Articles tagged with Noncoding Rna
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Researchers found a progressive shift in RNA contents of sperm with age, potentially contributing to health risks of having kids later in life. The discovery may lead to improved fertility outcomes and diagnostic tools.
A Chinese Medical Journal study investigates the role of non-coding RNAs in pancreatic cancer, revealing how dysregulation of these molecules contributes to tumor growth and treatment resistance. The research highlights potential therapeutic targets for this devastating disease.
This study reveals TUG1's central role in CHS progression through its interaction with EZH2, influencing tumor growth, migration, and invasion. Exosomal TUG1 also enhances M2 macrophage polarization, promoting tumorigenesis.
Scientists have identified a brain molecule called NEAT1 that appears to play a central role in triggering light sensitivity (photophobia) during migraines. By disrupting the normal balance of nerve signaling and pain regulation, NEAT1 makes nerves more sensitive to light.
Research highlights the biological functions of small noncoding RNAs in modulating gene expression, cell signaling, and physiological homeostasis. These RNA molecules play significant roles in cardiovascular health, engaging processes like inflammation, apoptosis, and vascular remodeling.
Researchers Rob Martienssen and Thomas Gingeras analyzed maize and teosinte genomes to identify regulatory regions controlling gene expression. They found hundreds of thousands of enhancers and super enhancers that were strongly selected during domestication 9,000 years ago.
A novel small noncoding RNA, ManS, is produced by a unique RNase III-mediated processing mechanism and regulates Neu5Ac/ManNAc metabolism. This intricate regulatory mechanism influences bacterial adaptation within host environments, offering new insights into Salmonella pathogenesis.
Researchers summarize the organs involved in glucose regulation and emphasize RNAkines' crucial role in maintaining blood glucose levels. Various studies show RNAkines' potential as diagnostic and therapeutic agents for T2DM.
Researchers at Karolinska Institutet have mapped how microRNAs control cell development in the human embryo during the first days after fertilization. The atlas identifies crucial sncRNAs that guide embryonic growth and differentiation, shedding light on how to identify healthy embryos for improved fertility treatment.
Scientists at Gladstone Institutes have discovered a diverse range of retrons that can edit DNA more quickly and efficiently than current methods, including CRISPR. The new retrons showed high editing rates in both bacteria and human cells, with some performing 10-fold better than the gold-standard retron.
Researchers from Japan have discovered that Exportin-5 interacts with a broader spectrum of RNAs, including tRNAs, miRNAs, lncRNAs, and specific mRNAs. This study sheds light on the unique roles of Exp5 in RNA export within Drosophila cells.
A new study has identified specific RNAs that may help identify stage II colon cancer patients who are likely to benefit from chemotherapy following surgery. The researchers found that certain housekeeping RNAs were up-regulated in patients with recurrence, suggesting their potential role in the metastatic process.
Researchers at Arizona State University created a detailed map of the 3'UTR regions of RNA in C. elegans, revealing crucial elements for gene regulation and protein production. The study provides valuable insights into the machinery of gene control, shedding light on fundamental biological processes essential to human health and disease.
Researchers at the Arc Institute have discovered a novel bispecific guide RNA, the bridge recombinase mechanism, which enables precise and powerful tool to recombine and rearrange DNA in a programmable way. The system can insert any desirable genetic cargo into any genomic location with high efficiency and specificity.
A research team from Göttingen University has discovered that antisense RNA (asRNA) plays a crucial role in cell transport, allowing cells to accelerate gene expression and produce proteins quickly in response to environmental stress or harm. This new understanding sheds light on the function of asRNAs and their potential link to disea...
A noncoding gene has been identified as the deciding factor in determining sex in Argentine ants, with a specific genomic region being crucial to this process. The gene does not encode a protein but rather produces an RNA that influences sex determination.
Researchers have identified the first inhibitors of the cancer-related RNA-modifier METTL16, which prevent its interaction with RNA. This breakthrough lays the foundation for novel RNA-targeting therapeutics and better investigation of METTL16's role in disease and health.
Researchers at Johns Hopkins Medicine have developed a novel approach to target group 3 medulloblastoma tumors in mice, reducing tumor growth by 40-50% and extending survival by up to 84 days. The therapy uses antisense oligonucleotides to block lnc-HLX-2-7 from binding to the HLX promoter region.
Researchers from the University of Queensland have identified a noncoding RNA called Gas5 that coordinates neuronal excitability in real time, contributing to learning and memory. The study found that this RNA is uniquely required for fear extinction memory, a type of critical input processing that leads to the formation of memory.
Researchers at Goethe University Frankfurt have identified a specific gene locus, MYNRL15, that is critical to the survival and replication of leukemia cells. Inhibiting this gene has been shown to deactivate genes necessary for AML cell survival, offering a new possibility for fighting leukemia.
A novel liquid biopsy technology developed by UCSC Assistant Professor Daniel Kim's lab leverages RNA 'dark matter' to enhance cancer diagnosis. The test detects both protein-coding and repetitive noncoding RNAs in the blood, showing improved sensitivity for early-stage cancer detection.
Researchers from the ALFA Score Consortium explore how nutrition and physical exercise can positively impact the aging process by modifying epigenetic changes. They find that healthy aging is associated with more tightly condensed chromatin, fewer histone post-translational modifications, and greater regulation by non-coding RNAs.
Researchers successfully delivered stabilized divalent siRNA molecules to animal models that blocked SARS-CoV-2 and prevented infection. The technology is adaptable for other pulmonary diseases such as pulmonary fibrosis and respiratory viruses.
Scientists have identified a new molecule that could help distinguish and treat patients with a specific subgroup of medulloblastoma, the most common malignant brain tumor in children. The discovery points to potential targeted therapies using a drug or drugs to block the molecule's activity.
A new study explores the value of 'trash data' from cancer genome sequencing, identifying new strategies to uncover previously unexplored information. The researchers found that genomic and transcriptomic data contain relevant information that can help elucidate carcinogenesis and discover putative biomarkers with clinical applications.
Researchers reveal the dynamic nature of RNA molecules, which can take on multiple shapes and regulate cellular processes. The 'RNA structurome' holds key to understanding disease mechanisms and developing new therapeutic strategies.
A study found that the HASTER lncRNA promoter regulates the activity of the HNF1A gene, which causes diabetes. This discovery paves the way for new therapeutic strategies by manipulating this regulatory element.
Researchers have discovered a new pathway for producing telomerase RNA from protein-coding messenger RNA, offering potential innovations in mRNA vaccines and understanding of telomere biology. This finding has implications for reversing cellular aging and extending human lifespan.
Researchers at Boyce Thompson Institute have created the first comprehensive annotation of long intergenic non-coding RNAs (lincRNAs) in four mustard species. The study identifies locations across all four genomes that encoded lincRNAs, proposed functions for them, and confirmed the function of some lincRNAs involved in germination. Th...
Researchers discovered a novel mechanism by which non-coding 7S RNA regulates mitochondrial gene expression in human cells. The study found that 7S RNA inhibits transcription via mitochondrial RNA polymerase dimerization, shedding light on the molecular basis of this process.
Researchers at Massachusetts General Hospital have discovered a new class of biological factors that can be targeted by small molecule drugs, including noncoding RNAs. This breakthrough could lead to new therapies for genetic disorders such as Rett syndrome and Fragile X syndrome.
Scientists at Karolinska Institutet have developed a new high-precision tool to identify the function of noncoding DNA sequences, which may eventually contribute to the development of targeted drugs. The study reveals that these noncoding parts of patients' DNA are linked to genetic changes in diseases.
Scientists have developed a gene-silencing tool that can quash gene activity across generations using small noncoding RNA molecules. This technique, called piRNAi, has expanded the molecular toolkit for gene manipulations and allows for more detailed investigations in nematode worms.
A team of scientists at the University of Würzburg has identified a previously unknown RNA sponge, OppX, that mimics a key regulator of bacterial membrane permeability. The discovery sheds light on how bacteria evade antibiotics and could lead to the development of new therapeutics.
Researchers have identified fragments of genetic material in Candida fungus that do not encode proteins but are specifically expressed during distinct stages of the infection process. These long non-coding RNA molecules show high specificity and differ between species, making them a potential target for new treatments.
Jpx RNA regulates CTCF anchor site selection and formation of chromosome loops, determining gene expression. This discovery may lead to new treatments for diseases influenced by chromatin looping.
Researchers discovered that noncoding RNA derived from pericentromeric repetitive sequences upregulates SASP-like inflammatory gene expression by disturbing chromatin interactions. hSATII RNA is highly detectable in cancer cells and supports tumor development via small EVs, highlighting a new role in age-related pathologies.
Researchers have built a comprehensive catalogue of human non-coding RNAs using three sequencing methods. The project uncovered thousands of novel non-coding RNA genes and found correlations between RNA abundance and regulatory functions.
A newly-discovered non-coding RNA molecule regulates protein translation in trypanosoma parasites, a key finding with potential applications in treating and preventing diseases such as sleeping sickness. The discovery sheds light on the previously unknown function of rRNA introns and may lead to the development of novel medications.
Researchers at Karolinska Institutet discovered a link between non-coding RNA mutations in the Neisseria meningitidis bacterium and severe invasive meningococcal disease. They also developed a PCR test to detect these mutations, which may aid in speedy identification and treatment.
Scientists at the University of Sussex have identified a potential pattern within blood that signals the presence of motor neuron disease. The discovery could significantly improve diagnosis with a future development of a blood test that identifies the unique biomarker, simplifying and speeding up diagnosis.
A recent study published in Nature Communications found that a circular RNA called circFndc3b plays a critical role in tissue repair after a heart attack. The RNA acts like a 'sponge' to bind harmful molecules, preventing cell death and promoting vascular growth, which aids the repair process.
A team of researchers has identified a tissue-specific non-coding RNA called NEAT1 that regulates memory formation in the hippocampus region of the brain. Increasing NEAT1 levels in younger mice impaired learning and memory, while decreasing NEAT1 levels improved cognitive function.
HKU biologists discovered centromeric DNA produces essential non-protein coding centromeric RNA (cenRNA) for chromosome stability. Excessive or deficient cenRNA leads to defective centromeres and lost chromosomes, causing genetic errors.
Scientists at the University of Bern have identified a unique mechanism in trypanosomes where non-coding RNA molecules stimulate ribosome activity, accelerating protein production during stress. This 'kick start' helps the cell recover quickly from nutrient scarcity or environmental challenges.
Researchers have identified potential drug targets for rhabdomyosarcoma, a rare and aggressive cancer affecting mostly children. A new compound, adavosertib, showed promising results when combined with chemotherapy.
Researchers at the University of California - San Diego have discovered that eRNAs play a significant role in activating tumor-developing genes. The findings suggest that eRNAs are functional molecules, rather than mere reflections of enhancer activation or transcriptional noise.
Researchers developed bpRNA, a big-data annotation tool for secondary RNA structures, featuring the largest and most detailed database to date. The tool enables statistical analysis of RNA structure formation and may shed light on disease-associated mutations in noncoding RNAs.
University of Bath scientists have identified a non-coding RNA, Paupar, that influences healthy brain development in young mice. The study shows how Paupar acts as a switch to regulate proteins involved in neurodevelopment.
Research reveals non-coding RNA in tumors may predict immunotherapy response and influence patients' outcomes. Specific repetitive elements were found to alter immune responses in colon and pancreatic cancers.
Researchers discovered that small noncoding RNAs orchestrate the resilience of Haloarchaea to oxidative stress by degrading messenger RNA and silencing transposons. This finding could lead to a better understanding of how other species, like humans, resist damage from oxidative stress.
Researchers have identified new prostate cancer markers in urine that show high specificity and sensitivity. A combination of these biomarkers could lead to a more accurate and reliable test for early diagnosis.
Researchers aim to shed light on non-coding RNA's function in plant regulation and defense against environmental challenges. The study focuses on temperature response and adaptation, which could lead to more resistant crop plants.
Scientists have identified a piece of non-coding RNA that stops cells from turning cancerous, regulating cell growth and metastasis. The discovery could lead to new treatments for cancer.
A team of researchers discovered non-coding RNA molecules in cancer cells that stimulate an immune response by mimicking pathogens. The findings suggest these molecules may play a significant role in mediating immune responses against cancer.
Researchers have identified a new mechanism for controlling genetic material altered in cancer, involving ultra-conserved RNA molecules that regulate microRNA activity. This discovery could lead to a better understanding of cancer development and potentially inform new treatments.
The National Cancer Institute has awarded a three-year grant of $2.2 million to Professor Yijun Ruan for his research on noncoding RNAs in cancer and other diseases. The grant aims to identify novel ncRNAs and their interactions with DNA, which could lead to diagnostic biomarkers and new genomic therapeutic targets.
Researchers at Simon Fraser University have discovered that non-coding RNAs are perturbed in cancerous human cells, allowing for early detection of breast and lung cancers. The study's findings suggest that these molecules can be used to classify patients into subgroups with different survival outcomes.
Researchers found that specific small non-coding RNAs near gene start sites can distinguish between cancerous and non-cancerous tissues. These RNA molecules may also predict cancer survival outcomes and have potential as diagnostic tools.
Sanford-Burnham researchers identify THRIL molecule that regulates immune response and associates with Kawasaki disease severity. THRIL may also contribute to other inflammatory diseases like rheumatoid arthritis and inflammatory bowel disease.