Articles tagged with Ulcers
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A new study found that quadrivalent human papillomavirus (HPV) vaccination is associated with a reduced risk of high-grade vulvovaginal lesions. Expanding HPV vaccination, especially at younger ages, may help prevent these lesions.
The study found substantial interrater reliability for active disease grades, but variability in individual grade assignments. The NHI showed substantial interrater reliability (ICC = 0.79) among US gastrointestinal pathologists for assessing histologic remission in treated ulcerative colitis biopsies.
A new study published in JAMA Network Open reveals a strong association between increased utilization of overtime and agency nurses and patient safety. The research found that prolonged exposure to high-stress work environments contributes to a higher incidence of pressure ulcers among patients.
Researchers developed a novel approach using electrospun poly(Lactic-co-Glycolic Acid) membrane with autologous cells to treat oral mucositis, a painful side effect of chemotherapy. The study showed significant results, with ulcers healed completely within six days and reduced inflammation.
A new study published in Aging found that pioglitazone reduced the frequency of skin ulcers in Werner syndrome patients. The research suggests that pioglitazone's anti-inflammatory properties may help wounds heal faster and prevent ulcers from forming.
A recent study found that U.S. soldiers are 10 times more likely to use nicotine pouches, which can cause serious health issues, compared to the general population. The study analyzed anonymous responses from 1,957 soldiers and found that 23.8% reported using nicotine pouches in the previous 30 days.
A new study by the University of Nottingham found repeated paracetamol doses in older adults (65+) can lead to increased risks of peptic ulcers, heart failure, hypertension, and chronic kidney disease. The study suggests paracetamol use should be carefully reconsidered for long-term conditions such as osteoarthritis.
A study published in JAMA Network Open found that hospital-acquired pressure ulcers are associated with poorer neurological outcomes and reduced motor function in patients with acute cervical spinal cord injury. The findings suggest that preventing pressure ulcers can help protect these patients and lead to improved medical care.
Researchers developed porous dermal fillers that accelerate tissue healing and regeneration for diabetic wounds. The novel approach combining electrospinning and electrospraying technologies creates biocompatible microspheres that promote cell migration, granulation tissue formation, and neovascularization.
A study highlights a significant educational gap in identifying early stages of pressure ulcers in people with dark skin tones, putting them at risk of severe bedsores. Researchers recommend updated clinical guidelines and inclusive education to ensure all nurses can provide equitable care.
A new study found that nursing shortages result in longer hospital stays and worse patient outcomes, including higher mortality rates. Understaffing by registered nurses and nurse assistants is associated with increased risks of adverse events, such as readmissions, deep vein thrombosis, pneumonia, and pressure ulcers.
A new technology uses autofluorescence imaging to detect bacteria in wounds, allowing for early detection and removal of harmful microorganisms. The study reveals that this method can identify bacteria in approximately 9 out of 10 patients that traditional assessments miss.
A new index uses inflammatory cell proportions to predict tissue healing and outcomes in patients with ulcerative colitis. The index, called the inflammatory cell enumeration index (ICEI), was developed by analyzing data from 220 patients who achieved healing.
A new stability-indicating RP-HPLC method was developed to estimate impurities in esomeprazole gastro-resistant tablets using the analytical quality by design (AQbD) approach. The validated method demonstrated excellent linearity, specificity, and precision, making it a reliable tool for accurate analysis.
Marilyn Rantz's Quality Improvement Program for Missouri (QIPMO) improves care quality in nursing homes, reducing avoidable hospitalizations. The program is now being emulated nationwide for its proven track record of success.
Researchers have developed a pressure-alternating shoe insole that provides periods of rest to the soft tissues, thereby reducing the risk of diabetic foot ulcers. This innovative technology aims to mitigate the risk of complications from poor circulation and foot sores.
A team of international scientists has developed an effective treatment for preventing infection in chronic wounds that does not involve antibiotics. The new method involves the plasma activation of hydrogel dressings, producing a unique mix of chemical oxidants that are effective in decontaminating and aiding healing.
A team of scientists has developed a new treatment for chronic wounds that uses ionized gas plasma to decontaminate and heal wounds. The technology shows promise in treating diabetic foot ulcers, internal wounds, and potentially cancerous tumours.
A new study from Uppsala University found that people who have had herpes virus are twice as likely to develop dementia as those who have never been infected. The researchers studied 1,000 70-year-olds over 15 years and confirmed previous research on the potential link between herpes and dementia.
Researchers at University of Tsukuba discovered a correlation between hypoxia levels and clinical symptoms in UC patients. Lower oxygen saturation in the rectal mucosa was associated with greater severity of colitis, making this method a potential tool for objective measurement of disease activity.
A large-scale genome study of over 50,000 patients and 900,000 controls has identified 25 genetic markers associated with peptic ulcers, which may lead to new population-specific treatments. The study also found a link between Helicobacter pylori and peptic ulcer disease.
Researchers from NUS have developed a novel magnetic gel that heals diabetic wounds by activating dormant skin cells and repairing damaged blood vessels. The treatment has shown promising results, healing wounds up to three times faster than conventional approaches.
The study, which analyzed data from older adults with peptic ulcer disease, revealed that approximately 1 in 8 individuals developed depression for the first time during the pandemic. Women, those who felt lonely, and those with functional limitations were at higher risk of depression. Targeted screening and intervention are being reco...
A new study reveals that being divorced is associated with a two-thirds higher risk of lower limb amputation (LLA) in individuals with diabetes compared to those who are married. Additionally, men have a 57% higher risk of LLA than women. The study also found that obesity has a less-than-half the risk of LLA for people with normal weight.
Physicians can remotely drive a miniature video capsule to visualize and photograph potential problem areas in the stomach using an external magnet and hand-held joysticks. The new technology has been shown to be effective in detecting high-risk lesions with a 95% rate of visualization.
A breakthrough surveillance tool has been developed to detect elevated risks of Buruli ulcer outbreaks in Victoria, utilizing possum 'poo' analysis. The tool reveals significant spatial correlation between clusters of Mycobacterium ulcerans positive possum excreta and human Buruli ulcer cases.
A patient in Cleveland was diagnosed with a corneal ulcer caused by Pseudomonas aeruginosa, a drug-resistant bacterium that's rarely found in eye infections. The contaminated eye drops were identified as the source of infection, and treatment required strong antibiotics to prevent vision loss.
The PROMISE II clinical trial showed that LimFlow therapy enabled 76% of patients to avoid amputation and experience wound healing. This minimally invasive procedure bypasses blocked arteries in the leg and rushes blood back into the foot through the veins, providing a unique alternative to major amputation.
Researchers developed smart bandages that can monitor wound conditions and deliver medication to treat inflammation and infection. The bandages have shown promising results in animal models, offering real-time updates and speed healing of chronic infected wounds.
Researchers from China conducted a comprehensive review of dual therapy (DT) for H. pylori eradication, highlighting its high efficacy and patient compliance with minimal adverse events. High-dose DT administered over 14 days has emerged as the most effective treatment option.
Researchers found that COVID-19 infections are linked to an increased risk of developing liver problems, acute pancreatitis, and other GI disorders. The study analyzed over 14 million medical records and estimated that SARS-CoV-2 infections have contributed to over 6 million new cases of GI disorders in the US.
A new paper from a team including experts from the University of Huddersfield focuses on the role podiatrists have in preventing the progression of venous diseases, such as varicose veins and varicose eczema. The study highlights an opportunity for podiatry to contribute more overtly towards prevention, which is crucial in the current ...
Researchers developed a nanofiber aerogel that promotes faster and more effective healing of diabetic wounds. The aerogel facilitates cell migration, oxygen, and nutrient delivery to the wound bed, while incorporating an anti-microbial peptide prevents bacterial growth and promotes healing.
Researchers at UVA Children's will use a sophisticated computer model to better understand and treat Crohn's disease, which can have lifelong consequences for young patients. The team hopes to identify biological markers or metabolic signatures that can be used for early diagnosis and personalized medicine.
A new day-case surgical procedure for diabetic foot ulcers has been shown to accelerate effective healing, reduce recurrence, and prevent amputations. The procedure, which involves adjusting the mechanics of the foot, was found to be effective in treating up to 19 patients with successful ulcer resolution in just 3-4 weeks.
Researchers at the University of Chicago found that Medicare residents in US nursing homes report only 59.7% of pressure ulcers, with disparities affecting Black and Hispanic residents, who experience more severe stage 4 ulcers.
A study published in eLife identified three microRNAs that may impair healing in venous ulcers, a common type of chronic wound. The findings suggest that drugs targeting these microRNAs could help facilitate healing in patients, offering new approaches for treating this painful and slow-to-heal condition.
Researchers at the University of South Australia have developed tiny optical fibre sensors to monitor movement and record vital signs, reducing the risk of pressure sores. The technology can detect when patients remain motionless for extended periods, prompting nurses to adjust their position.
Researchers have developed unique self-regulating footwear for persons with diabetes, featuring snapping mechanisms that distribute pressure evenly. The sandals can be customized to an individual's foot dimensions and walking style, promoting faster healing of injured regions and preventing further injuries.
Researchers and academics from the UK and Germany come together to discuss therapeutic footwear for people with diabetes. The workshop aims to establish new research links and develop research capacity to improve the lives of those affected.
A large cohort study of almost 125,000 patients found that diabetic foot ulcer outcomes are associated with race, ethnicity, and rurality. Higher rates were observed among rural and Black patients, highlighting the need for targeted interventions to address health disparities.
Researchers at Beth Israel Deaconess Medical Center used single-cell RNA-sequencing analysis to study skin cells in patients with diabetic foot ulcers. The study revealed specific fibroblast subtypes play a crucial role in healing these ulcers, suggesting targeting these cells as a potential therapeutic option.
A recent study found that antibiotic resistance rates for Helicobacter pylori are decreasing in European countries. The use of three antibiotics over 10-14 days resulted in success rates of over 90%. The researchers hope to reduce antibiotic consumption to prevent further resistance.
Scientists from Japan discover IL-36Ra plays a pivotal role in wound healing, and Cl-amidine normalizes exacerbated I/R injury. The study's findings suggest IL-36Ra as a potential therapeutic target for cutaneous I/R injuries.
Scientists have improved understanding of a key protein that makes the stomach acidic, shedding light on potential applications in drug development. The study found an unusual feature in the protein, which needs to bind to only one potassium ion to trigger its pump mechanism.
A recent University at Buffalo study found that patients using proton pump inhibitors (PPIs) for heartburn had smaller probing depths in their gums, indicating less severe gum disease. The researchers suggest that PPIs' side effects may be linked to reduced periodontitis severity.
Researchers have created a flexible polymer composite microneedle array that can effectively pierce biofilm in chronic wounds, delivering oxygen and bactericidal agents simultaneously. This innovation has the potential to improve treatment outcomes for millions suffering from diabetic foot ulcers.
Researchers discovered that cannabidiol accelerates oral ulcer healing by inactivating the CMPK2-mediated NLRP3 inflammasome. This mechanism may lead to the development of new treatments for oral ulcers.
A new, inexpensive biopolymer dressing is being developed to heal chronic wounds such as diabetic foot ulcers. The dressing addresses the high cost of existing treatments and has shown promising results in pilot trials with 13 patients.
Researchers at Staffordshire University have developed a novel, low-cost method to detect foot ulcer risk without electronic sensors. This new technique uses 3D-printed structures to identify areas with high pressure, enabling clinicians to prescribe custom footwear or insoles.
A new stem cell therapy has induced regeneration of blood vessels surrounding non-healing diabetic foot ulcers, accelerating healing. The treatment uses adult stem cells harvested from fat tissue, demonstrating a novel cell injection therapy that can alleviate pain and infection.
Researchers discovered a powerful approach for treating diabetic foot ulcers by targeting a gene that controls tissue growth and regeneration. The new treatment has shown promising results in animal models and human skin equivalents, and may hold potential for repairing internal organs.
A link between depression and stomach ulcers has been confirmed in the world's largest study of genetic factors in peptic ulcer disease, involving nearly half a million people. Genetic variations associated with an increased risk of peptic ulcer disease have also been identified.
A whole foods, plant-based diet has been shown to ease the symptoms of livedoid vasculopathy, a blood vessel disorder causing painful ulcers on the feet and lower legs. The condition affects mostly women in their 30s, with poor blood flow being a contributing factor.
A clinical trial led by Imperial College London researchers found that early surgical treatment of leg ulcers reduces the risk of recurrence and improves healing times compared to current methods. The study suggests revising guidelines to include earlier assessment and surgery, potentially saving the NHS £100 million per year.
Researchers have developed a bioengineered scaffold using human mesenchymal stem cells and timolol, which significantly improved wound epithelialization and reduced inflammatory response in diabetic mice. The combination therapy resulted in more than a 70% increase in tissue repair compared to the control group.
Researchers developed a device that circulates cool water into pressure-relieving insoles to reduce foot temperature and diminish the risk of tissue breakdown. The device, TAPMARI, was tested in eight volunteers and showed promising results, potentially preventing thousands of amputations worldwide.
The PEPTIC trial compared two strategies for preventing stress ulcers in ICU patients requiring mechanical ventilation. The study found no significant difference in in-hospital death rates between proton pump inhibitors and histamine-2 receptor blockers.
A research team studied 593 gorillas over a decade, finding females migrate to healthier groups to avoid transmission of yaws, a contagious skin disease. The scientists discovered that females can detect one symptom of the disease: disfigurement.
A recent study by the University of Leeds found that high-tech air mattresses provide only minimal gains in preventing pressure ulcers compared to specialist foam mattresses. The study involved over 2000 patients and showed that the benefits were mostly limited to those who were completely immobile, confused, or had nutritional deficits.