Exploring how breast milk composition changes throughout the day
Research investigates how bioactive molecules in human milk shape infant metabolism and informs formula development.
Microrna
Articles tagged with Microrna
Scientists at UMass Chan Medical School develop microRNA-based gene therapy that halts ALS progression in mice
Researchers at UMass Chan Medical School have developed a microRNA-based gene therapy that suppresses mutant SOD1 production, delaying disease onset by 60 days and extending lifespan by 100 days in mice models of ALS. The therapy, delivered via adeno-associated virus (AAV) vector, preserves motor neurons and maintains neuromuscular con...
SourceUMass Chan Medical School·JournalNature Communications·TypeExperimental study·DateJul 29, 2026
Lifestyle interventions reshape a liver microRNA pathway to combat MASLD
Researchers discovered a molecular link between exercise, dietary timing and liver protection against metabolic dysfunction-associated steatotic liver disease (MASLD). The study found that exercise and time-restricted feeding suppress a specific signaling axis involving miR-802, PPARγ and Psmd2.
Could circulating microRNAs offer insights for detecting and treating muscle wasting associated with cancer?
Researchers discovered specific microRNAs, including miR-16 and miR-140, which may help detect cancer-related muscle wasting in dogs. The study's findings have implications for human medicine, suggesting a potential new approach for earlier diagnosis and monitoring of cancer-related cachexia.
Tiny molecules, big possibilities: Researchers explore a new way to slow lung cancer
A new study has identified two naturally occurring microRNAs, microRNA-15a and microRNA-16, which can significantly reduce the growth and protein synthesis of non-small cell lung cancer cells. This finding suggests that these microRNAs could serve as targets for therapies designed to slow cancer progression.
Novel nanowire device offers rapid, noninvasive cancer detection
Researchers developed a nanowire device that selectively captures cancer-related extracellular vesicles from the blood serum of ovarian cancer patients. The technology uses high-performance zinc oxide nanowires and achieves efficient capture of cancer biomarkers with minimal physical burden on patients.
Scientists reveal how argonaute, a key protein for RNA therapeutics, becomes activated
Researchers have uncovered the structural basis of Argonaute assembly, revealing that chaperone proteins hold it in an open conformation allowing miRNA loading. The study also found that RNA plays a key role in guiding Argonaute folding.
Senescent muscle cells send molecular messages that may contribute to age-related muscle decline
Researchers found that senescent myoblasts released EVs carrying specific miRNAs that impaired normal muscle cell development and triggered cellular stress responses in healthy muscle cells. The study suggests that extracellular vesicles may play a role in shaping the aging muscle environment.
How our biological clock starts and keeps ticking
A team of researchers at Cold Spring Harbor Laboratory has identified a unique biological clock mechanism in the worm C. elegans, comprising two previously known proteins MYRF-1 and LIN-42. This feedback circuit governs the timing of gene expression pulses, crucial for proper developmental progression.
SourceCold Spring Harbor Laboratory·JournalProceedings of the National Academy of Sciences·DateJun 3, 2026
Findings from the first randomised trial assessing RNA therapy in heart failure
The HF-REVERT trial found that CDR132L improved secondary endpoints, including LVEF and NT-proBNP, but not the primary endpoint of LVESVI. Target engagement was confirmed by decreased plasma levels of microRNA-132. The therapy was well-tolerated with no significant safety concerns.
NTU Singapore scientists invent AI-powered biochip that detects genetic markers in 20 minutes
A team of scientists from NTU Singapore has developed a new biochip that, when paired with Artificial Intelligence (AI), can detect quickly and accurately extremely small amounts of microRNAs. The device can cut detection time from hours to 20 minutes.
SourceNanyang Technological University·JournalAdvanced Materials·TypeExperimental study·DateApr 15, 2026
Scientists reverse brain aging, with a nasal spray
Researchers developed a nasal spray that reversibly reduces brain inflammation, restores cellular power plants, and improves memory. The treatment bypasses the brain's protective shield through intranasal delivery, suppressing chronic inflammation and promoting successful brain aging.
Exosome-based therapies for androgenetic alopecia: Mechanisms, microRNAs, and clinical prospects
Exosome-based therapies harness the power of microRNAs to activate hair follicle stem cells, promoting hair growth. Key findings include the identification of pro-anagen and inhibitory microRNAs that regulate Wnt/β-catenin, Shh, and HIF-1α pathways.
In Rett syndrome, leaky brain blood vessels traced to microRNA
MIT neuroscientists have found that two genetic mutations causing Rett syndrome compromise the structural integrity of developing blood vessels, leading to leaky vessels. Overexpression of miRNA-126-3p is responsible for the vascular defect, which can be rescued by reducing the miRNA's levels.
Chronic kidney disease poisons patients’ hearts, scientists discover
Researchers identify circulating extracellular vesicles produced in diseased kidneys as the culprit behind toxicity in the heart. The discovery could lead to the development of a blood test to identify patients at high risk for serious heart problems and novel treatments to prevent and treat heart failure.
An AI-guided framework reveals conserved features governing microRNA strand selection
Researchers have decoded the logic of microRNA strand selection using AI, revealing a conserved and programmable mechanism governing gene regulation. The study found that this decision follows conserved rules rather than chance, with mammalian microRNAs showing a strong bias towards a single dominant strand.
SourceArizona State University·JournalNucleic Acids Research·TypeExperimental study·DateJan 14, 2026
Circular single-stranded DNA for multi-target miRNA therapy
A new circular single-stranded DNA molecule has been developed to simultaneously silence multiple oncogenic miRNAs. The molecule, called circAMO, exhibits high biostability and can inhibit tumor cell proliferation, migration, and invasion in a concentration-dependent manner. It shows superior efficiency compared to existing anti-miRNA ...
A microRNA cocktail to weaken brain tumors
A microRNA cocktail has been developed to weaken glioblastoma, a type of aggressive brain tumor. The formulation, comprising 11 different non-coding RNAs, slows the growth of cancer cells and enhances chemotherapeutic drug activity.
SourceIstituto Italiano di Tecnologia - IIT·JournalMolecular Therapy — Nucleic Acids·TypeExperimental study·DateNov 20, 2025
The world’s oldest RNA extracted from woolly mammoth
Researchers have successfully isolated and sequenced RNA molecules from Ice Age woolly mammoths, providing new insights into the biology of extinct species. The study reveals that RNA can be preserved for nearly 40,000 years, offering a glimpse into the final moments of life.
RNA tech could make fast test for Alzheimer’s disease
Researchers at the University of Connecticut have developed two fast tests for early markers of Alzheimer's disease using CRISPR technology. The tests recognize microRNA molecules associated with Alzheimer's, allowing for quick identification in doctor's offices.
Overactive microRNAs block fat cell development in progeria
A new study found that miR-145-5p and miRNA-27b-3p interfere with fat cell formation in children with Hutchinson-Gilford progeria syndrome, a rare and fatal premature aging disorder. These microRNAs silence genes required for fat cell growth and function, suggesting they could be a promising therapeutic strategy to restore fat tissue.
Scientists reveal long-standing mystery of ENOD40, a pioneering gene in legume nodulation research that marks nodule identity
A long-standing mystery of ENOD40, a pioneering gene in legume nodulation research, has been solved. ENOD40 acts as a natural microRNA sponge to regulate the legume nodulation pathway, enabling nitrogen-fixing nodule formation. The discovery sheds light on a new layer of control in plant-microbe symbiotic relationships.
SourceUniversity of Cambridge·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateAug 18, 2025
Chinese Medical Journal article review explores extracellular vesicles in oocyte health and therapies
Extracellular vesicles play a crucial role in regulating oocyte maturation, follicular growth, and quality. In pathological conditions, EVs can disrupt communication, leading to impaired oocyte development and ovarian failure. Therapeutic EVs show promise in reversing ovarian pathologies by delivering functional molecules.
SourceChinese Medical Journals Publishing House Co., Ltd.·JournalChinese Medical Journal·TypeLiterature review·DateAug 15, 2025
miRNA dysregulation of AGE/RAGE pathway in metabolic syndrome: a novel analysis strategy utilizing miRNA-profiling data
This review systematically maps miRNA-mediated dysregulation of the AGE/RAGE pathway in MetS, revealing widespread but understudied miRNA dysregulation across adipose tissue, liver, and immune cells. Prioritizing poorly studied receptors and multi-pathology miRNAs could accelerate targeted therapies for MetS.
microRNAs emerge as biomarkers and diagnostic tools in soft tissue sarcoma
Researchers highlight microRNAs as crucial biomarkers for diagnosing and monitoring soft tissue sarcomas, with potential for precision medicine. MicroRNAs could help distinguish between tumor types and guide treatment decisions.
‘Stealthy’ lipid nanoparticles give mRNA vaccines makeover
Researchers at Cornell University have developed a new lipid nanoparticle that replaces PEG with poly(carboxybetaine) to improve mRNA vaccine delivery. This stealthy material helps vaccines evade the immune system while inducing targeted immune responses, making it more effective for cancer vaccines.
MicroRNAs in the regulation of immune response in cardiovascular diseases: New diagnostic and therapeutic tools
MicroRNAs modulate inflammation across major cardiovascular risk factors, making them potential biomarkers for early detection and targets for prevention. Specific miRNAs regulate individual immune cell types in cardiovascular pathology, such as promoting M2 polarization and reducing plaque burden.
MicroRNA-124-3p and brain-derived neurotrophic factor in rat spinal cord injury: Inverse expression pattern
This study investigated the correlation between miR-124-3p expression and BDNF levels in a rat model of spinal cord injury. The findings show a significant downregulation of miR-124-3p and upregulation of BDNF levels following SCI, suggesting a potential regulatory role of miR-124-3p in BDNF expression and SCI pathophysiology.
New insights into migraine-related light sensitivity
Scientists have identified a brain molecule called NEAT1 that appears to play a central role in triggering light sensitivity (photophobia) during migraines. By disrupting the normal balance of nerve signaling and pain regulation, NEAT1 makes nerves more sensitive to light.
SourceXi'an Jiaotong-Liverpool University·JournalThe Journal of Headache and Pain·TypeExperimental study·DateMay 21, 2025
Novel blood-based biomarker analysis provides insights to improve therapy decisions and treatment outcomes for patients with metastatic disease
Researchers identified platelets, C-reactive protein, and chromogranin A as markers that can predict the failure of hormone-sensitive prostate cancer treatment. The study also found that miR-375 expression and lymphocyte-to-monocyte ratio are negative predictors for therapy failure in castration-resistant prostate cancer patients.
Breakthrough provides new hope for patients with knee osteoarthritis
Scientists at Henry Ford Health + Michigan State University Health Sciences have identified a circulating microRNA called miR-126-3p as a mechanistic biomarker of knee osteoarthritis. This discovery may lead to the development of blood tests for early detection and therapeutics for slowing or stopping disease progression.
SourceHenry Ford Health·JournalNature Communications·TypeRandomized controlled/clinical trial·DateMay 1, 2025
Gene circuits enable more precise control of gene therapy
Researchers at MIT developed a control circuit that can precisely regulate gene expression levels, improving the efficacy and safety of gene therapy treatments. The 'COMMAND' circuit uses microRNA to suppress gene expression, allowing for tighter control over treatment outcomes.
Prostate cancer discovery opens door to more tailored treatments
Researchers have discovered genetic properties in prostate cancer that can be targeted to improve patient outcomes, particularly for Chinese men. The findings highlight the potential of precision medicine and more effective treatments.
miR-146b/ BTG2 axis in the progression of obesity to T2DM
Researchers identified miR-146b as a key regulator of beta-cell decline during obesity-to-T2DM progression. The study showed that miR-146b suppresses the expression of Btg2, leading to increased apoptosis and decreased insulin synthesis and secretion.
Shining a light on age-related blindness
A new study from the University of Oklahoma is targeting cell communication in the hunt for therapies to slow macular degeneration. The research team is studying how cells in the retina communicate and whether the messages they send could be programmed to treat or slow AMD.
Unraveling the oncogenic potential of microRNAs in lung cancer
Research highlights the oncogenic potential of microRNAs in lung cancer, their dysregulation, and functional roles. Dysregulated miRNAs can contribute to tumor progression, metastasis, and chemotherapy resistance.
Test predicts which patients with prostate cancer are most likely to develop long-term side effects from radiation therapy
A UCLA study validates the predictive power of PROSTOX, a genetic test that uses microRNAs to identify patients at higher risk of developing long-lasting urinary side effects from radiation therapy. The test helps doctors and patients choose safer treatment options, reducing the burden of long-term complications.
SourceUniversity of California - Los Angeles Health Sciences·JournalClinical Cancer Research·DateApr 7, 2025
How microRNAs act as a “blueprint” for the developing brain
Scripps Research scientists discovered how microRNAs impact Purkinje cell development, shedding light on the intricate process required to build brain complexity. The team found that microRNAs are critical during two phases in Purkinje cell development, controlling precise timing of different aspects.
Predatory behavior is an inherited trait across multiple generations in nematodes
Research by the Max Planck Institute reveals how nematodes can shift to 100% predatory behaviour over 101 generations in response to dietary changes. The study highlights the role of multi-generational genetic memory and microRNA involvement in shaping evolutionary adaptations.
Influence of pre-analytical conditions on cell-free microRNA stability in blood plasma samples
Researchers investigated the impact of plasma storage conditions on endogenous miRNA stability. They found that degradation rates can be affected by miRNA structure and packaging, as well as extraction methods.
RNA cargo in motion: The exosomal connection to head and neck cancers
Exosomal RNAs modulate key signaling pathways and influence tumor microenvironment, promoting metastasis and therapy resistance. Liquid biopsy through saliva and blood samples offers promising avenue for early diagnosis and treatment monitoring.
MicroRNAs have an immunomodulatory role in diabetes mellitus and diabetic cardiomyopathy
Recent research has shown that microRNAs (miRNAs) are involved in myocardial cell proliferation, differentiation, and metastasis, promoting the progression of diabetic cardiomyopathy. Targeted regulation of immune cells through miRNA-mediated therapy may provide new avenues for treating this debilitating condition.
MicroRNA profiling as novel biomarkers for detecting gutter oil using machine learning
Researchers developed a novel approach using microRNAs as biomarkers to detect gutter oil, achieving accurate classification with high accuracy. The study found that specific miRNAs like miR-16 and let-7a can distinguish between pure and recycled oils.
Why don’t pandas eat more meat? Molecules found in bamboo may be behind their plant-based diet
Studies found that plant-derived miRNA can enter giant pandas' bloodstream and regulate gene expression, aiding adaptation to a bamboo-based diet. These tiny molecules may also influence taste and smell, enabling pandas to pick out nutritious bamboo.
A new study analyses how mRNA changes during the progression of atherosclerosis
Researchers studied mRNA length variations during atherosclerosis progression in mice, discovering shorter mRNAs as the disease advances. The findings suggest alternative splicing mechanisms may play a role in generating diverse mRNA sequences related to the disease.
SourceGermans Trias i Pujol Research Institute·JournalBiomedicines·TypeExperimental study·DateFeb 20, 2025
Could microRNAs help us understand why different birds react differently to being infected with bird flu?
A recent study found that different birds react differently to being infected with bird flu, and microRNAs may play a key role in this variation. The researchers analyzed blood samples from ruddy turnstones and found 163 different forms of microRNA, including two unique to birds.
SourceNorwegian University of Science and Technology·JournalJournal of Avian Biology·TypeSurvey·DateFeb 18, 2025
Peri-centrosomal localization of small interfering RNAs in C. elegans
Researchers identified peri-centrosome-localized siRNAs in C. elegans, which accumulate at the centrosome during cell cycle and are essential for development. The study provides new insights into RNAi-mediated gene regulation in C. elegans.
Influence of radiotherapy on miRNA dynamics in urine extracellular vesicles
Researchers found that radiotherapy affects the levels of microRNAs in urine extracellular vesicles, making them a promising diagnostic tool for prostate cancer. The study identified specific miRNA ratios with high sensitivity and specificity, showing their potential to evaluate treatment response and track disease progression.
University of Cincinnati Cancer Center study identifies potential new target to overcome breast cancer resistance
A University of Cincinnati Cancer Center study identifies microRNA miR-205 as a promising new target to overcome breast cancer treatment resistance and improve outcomes. The research found that boosting levels of miR-205 could block the production of MED1, a protein responsible for treatment resistance, and improve treatment outcomes.
New study suggests RNA present on surfaces of leaves may shape microbial communities
A new study found that plant leaves are coated with diverse RNA molecules that may play a role in shaping microbial communities. The RNA present on the leaf surface can regulate gene expression in microbes, potentially impacting plant health and environmental interactions.
The secret life of ALAS1: How a basic science discovery could pave the way for better sirna therapies
Researchers at Memorial Sloan Kettering Cancer Center discovered an unrecognized role for ALAS1 in regulating microRNAs, which could improve the efficacy of siRNA drugs against disease-causing genes. The finding offers new potential for developing targeted therapies against cancer and other diseases.
Programming cells: Revolutionizing genetic circuits with cutting-edge RNA tools
The team developed a Synthetic Translational Coupling Element (SynTCE) that enhances the precision and integration density of genetic circuits in synthetic biology. This allows for more efficient gene circuit integration, minimizing interference between biological parts and enabling precise control over multiple genes.
SourcePohang University of Science & Technology (POSTECH)·JournalNucleic Acids Research·DateDec 20, 2024
Lipoproteins as overlooked RNA carriers in saliva: implications for extracellular vesicle biomarker studies
Researchers found lipoproteins in saliva carry RNA, potentially contaminating EV studies and influencing miRNA profiles. The study advocates for refined isolation methods to improve EV research and explores lipoproteins as potential biomarkers.
Chung-Ang University researchers unveil the biogenesis and role of transfer RNA fragments in cancer progression
Researchers at Chung-Ang University have identified a crucial role for specific tRNA fragments in cancer progression, revealing their ability to regulate gene expression and influence tumor growth. The study suggests that these fragments could serve as biomarkers for early-stage cancer detection and targets for therapeutic interventions.
NUS study: A microRNA solves an evolutionary mystery of butterfly and moth wing colouration
A team of researchers discovered that a previously ignored microRNA, mir-193, is the actual melanic color switch in butterflies and moths. Disrupting mir-193 eliminated black and dark wing colors in three butterfly species.
Plasma extracellular vesicle-derived microRNA associated with human alpha-1 antitrypsin deficiency-mediated liver disease
Researchers identified plasma extracellular vesicle-derived microRNAs as potential biomarkers for AATD liver disease. They found 39 differentially expressed miRNAs, which were validated in an independent cohort for predicting AATD liver disease.
SourceXia & He Publishing Inc.·JournalJournal of Clinical and Translational Hepatology·DateDec 3, 2024
The Microprocessor inside you
Researchers use cryo-electron microscopy to study Microprocessor's interactions with primary microRNAs. The protein can process multiple pri-miRNAs due to its flexibility and 'tentacle-like' properties.
New technology points to unexpected uses for snoRNA
Scientists at UChicago developed a new approach to study snoRNAs, uncovering thousands of previously unknown targets in human cells and mouse brain tissues. These discoveries suggest that snoRNAs may have a broader range of functions beyond guiding RNA modifications.
A bioinspired capsule can pump drugs directly into the walls of the GI tract
Researchers developed an ingestible capsule that releases a burst of drugs into the stomach or other organs, eliminating the need for injections. The capsule uses compressed carbon dioxide or tightly coiled springs to propel liquid drugs out, targeting specific parts of the digestive tract.
Climate change can cause stress in herring larvae
Exposure to multiple environmental stressors simultaneously impairs the ability of herring larvae to react at a molecular level, reducing their capacity for acclimatization. This can lead to increased protein damage and cell injury, potentially affecting growth and survival.
SourceUniversity of Oldenburg·JournalScience of The Total Environment·TypeExperimental study·DateNov 18, 2024