Articles tagged with Microrna
The HF-REVERT trial found that CDR132L improved secondary endpoints, including LVEF and NT-proBNP, but not the primary endpoint of LVESVI. Target engagement was confirmed by decreased plasma levels of microRNA-132. The therapy was well-tolerated with no significant safety concerns.
A team of scientists from NTU Singapore has developed a new biochip that, when paired with Artificial Intelligence (AI), can detect quickly and accurately extremely small amounts of microRNAs. The device can cut detection time from hours to 20 minutes.
Researchers developed a nasal spray that reversibly reduces brain inflammation, restores cellular power plants, and improves memory. The treatment bypasses the brain's protective shield through intranasal delivery, suppressing chronic inflammation and promoting successful brain aging.
Exosome-based therapies harness the power of microRNAs to activate hair follicle stem cells, promoting hair growth. Key findings include the identification of pro-anagen and inhibitory microRNAs that regulate Wnt/β-catenin, Shh, and HIF-1α pathways.
MIT neuroscientists have found that two genetic mutations causing Rett syndrome compromise the structural integrity of developing blood vessels, leading to leaky vessels. Overexpression of miRNA-126-3p is responsible for the vascular defect, which can be rescued by reducing the miRNA's levels.
Researchers identify circulating extracellular vesicles produced in diseased kidneys as the culprit behind toxicity in the heart. The discovery could lead to the development of a blood test to identify patients at high risk for serious heart problems and novel treatments to prevent and treat heart failure.
Researchers have decoded the logic of microRNA strand selection using AI, revealing a conserved and programmable mechanism governing gene regulation. The study found that this decision follows conserved rules rather than chance, with mammalian microRNAs showing a strong bias towards a single dominant strand.
A new circular single-stranded DNA molecule has been developed to simultaneously silence multiple oncogenic miRNAs. The molecule, called circAMO, exhibits high biostability and can inhibit tumor cell proliferation, migration, and invasion in a concentration-dependent manner. It shows superior efficiency compared to existing anti-miRNA ...
A microRNA cocktail has been developed to weaken glioblastoma, a type of aggressive brain tumor. The formulation, comprising 11 different non-coding RNAs, slows the growth of cancer cells and enhances chemotherapeutic drug activity.
Researchers have successfully isolated and sequenced RNA molecules from Ice Age woolly mammoths, providing new insights into the biology of extinct species. The study reveals that RNA can be preserved for nearly 40,000 years, offering a glimpse into the final moments of life.
Researchers at the University of Connecticut have developed two fast tests for early markers of Alzheimer's disease using CRISPR technology. The tests recognize microRNA molecules associated with Alzheimer's, allowing for quick identification in doctor's offices.
A new study found that miR-145-5p and miRNA-27b-3p interfere with fat cell formation in children with Hutchinson-Gilford progeria syndrome, a rare and fatal premature aging disorder. These microRNAs silence genes required for fat cell growth and function, suggesting they could be a promising therapeutic strategy to restore fat tissue.
A long-standing mystery of ENOD40, a pioneering gene in legume nodulation research, has been solved. ENOD40 acts as a natural microRNA sponge to regulate the legume nodulation pathway, enabling nitrogen-fixing nodule formation. The discovery sheds light on a new layer of control in plant-microbe symbiotic relationships.
Extracellular vesicles play a crucial role in regulating oocyte maturation, follicular growth, and quality. In pathological conditions, EVs can disrupt communication, leading to impaired oocyte development and ovarian failure. Therapeutic EVs show promise in reversing ovarian pathologies by delivering functional molecules.
This review systematically maps miRNA-mediated dysregulation of the AGE/RAGE pathway in MetS, revealing widespread but understudied miRNA dysregulation across adipose tissue, liver, and immune cells. Prioritizing poorly studied receptors and multi-pathology miRNAs could accelerate targeted therapies for MetS.
Researchers highlight microRNAs as crucial biomarkers for diagnosing and monitoring soft tissue sarcomas, with potential for precision medicine. MicroRNAs could help distinguish between tumor types and guide treatment decisions.
Researchers at Cornell University have developed a new lipid nanoparticle that replaces PEG with poly(carboxybetaine) to improve mRNA vaccine delivery. This stealthy material helps vaccines evade the immune system while inducing targeted immune responses, making it more effective for cancer vaccines.
MicroRNAs modulate inflammation across major cardiovascular risk factors, making them potential biomarkers for early detection and targets for prevention. Specific miRNAs regulate individual immune cell types in cardiovascular pathology, such as promoting M2 polarization and reducing plaque burden.
This study investigated the correlation between miR-124-3p expression and BDNF levels in a rat model of spinal cord injury. The findings show a significant downregulation of miR-124-3p and upregulation of BDNF levels following SCI, suggesting a potential regulatory role of miR-124-3p in BDNF expression and SCI pathophysiology.
Scientists have identified a brain molecule called NEAT1 that appears to play a central role in triggering light sensitivity (photophobia) during migraines. By disrupting the normal balance of nerve signaling and pain regulation, NEAT1 makes nerves more sensitive to light.
Researchers identified platelets, C-reactive protein, and chromogranin A as markers that can predict the failure of hormone-sensitive prostate cancer treatment. The study also found that miR-375 expression and lymphocyte-to-monocyte ratio are negative predictors for therapy failure in castration-resistant prostate cancer patients.
Scientists at Henry Ford Health + Michigan State University Health Sciences have identified a circulating microRNA called miR-126-3p as a mechanistic biomarker of knee osteoarthritis. This discovery may lead to the development of blood tests for early detection and therapeutics for slowing or stopping disease progression.
Researchers at MIT developed a control circuit that can precisely regulate gene expression levels, improving the efficacy and safety of gene therapy treatments. The 'COMMAND' circuit uses microRNA to suppress gene expression, allowing for tighter control over treatment outcomes.
Researchers have discovered genetic properties in prostate cancer that can be targeted to improve patient outcomes, particularly for Chinese men. The findings highlight the potential of precision medicine and more effective treatments.
Researchers identified miR-146b as a key regulator of beta-cell decline during obesity-to-T2DM progression. The study showed that miR-146b suppresses the expression of Btg2, leading to increased apoptosis and decreased insulin synthesis and secretion.
A new study from the University of Oklahoma is targeting cell communication in the hunt for therapies to slow macular degeneration. The research team is studying how cells in the retina communicate and whether the messages they send could be programmed to treat or slow AMD.
Research highlights the oncogenic potential of microRNAs in lung cancer, their dysregulation, and functional roles. Dysregulated miRNAs can contribute to tumor progression, metastasis, and chemotherapy resistance.
A UCLA study validates the predictive power of PROSTOX, a genetic test that uses microRNAs to identify patients at higher risk of developing long-lasting urinary side effects from radiation therapy. The test helps doctors and patients choose safer treatment options, reducing the burden of long-term complications.
Scripps Research scientists discovered how microRNAs impact Purkinje cell development, shedding light on the intricate process required to build brain complexity. The team found that microRNAs are critical during two phases in Purkinje cell development, controlling precise timing of different aspects.
Research by the Max Planck Institute reveals how nematodes can shift to 100% predatory behaviour over 101 generations in response to dietary changes. The study highlights the role of multi-generational genetic memory and microRNA involvement in shaping evolutionary adaptations.
Researchers investigated the impact of plasma storage conditions on endogenous miRNA stability. They found that degradation rates can be affected by miRNA structure and packaging, as well as extraction methods.
Exosomal RNAs modulate key signaling pathways and influence tumor microenvironment, promoting metastasis and therapy resistance. Liquid biopsy through saliva and blood samples offers promising avenue for early diagnosis and treatment monitoring.
Recent research has shown that microRNAs (miRNAs) are involved in myocardial cell proliferation, differentiation, and metastasis, promoting the progression of diabetic cardiomyopathy. Targeted regulation of immune cells through miRNA-mediated therapy may provide new avenues for treating this debilitating condition.
Researchers developed a novel approach using microRNAs as biomarkers to detect gutter oil, achieving accurate classification with high accuracy. The study found that specific miRNAs like miR-16 and let-7a can distinguish between pure and recycled oils.
Studies found that plant-derived miRNA can enter giant pandas' bloodstream and regulate gene expression, aiding adaptation to a bamboo-based diet. These tiny molecules may also influence taste and smell, enabling pandas to pick out nutritious bamboo.
Researchers studied mRNA length variations during atherosclerosis progression in mice, discovering shorter mRNAs as the disease advances. The findings suggest alternative splicing mechanisms may play a role in generating diverse mRNA sequences related to the disease.
A recent study found that different birds react differently to being infected with bird flu, and microRNAs may play a key role in this variation. The researchers analyzed blood samples from ruddy turnstones and found 163 different forms of microRNA, including two unique to birds.
Researchers identified peri-centrosome-localized siRNAs in C. elegans, which accumulate at the centrosome during cell cycle and are essential for development. The study provides new insights into RNAi-mediated gene regulation in C. elegans.
Researchers found that radiotherapy affects the levels of microRNAs in urine extracellular vesicles, making them a promising diagnostic tool for prostate cancer. The study identified specific miRNA ratios with high sensitivity and specificity, showing their potential to evaluate treatment response and track disease progression.
A University of Cincinnati Cancer Center study identifies microRNA miR-205 as a promising new target to overcome breast cancer treatment resistance and improve outcomes. The research found that boosting levels of miR-205 could block the production of MED1, a protein responsible for treatment resistance, and improve treatment outcomes.
A new study found that plant leaves are coated with diverse RNA molecules that may play a role in shaping microbial communities. The RNA present on the leaf surface can regulate gene expression in microbes, potentially impacting plant health and environmental interactions.
Researchers at Memorial Sloan Kettering Cancer Center discovered an unrecognized role for ALAS1 in regulating microRNAs, which could improve the efficacy of siRNA drugs against disease-causing genes. The finding offers new potential for developing targeted therapies against cancer and other diseases.
The team developed a Synthetic Translational Coupling Element (SynTCE) that enhances the precision and integration density of genetic circuits in synthetic biology. This allows for more efficient gene circuit integration, minimizing interference between biological parts and enabling precise control over multiple genes.
Researchers found lipoproteins in saliva carry RNA, potentially contaminating EV studies and influencing miRNA profiles. The study advocates for refined isolation methods to improve EV research and explores lipoproteins as potential biomarkers.
Researchers at Chung-Ang University have identified a crucial role for specific tRNA fragments in cancer progression, revealing their ability to regulate gene expression and influence tumor growth. The study suggests that these fragments could serve as biomarkers for early-stage cancer detection and targets for therapeutic interventions.
A team of researchers discovered that a previously ignored microRNA, mir-193, is the actual melanic color switch in butterflies and moths. Disrupting mir-193 eliminated black and dark wing colors in three butterfly species.
Researchers identified plasma extracellular vesicle-derived microRNAs as potential biomarkers for AATD liver disease. They found 39 differentially expressed miRNAs, which were validated in an independent cohort for predicting AATD liver disease.
Researchers use cryo-electron microscopy to study Microprocessor's interactions with primary microRNAs. The protein can process multiple pri-miRNAs due to its flexibility and 'tentacle-like' properties.
Scientists at UChicago developed a new approach to study snoRNAs, uncovering thousands of previously unknown targets in human cells and mouse brain tissues. These discoveries suggest that snoRNAs may have a broader range of functions beyond guiding RNA modifications.
Researchers developed an ingestible capsule that releases a burst of drugs into the stomach or other organs, eliminating the need for injections. The capsule uses compressed carbon dioxide or tightly coiled springs to propel liquid drugs out, targeting specific parts of the digestive tract.
Exposure to multiple environmental stressors simultaneously impairs the ability of herring larvae to react at a molecular level, reducing their capacity for acclimatization. This can lead to increased protein damage and cell injury, potentially affecting growth and survival.
Scientists use machine learning-based classifiers to differentiate lung cancer and noncancer based on urinary miRNA ensembles. The study reveals high specificity and sensitivity in detecting early-stage lung cancer, offering new hope for improved patient outcomes.
This study identifies the hsa_circ_0001726/miR-140-3p/KRAS axis as a key regulator in hepatocellular carcinoma (HCC) progression and lenvatinib resistance. The axis is involved in promoting cell proliferation and migration, and is also linked to overall survival in HCC patients.
Researchers grew personalized brain organoids from patients with a rare form of autism spectrum disorder to study its impact on brain development. The study revealed that microRNAs play a crucial role in determining the fate of developing brain cells, and an experimental drug may reverse critical cellular signs of autism.
Researchers at Karolinska Institutet have mapped how microRNAs control cell development in the human embryo during the first days after fertilization. The atlas identifies crucial sncRNAs that guide embryonic growth and differentiation, shedding light on how to identify healthy embryos for improved fertility treatment.
Researchers have discovered innovative strategies and technologies related to miRNA, a type of non-coding RNA that can target more than 60% of human protein-coding genes. The study found that miRNA can be used as a biomarker for cancer diagnosis and as a therapeutic molecule with broad applications in cancer treatment.
A new study reveals a promising therapy using antimiRs to treat myotonic dystrophy type 1 (DM1), a genetic disorder caused by abnormally high CTG repeats in the DMPK gene. The treatment increased MBNL1 levels and improved muscle cell functions, reducing disease symptoms.
Researchers analyzed changes in 72 pairs of microRNAs in patients' blood extracellular vesicles before and after radical prostatectomy, identifying significant changes in 11 miRNA ratios. The study suggests a potential new biomarker for monitoring treatment efficacy and predicting cancer relapse.
Researchers at UConn have discovered a novel miRNA-141-3p inhibitor that successfully reduces stroke damage and extinguishes inflammatory fires in the brain. The treatment has shown swift restoration of motor function and memory in mouse models, offering new hope for patients affected by strokes.
Researchers at Tokyo Institute of Technology developed a method to precisely control the timing of DNA droplet division, mimicking biological Liquid-Liquid Phase Separation (LLPS) droplets. This breakthrough enables precise control over synthetic droplet dynamics, key to developing bio-inspired systems.