Research on opioids, addiction, and treatment. Covers traditional care practices, opioid treatment in pregnancy, illicit fentanyl, and treatment disparities.
A new study reveals that laws restricting pain clinics, or 'pill mills,' where opioids were often prescribed, reduced risky opioid use by 5 percent. Enacting such laws near the onset of the crisis in the 1990s could have reduced risky use by 30 percent over time.
A Norwegian study of over 21,000 adolescents and young adults found that those with persistent parental opioid prescriptions faced more than double the risk of persistent opioid use. The study suggests considering family-based approaches to managing pain conditions in adolescents and young adults.
A new study finds that ChatGPT can provide trustworthy information for pregnant women seeking medical advice on treating opioid use disorder, with over 97% of responses scoring as safe and accurate. The researchers used a persona to frame conversations with the AI, which showed consistency with accepted clinical practice.
A recent study found that cannabis may reduce opioid use among commercially insured patients with cancer diagnoses, indicating potential benefits for pain management. However, further research is needed to confirm the efficacy of cannabis as a treatment for cancer-related pain.
A study published in The Lancet Primary Care found that older adults with HIV are more likely to receive opioids and experience opioid use disorder compared to those without HIV. This disparity highlights the need for tailored strategies to safely prescribe opioids and expand access to treatment.
A recent study found that primary care providers in Ohio perceive and treat opioid use disorder (OUD) differently from other chronic conditions like type 2 diabetes. Despite recognizing OUD as a chronic brain disease, providers were less likely to offer treatment themselves.
Research reveals an increase in emergency calls for pediatric opioid exposure among middle-school aged children, with a national trend of rising calls from 255 in 2019 to 553 in 2023. Teenagers showed a decline after 2022. Demographics varied by age group, with females outnumbering males in the middle school age group.
A recent analysis reveals a modest decline in new and additional opioid prescriptions for patients with cancer from 2016 to 2020. For patients with metastatic cancer, prescribing remained stable for those reporting any pain but declined steeply for those reporting no pain.
A new study finds that prompt administration of opioid pain relief in emergency departments can reduce hospitalization rates for children with sickle cell disease. Children who received timely first-dose administration within 60 minutes and second-dose administration within 30 minutes showed reduced hospitalization odds.
A Swedish study of over 1.2 million children found no significant association between prenatal exposure to opioids and increased risk of autism spectrum disorder (ASD) or attention-deficit/hyperactivity disorder (ADHD). The researchers attributed the observed differences in ASD rates among exposed versus unexposed children to other pre...
A new study published in the American Cancer Society's journal reveals that nearly 1 in 10 patients undergoing surgery for early-stage cancer will initiate opioid prescriptions long-term. The research found that those with a prior history of chronic pain, comorbidities, and lower socioeconomic status were at higher risk.
A new study from the University of Colorado Anschutz Medical Campus introduces a more individualized approach to restarting methadone treatment for people with opioid use disorder. The findings suggest that tailoring methadone doses to each patient's unique circumstances can improve care without compromising safety.
Researchers at Kyoto University have discovered a novel analgesic called ADRIANA, which targets the α2B-adrenoceptor and exerts its effect without causing cardiovascular instability. The compound has shown highly promising results in non-clinical studies and early clinical trials.
Researchers detected traces of nitazene in discarded injecting equipment and syringes in Adelaide, Australia. Nitazenes led to 32 overdose deaths with 84% of patients unaware of the synthetic opioid's presence.
A study of 22 million urgent care visits found 12.4% of patients received antibiotics, 9.1% glucocorticoids, and 1.3% opioids for generally inappropriate diagnoses. The trends highlight the need for improved clinician knowledge, patient demand, and decision support.
A study published in Alzheimer's & Dementia found that regular opioid use is associated with a 20% increased risk of all-cause dementia and over 70% increased risk of dementia among those taking strong opioids. Regular opioid use was also linked to reduced brain volume, lower fluid intelligence, and higher risk of vascular dementia.
A JAMA Psychiatry study recommends increasing contingency management incentives to improve opioid addiction recovery outcomes. The research team suggests using evidence-based incentive amounts, such as $128 per week for vouchers or $55 per week for prizes over 12 weeks, to effectively reduce stimulant and/or opioid use.
A new study found that Black emergency department patients are less likely to be treated with opioids, but when their preferences are not met, they are at a higher risk of misusing opioids three months later. Patients who were satisfied with their pain care had lower rates of opioid misuse.
A new study found that providing housing and supportive services without requiring drug treatment is a surprisingly cost-effective approach to helping unhoused people with opioid use disorder. The 'housing first' model output showed that people with stable housing are more likely to enter treatment for opioid use and have a higher like...
A new study found that almost all Medicaid managed care plans (MCPs) cover at least one form of naloxone, with 94% covering generic injectables or 4-mg nasal sprays. However, certain restrictions and quantity limits may prevent people from accessing this life-saving drug.
Most opioid treatment programs still do not offer all three forms of medication-assisted treatment (MAT) as of 2023. Government-operated programs and those accepting Medicare are more likely to provide comprehensive MAT offerings.
Access to buprenorphine and naltrexone for opioid use disorder is affected by race and ethnicity, as well as insurance type. Targeted interventions, including culturally tailored care and expanded access points, are needed to address disparities and reduce inequities contributing to the overdose crisis.
A new study found that new psychoactive substances (NPS) are a significant concern in roadway crashes in California. NPS, also known as ‘designer drugs’, were detected in the blood of 17 patients, with most frequent being designer benzodiazepines and fentanyl analogs.
Researchers developed a pen-like tool that can quickly collect molecules from the skin's surface to screen for opioids with mass spectrometry. The 'MasSpec Pen' delivers a droplet of liquid, extracts molecules, and analyzes them using electrospray ionization mass spectrometry.
A new online toolkit developed by the University of Ottawa and Health Canada aims to educate healthcare providers on managing opioid-related issues. The toolkit's co-creation model involves patient input, leading to a deeper understanding of chronic pain and opioid use, and a more compassionate approach to care.
Researchers from Florida Atlantic University's Charles E. Schmidt College of Medicine aim to reduce falls and adverse drug events among older adults by using personalized approach tailored to individual genetic profiles.
A Penn study shows providing surgeons with tailored data improves prescribing and maintains patient pain control without increasing opioid use. The approach reduced overprescribing by 40% and improved guideline adherence.
A recent study found that regional disparities in opioid overdose mortality continue, with the western US experiencing an increase in overdoses despite a national decline. The research highlights the need for region-specific strategies to address differing patterns of substance use and overdose risk.
Researchers found that urban areas and male middle-aged patients are more likely to receive high-dose opioid prescriptions. The study analyzed over 3 million Medicaid claims in Missouri from 2017 to 2021, identifying risk factors for opioid use disorder.
A national survey found that 11.0% of adults reported using illicit opioids within the past year, with even higher rates of fentanyl use, indicating a pressing need for improved data collection efforts to inform policy and intervention strategies.
A recent study found that 11% of Americans used illicit opioids within the past 12 months, with fentanyl use rates significantly higher than previously reported. The survey also revealed intentional and unintentional use patterns, emphasizing the need for more accurate tracking methods to address the nation's opioid crisis.
A new study published in JAMA finds that Mindfulness-Oriented Recovery Enhancement (MORE) can help individuals with opioid use disorder (OUD) regain control over their emotions and cravings. The therapy has been shown to decrease opioid cravings by 50% and improve mood, making it a promising tool in the fight against OUD.
A cohort study of pregnant individuals with opioid use disorder found that buprenorphine treatment was associated with improved maternal and infant outcomes. The study highlights the need to improve access to treatment nationwide for these patients.
A new study from Thomas Jefferson University investigates the use of ondansetron to ease withdrawal symptoms in newborns with neonatal opioid withdrawal syndrome (NOWS). Researchers found that a specific concentration of ondansetron can significantly reduce withdrawal symptoms.
Researchers at Texas Tech University Health Sciences Center have received a $1.94 million grant to study inhibitors that target peripheral neuropathic pain. The project aims to develop novel non-opioid and non-addicting therapies capable of effectively managing chronic pain.
A new study led by the University of South Florida reveals a correlation between opioid misuse and domestic violence, with opioid control programs contributing to a 10% reduction in simple assaults. The effect was strongest in states with higher opioid prescription rates.
A new study found that listening to favorite music activates the brain's opioid receptors, explaining why it evokes strong feelings of pleasure. The release of opioids is also linked to individual differences in music enjoyment and may help develop new music-based interventions for pain management and mental health disorders.
Eight hospitals, including Oklahoma Children’s Hospital, receive funding to refine discharge processes for mothers and babies with neonatal abstinence syndrome. The program aims to provide continuity of care through prenatally-based education and post-discharge support.
A study found that New York's opioid restriction law led to decreased opioid quantities after total joint replacement surgeries. The findings suggest refining laws may further reduce opioid prescribing nationwide.
A team of scientists at the University of Florida has developed a new drug compound that selectively targets delta opioid receptors, providing pain relief without the dangerous side effects associated with opioids. The study's findings offer a promising approach to developing safer pain treatments, which could also be applied to treati...
A new study by RAND Corporation found that a specialized hospital service can significantly increase patients with opioid use disorder to start FDA-approved medication treatment. The trial showed that patients receiving the service were twice as likely to begin treatment and 72% more likely to link to post-discharge care.
A new randomized clinical trial found that mindfulness-based therapy and cognitive behavioral therapy improved physical function, quality of life, and reduced pain among adults with opioid-treated chronic low back pain. The benefits persisted for up to 12 months.
Researchers discovered a mechanism that harnesses immune cells to produce opioids, potentially alleviating chronic pain. Estrogen and progesterone drive this process, which could lead to more effective treatments for women experiencing pain after menopause.
Researchers found that placing naloxone kits in transit stations could improve availability and save more lives. By optimizing distribution strategies using mathematical models, the team discovered that just 60 kits at 650 locations could cover over half of opioid poisonings in Vancouver.
Restricting telehealth prescriptions for opioid use disorder could keep thousands from accessing buprenorphine, a medication that helps people recover from addiction. Researchers found that requiring in-person visits may undo the progress made during the COVID-19 pandemic when telehealth increased access to this life-saving treatment.
Researchers found that placing naloxone kits at public transit locations using an optimization strategy and ensuring blanket placement at take-home naloxone program locations effectively covered a major proportion of opioid poisonings in Vancouver. The study suggests that easy accessibility of kits is crucial to prevent deaths from opi...
A new study by Boston University School of Public Health refutes claims that Medicaid expansion increases misuse of prescription opioids and benzodiazepines. Despite initial concerns, the study found no association between Medicaid expansion and non-prescribed opioid use among people who inject drugs.
A new rat study by researchers at Washington University School of Medicine suggests that biological differences in males and females may contribute to the gender disparity in opioid misuse. Female rats with chronic pain showed no increase in opioid intake, whereas male rats increased their fentanyl consumption over time.
Fentanyl poisoning among US children has surged by 924% and 1,506% for teens aged 13-19 over the past eight years. Parents are advised to be vigilant about hidden fentanyl risks and know the signs of overdose symptoms to save their children.
Researchers are conducting a clinical trial to find the optimal combination of pain management tools for patients undergoing mastectomy procedures. The study will enroll approximately 100 patients and examine various combinations of pectoralis nerve blocks, non-opioid analgesics, and administration methods.
Researchers developed a custom-designed compound that mimics natural cannabis molecules to alleviate chronic pain without psychoactive side effects. The modified synthetic cannabinoid compound showed promise as a nonaddictive pain reliever, offering prolonged relief and minimizing tolerance.
A new study provides the first nationwide picture of who knows about, carries, and uses naloxone to reverse deadly opioid overdoses. The survey found that people's perception of overdose risk correlates with their decision to carry naloxone, and those with high-risk profiles are more likely to carry the drug.
A study published in JAMA Network Open found that a proposed US Drug Enforcement Administration rule could prohibit more than 4,500 tele-buprenorphine initiations for patients with opioid use disorder. The rule requires an in-person visit with the tele-initiating clinician prior to or within 30 days after tele-initiation.
A study analyzing millions of U.S. prescriptions over 10 years found that co-prescribed stimulants and opioids are associated with escalating opioid intake. Patients taking both stimulants and opioids had a higher average monthly intake of morphine milligram equivalents (MME) compared to those taking only opioids.
Experts disagree on how to treat chronic pain, with some believing long-term opioid therapy is beneficial and others that it should be discontinued. The study highlights the need for individualized care decisions that weigh relative harms and benefits.
A new treatment for post-amputation pain may have reduced residual limb pain and opioid dependence, according to a Northwestern Medicine study. Hydrodissection, a simple procedure that injects fluid around nerves, showed significant improvements in pain relief and mental health benefits.
A University of Cincinnati researcher has been awarded a $2.1 million grant to investigate postoperative pain at the molecular and cellular levels. The goal is to develop new, safer non-addictive treatments for chronic pain conditions, including lower back pain and pain associated with diabetes or chemotherapy treatments.
A new study published in JAMA Internal Medicine found that the 2019 Medicare opioid safety policy reduced initial opioid prescriptions and high-dose prescriptions from multiple prescribers among Medicare beneficiaries with disabilities. However, these reductions diminished over time, highlighting the need for ongoing research to unders...
A study found that patients who received opioid prescriptions in the emergency department were more likely to receive additional opioid prescriptions or require hospital admissions in the following year. Patient characteristics, such as age and health conditions, played a significant role in determining risk.
Researchers at Tokyo University of Science have found that opioid delta-receptor agonists can alleviate stress-induced IBS symptoms in a validated mouse model by targeting the central nervous system. The study suggests that these drugs could provide a more definitive solution for IBS with minimal adverse effects.