A study has identified a set of plasma proteins that can be used to diagnose and monitor patients with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD). The researchers created a molecular disease trajectory, which identifies key sets of genes involved in the disease progression.
Researchers developed a human-safe drug that repairs DNA breaks and reduces inflammation in a mouse model of Alzheimer's disease. The approach targets multiple disease-relevant cellular pathways, providing a broader therapeutic strategy than previous approaches focused on individual disease hallmarks.
Scientists at King's College London have developed a human-safe drug that repairs DNA breaks and reduces inflammation in a mouse model of Alzheimer's disease. This approach targets multiple features of the disease simultaneously, providing a broader therapeutic strategy than previous approaches focused on individual disease hallmarks.
A new study using the EUSTAR database found that patients with active disease at baseline had higher cumulative incidence rates of organ and multi-system involvement. Early disease activity monitoring is crucial for identifying patients at risk, guiding treatment decisions, and improving patient outcomes.
Chronic liver disease is a significant burden in Europe, with millions affected by premature illness and death. The Series calls for coordinated prevention, earlier detection, care pathways, and non-judgemental approaches to connect liver health with other chronic conditions.
A new science advisory calls for coordinated international efforts to reduce disparities in care for children with Kawasaki disease, a rare but serious illness primarily affecting young children. The advisory highlights the importance of sharing data, expertise, and best practices to improve heart health outcomes for children with Kawa...
Researchers at Penn Medicine have identified a previously unrecognized form of diabetic kidney disease marked by clusters of immune cells, specifically B cells, that are linked to faster disease progression. The study's findings could guide more targeted treatments in the future.
Chronic liver disease in the US costs $41.57 billion, with prescription medication expenditures accounting for nearly half of all-cause healthcare expenditures. Poor adherence to antiviral medications is a key factor in preventing disease progression and treatment, with high out-of-pocket costs increasing non-adherence risk.
A study published in PLOS Medicine has identified two new genetic pathways contributing to cardiometabolic disease, including heart disease and obesity. The research analyzed lipid metabolites and their link to disease, suggesting that targeting specific metabolic pathways could prevent or lower the risk of disease.
A new $15 million research network will investigate the causes and treatments of heart valve disease, which affects over 80 million people worldwide. The American Heart Association hopes to develop early warning signs and diagnosis methods to expand treatment options and improve quality of life for patients.
A recent study from the University of Eastern Finland found that people with Parkinson's disease are using psychotropics more frequently than controls, even before diagnosis. The use of psychotropic medications increases as the disease progresses, reflecting emerging non-motor symptoms and worsening disease progression.
A new study reveals that people with Parkinson's disease have a distinct gut microbiome, as do those at genetic risk but without symptoms. This could lead to early detection and potential prevention strategies.
A large-scale study linked loneliness to an increased risk of degenerative heart valve disease, including aortic valve stenosis and mitral valve regurgitation. Researchers say addressing loneliness could help delay disease progression and reduce the clinical and economic burden of valvular heart disease.
A new study by Lund University researchers found that genetic risk scores can predict coronary artery disease even before diabetes onset. The study identifies a group at high risk of developing both conditions, offering potential for early detection and prevention.
Researchers at Aalborg University aim to identify biological changes driving disease development with a comprehensive pre-diagnostic study of early Crohn's disease. They will analyze thousands of blood samples from patients prior to diagnosis to develop a predictive model.
Elevated uric acid promotes liver damage and disease severity through inflammation, oxidative stress, and metabolic disturbances. Lifestyle interventions, medications, and potential biomarkers are being explored to improve diagnostic efficacy and treatment.
Fusarium head blight (FHB) is a destructive wheat disease that can reduce yields and contaminate grain with toxins. New research in Plant Disease identified several emerging fungal pathogens, including a previously undescribed species, responsible for the severe outbreak in Ethiopia.
The inaugural US-based Chagas disease conference will strengthen research and patient care efforts in the US, building on recognition of the disease as a national concern. Approximately 300,000 Americans are infected with Chagas disease, and improved surveillance, testing, and research can help address severe heart complications.
A new study from Columbia University Vagelos College of Physicians and Surgeons has found that analyzing the APOL1 gene in Black patients with kidney disease can provide more accurate diagnoses. The study suggests that incorporating M1 into routine APOL1 genetic testing could help doctors determine the true cause of a patient's kidney ...
Researchers at Worcester Polytechnic Institute developed an AI tool that analyzes brain scans to predict Alzheimer's disease. The method is accurate in detecting the disease among normal brains and those with mild cognitive impairment, highlighting key anatomical changes such as volume loss in the hippocampus and entorhinal cortex.
A new Danish study found that people with a higher genetic risk of developing chronic inflammatory bowel disease are more likely to experience a severe course. The researchers discovered a correlation between genetics and disease severity, which could lead to tailored treatment strategies.
A study found that COVID-19 infection significantly increases the risk of acute kidney injury, chronic kidney disease, and kidney failure in US adults. The research used machine learning models to analyze data from over three million patients, revealing a 2.3-times higher risk of acute kidney injury compared to influenza.
Researchers found that male patients with early Lyme disease present with different signs of the disease, including symptoms, physical exams, and laboratory test results. These findings suggest that sex and menopause status are important to consider in understanding early Lyme disease.
New research from the American Heart Association finds a strong association between gum disease and increased risk of heart attack, stroke, atrial fibrillation, heart failure, and cardiometabolic health conditions. The study suggests that effective prevention and treatment of gum disease could potentially decrease the burden of cardiov...
A nationwide study found that water treatment methods using chlorine as a primary disinfectant increase the risk of Legionnaires' disease. Chlorine used as a secondary disinfectant also increases disease rates, whereas monochloramine reduces the risk.
A new dataset, TripletDGC, reveals the association between disease genes and diseases by characterizing specific cell types. The study highlights critical cell types linked to disease mechanisms, providing deeper insights into molecular basis of diseases.
Research discovered that eliminating a specific brain protein, Centaurin-α1, can lessen cognitive deficits and brain damage caused by Alzheimer's disease in mice. The study found reduced amyloid plaque formation, improved neuroinflammation, and protected neural connections, suggesting Centaurin-α1 as a potential therapeutic target.
The 2025 European Scientific Conference on Applied Infectious Disease Epidemiology (ESCAIDE) brings together over 3,000 participants to exchange knowledge and strengthen collaboration in infectious disease prevention and control. The conference highlights urgent priorities such as building trust in science, demonstrating science-based ...
A study by The Hospital for Sick Children reveals a previously overlooked layer of genetic variation in short tandem repeats (STRs) that can influence gene regulation and shape disease risk. This discovery may inform future research and precision therapeutic development in support of Precision Child Health.
A study led by SickKids scientists discovered a previously overlooked layer of genetic variation that could help explain individual differences in disease risk and treatment response. The researchers found that subtle changes in short tandem repeats can impact gene function, revealing new insights into neurodevelopmental conditions.
Researchers have discovered that Batten disease progression varies by sex and age, with male mice showing early auditory problems that improve with age, while female mice experience persistent difficulties. The study provides a new model for tracking brain function over time and testing treatments for this devastating disease.
Alzheimer's disease disrupts the daily activity patterns of brain cells involved in removing amyloid plaques, suggesting a potential therapeutic target for treating the disease. Controlling these circadian rhythms could help prevent disease progression.
A new study has identified dry eye disease as a significant health concern for postmenopausal women, with 57.38% experiencing the condition compared to 53.22% of premenopausal women. The study highlights the need for greater awareness and education about dry eye disease, which can lead to serious complications if left untreated.
A new study led by Mount Sinai researchers has identified distinct biological signatures in patients with mild Crohn's disease, which may help avoid overtreatment and guide more personalized care. The findings suggest that these biomarkers can distinguish mild disease from more aggressive forms, potentially allowing for safer treatment...
A pilot clinical trial has been initiated to test the efficacy of alpelisib in treating Dent disease 2, a rare genetic disorder affecting kidney function. The trial aims to improve abnormal kidney function and potentially provide a breakthrough treatment for patients with life-threatening complications.
A Finnish population study reveals that middle-aged individuals can have high levels of blood-based biomarkers associated with Alzheimer's disease. The study found a link between kidney disease and higher biomarker levels in middle age, as well as an association between the APOE ε4 gene and older age biomarker concentrations. Further r...
Researchers propose a new method called sPGGM to identify pre-disease stages and discover signaling molecules using optimal transport theory and Gaussian graphical models. The study demonstrates the robustness and effectiveness of sPGGM in capturing critical signals across various disease categories.
Researchers at La Jolla Institute for Immunology discovered that T cell reactivity is highest during the prodromal period in Parkinson's disease, which can last for decades before noticeable symptoms. This finding may guide the development of early diagnostic tools and provide a new timeline for Parkinson's disease detection.
Researchers developed a digital motor score, HDDMS, using smartphone apps to track disease progression in Huntington's disease. The HDDMS is around twice as sensitive as the current clinical measure, allowing for more efficient clinical trials and potentially accelerating drug development.
This study analyzed changes in IMLD disease spectrum and epidemiological characteristics in two Chinese hospitals. The most common IMLD was Wilson’s disease, which remained prevalent across all age groups.
A team of researchers has developed a predictive model that uses genetic mutations to forecast the age of onset for familial Alzheimer's disease. The model suggests specific correlations between gene mutations and disease progression, enabling clinicians to tailor treatment strategies and improve early diagnosis.
A novel gene variant in Finns significantly increases the risk of Alzheimer's disease, affecting microglia function and leading to an earlier onset of the disease. The study provides valuable information for developing treatments and highlights the importance of translational research.
Researchers identified five blood proteins that can predict liver disease up to 16 years before symptoms. The combined levels of these proteins achieved high accuracy in predicting disease onset and progression, suggesting potential for early diagnosis and treatment.
A University of Maryland study reveals that young plants face a hidden trade-off between fighting disease and growing, leading to reduced reproductive fitness. Plants with stronger disease resistance as seedlings produce fewer flowers and seeds over their lifetime.
A new study by Intermountain Health finds that peripheral artery disease is often underdiagnosed and undertreated, particularly in women. The condition affects nearly 10% of the US population and has a high mortality rate, with patients having a 50% chance of dying from it.
A study by Ann & Robert H Lurie Children's Hospital of Chicago strongly suggests that Kawasaki disease is caused by a single respiratory virus that has yet to be identified. The research found inclusion bodies in tissue samples from 20 years, indicating a common virus, and contradicting the theory of multiple pathogens.
A comprehensive study found that people with fatty liver disease have almost twice the mortality rate of the general population. The disease is caused by overweight or obesity and increases the risk of dying from various causes, including liver disease, cancer, cardiovascular disease, and infections.
Chronic kidney disease rates increased by 24% globally from 1990 to 2021, linked to higher cardiovascular disease risk. Collaborative care and screening for cardiovascular-kidney-metabolic syndrome can reduce mortality and improve patient lives.
Researchers at the Texas A&M Gastrointestinal Laboratory discovered biomarkers that can predict gastrointestinal disease risk in dogs. The study found multiple signs of high-risk disease, including inflammation and leaky guts, which can contribute to the development of GI disease if left unchecked.
A new study projects that Parkinson's disease cases will increase by 112% to 25.2 million worldwide by 2050, mainly due to population ageing. The largest number of cases is expected in East Asia, with the highest prevalence among people aged over 80.
A nationwide study found that patients with alcoholic liver disease have a significantly higher risk of developing colorectal cancer. The study highlights the importance of comprehensive CRC screening and risk stratification based on new consensus-based definitions of liver disease.
Researchers discovered that mismatch repair genes are critical in eliciting damages to neurons vulnerable to Huntington's disease, triggering downstream pathologies and motor impairment. Targeting these genes may offer novel therapeutic approaches, including improving locomotor and gait deficits and reducing neuronal cell death.
Next-generation tau radiotracers demonstrate higher binding to Alzheimer's disease brain tissue and greater selectivity than existing imaging agents. This could lead to improved diagnosis and staging of the disease, as well as better outcomes in clinical trials.
A new AI model developed by researchers at Penn State College of Medicine can predict the progression of autoimmune disease among those with preclinical symptoms up to 1,000% more accurately. The GPS model integrates data from large genetic studies and electronic health records to identify individuals at high risk of disease progression.
Switzerland is affected by Chagas disease, a tropical disease that can cause severe cardiac and digestive complications if left untreated. The Swiss government has established the Swiss Chagas Network to address this issue through coordinated measures.
Researchers identified plasma extracellular vesicle-derived microRNAs as potential biomarkers for AATD liver disease. They found 39 differentially expressed miRNAs, which were validated in an independent cohort for predicting AATD liver disease.
Global incidence of ischemic heart disease and stroke is shifting, with declines in some regions but increases in others. The study identifies eight key factors contributing to these disparities, including diet, high BMI, and household air pollution.
The International Working Group proposes a new approach to diagnosing Alzheimer's disease, focusing on clinical evaluation supported by biomarkers. This distinction is crucial for identifying those who have the disease and those at risk, paving the way for targeted research and personalized treatments.
Researchers validate a new blood test platform that can measure multiple biomarkers of Alzheimer's disease, potentially improving early diagnostics and treatment. The platform captures changes in proteins related to neurodegenerative diseases and may help track disease progression over time.
McMaster researchers found that the mutated huntingtin protein doesn't stimulate Poly [ADP-ribose] (PAR) production, resulting in less effective DNA repair. This discovery has implications for understanding Huntington’s Disease and potentially treating cancer.