Articles tagged with Skeletal Muscle
Researchers found that energy-demanding tissues have larger macrophage crews to manage waste, with the number of macrophages tracking mitochondrial activity and waste production. This system is critical for tissue health and function, and may help preserve tissue function as we age.
A molecular brake in muscle architecture prevents T-tubule growth, maintaining muscle fibre coordination. The cortical actin network restricts membrane availability, allowing for controlled T-tubule formation.
Researchers identified dormant progenitor cells in skeletal muscle that migrate to fracture sites and become bone-forming cells. Muscle is the main source of these regenerative cells, which can contribute to both normal fracture healing and heterotopic ossification.
A preclinical study reveals that different muscles remodel on different timelines after hemorrhagic stroke, with specific adaptations occurring between 2-12 weeks. Rehabilitation programs may need to be timed to these post-stroke windows to effectively leverage muscle plasticity for functional recovery.
A new study reveals that p38MAP kinase plays a central role in regulating senescence-related changes in human muscle cells. The researchers developed a human cell-based model to investigate how senescence develops in skeletal muscle cells and identified a signaling pathway that appears to drive aging in mature muscle fibers.
A new study reveals substantial differences in gene expression patterns between aging mouse and human skeletal muscle. Fewer than 5% of biological pathways show shared changes, emphasizing the need for cross-species targets in aging research.
Monash University researchers found that exercise may boost muscle mass and strength in older adults by boosting a key protein called NOX4, which naturally declines with age. The study suggests restoring NOX4 levels could combat biological ageing and improve overall health.
Dr. Hannah Cabré has been appointed as an Assistant Professor and Director of the Aging, Gynecology, and Endocrinology Laboratory at Pennington Biomedical Research Center. Her research focuses on the role of female sex hormones in shaping nutrition, health, and performance across the lifespan.
The study found that ATF5 plays a critical role in coordinating mitochondrial quality control and adaptive stress signaling in skeletal muscle. Absence of ATF5 resulted in increased muscle fatigability and elevated ROS production, highlighting its importance in maintaining muscle function with age.
A research team from Xi'an Jiaotong University has developed a method to align cells in muscle tissue using electric forces during electrohydrodynamic bioprinting. This breakthrough allows for the creation of living muscle tissues with tightly aligned cells, enabling the production of functional muscle constructs.
A new study introduced epigenetic clocks in skeletal muscle from an Asian population, identifying DNA methylation sites associated with age and developing accurate age prediction models using NGS and SBE. The findings offer a reliable method for estimating age and its potential applications in forensic science.
Researchers are developing 'biohybrid robots' that flex and move using biological tissue, offering potential applications in medicine and industry. The field is advancing through advanced fabrication methods, such as 3D bioprinting and electrospinning, which enable precise control over muscle cells.
Researchers found that large MAF family transcription factors can reactivate the dormant 'Type IIb fast-twitch program' in human muscle, leading to improved glycolytic capacity and increased exercise capacity. Athletes with higher expression levels of these factors had faster and more powerful movements.
Two new studies from Karolinska Institutet investigate how somatic mutations in muscles and blood vessels affect ageing. The results show that such mutations can reduce muscle strength and accelerate blood vessel ageing.
New research from the University of Copenhagen found that reducing skeletal muscle NAD+ levels in mice by 85% did not accelerate aging or impair whole-body metabolism. The study suggests that skeletal muscle can tolerate substantial NAD depletion without loss of function or accelerated aging.
A recent study found that women are more metabolically efficient under extreme conditions, closing the performance gap with men. Women's greater fat mass may contribute to this advantage, enabling them to complete longer distances without burning out.
A study by the University of Jyväskylä found that muscles retain a memory trace of previous resistance training at the protein level for up to two and a half months. This persistence can make it easier to start training again after a break.
A six-month study found that patients using GLP-1 and dual GLP-1/GIP receptor agonist therapy experienced minimal lean muscle mass loss as they lost weight. Regular resistance training, consistent protein intake, and close supervision by an expert obesity doctor were associated with better muscle retention.
Researchers at the University of Houston College of Pharmacy have identified a potential therapeutic target to repair injured muscles. They discovered that fibroblast growth factor–inducible 14 (Fn14) plays a crucial role in regulating satellite cell stability and function, which are responsible for muscle growth, repair, and regenerat...
A new study suggests that a low creatinine-to-cystatin C ratio may be associated with lower muscle volumes and poorer gait speeds in midlife women. Researchers found that this biomarker was linked to an increased risk of developing sarcopenia, which can lead to immobility and related health problems.
MIT engineers have developed a way to grow artificial muscles that twitch and flex in multiple coordinated directions. This breakthrough allows for the creation of soft, wiggly robots with enhanced flexibility and range of motion.
A new study suggests that statins can reduce chest muscle loss in smokers, while aspirin may contribute to increased muscle loss. The study examined data from 4,191 participants and found that statins protected pectoralis muscle area and density, whereas aspirin led to decreased muscle mass.
Researchers found that melatonin improves mitochondrial function, reduces cellular stress, and prevents programmed cell death, promoting the conversion of glycolytic to oxidative fibers in muscle tissue. This change optimizes energy production and protects against muscle deterioration caused by obesity and type 2 diabetes.
New research from McMaster University challenges the popular notion that women can build more muscle by syncing their workouts with their menstrual cycles. The study found no difference in muscle protein synthesis regardless of cycle timing, contradicting long-held advice and internet trends.
A team from Tokyo Metropolitan University has successfully implanted myoblasts onto healthy muscle in mice using an extracellular matrix scaffold. This breakthrough treatment could treat ageing-related muscular atrophy without scarring, offering a promising avenue for regenerative medicine.
Researchers discovered that PanK4 plays a crucial role in regulating glucose uptake and fatty acid oxidation in skeletal muscles. The protein is activated by physical exercise and has potential as a target for treating metabolic diseases such as type 2 diabetes.
Researchers have identified a new mechanism for the male sex hormone 5α-DHT, which increases bone mineral density and promotes skeletal muscle growth. The discovery of the GPR133 receptor's activation by AP503 could lead to the development of new muscle-strengthening drugs with a lower side-effect profile.
Researchers discovered that removing arginase-II gene can slow down muscle aging in mice, leading to improved muscle health and reduced inflammation. This finding suggests targeting the Arg-II gene could help maintain muscle strength and mobility in older adults.
Research published in the European Heart Journal found that people with high amounts of intermuscular fat are more likely to develop coronary microvascular dysfunction and future serious heart disease. The study's lead author suggests that existing measures of obesity may not be accurate for all individuals, particularly women.
A study published in Nature Metabolism found that four percent of Greenland's Inuit population has a gene variant that increases their risk of type 2 diabetes by tenfold. Exercise has been shown to increase insulin sensitivity in these individuals, suggesting it may be an effective way to reduce their risk of developing the disease.
Researchers have identified a key protein that plays a crucial role in energy production in muscle cells, which can be activated by physical exercise. This discovery may lead to the development of treatments for over 200 disorders related to muscle energy production.
Researchers have developed a non-invasive strategy that assesses blood flow through skeletal muscle to detect early signs of sepsis. The technique, combining hyperspectral near-infrared spectroscopy and diffuse correlation spectroscopy, was tested in rodents and detected sepsis before vital organs were affected.
A study published at the Radiological Society of North America annual meeting found that ultra-processed food intake is associated with higher amounts of intramuscular fat in thigh muscles. This increase in fat can lead to knee osteoarthritis, a condition affecting millions worldwide.
Researchers found that small doses of MYC can stimulate muscle growth in skeletal muscles, even in the absence of exercise. This discovery has implications for developing therapies to reduce muscle loss from aging and improving independence and mobility.
A study found that skeletal muscle loss, particularly in the temporalis muscle, is associated with an increased risk of developing Alzheimer's disease dementia. Participants with smaller temporalis muscle size were more than twice as likely to develop dementia over a median follow-up period of 5.8 years.
A new study published in Nature Aging details the changes in muscle regeneration over time, finding that immune cells exhibit differences in abundance and reaction time between age groups. The research also identifies altered stem cell states, leading to discoordination in the process of muscle repair in older mice.
Long-term hormone therapy in transgender individuals leads to significant changes in body composition and risk factors for cardiovascular disease. Transgender men experience increased muscle volume and abdominal fat, while women's muscle mass decreases, according to a new study published in the Journal of Internal Medicine.
A global team, including Lehigh University researcher Xuanhong Cheng, is exploring molecular- and cellular-level changes in muscle tissue that could lead to better diagnostic tools and therapeutic options for CFS and long COVID. The team aims to develop noninvasive diagnostic tools using electrical signatures.
A Japanese study found that lower masseter muscle volume is associated with increased sarcopenia risk, particularly in men. The research suggests using MRI measurements of MMV for early diagnosis and personalized interventions.
Researchers from Kyushu University have developed an antibody that targets and prevents the dysfunction of hepatocyte growth factor (HGF), a critical protein for skeletal muscle development, regeneration, and repair. The new antibody, 1H42F4N, blocked nitration of HGF and did not disrupt its activity.
New studies using magnetic resonance imaging show that GLP-1 RA treatments cause a normal, adaptive process in skeletal muscle changes. Weight loss leads to improved insulin sensitivity and reduced fat in muscles, improving quality. Better muscle quality is associated with lower risk of strength and function loss.
The US Department of Defense has awarded $514,000 to study the efficacy of gene editors in treating Duchenne Muscular Dystrophy. Researchers will explore non-viral options for delivering gene therapy through 'self-delivering' gene editors, aiming to improve safety and efficacy.
Medically induced weight loss with GLP-1 receptor agonists can lead to substantial muscle loss, compromising physical strength and immune function. The authors emphasize the need for a multimodal approach combining medication with exercise and nutritional interventions to preserve muscle mass.
Researchers have discovered a gene called NANOG that can improve nerve regrowth and re-establish innervation in damaged muscles after traumatic nerve injuries. This discovery has significant potential to help mitigate long-term disability for people with debilitating nerve injuries.
Researchers found that physically fitter patients with metastatic lung cancer live longer and respond better to chemotherapy. The study identified biomarkers in blood plasma that can indicate which patients are most likely to respond to treatment.
The study reveals that the lack of muscle formation at the distal wings leads to bone reduction and asymmetry due to insufficient mechanical stress during development. This is caused by muscle progenitor cells with a dual identity undergoing cell death, preventing proper muscle formation.
The Harvard team successfully recreated the satellite cell niche using 3D organoid culture techniques, generating stem cells that closely resemble native adult stem cells. These cells can engraft, repopulate the stem cell niche, persist long-term, and regenerate muscle after repeated injury.
Researchers explore the effect of exercise on age-related biomarkers in human skeletal muscle, revealing its potential to foster healthier aging. The study represents the first quantitative and qualitative analysis of this impact, highlighting the benefits of exercise for age-related diseases.
A new study found that females' and males' muscles handle glucose and fatty acids differently, but regular physical activity cancels out these differences and triggers similar beneficial metabolic changes in both sexes. This research has important implications for preventing type 2 diabetes.
A group of scientists discovered that the Black and white tegu lizard can raise its own body temperature during the reproductive season, even in a dark burrow. The study found that this phenomenon is due to the increased production of mitochondria and a protein called ANT, which generates heat.
The study identified DUSP13 and DUSP27 as crucial enzymes that regulate the transition of proliferating skeletal muscle stem cells into the differentiation stage. Mice lacking these genes exhibited delayed muscle regeneration, highlighting their importance in maintaining muscle function.
Researchers are studying the role of stress hormones and mineralocorticoid receptors in bone health as we age. The goal is to understand how balance between these factors affects our skeletons. By investigating this complex relationship, scientists hope to develop new insights into osteoporosis and other age-related bone disorders.
University of California San Diego researchers used cryo-electron microscopy to capture the first 3-D images of a key muscle receptor, shedding light on why newborn humans develop slowly while cows mature quickly. The study's findings may help develop future treatments for muscular disorders.
A new zwitterionic polymer complex has been developed to deliver plasmid DNA into skeletal muscle, achieving widespread gene expression in mice. This breakthrough could lead to new therapies for serious muscular diseases.
Researchers developed a triple-adeno-associated virus vector system to deliver full-length dystrophin protein into muscles, restoring muscle health and strength in mice models with Duchenne muscular dystrophy. The approach has shown promise for treating patients with the genetic disorder.
Researchers at the University of Houston College of Pharmacy discovered key mechanisms of skeletal muscle regeneration and growth following resistance exercise. Increasing levels of Inositol-requiring enzyme 1 (IRE1) or X-box binding protein 1 (XBP1) in muscle stem cells may improve muscle repair and reduce disease severity.
Researchers identified a protein that travels from brain to muscles, causing muscle fatigue. Studies in fruit flies and mice found that this process is relevant to inflammatory diseases, including bacterial infections, Alzheimer's disease, and long COVID. Blocking this pathway may prevent or treat muscle weakness.
Researchers found that mice lacking certain signal molecules produced during exercise had reduced oxygen consumption and fat burning, leading to increased susceptibility to weight gain. In humans, those producing more of these alternative versions consumed less oxygen and had lower body fat.
The study found that MCT1 regulates mitochondrial biogenesis and exercise activity in skeletal muscle, improving exercise endurance and metabolic phenotypes. MCT1 also plays a crucial role in the 'lactate shuttle' between muscle fibers, enabling efficient energy metabolism.
A new global definition of sarcopenia is proposed, aiming to unify research and clinical practice. The definition may help identify low muscle mass or strength in older people, increasing the risk of poor outcomes such as fragility and disability.