A recent study found that human lung tissue contains a vast reservoir of tissue-resident memory T cells (T RM cells) capable of targeting a range of viruses, bacteria, and fungi. These cells reside only in the lungs and can live for years, providing a vital line of defense against severe respiratory infections.
The Bulgarian Association of Clinical Immunology (BACI) has joined forces with Pensoft Publishers to host its official journal, Immunology in Medicine, which now operates under the open-access platform ARPHA. The journal aims to bridge basic immunological science with clinical applications, inviting researchers and clinicians to submit...
The new journal features cutting-edge research across basic, clinical, and translational immunology. It is designed to connect researchers across the full breadth of immunology, deepening understanding of the immune system in health and disease.
Scientists at La Jolla Institute for Immunology and Scripps Research have developed an HIV vaccine that trains immune cells to see past HIV's defenses. The vaccine resulted in the best HIV-fighting antibody response ever seen in primates, with human trials now underway.
A review published in Diabetes Care suggests that physical exercise could play a role in promoting immune regulation, preserving beta-cell function, and reducing inflammation in type 1 diabetes. The evidence highlights the potential benefits of exercise on immune profiles displaying anti-inflammatory characteristics.
Scientists at La Jolla Institute for Immunology have discovered that 'cross-reactive' T cells can recognize multiple species of paramyxovirus, including measles and Nipah viruses. This broad protection is essential in combating emerging diseases with unknown viral strains.
A Dartmouth Cancer Center study reveals that the location of immune cells within a tumor can determine whether they aid or hinder the anti-cancer response. Macrophages, often seen as helpful in clearing debris, have been found to play complex roles depending on their location and signals produced.
Researchers at La Jolla Institute for Immunology have discovered that combining key vaccine ingredients could give the body the tools it needs to fight the entire family of arenaviruses with a single vaccine. This approach may protect against life-threatening infections from Lassa virus, Junin virus, and many other arenaviruses.
Hongbo Chi's election recognizes his pioneering work in immunometabolism and its impact on next-generation cancer immunotherapies. He continues to contribute to St. Jude's mission-driven institution, advancing fundamental science and meaningful impact.
Researchers at La Jolla Institute for Immunology discovered that FluMist can trigger an immune response directly in nasal tissue, training immune cells to recognize and fight influenza virus infection. This response stays in the upper airways and cannot be detected via blood samples.
Luis Daniel Sansores España, a Doctoral Candidate at the University of Chile, has been awarded the 2026 IADR Norton Ross Fellowship for his research on molecular pathways involved in periodontal diseases. The fellowship provides training and experience in dental or related research.
Dr. Kenneth M. Murphy is being recognized for his groundbreaking research on dendritic cell subsets, which regulate adaptive immune responses and have advanced the understanding of antigen presentation and immune system regulation. His work has informed strategies to enhance antitumor immunity and cancer immunotherapy.
Renowned cancer scientist Thales Papagiannakopoulos is joining the Salk Institute as a professor, bringing expertise in cancer metabolism and immunology. He will collaborate with colleagues to uncover how tumors interact with the nervous system and develop new therapeutic strategies.
Researchers found that cancer cells lose MHC I expression, making them vulnerable to CD4+ T cell attack and ferroptosis triggered by iron and oxidative stress. This discovery challenges long-held assumptions in immunology and has implications for cancer immunotherapy and bone marrow transplantation.
Anand Balasubramani joins AAI with expertise in scientific publishing, program development, and community engagement. As CSPO, he will shape AAI's scientific agenda and oversee publications, education, and scientific affairs.
A new Tulane University study reveals that SARS-CoV-2 infection causes persistent brain inflammation and small blood vessel injury, even after the virus is no longer detectable. This finding helps explain why long COVID often includes neurological symptoms such as brain fog and fatigue.
A new Immunology Center will accelerate discoveries in muscle immunology and immune responses to gene therapies. Klaudia Kuranda brings expertise in immunology, onco-immunology, and leadership experience to the center.
The Michelson Medical Research Foundation has awarded $750,000 to five early-career scientists for their innovative work in immunology, vaccine discovery, and immunotherapy. The recipients will use the funding to accelerate their research and develop new treatments for diseases such as cancer and autoimmune disorders.
Researchers develop model to estimate animal's immune response based on genetic data, aiming to reduce antibiotic use and improve sustainability in livestock farming. The study found that non-genetic factors like seasonality explain much of the immune variability observed between animals.
Dr. George Coukos, a leading authority on tumor immunology and cellular immunotherapy, joins Weill Cornell Medicine to lead the Ludwig Laboratory for Cell Therapy.
Researchers found that certain gut bacteria can deplete amino acids, affecting tumor growth or activating immune cells. Tailoring diets and microbiome strategies may enhance anti-tumor activity and support personalized therapy.
Researchers at the Medical University of South Carolina are developing a new therapy for Type 1 diabetes that combines stem cell biology, immunology, and transplantation science. The goal is to restore beta cell function and insulin production in people with T1D without using immunosuppressive drugs.
A new study from the Medical University of South Carolina suggests that the complement system, a part of the body's innate immune system, plays a major role in brain damage after repeated concussions. The research found that reducing complement activation can help protect the brain and reduce cognitive impairments.
A University of Toronto-led study has discovered a potential biomarker linked to multiple sclerosis disease progression that could help identify patients most likely to benefit from new drugs. The findings were validated in both mouse models and humans, suggesting a possible surrogate marker for leptomeningeal inflammation.
Researchers from MSK discovered that two distinct subtypes of regulatory T cells play opposing roles in colorectal cancer, with one restraining tumor growth and the other fueling it. The study suggests that selective approaches to targeting these cells could improve immunotherapy treatment for most patients with colorectal cancer.
Researchers at LJI have discovered a cellular driver that leads to the development of tissue-resident memory T cells, which specialize in defending specific organs. The study found that GPR25 sustains TGF-\u00b2 signaling, promoting differentiation and transformation into these specialized immune cells.
The 'Cancer Immunology Data Engine' platform integrates clinical outcomes from 5,957 cancer patients worldwide with comprehensive multi-omics datasets covering 17 cancer types. Researchers can explore and analyse clinical trial data in depth, accelerating advances in cancer immunotherapy research.
Ten Scripps Research scientists, spanning chemistry, microbiology, immunology, and more, have been recognized on Clarivate's Highly Cited Researchers list. The list highlights researchers whose publications rank in the top 1% by citations for their field and publication year.
Allergist Cherie Zachary, MD, was installed as president of the ACAAI, replacing David Stukus, MD. Dr. Zachary brings experience in leadership and equity initiatives to her role.
A new study published in the American College of Allergy, Asthma and Immunology's annual meeting reveals a significant association between military deployment and an increased risk of developing chronic respiratory conditions. Deployed veterans were found to have a 55% higher risk of asthma compared to non-deployed peers.
A new study found that nearly half of obstetricians refer pregnant patients to allergists only once a year, and about one in four never refer them at all. The most frequently cited barriers are limited knowledge about referral indications and long wait times for appointments.
Researchers developed a protein language model that can generate functional antibodies against specific viral antigens. This approach enables rapid generation of antibodies against emerging health threats without requiring blood samples or antigen proteins.
A multidisciplinary team of scientists at Scripps Research has been awarded $6.9 million to identify more effective vaccines for treating HIV. By combining cutting-edge techniques and leveraging novel mouse models, the researchers aim to create a roadmap for building vaccines that provide lasting protection against HIV.
The Allison Institute's third annual scientific symposium featured a panel discussion with five Nobel laureates, highlighting breakthroughs in cancer vaccines, immunotherapy, and immunology research. The event also recognized scientific achievement and leadership through award presentations.
Researchers at St. Jude Children's Research Hospital found that metabolism guides the activation states of regulatory T cells, which dampen inflammation. The study reveals a link between mitochondrial function and lysosome activity in controlling these immune cells.
Researchers identified key genes connected to cellular lipid metabolism that guide the precise release of cytotoxic granules in human NK and T cells. This discovery explains how immune cells work and sheds light on diseases caused by genetic defects.
A comprehensive guide describes the effects of spaceflight on the immune system, including microgravity, cosmic radiation, and sleep disruptions. The study provides integrated mechanistic insights into how these stressors alter immune physiology, with potential relevance in aging research.
Researchers at La Jolla Institute for Immunology discovered that ALS is likely caused by an autoimmune reaction triggered by inflammatory CD4+ T cells targeting specific proteins in the nervous system. Anti-inflammatory CD4+ T cells may slow disease progression and prolong survival times.
A study published in Frontiers in Immunology has identified pentraxin 3 (PTX-3) as a potential biomarker for existing tissue damage and long-term immune activation following severe COVID-19. PTX-3 levels were found to be significantly higher in convalescent patients with a severe disease course persisting ten weeks post-infection.
Immunology Explained aims to counter false claims and distrust in science by offering accessible content across a new website and social media platforms. The initiative connects immunology to overall health, helping people understand its link to common concerns such as allergies and cancer.
Hawa Racine Thiam will be recognized for her groundbreaking work on biophysical immunology and subcellular biophysics. She is being honored with the 2026 Margaret Oakley Dayhoff Award for her trailblazing research, which has the potential to usher biophysical immunology into the future.
The new journal aims to publish high-quality research on immunity and inflammation, covering all areas of immunology and focusing on the role of inflammation. It seeks to foster a deeper understanding of inflammation's role in immunity and promote innovative approaches to prevent and treat inflammation-related diseases.
Dr. Carl Nathan's groundbreaking research has advanced our understanding of innate immunity, tuberculosis, and cancer. His discovery of macrophage-activating factor (MAF) and its role in driving immune responses has led to the development of new treatments for previously intractable diseases.
Research by University of Pittsburgh scientists discovered that damaging telomeres can lead to dysfunctional T cell function. To combat this, they developed a targeted antioxidant approach that rescued T cell function, opening the door for novel therapies in cancer immunotherapies.
Ana Campos Codo, a Weill Cornell Immunology and Microbial Pathogenesis Ph.D. student, has been selected for the 2025 cohort of the HHMI Gilliam Fellows Program. The program provides $65,000/year support for up to three years to students and their faculty thesis advisors.
Researchers found two types of peripheral helper T cells in inflamed joints: stem-like and effector cells. Stem-like cells live in immune hubs and help activate B cells, while effector cells cause inflammation outside the hubs. Targeting stem-like cells may offer new treatment hope for RA patients.
Researchers at La Jolla Institute for Immunology examine how genetics, sex hormones, and environmental factors shape the immune system. Women have a stronger immune response due to their XX chromosomes and estrogen, but also face an increased risk of autoimmune diseases.
Researchers at La Jolla Institute for Immunology investigate the fundamentals of allergy immunotherapies by examining T cells in children with cockroach allergies, finding that dosage and underlying response don't affect treatment efficacy.
Researchers discovered a new pathway to boost immunity against parasitic infections, suggesting that NSAIDs like ibuprofen could be repurposed as anti-parasitic treatments. Gasdermin C plays a crucial role in this process, targeting and penetrating Rab7-positive vesicles to reduce prostaglandin d2 levels.
A new study led by McMaster University researchers compared over 40 treatment options for chronic hives and found that certain treatments are more effective and safer than others. The findings will inform upcoming international clinical guidelines, providing patients and clinicians with a clear 'menu of treatment options' to choose from.
A new study from the University of Pittsburgh shows exercise improves cancer outcomes and enhances response to immunotherapy in mice by reshaping the gut microbiome. The research found that a specific compound called formate, produced by gut bacteria in exercised mice, was associated with better outcomes in patients with melanoma.
Deepshika Ramanan, a Salk Assistant Professor, has been recognized as a Rita Allen Foundation Scholar for her innovative research on maternal immunity and lactation. She will receive annual grants of up to $110,000 to conduct groundbreaking work in neuroscience, cancer, immunology, and pain.
Researchers at La Jolla Institute for Immunology discovered that T cell reactivity is highest during the prodromal period in Parkinson's disease, which can last for decades before noticeable symptoms. This finding may guide the development of early diagnostic tools and provide a new timeline for Parkinson's disease detection.
Researchers at La Jolla Institute for Immunology discovered that CD4+ T cells target Chikungunya virus, leading to chronic inflammation and joint pain. The study suggests that these monofunctional T cells may be the culprits behind arthritis-like symptoms in CHIKV patients.
Dr. Miriam Merad has been recognized for her groundbreaking research on macrophage biology and immunology, with a focus on cancer and chronic inflammatory disease. Her work has led to the development of novel therapeutic targets and has improved treatment outcomes for patients with lung cancer.
Researchers explore the psychological impact of chronic illnesses on patients with asthma and allergies, finding that fear, anxiety, and social stigma can greatly interfere with treatment. The American College of Allergy, Asthma, and Immunology discusses ways clinicians can mitigate these effects and provide better care for patients.
Dr. Sabine Ehrt takes the helm of microbiology and immunology at Weill Cornell Medicine, aiming to build on the department's reputation in tuberculosis research and expand into other areas. She seeks to foster cross-disciplinary collaborations and boost junior faculty mentorship.
Researchers discovered that gut bacteria can transform cholesterol-derived bile acids into powerful metabolites that strengthen anti-cancer immunity by blocking androgen signaling. These microbially modified bile acids antagonize the androgen receptor, driving anti-tumor immunity in mice with bladder cancer.
Dr. Crystal L. Mackall is being honored for her work on CAR T-cell therapy and its impact on pediatric cancer patients. Her research has led to the development of novel strategies to enhance durability of clinical responses and broaden the impact of CAR T-cells beyond hematological malignancies.
Researchers from La Jolla Institute for Immunology and UC San Diego discover Zika virus blocks dendritic cells' ability to alert T cells, while dengue virus stimulates pro-inflammatory cytokines, leading to a stronger but uncontrolled immune response. Understanding these differences is key to developing life-saving vaccines.