Articles tagged with Inflammatory Bowel Diseases
A new experimental rat model reproduces creeping fat in Crohn's disease, characterized by mesocolic adipose tissue hyperplasia with macroscopic, histological, immunological, and molecular similarities to human disease. The model supports the hypothesis that intestinal microbiota contributes to remodelling of mesenteric adipose tissue.
Researchers identified a link between clonal hematopoiesis of indeterminate potential (CHIP) and IBD severity. Using a drug called APX3330, the team reduced inflammation and restored colon health in mouse models.
The study found that terminal ileum intubation significantly increases the diagnostic yield for inflammatory bowel disease, anemia, abdominal pain, and chronic diarrhea. Routine ileal biopsy is recommended during colonoscopy for patients with abnormal mucosal findings or red-flag symptoms.
Researchers found that mice without the ANGPTL4 gene were protected from intestinal inflammation and colon tumors due to altered macrophage behavior. The study suggests that early-life inflammatory events can shape long-term immune programming, providing resistance to future challenges.
A study by NYU researchers found that children with Crohn’s disease have a unique microbiome signature, characterized by more pro-inflammatory and less protective bacteria. This could lead to personalized treatments for pediatric Crohn’s disease.
A randomized clinical trial found that time-restricted feeding reduced Crohn's disease activity by 40% and halved inflammation in adults with the condition. Participants practicing intermittent fasting also showed notable improvements in blood markers of inflammation and immune health, including lower levels of leptin.
A global study found that a group of bacteria, CAG-170, consistently appeared in high numbers in the gut microbiomes of healthy individuals. This species has the capacity to produce Vitamin B12 and break down carbohydrates, suggesting it plays a crucial role in maintaining human health.
A long-term study of over 2,500 individuals found that two out of three adolescents with IBS no longer met the criteria by adulthood. Factors such as sleep, mental wellbeing, gastrointestinal disorders, and family history played a role in the persistence of symptoms.
Researchers at UC Riverside find that faulty gene PTPN2 increases susceptibility to harmful bacteria like AIEC, leading to gut inflammation and IBD. The studies suggest that restoring PTPN2 function or using medications like JAK inhibitors may help control harmful bacterial growth.
Insilico Medicine presents three abstracts at the 2026 Crohn's & Colitis Congress highlighting clinical, preclinical safety, and efficacy data for ISM5411. The first-in-human Phase 1 results show no serious adverse events or deaths reported, with a favorable pharmacokinetic profile supporting gut restriction.
Researchers developed a tool to measure gut inflammation levels using luminescent reporting, detecting high levels of granzyme A enzyme in inflamed gut tissue. The new technique shows promise for accurate IBD diagnosis and monitoring, reducing invasive procedures.
Researchers develop a novel approach to precisely encapsulate individual probiotics into microgels, enhancing survival and targeted delivery in the gastrointestinal system. The study demonstrates improved therapeutic efficacy in treating IBD using this technology.
Research reveals that fat located near the colon contains an unusually high number of inflammatory fat cells and immune cells, suggesting a unique function in communicating with the immune system in the gut region. This tissue may be an adaptation to the gut microbiome and could contribute to amplifying or sustaining inflammation.
A new study found that bowel preparation procedures for colonoscopies can disrupt the gut environment, making mice more susceptible to infection and inflammation. The researchers hope to understand whether these procedures may put people with inflammatory bowel disease (IBD) at risk of exacerbation.
Researchers identified a novel natural decoy receptor, IL-17REL, that plays a protective role in inflammatory bowel disease. The decoy receptor suppresses downstream inflammatory genes and improves colitis in mice, suggesting its therapeutic potential.
The Crohn's & Colitis Foundation survey found that 18% of young adults with IBD work extra hours to afford care, while over 1 in 3 lack confidence in navigating insurance. The study highlights the need for targeted educational resources and policy attention to improve equitable access to care.
Researchers developed a soft, wireless implant that modulates the splenic nerve to restore immune balance in patients with chronic inflammatory diseases. The device showed excellent biocompatibility and reduced inflammation in a rat model of chronic colitis.
A new international study found significant changes in gut bacteria at the onset of inflammatory bowel disease (IBD), a condition that affects the digestive system. The study reveals a loss of beneficial anaerobic bacteria and an increase in oxygen-tolerant bacteria, which may trigger inflammation.
Colectomy and liver transplantation alter disease behavior in IBD-Associated PSC, highlighting unique risks and challenges. PSC patients face heightened cancer risk after colectomy, while transplant reshapes risks of de novo IBD and recurrent PSC.
A multinational study found PSC prevalence among Asian IBD patients to be markedly lower than in Western countries, associated with more favorable clinical outcomes. The proportion of asymptomatic PSC cases has increased due to improved imaging modality detection, allowing for early-stage diagnosis and reduced liver transplantation rates.
The American Gastroenterological Association has released an updated clinical guideline on the pharmacological management of moderate-to-severe Crohn’s disease, recommending early use of high-efficacy therapies to improve patient outcomes. The guideline organizes treatments by efficacy to simplify decision-making for gastroenterologist...
The coralME tool creates detailed genome-scale models of metabolism, gene and protein expression from large amounts of data. The models uncover how microbes respond to certain nutrients and predict what nutrients favor the formation of undesired products.
Renowned gastroenterologist Jean-Frédéric Colombel, MD, will deliver the 31st Anatomy Lesson on November 20, exploring Mount Sinai's pioneering work in IBD prevention and treatment. His presentation aims to highlight the growing problem of immune diseases, including Crohn's disease.
Research from the University of Gothenburg has identified two bacteria that can produce bioactive serotonin, a key player in bowel movements and brain function. These findings suggest new avenues for treating functional gastrointestinal disorders like IBS.
Researchers analyzed 659 posts on Reddit to better understand the role of social media in managing inflammatory bowel disease. The study found that patients use social media to track symptoms, manage medications, and cope with stress.
Double negative T cells (DNT cells) play an indispensable role in suppressing intestinal inflammation, acting as antigen-presenting cells. Their impaired function may contribute to the pathogenesis of Crohn’s disease, suggesting they could be a potential therapeutic target.
Researchers at uOttawa are developing an AI tool to provide personalized dietary strategies for people living with inflammatory bowel disease (IBD). The project aims to match specific types of carbohydrates to individual patients' unique gut microbiomes.
A UCLA Health study found that taking an 8-strain probiotic daily reduces the risk of pouchitis, a common inflammatory condition. However, the treatment's cost-effectiveness depends on the patient's likelihood of flare-ups, with benefits only seen in patients with frequent relapses.
A new study published in Clinical Gastroenterology and Hepatology shows that AI analysis can accurately identify mucosal ulceration as well as human reviewers, providing a more objective and reproducible assessment of Crohn's disease. The findings have potential implications for education, drug development, and automated care.
This study identifies ulcerative colitis as the most common subtype of IBD in Nigeria, with rectal bleeding being the predominant clinical feature. The findings highlight significant management challenges due to high medication costs and limited availability, affecting nearly half of patients.
Researchers discovered that smoking produces metabolites that encourage mouth bacteria to grow in the large intestines, triggering an immune response. These bacteria, specifically Streptococcus mitis, help reduce inflammation in ulcerative colitis by triggering a specific immune response.
Researchers discovered that inflammatory bowel disease (IBD) leads to blood clotting due to a lack of layilin protein, which prevents platelets from forming unwanted clots. A drug targeting Rac1 activity could reduce excessive clotting and alleviate day-to-day IBD symptoms.
A large-scale study published in PLOS Medicine found no association between early life antibiotic exposure and the development of autoimmune diseases in children. Researchers analyzed data from over 4 million Korean children and discovered no increased risk of Type 1 diabetes, Juvenile idiopathic arthritis, or other autoimmune conditions.
A new study published in Molecular Nutrition and Food Research found that red meat consumption causes an imbalance of bacteria in the intestinal microbiota, leading to exacerbated colonic inflammation. The diets resulted in a decrease in beneficial bacterial strains and an increase in pro-inflammatory cells.
The study found substantial interrater reliability for active disease grades, but variability in individual grade assignments. The NHI showed substantial interrater reliability (ICC = 0.79) among US gastrointestinal pathologists for assessing histologic remission in treated ulcerative colitis biopsies.
Researchers discovered a new pathway to boost immunity against parasitic infections, suggesting that NSAIDs like ibuprofen could be repurposed as anti-parasitic treatments. Gasdermin C plays a crucial role in this process, targeting and penetrating Rab7-positive vesicles to reduce prostaglandin d2 levels.
A study reveals that a combination of dysbiosis, OTUD3 gene mutations, and STING signaling aggravate ulcerative colitis. The intestinal flora plays a vital role in UC, but an unbalanced microbiome with fewer beneficial microbes and more harmful ones contributes to the disease.
A study by University of California, Riverside researchers found that inhaling agricultural dust can alter the gut microbiome and impair intestinal function, leading to increased 'leaky gut' and associated chronic diseases. The study highlights the need for protective measures for agricultural workers.
A large prospective study found that a healthy plant-based diet is associated with an 8% lower risk of ulcerative colitis and a 14% lower risk of Crohn’s disease. Fruits and vegetables were identified as key protective factors against inflammatory bowel disease.
A new online program aims to improve body image and wellbeing for people with Inflammatory Bowel Disease (IBD). The 10-module program uses mindfulness techniques, cognitive behavioural therapy, and self-compassion training to help patients overcome negative thought patterns and social comparisons.
A large-scale study found no association between medication use and the development of microscopic colitis, contradicting previous findings. SSRIs were linked to a slightly higher risk, but also increased the likelihood of receiving a colonoscopy.
The study found that significant changes in sleep metrics occurred only when inflammation was present in the body, with symptoms alone not resulting in any notable sleep disruption. Sleep disturbances worsened leading up to inflammatory flares and improved afterward, suggesting that sleep changes may signal upcoming disease activity.
Damage to the intestinal barrier is a key factor in IBD pathogenesis. The barrier maintains homeostasis by preventing harmful substances from entering systemic circulation. Emerging therapeutic strategies target oxidative stress modulation, microbiota restoration, and autophagy regulation.
Researchers have discovered that supplementing with isobutyrate eases intestinal inflammation and restores gut balance in a pig model of colitis. The study shows that isobutyrate shifts the microbiome toward beneficial bacteria, reduces diarrhea and bleeding, and strengthens the intestinal barrier.
This article highlights the regulatory effects of copper metabolism on cuproptosis in intestinal diseases like colitis and carcinogenesis. Cuproptosis exhibits a bidirectional regulatory role in modulating oxidative stress responses, metabolic reprogramming, and immunotherapeutic efficacy.
Recent research highlights the gut microbiome's pivotal role in IBD pathogenesis, alongside metabolomic and immunological dysregulation. An integrative model links microbiome shifts to reduced butyrate, disrupting Th17/Treg balance and elevating IL-6/IL-17.
Researchers identified a gene mutation that disrupts iron absorption in patients with Crohn's disease, leading to persistent anemia. The study sheds light on how genetic risk factors for IBD can compound patient symptoms by interfering with nutrient absorption.
New research warns against widespread use of Fecal Microbiota Transplants (FMT) due to potential for long-lasting, unintended health consequences. Mismatches in gut ecosystems can lead to changes in metabolism, behavior, and energy balance.
A study in Gastroenterology Nursing found that popular IBD-related TikTok videos have very low scores for quality of medical information, despite their high views. The research suggests that tailored educational content on IBD can be created for the platform, addressing gaps in IBD education.
A pioneering research brings psychedelic medicine into gastroenterology, exploring psilocybin's effects on treatment-resistant irritable bowel syndrome (IBS). Dr. Erin E. Mauney's study modulates interoception and uses integrated therapy sessions with neuroimaging to track brain changes.
This study investigates UGIT involvement in adult Egyptian UC patients, finding significant esophagitis and gastritis. The results demonstrate a strong association between colonic disease severity and UGIT endoscopic and histopathological findings.
A global study describes four distinct stages of inflammatory bowel disease (IBD) as it spreads to newly developing regions in Africa, Asia, and Latin America. The research provides resources and guidance for local healthcare systems coping with the growing burden of IBD patients.
Research in rats suggests that Arbutus unedo extract can prevent changes in the colon's lining and reduce colonic lesions. The treatment also caused decreased expression of proteins promoting oxidative stress and inflammation.
Researchers at The University of Osaka found that localized oxygen deficiency in colon tumors can promote tumor growth by transforming normal fibroblasts into inflammatory fibroblasts. These altered cells release factors that help tumors grow, offering a potential new target for cancer therapy.
Researchers find inhibiting TMEM219 signaling restores mucosal healing in inflammatory bowel diseases and protects intestinal stem cells from death. The study suggests TMEM219 overactivation induces intestinal stem cell death, preventing mucosal renewal during inflammation.
A new approach, GlycoCaging, delivers medicine directly to the lower gut at significantly lower doses than current treatments, potentially helping people with inflammatory bowel disease. The technique has been shown to be effective in mice and has potential for treatment in humans, as most people have the ability to activate the drugs.
Researchers from UCalgary and Chinese University of Hong Kong found that IBD progresses through four predictable epidemiological stages as it spreads globally. The study forecasts a major rise in IBD prevalence in Canada by 2045, with countries in North America, Europe, and Oceania reaching Stage 3 (compounding prevalence). Developing ...
Preet Chaudhary and Michael Selsted, USC innovators, recognized by the National Academy of Inventors for their work on harnessing the power of the immune system. Their research aims to develop new treatments for diseases such as cancer, rheumatoid arthritis, and sepsis.
A longitudinal study found that EBV infection predisposes people to develop Crohn's disease, with a five-to-seven-year delay between exposure and diagnosis. The study suggests that EBV may alter the immune system leading to Crohn's disease.
Researchers at U of T discover a ginger compound called furanodienone that selectively binds to and regulates nuclear receptor PXR, reducing inflammation in the colon. FDN has been shown to increase tight junction proteins, repairing damage to the gut lining caused by inflammation.