The ARTICA meta-analysis investigated the safety and effectiveness of coronary revascularisation in patients undergoing TAVI, providing comprehensive insights into the optimal role of PCI. The findings suggest a potential benefit of selective, physiology-informed PCI in patients with severe aortic stenosis and CAD undergoing TAVI.
A new editorial provides guidance on writing constructive peer reviews, emphasizing key takeaways such as 'picking battles' and maintaining professional courtesy. The guidance aims to elevate scientific data quality while mitigating impacts on authors' reputation and mental wellbeing.
A new study found that fur seals' heart rate peaks six to eight hours after returning to land, indicating a delayed recovery from the physiological costs of foraging at sea. This suggests that seals use their time onshore to actively recover and replenish oxygen stores.
A new review reveals major blind spots in Bhutan's amphibian and reptile research, with most studies focusing on species records and ecology. The study highlights the need for deeper research on genetics, disease, physiology, and long-term conservation to strengthen conservation efforts.
The São Paulo School of Advanced Science in Obesity will provide graduate students and early career researchers with a two-week training program on obesity research and prevention. The school will feature renowned keynote speakers and cover topics such as epidemiological aspects, genetic nutrition, epigenetics, and emerging preventive ...
A new study reveals that ectotherms, including fish and reptiles, are unable to fine-tune their physiology to cope with daily temperature changes, leaving them vulnerable. The research suggests that these animals will rely on behavioral strategies or genetic adaptation to survive in a warmer climate.
New research from the University of Oregon finds that women's hormone levels do not affect their ability to exercise hard, but they do change how difficult it feels. The study recruited 15 women and 15 men and found that women reported feeling more fatigued during workouts when progesterone levels were high.
The Society for Cardiovascular Angiography & Interventions has released an expert opinion on the use of wire-free angiography-derived physiology (ADP) in coronary artery disease assessment. ADP uses computational modeling or AI to analyze standard coronary angiographic images, offering a potentially more efficient and effective approac...
A UBC study found that exercise physiology research predominantly focuses on male bodies and voices, while women are underrepresented as participants and researchers. The study highlights the need for greater equity in exercise physiology research to improve understanding of sex-based differences in physiology and treatment.
A new study led by Dr. Chu Chen suggests that combining THC with celecoxib may improve cognition and reduce Alzheimer's-related brain pathology in mice. The combination produced better outcomes than low-dose THC alone, including improved learning and memory performance and reduced markers of neuroinflammation.
In experiments, horses demonstrated a strong response to sweat from scared humans, exhibiting increased fear and avoidance behaviors. The study found that horses can smell human emotional odors, influencing their behavior and physiology
Stuart S. Martin, PhD, has been appointed Chair of the Department of Pharmacology & Physiology at UMSOM, bringing over 20 years of success in advancing basic science research efforts and developing new drug therapies. His groundbreaking discovery of microtentacles on cancer cells promises to lead to new life-extending therapies.
The review reveals m⁶A's dynamic role in regulating female reproductive physiology, including oocyte maturation, granulosa cell function, and endometrial receptivity. Dysregulation of m⁶A is linked to pathologies such as endometriosis, PCOS, and recurrent miscarriage.
The implementation of a surgical handover system prioritizing sickest patients first improved handover quality, patient physiology, and staff perceptions of safety. The study found no increase in meeting duration.
The Whole Person Physiome Research and Coordination Center aims to create a comprehensive digital map of the healthy human body, combining physiology, precision medicine, and computational biology. The initiative will empower researchers and clinicians to better understand health and disease using AI-ready models.
Dr. Collet joins CRF to accelerate integration of cutting-edge research into clinical practice and expand global leadership in cardiovascular education. He will lead efforts to unify translational science, technological innovation, and education.
A study found that physiology-guided complete revascularization in older patients (75 years+) with myocardial infarction and multivessel disease provides sustained benefit at 3 years compared to culprit-lesion-only treatment. This approach may improve outcomes for elderly patients with complex coronary artery disease.
Researchers found that Ozempic-induced weight loss decreased lean mass by 10% in mice, with most of the lost weight coming from non-skeletal tissues. While some skeletal muscles did shrink, others stayed the same size, and strength was affected for some but not all muscles.
A new study by researchers at the University of Oregon found that hot-water immersion helped lower blood pressure and boost the immune system, while also improving vascular health. The study compared the physiological effects of soaking in a hot tub to sitting in a traditional dry heat sauna or a far-infrared sauna.
A University of Florida Health study found that earlier and more consistent daily activity patterns are associated with better heart and lung fitness in older adults. The research suggests that understanding individual circadian rhythms could lead to personalized health strategies, including tailoring activity and treatment schedules.
A study by Leipzig University researchers has provided high-resolution insights into the energy balance of brain neurons during spreading depolarizations. The findings show that even in 'healthy' brain tissue, these waves cause a temporary drop in ATP levels.
Dr. Pasiakos joins Pennington Biomedical to lead research on muscle physiology, nutrition, neuroscience, and technology to optimize human performance in extreme conditions. His expertise strengthens capabilities for U.S. Military resilience, spaceflight bioenergetics, and elite athlete development.
The FAVOR III China Trial showed that machine learning-based approach identify top 10 prognostic factors for predicting 2-year major adverse cardiovascular events (MACE) after Quantitative Flow Ratio (QFR)-guided Percutaneous Coronary Intervention (PCI). Patients with pre-random PCI strategy changed, Left Circumflex artery (LCX) lesion...
Dr. Krause's pioneering work on neural circuits and internal body sensing has led to two pivotal studies illuminating the complex interactions between stress, neural circuitry, and the heart-gut axis. His research holds therapeutic promise for advancing treatments for obesity, hypertension, and other cardiometabolic diseases.
A new study from the University of Ottawa's Human and Environmental Physiology Research Unit has validated lower limits of human heat tolerance, highlighting the urgent need to address climate change impacts on human health. The research found that many regions may soon experience conditions exceeding safe limits for human survival.
Beth Beason-Abmayr, a renowned educator, has received the Arthur C. Guyton Distinguished Educator Award for her exceptional contributions to physiology education. Her innovative approach to teaching and mentoring has profoundly impacted generations of students.
The American Society of Plant Biologists is searching for a new Editor-in-Chief to drive the editorial direction of Plant Physiology. The successful candidate will have a vision for the journal's future and be responsible for elevating its profile within the community.
Oregon Health & Science University researchers found that maternal THC consumption can decrease lung volume in developing fetuses and alter lung gene expression. This study is the first to examine the effects of prenatal cannabis exposure on offspring respiratory health, raising concerns for potential long-term impacts.
Genes & Development has appointed Professor Andrew Dillin as Editor-in-Chief and Dr. Eric Sawey as Executive Editor, expanding the journal's scope into new fields such as physiology, metabolism, and molecular neuroscience. The journal will continue to publish groundbreaking discoveries in molecular and cellular biology.
Researchers discovered special proteins that keep tiny particle membranes intact during transport, and found these proteins influence cargo function. Animal experiments showed ion channel protein is crucial for repairing heart damage in mice.
A new gene therapy has shown promise in reversing a condition that causes significant stillbirths and premature deliveries globally. The therapy, developed by University of Florida Health researcher Helen N. Jones, successfully boosted placental function and delivered normal-weight offspring in guinea pig models.
A new genetic breast cancer model developed by MSU researcher could help scientists better understand why and where cancer metastasizes. The model uses a genetically engineered mouse to study the E2F5 gene's role in breast cancer development, revealing altered regulation of Cyclin D1 and tumor formation.
Researchers found that prenatal exposure to synthetic cannabinoid led to cardiovascular problems in female rats and increased respiratory sensitivity to carbon dioxide in male rats. Sleep quality also deteriorated in both sexes, with males experiencing sleep fragmentation due to frequent wakefulness episodes.
Climate change affects deer populations by altering their physiology, behavior, and distribution. As temperatures rise, some species adapt to milder winters, while others struggle with heat stress and parasites.
A new study led by Penn State researchers found that high-level collegiate sports stress can lead to unhealthy attitudes about eating and inadequate caloric intake. Athletes, especially female ones, are at risk for energy deficiency, eating disorders, and bone loss if they don't consume enough calories.
A new study by Penn State researchers found that middle-aged and older women are more susceptible to extreme heat due to physiological changes. The study identified specific temperature/humidity levels safe for women as they age, providing valuable information for setting policies during heat waves.
A research study by UCD and McGill University in collaboration with NASA found that spaceflight profoundly alters the gut microbiome, leading to immune and metabolic dysfunction. The study offers new insights into how these changes may affect astronaut health during extended missions.
Researchers from the Linda Crnic Institute for Down Syndrome identified lower oxygen availability and dysregulated red blood cell function in individuals with Down syndrome. The study highlights potential targets for effective medical interventions to improve oxygen physiology in this population.
Researchers uncover the importance of kainate receptors in enabling synaptic plasticity and transmission in the cerebellum. The study's findings have significant implications for understanding neurological disorders and developing new treatments.
Researchers found that simulated microgravity significantly disrupted rhythmicity and sleep patterns in humans, leading to reduced sleep duration and increased daytime naps. The study's findings have important implications for future spaceflight and conditions involving prolonged bed rest.
A study published in the Journal of Physiology reveals a new approach to accelerate recovery from muscle injuries, utilizing hypoxia and hypobaric chambers. This strategy has potential applications for athletes and the general population, offering a faster and more effective recovery process.
Researchers have discovered plant enzymes capable of performing complex bioluminescence reactions, enabling the creation of self-sustained light displays. This breakthrough technology has the potential to monitor disease progression and assist in drug screening, offering a non-invasive tool for understanding plant molecular physiology.
A recent study published in the Journal of the American Heart Association found that digoxin treatment significantly reduced mortality and the need for a transplant among infants undergoing a hybrid procedure for single-ventricle physiology. The researchers analyzed data from 259 infants who received digoxin during their interstage per...
A new review found sparse research on women and exercise, as well as limited understanding of the effect of menstrual periods on sports performance, physiology, or physical fitness. Hormone levels vary substantially between women during their menstrual periods, making a one-size-fits-all approach to training ineffective.
A new study found significant differences in cerebral blood flow and arterial transit time between women at different menopause stages and age-matched men. The researchers discovered distinct spatial distributions of these changes, with sex differences being more pronounced than any effect of menopause stage.
Researchers at the University of Otago have found that gluten can cause brain inflammation in mice, a discovery that may have implications for human physiology. The study showed that gluten increased the number of immune cells in the brain, leading to hypothalamic inflammation.
A new study suggests that even moderate amounts of alcohol can accelerate brain atrophy and increase amyloid plaques in Alzheimer's disease. Researchers found that chronic drinking altered healthy brain function and behavior, potentially setting the stage for increased plaque proliferation.
A new framework incorporates plant physiology into fine-scale computer models of wildland fire, improving global fire forecasting. Plants' water and carbon dynamics influence combustion and heat transfer, affecting fire behavior and effects.
Exercise promotes a molecular profile consistent with expression of youthfulness-promoting Yamanaka factors, according to a recent study published in the Journal of Physiology. The researchers found that exercise induces Myc protein in muscle, which may serve as a naturally induced reprogramming stimulus.
Researchers found that muscle wasting severity is related to the type, size and location of tumors in mice, with different tumors causing varying levels of wasting. The study's findings have crucial implications for understanding how different cancers affect muscle mass and developing effective treatments.
A UCF researcher is studying the potential long-term effects of COVID-19 on people with diabetes, including how it can advance their risk for heart disease and other complications. Dr. Singla believes that COVID-19 can alter a person's genetic makeup, leading to enhanced proliferation of disease.
Researchers found that short bursts of activity after meals can improve the body's ability to use amino acids from food to build muscle proteins. Breaking up prolonged sedentary periods with brief activity 'snacks' may help maintain muscle mass and quality, according to a University of Toronto study.
Researchers found reduced lung function and scarring in mice exposed to e-cigarette vapor with or without nicotine. Female mice also showed increased body weight in adulthood. The study suggests vaping during pregnancy can have long-term health effects on offspring.
Researchers discovered that even short-term exposure to diacetyl can cause lung damage when paired with a second insult like the flu. Mice exposed to low-level diacetyl over five consecutive days then infected with flu showed significant impairment of lung function and airway repair.
Researchers at UC Davis aim to develop monoclonal antibodies that can bind to specific ion channels in nerve cells, inhibiting pain signal transmission. The goal is to create a monthly, non-addictive pain medication to replace opioids, which can lead to addiction.
A study by PLOS analyzed Australian race yards and found no significant difference in performance between male and female jockeys. The research suggests that the sex of the jockey does not impact the physiology or performance of the racehorse.
Chapman University biologist Patricia C. Lopes' research shows that our bodies can shift into defense mode before becoming sick, triggered by information from diseased individuals. This physiology change could have major impacts on disease spread and human care.
Research by Oregon State University shows that songbirds can use social information about food shortages to adapt their behavior and physiology. By receiving advance warning of declining food resources, birds can better conserve body mass and intestinal mass during times of scarcity, leading to improved survival.
A new study suggests that heat waves can lead to avian population decline by altering gene activity in the testis and brain, affecting reproductive behavior and physiology. The research found that sub-lethal heat may change a bird's ability to reproduce via changes in motivational circuits for song production.
A study by researchers at Hebrew University found that couples who synchronize their physiology and behavior during a first date are more romantically attracted to each other. The degree of synchrony also affects men and women differently, with women being more sexually attracted to 'super-synchronizers'.