Articles tagged with Insulin Sensitivity
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A controlled feeding study out of South Dakota State University shows that older adults who reduced ultra-processed foods naturally consumed fewer calories, lost weight and abdominal fat, and showed improvements in insulin sensitivity and inflammation. This study provides evidence that the Dietary Guidelines for Americans can deliver s...
Researchers at Northern Arizona University are developing a breakthrough tool to detect early signs of Alzheimer's disease. The new technology uses microvesicles in the blood to identify biomarkers indicating improved neuroplasticity, which can help track the disease's progression.
A large-scale U.S-based randomized trial shows that intensive lifestyle changes can significantly improve global cognition in older adults at high risk of cognitive decline. The intervention emphasized regular physical activity, healthy diet, cognitive stimulation, and social engagement, leading to clinically meaningful improvements. T...
Researchers have uncovered unique molecular fingerprints for insulin sensitivity, challenging traditional binary classification of people with type 2 diabetes. These signatures can help identify individuals at risk earlier than current methods, paving the way for personalized treatments and precision medicine.
A study found that pedometers capture a remarkable 88% of the health information provided by more advanced accelerometer measurements. Walking at a brisk pace is essential for cardiovascular health optimization, with a minimum cadence of 80 steps per minute strongly associated with good aerobic fitness.
Research suggests flavonoids improve insulin sensitivity, enhance β-cell function, modulate the gut microbiota, inhibit gluconeogenesis, and regulate enteroendocrine hormones in type 2 diabetes management. Flavonoid-specific effects on GLP-1, GIP, PYY, and CCK secretion contribute to improved glycemic control.
A new study published in Nutrients found that eating two cups of mango daily can help lower insulin concentration levels and improve insulin sensitivity in overweight or obese adults. The study, conducted at the Illinois Institute of Technology, showed significant reductions in insulin resistance and improved beta-cell function.
A recent study found that a brief consumption of highly processed foods can alter the brain's sensitivity to insulin in healthy individuals, potentially leading to obesity and type 2 diabetes. This effect was observed even after returning to a balanced diet for one week.
Researchers identified 14 proteins and 2 metabolites associated with prediabetes progression to diabetes, including DCXR and GSTA3. Inflammation and immune system pathways also play a key role in glucose homeostasis.
A study published in Nature Metabolism found that four percent of Greenland's Inuit population has a gene variant that increases their risk of type 2 diabetes by tenfold. Exercise has been shown to increase insulin sensitivity in these individuals, suggesting it may be an effective way to reduce their risk of developing the disease.
A clinical study found increased permeability of the small intestine and inflammation in the gut, linked to higher body weight and insulin resistance. The researchers emphasize the need for further investigations into carrageenan's effects on human health.
Researchers found a novel link between aortic stenosis and insulin resistance, with certain biomarkers increasing the risk of the disease. The study's findings suggest that managing metabolic health could be a new approach to reduce the risk of AS and improve cardiovascular health in aging populations.
A recent study published in Nutrition & Diabetes found that consuming over 45% of daily calorie intake after 5 p.m. is associated with increased glucose levels, regardless of individual weight or body fat composition. This can lead to a higher risk of type 2 diabetes, cardiovascular disease, and chronic inflammation.
A new treatment strategy combining ReCET and semaglutide has been shown to eliminate insulin therapy in 86% of type 2 diabetes patients, improving sensitivity to endogenous insulin. The novel procedure, which employs electroporation, is compliance-free and disease-modifying, addressing ongoing patient adherence issues.
A six-month study found that reducing daily sitting by 40 min/day can prevent back pain from worsening. The researchers suggest trying to reduce sitting at work or leisure time, but emphasize the importance of physical activity such as walking or brisk exercise.
Researchers at Pennington Biomedical are conducting a 12-week study to examine the impact of soy on blood sugar, mood, and energy levels. Participants will receive meals with or without activated soy flour and undergo various tests, including insulin sensitivity and bone density assessments.
Researchers found distinct molecular responses in skeletal muscle following bariatric surgery between obese individuals and those with additional T2D. Obesity individuals showed improvements in metabolic health, while T2D participants had limited changes.
A systematic review published in Nutrients highlights the positive health outcomes associated with pulse consumption. The study found that eating more pulses reduces the risk of type 2 diabetes and heart disease.
Research highlights need for prevention and treatment approaches for children with obesity born underweight, finding links between low birth weight and cardiometabolic disease risks. Visceral fat storage issues contribute to type 2 diabetes risk.
A potential new strategy for reducing diabetes risk associated with antipsychotic medications involves co-administering drugs that block dopamine receptors in the brain alongside those that stop these same receptors in the pancreas. This approach may limit metabolic side effects and improve glucose metabolism.
Researchers at Max Planck Institute discover that liver mitochondria adapt to food presence via nerve cells, leading to improved insulin sensitivity. This finding could pave the way for new type 2 diabetes treatments.
A low-fat vegan diet was found to reduce insulin needs by 28% and improve insulin sensitivity by 127% in people with type 1 diabetes, according to a groundbreaking new study. The diet also led to improvements in cholesterol levels, kidney function, and weight.
A comparative study of four major type 2 diabetes medications reveals differences in medication acceptance, quality of life, insulin secretion, and mortality. The GRADE Study found that younger age and higher blood sugar levels at baseline were associated with poor blood sugar control over time.
Researchers found that Kallistatin expression increases after weight loss, improving hepatic insulin sensitivity in obese mice. This protein may be an interesting therapeutic target for treating obesity and type 2 diabetes.
A recent study found that liraglutide, a GLP-1R agonist, rapidly improves insulin sensitivity in individuals with obesity and pre-diabetes. Insulin sensitivity is crucial for controlling blood glucose levels, and improved sensitivity reduces the risk of developing Type 2 diabetes or improving its treatment.
A new study published in the University of East Anglia shows that automated insulin delivery technology can help pregnant women with type 1 diabetes better manage their blood sugars. The technology, known as Hybrid Closed-Loop or Artificial Pancreas, helps to substantially reduce maternal blood sugars throughout pregnancy.
Researchers discovered a gut bacteria that helps reduce insulin resistance and protect against diabetes. The study found that a specific bacteria, Alistipes indistinctus, consumed excess monosaccharides in the gut, lowering blood sugar levels and reducing insulin resistance.
Researchers found that liraglutide improves associative learning in people with obesity by restoring brain activity to normal-weight levels. The study showed that participants with obesity had reduced ability to associate sensory stimuli and decreased brain activity compared to those with normal weight.
Researchers at UC Berkeley discovered that deep-sleep brain waves can regulate the body's sensitivity to insulin, improving blood sugar control. The study found that synchronized brain waves during deep sleep predict next-day glucose control, even after controlling for other factors.
Research from University of Illinois Chicago found water fasts spur noticeable short-term weight loss, but metabolic benefits disappear soon after fast ends. Participants lost 4-10% of their weight during the fast, and some gained back the lost weight within three months.
A randomized phase II study found that adding metformin to androgen deprivation therapy did not reduce the risk of metabolic syndrome or improve PSA response in patients with advanced prostate cancer. Metformin showed some antitumor effects through mTOR inhibition, but these were not significant.
Researchers have found a hidden mechanism connecting cancer and diabetes, where cancer cells don't respond well to insulin, leading to faster cancer growth. Insulin resistance can also cause muscle loss and strength decline in cancer patients.
Researchers found that alternate-day fasting combined with exercise decreased liver fat, weight, and ALT enzymes in patients with nonalcoholic fatty liver disease. The study suggests that this lifestyle modification may be a good option for treating the condition without pharmaceuticals.
Researchers found that people with higher levels of Coprococcus tended to have higher insulin sensitivity, while those with Flavonifractor had lower insulin sensitivity. The study aimed to understand the relationship between microbiome composition and diabetes development.
A study published in the Hypertension journal suggests that bromocriptine, a Parkinson's disease medication, may help prevent heart disease in youth with Type 1 diabetes. The research found that teens with Type 1 diabetes who took bromocriptine had lower blood pressure and less stiff arteries after one month of treatment.
A recent study shows that eight weeks of exercise can restore the brain's insulin sensitivity in severely overweight adults, leading to improved metabolism and reduced visceral fat. This opens up new therapeutic possibilities for reducing obesity and diabetes risk factors.
A new study from the University of Missouri School of Medicine found that short-term exposure to reduced physical activity and increased sugar consumption disrupts insulin response in blood vessels, with men more prone to vascular insulin resistance. In contrast, young women are protected against this condition.
Researchers identified protein levels that were higher or lower than normal in tissues from individuals at different stages of type 2 diabetes. The study found a correlation between metabolic pathway disturbances and disease progression, suggesting new potential causal mechanisms for the disease.
A new study found a correlation between colder temperatures and northern regions in the US and an increased risk of diabetes diagnoses in dogs. Diabetes diagnoses were more common in winter and in the North compared to other seasons and regions.
A retrospective cohort study of patients with atrial fibrillation and diabetes found that non-vitamin K antagonist oral anticoagulants (NOAC) were associated with a lower risk of diabetes complications and mortality than warfarin. The study suggests that NOAC may be a better therapeutic choice for this patient population.
Research reveals that obesity leads to a decline in adipose tissue's ability to respond to changes, causing insulin resistance and inflammation. This loss of function can be addressed through modulating fat tissue phenotypes for therapeutic purposes.
Regular physical activity significantly changes metabolite profiles, associated with a lower risk of type 2 diabetes. The study found improved insulin secretion and reduced fasting glucose levels in physically active men.
Researchers discovered that Black women have a greater relative abundance of Actinobacteria, associated with reduced insulin sensitivity and elevated inflammation. The study highlights the importance of understanding the role of gut microbiome in cardiometabolic health disparities among Black women.
Researchers discovered distinct gut microbiomes in Black and white US women, with potential associations to insulin resistance. The study highlights the importance of understanding individual microbiome variations in relation to metabolic health.
A green Mediterranean diet rich in polyphenols and low in red and processed meat may slow age-related brain atrophy. The DIRECT PLUS 18-month trial found significant attenuation of brain atrophy among participants who adhered to both diets.
Researchers found that SGLT2 inhibitor empagliflozin can improve insulin sensitivity in the brain, leading to better glucose control and reduced liver fat content. This breakthrough discovery positions SGLT2 inhibitors as a potential treatment for insulin resistance in the brain.
Individuals with high-risk prediabetes significantly improved their blood glucose levels through more exercise and healthy eating behavior, while those at low risk showed limited benefits from conventional lifestyle intervention. The study's findings support personalized interventions tailored to each patient's risk profile for effecti...
A study at the University of Turku found that brain function regulating satiety and appetite is altered before obesity develops, with family background risk factors contributing to these changes. The findings suggest the brain and central nervous system are key targets for treating obesity.
Researchers identified five genes mutated in people with liver disease, affecting insulin sensitivity and fat metabolism. These mutations reduce the liver's ability to respond to dietary sugars and fats.
A two-hour glucose tolerance test is linked to cognitive decline in a 10-year follow-up study. Higher blood glucose levels measured in the test were associated with weaker performance in a memory test and a greater decline in results.
A Finnish study discovered a positive association between standing and improved insulin sensitivity in adults with increased risk of type 2 diabetes and cardiovascular diseases. The researchers found that increasing daily standing time can help prevent chronic diseases, even if physical activity recommendations are not met.
A University of California, Davis study found that consuming sucrose and high fructose corn syrup can increase liver fat and decrease insulin sensitivity, highlighting the need for consumers to read labels carefully. The study also found no significant differences between the effects of sucrose and high fructose corn syrup.
Researchers at Karolinska Institutet discovered three different subtypes of mature fat cells in white adipose tissue, with only one subtype, Adipo PLIN, responding to insulin. The study suggests that changes in this specific subtype may contribute to metabolic diseases like Type 2 diabetes.
A synthetic hinge concept developed by Indiana University School of Medicine Professor Michael A. Weiss and his team could lead to a breakthrough in 'smart' insulin therapy. The invention exploits a natural mechanism that allows the insulin to adjust its activity based on blood glucose levels, which could transform diabetes care.
Eating at least two serves of fruit daily has been found to lower the risk of developing type 2 diabetes by 36%. The study suggests that whole fruits, not juice, contribute to improved insulin sensitivity and reduced blood glucose levels. Higher consumption of fruits rich in phytochemicals and fibre may also play a role.
A new study published in the American Journal of Clinical Nutrition found that consuming dairy foods did not directly affect blood sugar levels in people with metabolic syndrome. However, participants on a full-fat dairy diet gained weight and those on low-fat or full-fat diets experienced reduced insulin sensitivity.
A new study found that high-intensity interval training (HIIT) combining cycling and rowing improves insulin sensitivity and reduces blood sugar levels in individuals with obesity and type 2 diabetes. The study also showed improvements in body composition, including a reduction in fat mass and an increase in muscle mass.
A new study led by UT Southwestern scientists suggests that breastfeeding changes the body's insulin sensitivity, particularly in highly insulin-sensitive organs like the liver and fat tissue. This increase in insulin sensitivity may provide a buffer against insulin resistance even decades later, lowering the risk of Type 2 diabetes.
A genetic variant of the DUSP8 gene impairs brain response to insulin, leading to increased risk of type 2 diabetes. Research reveals protein Dusp8's regulatory effects on hypothalamic insulin sensitivity and inflammatory processes.
A long-term study found that brain insulin sensitivity determines both body weight and the distribution of fat in the body. Participants with high insulin sensitivity in the brain experienced a significant reduction in visceral fat and weight, which was maintained over nine years.