Articles tagged with Crohn Disease
Researchers have identified HERC4 as a crucial component of the TNF-induced cell death pathway, linking survival and death signalling. The protein's ubiquitination of RIPK1 initiates the formation of Complex II, triggering cell death through apoptosis or necroptosis.
Researchers at the University of Gothenburg identified a link between specific gut bacteria activities and primary sclerosing cholangitis, a rare chronic liver disease. Elevated levels of the metabolite ImP, formed by gut bacteria breakdown, can predict poorer survival outcomes and induce liver inflammation in PSC patients.
A Swedish registry study found that IBD patients with multiple close relatives having colorectal cancer are significantly more likely to develop the disease. The study suggests that future cancer screening guidelines should consider the number of cancer cases in a patient's family.
A preliminary study by Weill Cornell Medicine investigators found that antifungal therapy can reduce IBD symptoms and improve the gut microbiome in patients with Candida overgrowth. The study compared the effects of two weeks of treatment with nystatin or fluconazole in 53 patients with mild-to-moderate Crohn's disease or ulcerative co...
Researchers have created a detailed map of childhood Crohn's disease before and after treatment, identifying specific cell signatures that predict disease severity and treatment outcomes. The study suggests that anti-TNF therapy may push the pediatric cell ecosystem towards more resistant disease.
Researchers combined AI, genetics, and gut microbiome analysis to shed light on intestinal fibrosis in Crohn's disease. They identified a shared set of 43 key genes linked to disease progression and found that bowel fibrosis is driven by ongoing immune activation, damage to the intestinal lining, and changes in gut bacteria.
Researchers found that patients with inflammatory bowel disease (IBD) are at a significantly higher risk of developing psychiatric disorders, particularly depression and anxiety. The study highlights the importance of early screening and integration of psychological care into routine IBD management to improve quality of life.
Researchers identified unique antibody signatures against viruses and bacteria in nearly 2,000 blood samples collected over a decade, showing immune system changes years before diagnosis. The study supports the theory of molecular mimicry and provides an important framework for understanding IBD's earliest stages.
A new study found that beef protein worsens gut inflammation in mice with IBD, while pea protein shows protective effects. The research suggests that dietary protein source plays a key role in shaping gut health.
Researchers have identified a previously unknown genetic cause of Crohn’s disease and uncovered its link to inflammation through the RIPK1 pathway. This discovery may guide more precise treatments and improve patient matching based on unique biology.
Scientists discovered a direct link between estrogen and gut inflammation in Crohn's disease. The study used zebrafish models to show that estrogen signalling plays a crucial role in maintaining normal gut health. This finding could lead to more personalized approaches to treatment, especially for females affected by the disease.
A team of researchers has identified a distinct blood protein pattern that can accurately diagnose pediatric inflammatory bowel disease and differentiate between its two main forms. The discovery, using proteomics technology, showed high accuracy in identifying IBD and distinguishing ulcerative colitis from Crohn's disease.
Researchers mapped gene activity changes across over 1 million gut cells from patients with Crohn's and healthy controls, identifying key drivers of inflammation and potential therapeutic targets. The study also revealed a 'molecular scar' in the gut lining that leaves lasting marks on stem cells.
Researchers identified a driver of inflammatory bowel disease, a group of biologically distinct diseases driven by different underlying mechanisms. Autoimmune responses to interleukin-10 lead to uncontrolled inflammation in ~3.5% of IBD patients, carrying a genetic variant linked to severe disease.
A new study replicated patient- and sex-specific hallmarks of Inflammatory Bowel Disease (IBD) in a human organ chip, identifying stromal fibroblasts as key drivers of inflammation, fibrosis, and enhanced cancer risk. The model also recapitulated the impact of pregnancy hormones on IBD severity in female patients.
Researchers have developed a new combination therapy that shows promising results in treating patients with Crohn's disease and ulcerative colitis. The treatment, which combines two mechanisms of action, has been shown to improve clinical remission rates by more than 20 percentage points compared to existing therapies.
Researchers from UH, Baylor College of Medicine and MD Anderson Cancer Center propose a new treatment approach for Crohn's disease by targeting the stress signal that fuels inflammation. They found that repurposing two existing cancer medications can promote natural repair and regeneration of the intestinal lining.
A protein interaction between iNOS and IRG1 has been identified as a key regulator of the immune response. This discovery could lead to new treatments for conditions such as cardiovascular disease, arthritis, and Crohn's disease.
Researchers at Aalborg University aim to identify biological changes driving disease development with a comprehensive pre-diagnostic study of early Crohn's disease. They will analyze thousands of blood samples from patients prior to diagnosis to develop a predictive model.
Dr. David H. Ballard, MD, has been awarded a $100,000 grant from the SNMMI Mars Shot Research Fund to develop novel PET/MR imaging techniques for metabolic activity and inflammation in Crohn's disease. The study aims to improve biologically informed decision-making and guide treatment decisions.
Researchers have uncovered unusual clustering of endothelial cells around immune cells, signaling the start of excessive collagen production and scarring. This discovery could lead to new treatments for fibrosis, a common complication in Crohn's Disease affecting 10-20% of patients.
A new experimental rat model reproduces creeping fat in Crohn's disease, characterized by mesocolic adipose tissue hyperplasia with macroscopic, histological, immunological, and molecular similarities to human disease. The model supports the hypothesis that intestinal microbiota contributes to remodelling of mesenteric adipose tissue.
A new Danish study found that people with a higher genetic risk of developing chronic inflammatory bowel disease are more likely to experience a severe course. The researchers discovered a correlation between genetics and disease severity, which could lead to tailored treatment strategies.
A study by NYU researchers found that children with Crohn’s disease have a unique microbiome signature, characterized by more pro-inflammatory and less protective bacteria. This could lead to personalized treatments for pediatric Crohn’s disease.
A global study found that a group of bacteria, CAG-170, consistently appeared in high numbers in the gut microbiomes of healthy individuals. This species has the capacity to produce Vitamin B12 and break down carbohydrates, suggesting it plays a crucial role in maintaining human health.
A new survey by the Crohn's & Colitis Foundation found that 93% of people with inflammatory bowel disease (IBD) or at risk for it would be interested in a test to predict their risk of developing IBD. Lifestyle interventions, such as diet and exercise, were preferred over pharmaceutical approaches.
Researchers at UC Riverside find that faulty gene PTPN2 increases susceptibility to harmful bacteria like AIEC, leading to gut inflammation and IBD. The studies suggest that restoring PTPN2 function or using medications like JAK inhibitors may help control harmful bacterial growth.
Insilico Medicine presents three abstracts at the 2026 Crohn's & Colitis Congress highlighting clinical, preclinical safety, and efficacy data for ISM5411. The first-in-human Phase 1 results show no serious adverse events or deaths reported, with a favorable pharmacokinetic profile supporting gut restriction.
A new diet option has been shown to improve both physical symptoms and biological indicators of mild-to-moderate Crohn's disease. Participants in the fasting mimicking group experienced significant declines in fecal calprotectin, a protein indicating gut inflammation, and showed clinical benefits even after just one cycle.
Researchers have developed a blood test that can predict Crohn's disease years before symptoms appear. The test measures immune response to flagellin, a protein found on gut bacteria, which is elevated in individuals long before they develop the disease.
A new international study found significant changes in gut bacteria at the onset of inflammatory bowel disease (IBD), a condition that affects the digestive system. The study reveals a loss of beneficial anaerobic bacteria and an increase in oxygen-tolerant bacteria, which may trigger inflammation.
The Algae for Health in Food and Pharma summit explores the latest developments in algae cultivation and processing, food innovation, and pharmaceutical applications. The event aims to advance the understanding of algae's health potential and highlight its applications across the food and pharmaceutical sectors.
A multinational study found PSC prevalence among Asian IBD patients to be markedly lower than in Western countries, associated with more favorable clinical outcomes. The proportion of asymptomatic PSC cases has increased due to improved imaging modality detection, allowing for early-stage diagnosis and reduced liver transplantation rates.
The American Gastroenterological Association has released an updated clinical guideline on the pharmacological management of moderate-to-severe Crohn’s disease, recommending early use of high-efficacy therapies to improve patient outcomes. The guideline organizes treatments by efficacy to simplify decision-making for gastroenterologist...
Researchers at UGA engineered a live bacterium to deliver Levodopa steadily from the gut to the brain, alleviating motor deficits in models of Parkinson's disease. This breakthrough could lead to fewer pills, steadier symptom control, and better quality of life for patients.
Renowned gastroenterologist Jean-Frédéric Colombel, MD, will deliver the 31st Anatomy Lesson on November 20, exploring Mount Sinai's pioneering work in IBD prevention and treatment. His presentation aims to highlight the growing problem of immune diseases, including Crohn's disease.
Researchers at UC San Diego School of Medicine developed an AI-powered approach to decode macrophage gene expression patterns. They identified a 53-gene signature that separates reactive from tissue-healing macrophages, resolving a longstanding debate in Crohn's disease.
Researchers analyzed 659 posts on Reddit to better understand the role of social media in managing inflammatory bowel disease. The study found that patients use social media to track symptoms, manage medications, and cope with stress.
Researchers discovered a new enzyme produced by Bacteroides fragilis that activates pain signaling. The enzyme is targeted with nanoparticles to develop treatments for gut pain in inflammatory bowel disease and irritable bowel syndrome. The studies aim to restore balance between good and bad bacteria to reduce symptoms.
Double negative T cells (DNT cells) play an indispensable role in suppressing intestinal inflammation, acting as antigen-presenting cells. Their impaired function may contribute to the pathogenesis of Crohn’s disease, suggesting they could be a potential therapeutic target.
Researchers at uOttawa are developing an AI tool to provide personalized dietary strategies for people living with inflammatory bowel disease (IBD). The project aims to match specific types of carbohydrates to individual patients' unique gut microbiomes.
The Crohn's & Colitis Foundation has launched GLIDE, an integrated global registry to connect patient data from IBD registries worldwide. This initiative aims to accelerate insights into complex clinical questions, driving improvements in care for those living with Crohn's disease and ulcerative colitis.
A study by Stanford Medicine researchers reveals that creeping fat, a type of abnormal adipose tissue, forms scars in the intestines of people with Crohn's disease. This triggers debilitating scarring, which worsens symptoms and treatment options for patients.
Researchers discovered that smoking produces metabolites that encourage mouth bacteria to grow in the large intestines, triggering an immune response. These bacteria, specifically Streptococcus mitis, help reduce inflammation in ulcerative colitis by triggering a specific immune response.
A large-scale study published in PLOS Medicine found no association between early life antibiotic exposure and the development of autoimmune diseases in children. Researchers analyzed data from over 4 million Korean children and discovered no increased risk of Type 1 diabetes, Juvenile idiopathic arthritis, or other autoimmune conditions.
Researchers at ETH Zurich and Stanford University quantified the number of molecules produced by gut bacteria that reach the human body daily. This knowledge helps understand how the gut microbiome influences health and behavior.
A new study led by Mount Sinai researchers has identified distinct biological signatures in patients with mild Crohn's disease, which may help avoid overtreatment and guide more personalized care. The findings suggest that these biomarkers can distinguish mild disease from more aggressive forms, potentially allowing for safer treatment...
A study by University of California, Riverside researchers found that inhaling agricultural dust can alter the gut microbiome and impair intestinal function, leading to increased 'leaky gut' and associated chronic diseases. The study highlights the need for protective measures for agricultural workers.
The study found that guselkumab significantly improved endoscopic response and deep remission in patients with Crohn's disease. The therapy also demonstrated a corticosteroid-sparing effect, making it a valuable alternative to long-term steroid use.
A large prospective study found that a healthy plant-based diet is associated with an 8% lower risk of ulcerative colitis and a 14% lower risk of Crohn’s disease. Fruits and vegetables were identified as key protective factors against inflammatory bowel disease.
A study has discovered a connection between ferroptosis, a type of iron-dependent cell death, and inflammatory bowel disease. Lipid ROS activate ferroptosis, which drives cell death in the colon lining, and inhibiting this process may lead to new treatment options for IBD.
Researchers identified a gene mutation that disrupts iron absorption in patients with Crohn's disease, leading to persistent anemia. The study sheds light on how genetic risk factors for IBD can compound patient symptoms by interfering with nutrient absorption.
A study in Gastroenterology Nursing found that popular IBD-related TikTok videos have very low scores for quality of medical information, despite their high views. The research suggests that tailored educational content on IBD can be created for the platform, addressing gaps in IBD education.
A global study describes four distinct stages of inflammatory bowel disease (IBD) as it spreads to newly developing regions in Africa, Asia, and Latin America. The research provides resources and guidance for local healthcare systems coping with the growing burden of IBD patients.
A new approach, GlycoCaging, delivers medicine directly to the lower gut at significantly lower doses than current treatments, potentially helping people with inflammatory bowel disease. The technique has been shown to be effective in mice and has potential for treatment in humans, as most people have the ability to activate the drugs.
Researchers from UCalgary and Chinese University of Hong Kong found that IBD progresses through four predictable epidemiological stages as it spreads globally. The study forecasts a major rise in IBD prevalence in Canada by 2045, with countries in North America, Europe, and Oceania reaching Stage 3 (compounding prevalence). Developing ...
A new study published in the American Journal of Gastroenterology found significant disparities in healthcare utilization among racial and ethnic groups with inflammatory bowel disease (IBD) in the US. Black Americans over 65 had nearly 1.5 times higher use of emergency department services compared to White counterparts, while Asian an...
A study using machine learning models found that people with IBD are at risk for premature death when developing other chronic health conditions earlier in life. Chronic conditions like arthritis, hypertension, and mood disorders were common causes of death among those with IBD.
A Mount Sinai-led team has discovered a link between gamma delta intraepithelial lymphocytes and the development of Crohn's disease. By analyzing a mouse model, they found that impaired communication between these cells led to inflammation in the lower small intestine.
New guidelines support safe and efficient use of JAK inhibitors for treating chronic inflammatory diseases like rheumatoid arthritis, psoriasis, and Crohn's disease. The updated consensus statement considers safety concerns, including cardiovascular disease and cancer risk, to ensure individualized treatment decisions.