Articles tagged with Blindness
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A blind patient partially recovered natural vision through electrical stimulation of the visual cortex, independent of the implant. The recovery was sustained over time and remained even after the device was removed, suggesting individual factors may have contributed to this outcome.
A WVU research team is working to restore vision in people with inherited blindness due to genetic mutations in the Prominin1 gene. The team has observed encouraging early results using a mouse model and plans to investigate the therapy's effectiveness beyond initial restoration.
A new study estimates that over 1.6 million people in the UK will be living with glaucoma by 2060, with nearly 50% higher prevalence than previous estimates. The researchers call for expanded eye health services and increased awareness campaigns to detect early cases and prevent vision loss.
A new study from Nagoya University in Japan has found that petrolatum-based eye ointments can cause MicroShunt glaucoma implants to swell and potentially rupture. The study suggests that clinicians should avoid using these ointments on patients with the implant, particularly when it is exposed outside the conjunctiva.
A large-scale field trial in Ethiopia found no significant difference between fluorometholone and placebo treatments in reducing postoperative trachomatous trichiasis recurrence. The study, which involved over 2,400 participants, suggests that anti-inflammatory therapy may not be beneficial for improving TT surgery outcomes.
Researchers identified changes in RNA molecules involved in cell's splicing machinery, causing retinitis pigmentosa in ~30-40% of patients with genetic disorder. Variants in five non-coding RNA genes were found to be responsible for the disease, offering a new diagnostic pathway for families worldwide.
Researchers have discovered new genetic causes of inherited blindness, identifying changes in RNA genes as a key factor. This breakthrough provides clarity for dozens of families globally and opens new possibilities for diagnostics and counseling in hereditary conditions, offering hope for affected individuals and their loved ones.
A new study by Mass General Brigham researchers found that genetic variants thought to always cause inherited blindness occur in only 28% of people who carry them. The findings challenge traditional models of rare disease genetics, suggesting a need for updated understanding and potentially impacting the development of new treatments.
Philip R. Troyk, director of the Pritzker Institute of Biomedical Science and Engineering at Illinois Tech, has been elected as a Fellow of the National Academy of Inventors for his groundbreaking work on neuroprosthetic devices, including an implanted cortical visual prosthesis that provides artificial vision to individuals with profo...
A new study at Rice University found that individuals with age-related macular degeneration (AMD) can accurately estimate the arrival time of an approaching vehicle using a combination of visual and auditory cues. Despite impaired central vision, participants relied on both modalities to make collision judgments.
Spanish researchers at UMH have developed a new generation of visual neuroprosthesis capable of bidirectional communication with the cerebral cortex. The system uses a small external camera to capture images, which are processed electronically and converted into electrical stimulation patterns sent to the occipital cortex. Participants...
The Leopoldina discussion paper recommends realigning German development cooperation to focus on both prevention and medical treatment for childhood blindness. The approach, called 'Global Clinical Care', aims to strengthen local care capacities and provide training for ophthalmic specialists through institutional partnerships.
A pioneering eye device has restored reading vision to people with sight loss, allowing them to read letters, numbers, and words through a prosthetic eye. The PRIMA chip operation involves an implant paired with augmented-reality glasses, enabling patients to regain their independence and confidence.
A wireless retinal implant has been shown to restore central vision in patients with advanced age-related macular degeneration (AMD), with 81% of participants achieving clinically meaningful improvements in visual acuity. The device converted light into electrical signals, stimulating remaining retinal cells and restoring visual inform...
Researchers are testing whether low-concentrate atropine drops can delay the onset of myopia in children. The study aims to reduce the risk of sight-threatening complications later in life by decreasing how nearsighted someone becomes.
Researchers used AI to assess images of patients' eyes and predict those who needed prompt treatment, successfully sorting up to 90% of patients. The study's findings could lead to earlier treatment and reduced unnecessary monitoring for patients with keratoconus.
A team of researchers has received funding to study the PRPH2 gene, crucial for normal vision, but when mutated causes a range of retinal diseases leading to blindness. They aim to uncover the underlying mechanisms of PRPH2-associated pathology to develop effective therapies.
Scientists at the University of Alabama at Birmingham created novel mouse models with mutations in the DHDDS gene to study retinitis pigmentosa (RP) 59, a genetic cause of blindness. The studies revealed that both T206A/K42E and K42E/K42E mouse models exhibited changes in retinal structure and function similar to human RP59 disease.
Glaucoma is a leading cause of vision loss, with over 7.7 million people globally affected in 2020. The new microstent reduces excessive fluid buildup and intraocular pressure, supporting the eye's natural space and improving treatment efficacy. Its durable nickel-titanium alloy enables long-term safety and functionality.
Cohort study finds GLP-1 receptor agonist use associated with modestly increased risk of incident diabetic retinopathy; however, those with preexisting DR experience fewer sight-threatening complications. Regular screening and monitoring recommended for all T2D patients on GLP-1 RAs.
Researchers have established apple snails as a system to study eye regeneration, which may hold the key for restoring vision due to damage and disease. The team discovered that the snail eye is anatomically similar to humans and can regrow itself, with genes such as pax6 playing a crucial role in development.
In a breakthrough study, researchers at the University of Rochester Medical Center found that microglia cells respond differently than neutrophils to photoreceptor damage in the retina. This discovery has high implications for treating vision loss caused by photoreceptor cell damage.
A new route of delivering gene therapy is being explored, potentially reducing invasiveness and increasing accessibility. Researchers will test a novel approach on non-human primates, aiming to expand access to office-based treatments.
Researchers have identified a previously unknown organelle called the hemifusome that plays a crucial role in cellular sorting and recycling. This discovery could lead to targeted treatments for complex genetic disorders like Hermansky-Pudlak syndrome, which affects multiple systems in the body.
A new study found that increasing apolipoprotein M levels can slow or block progression of age-related macular degeneration, a leading cause of blindness in people over 50. The researchers also found that ApoM triggers a signaling pathway that breaks down cholesterol deposits.
Scientists have discovered that heparan sulfate in Bruch's membrane traps lipoproteins, leading to drusen formation and vision loss. Targeting this interaction may prevent or reverse early signs of AMD.
Researchers found that an inexpensive HIV drug can improve vision in patients with diabetic macular edema (DME) more effectively and at a lower cost than existing treatments. The drug, lamivudine, is taken orally and may represent a game-changing option for millions of patients worldwide.
A new study by Anglia Ruskin University found that global refractive correction rates are at 65.8%, six percentage points lower than in 2010, and urge urgent action to meet the WHO's target of a 40% increase by 2030.
Researchers at the University of Pennsylvania developed novel promoters that drive specific gene expression in rod and cone photoreceptors, outperforming most currently used promoters. These tools address the challenge of treating advanced stages of inherited retinal diseases, potentially restoring vision.
A recent study found that mildly elevated eye pressure can distort blood vessels and lead to oxygen deficit in the eye. Researchers used 3D modeling and fluorescent dye to investigate how ocular hypertension affects the eye, revealing a potential new method for diagnosing glaucoma earlier.
Researchers at Wayne State University are developing a new treatment to prevent diabetic corneal complications, which can lead to vision loss and poor healing. The project combines two naturally occurring peptides to target inflammation, delayed healing, and nerve degeneration.
A new study from the University of Oklahoma is targeting cell communication in the hunt for therapies to slow macular degeneration. The research team is studying how cells in the retina communicate and whether the messages they send could be programmed to treat or slow AMD.
The University of Texas at Arlington expert discusses the state's largest outbreak in 30 years, with fewer people getting vaccinated contributing to its spread. The MMR vaccine is 97% effective against measles and has been proven safe despite misconceptions about its safety.
A Northwestern University study found significant disparities in glaucoma monitoring, with rural and economically distressed communities facing barriers to care. The study identified strategies to improve access, including expanding tele-ophthalmology services, home monitoring technology, and financial support.
Researchers have created a new open-source tool to optimize the placement of visual brain implants on a large scale. The tool, developed by the Netherlands Institute for Neuroscience, uses data from participants with intact vision to predict optimal implant locations and minimize safety risks.
A new stem cell transplant treatment has shown promising results in clearing clinical safety hurdles for the treatment of wet age-related macular degeneration. The treatment involves removing abnormal blood vessels and transplanting stem cell-derived retinal cells to replace damaged or lost retinal cells.
A new genetic medicine has been developed to treat a rare genetic deficiency affecting the AIPL1 gene, causing severe retinal dystrophy. The treatment involves injecting healthy copies of the gene into the retina through keyhole surgery, resulting in dramatic improvements in sight for four young children.
Researchers demonstrate the effectiveness of Ziapin2 in restoring ON, OFF, and ON-OFF responses induced by light stimuli in retinas with retinitis pigmentosa. The molecule restores light-induced behavior and visual acuteness for up to two weeks without toxic or inflammatory effects.
A new study has identified genetic and demographic factors that increase the risk of developing age-related macular degeneration (AMD). The research found a significant difference in AMD risk between European and non-European descent populations, highlighting the importance of diverse ancestry groups in understanding this condition.
Two non-retinoid compounds were identified that improve cell surface expression of rhodopsin in 36 genetic subtypes of retinitis pigmentosa and protect against retinal degeneration in mice with the disease. The treatment showed improved overall retina health and function, prolonging photoreceptor survival.
A study published in Chinese Medical Journal explores the use of artificial intelligence to identify potential medications for treating glaucoma. Researchers used AI models to predict the effectiveness of small-molecule compounds targeting RIPK3, a key signaling molecule involved in programmed cell death.
A new shape-changing device called Shape has been developed to help people with visual impairment perform a location task as effectively as sighted people. The study found that participants with visual impairment located targets significantly faster using Shape than with vibration technology, and preferred it over current methods.
An experimental study in mice found that SARS-CoV-2 infection can damage the retinas, leading to long-term implications for vision. The virus caused widespread inflammation across the retinal pigment epithelium, including complement activation and increased production of inflammatory cytokines.
The University of Colorado Anschutz Medical Campus is developing a groundbreaking treatment for total blindness using whole eye transplantation. The $46 million award from ARPA-H will support research aimed at restoring vision to patients with total blindness.
Researchers at TU Wien found that retinal ganglion cells retain their ability to produce different signals even after blindness. These intrinsic properties are stable and can be utilized in retinal implants, leading to better stimulation strategies for blind patients.
Around 450,000 UK children with color blindness are being failed by the education system due to a lack of recognition and support from schools. Colour blindness affects how people see the entire visible colour spectrum, not just red and green.
A $6 million grant from the California Institute for Regenerative Medicine is driving research into a new treatment for dry age-related macular degeneration, a leading cause of blindness in older adults. The therapy aims to halt or reverse disease progression using stem cell-derived healthy retinal pigment epithelium cells.
Researchers propose a new working definition for CVI, a leading cause of blindness and visual impairment in children. The definition is based on five key elements and includes early detection, neuroplasticity, and functional deficits.
Researchers at Rensselaer Polytechnic Institute have developed a novel compound to treat dry age-related macular degeneration and Stargardt disease, both blindness-causing diseases. The compound has shown therapeutic potential in slowing down disease progression and preserving vision.
A new study found that consuming pistachios daily can significantly improve eye health by increasing macular pigment optical density due to the plant pigment lutein. Lutein may also benefit brain function by reducing oxidative stress and inflammation, supporting overall healthy aging.
WorldScribe, a new software, uses generative AI to provide real-time text and audio descriptions of surroundings for people who are blind or have low vision. The tool can adjust the level of detail based on user commands or camera frame time.
Researchers have developed two smartphone apps that provide safe indoor navigation, route guidance, and return to a previous location. The apps use built-in sensors, such as accelerometers and gyroscopes, to track the user's progress, reducing reliance on visual cues.
Researchers identified a crucial protein, TIMP3, overproduced in AMD and found that blocking its activity can reduce drusen formation, suggesting a promising treatment strategy. The study offers new avenues for preventing AMD and improving the lives of millions affected by this disease.
A large NIH-funded trial compares three surgical approaches for treating trachomatous trichiasis, finding that one technique is just as effective as another in reducing post-operative complications. The study suggests that existing standard surgeries are better options than a modified method with a larger incision height.
Researchers aim to find a new treatment pathway for diabetic retinopathy by targeting the IL-6 protein. They suspect that selectively inhibiting trans-signaling while allowing cis-signaling will stop damage and restore balance in the retina.
Researchers have introduced DSFN to improve the speed and accuracy of diagnoses of retinal disorders. This AI-powered medical imaging technique combines retina images with vascular distribution information to accurately locate the fovea in complex clinical scenarios, enabling doctors to detect early signs of ocular diseases.
Researchers at Karolinska Institutet successfully used gene therapy to improve vision in 11 out of 12 patients with Bothnia dystrophy, a form of hereditary blindness. The treatment involved injecting a specially designed virus under the retina, which produced normal protein and restored visual function.
Researchers developed a gene therapy that restored useful vision to most patients with Leber congenital amaurosis type I, a rare inherited blindness. The treatment showed a 10,000-fold improvement in light sensitivity and improved navigation abilities in patients who received the highest dose.
A competition encourages magicians to craft mesmerizing sound-based tricks that evoke wonder and amazement without relying on visual cues. The initiative aims to make magic more inclusive for individuals with visual impairments, allowing them to experience the art in a new way.
A new four-year, $459,000 grant will develop software and hardware tools to increase accessibility in STEM fields for persons with disabilities. The project aims to enhance data technologies for blind and low-vision users, making it easier for them to participate in STEM research and education.