit health.
TGF-β1 is a potent modulator of immune and glial cell functions, regulating processes like fibrosis, atrophy, and muscle regeneration. Researchers discuss therapeutic strategies to inhibit the deleterious actions of TGF-β1 in skeletal muscle.
Researchers at Trinity College Dublin have discovered the specific non-coding section of the 'speed gene' that limits myostatin protein production, affecting skeletal muscle development and race distance aptitude. The findings provide valuable insights for thoroughbred breeders and trainers, a multi-billion dollar industry.
A new study found that essential fats in the diet regulate protein secretion in muscles by changing gene expression. Omega-3 and omega-6 fatty acids were shown to improve glucose levels and insulin tolerance in obese rats after 12 weeks on a supplemented diet.
The LSD1 enzyme suppresses mitochondrial metabolism and slow-muscle genes, promoting glycolysis in fast muscles. Glucocorticoids promote LSD1 degradation, allowing for muscle fiber type differentiation.
Researchers from Brigham and Women's Hospital found that zebrafish larvae with a mutation in DDX27 showed reduced muscle growth and impaired regeneration. The study provides specificity to the processes controlling protein synthesis in muscles, which will hopefully allow for targeted treatments for skeletal muscle diseases.
Researchers at the Salk Institute have identified ERRγ as a key player in delivering benefits associated with endurance exercise. By increasing ERRγ, they found that skeletal muscle energy production and endurance were restored, making it a potential therapeutic target for conditions such as muscular dystrophy.
Research finds TAK1 is essential for maintaining muscle mass and mitochondrial function in mature skeletal muscle. Removing or reducing TAK1 has negative effects on muscle health, contradicting previous assumptions.
Researchers at UCLA have successfully created skeletal muscle from human pluripotent stem cells, a major step towards developing a cell replacement therapy for Duchenne Muscular Dystrophy. The study uses natural human development as a guide to mature muscle cells in the lab and restore dystrophin-producing muscle fibers.
A new investigation reveals that human brains are less impaired than skeletal muscles when experiencing extreme physical and mental exertion. The 'selfish brain' hypothesis suggests that the brain prioritizes its own energy needs over peripheral organs, potentially contributing to human evolution's trade-offs.
A research team measured chimpanzee muscles and found a modest performance advantage, contrary to popular accounts of chimp 'super strength'. Chimpanzees have twice as many fast-twitch fibers, but this translates to only about 1.35 times more dynamic force and power output than humans.
SLU researchers have made a breakthrough in understanding muscle regeneration, identifying the nuclear receptor REV-ERB as a key player. By targeting this receptor, scientists may be able to develop new drugs to treat a range of muscle disorders and injuries, including muscular dystrophy and sarcopenia.
Amazentis' Phase 1 clinical data show that Urolithin A is safe and effectively increases mitochondrial gene expression and modulates plasma metabolites linked to muscle function in healthy elderly individuals. The study's findings have significant implications for the treatment of age-related decline in mitochondrial and skeletal muscl...
The paper provides a detailed protocol for building muscle-powered biological machines, enabling the creation of complex behaviors like self-assembly and adaptation. Researchers designed flexible 3D printed hydrogels and living cells to power 'walking' bio-bots, paving the way for applications in health, medicine, and environment.
Researchers discovered that Huntington's disease affects muscle maturation, leading to disrupted skeletal muscle function and potentially improving motor symptoms. The study suggests targeting skeletal muscle tissue may provide a new opportunity to improve patient care.