Articles tagged with High Fat Diets
A new study from Emory University finds that live bacteria from an imbalanced gut microbiome can enter the brain via the vagus nerve, potentially initiating neurological conditions. The study used mouse models and found that high-fat diets increased intestinal barrier permeability, allowing bacteria to reach the brain.
A new review outlines the scientific explanations behind ketogenic diets' therapeutic benefits for epilepsy, including their ability to strengthen brain energy systems, reduce inflammation, and protect neurons. The review highlights the need for further research, particularly in adults, to develop new therapies that mirror the diet's e...
A ketogenic diet causes physical changes in brain cells that affect how they send information to one another, dampening the strength of signals between them. This quieter neural landscape might explain how the diet calms overactive electrical signaling characteristic of epileptic seizures.
A new study found that strength training is the most effective tool for achieving 'high-quality' weight loss, reducing body fat while preserving and even increasing muscle mass. This type of exercise also reduces waist circumference, a key indicator of abdominal obesity and cardiometabolic risk.
A Brown-led study of Rhode Island's Eat Well, Be Well Incentive Program found modest increases in fruit and vegetable consumption among participants, but highlights the need for better awareness and access to the program. The program aims to encourage healthy eating by giving SNAP recipients $0.50 back for every $1 spent on fresh produce.
Research found that high-fat and high-carbohydrate diets are controlled by separate neural pathways in the brain. Neuropeptide Y neurons activate AMPK-regulated corticotropin-releasing hormone neurons to promote high-carb intake, while inhibiting melanocortin 4 receptor neurons to increase high-fat intake.
Researchers found that voluntary running exercise mitigates cafeteria diet-induced behavioral changes via hormonal and microbial pathways. The study revealed specific metabolites, such as anserine and indole-3-carboxylate, were decreased by the cafeteria diet but partially restored by exercise.
A study published in Science Advances found that the ketogenic diet can have potentially dangerous impacts on metabolic health, including impaired blood sugar regulation and fatty liver disease. Mice fed the diet developed severe metabolic complications, with some changes starting within days.
This study investigates the effects of a long-term high-fat diet on lipid metabolism and hepatic lipotoxicity. Ganoderma lucidum alleviates HFD-induced liver injury by modulating the unfolded protein response (UPR) and endoplasmic reticulum-phagy, reducing serum lipids and improving cell viability in primary hepatocytes.
Researchers found that a high-fat diet impairs memory formation in fruit flies by reducing autophagy, a crucial cellular recycling process. This suggests that lifestyle interventions promoting autophagy, such as exercise or intermittent fasting, may improve cognitive decline associated with HFD.
Researchers at Salk Institute discover a new microprotein, SLC35A4-MP, that regulates mitochondrial structure and function in brown fat tissue. The study reveals the microprotein's role in maintaining healthy cellular metabolism and regulating body temperature.
A diet rich in omega-3 fatty acids is associated with a lower risk of myopia in children, according to the Hong Kong Children Eye Study. Higher intake of omega-3 fatty acids was linked to shorter axial length and less refractive error.
A new study from the University of California, Davis found that switching from a high-fat to a low-fat diet slowed precancerous changes in the pancreas, even after weight gain and precancerous changes began. Researchers observed normalized gut microbiome, gene expression, and intercellular communication after dietary change.
A study published in Cell Metabolism finds that a combination of gut bacteria and acetate reduces obesity in mice. The researchers discovered that the specific combination of Bacteroides species and acetate leads to increased fat burning and reduced sugar storage, resulting in weight loss.
This study found that intestinal depletion of TM6SF2 exacerbates high-fat diet-induced MASLD by altering the gut microbiota and liver lipid content. The absence of TM6SF2 also led to increased serum biomarkers associated with MASLD progression.
Research from the University of Sydney finds that high-fat, high-sugar diets can impair brain function, specifically location memory and spatial navigation. Participants who consumed fewer fatty and sugary foods were better able to navigate virtual reality mazes and recall locations.
Researchers discovered that a high-fat diet activates mechanisms facilitating breast cancer metastasis by promoting platelet activation and fibronectin expression, creating a fertile breeding ground for tumor cells to take root. This study provides new insights into the relationship between obesity and breast cancer spread.
A high-fat diet reduces neurotensin, a brain peptide that interacts with the dopamine network, leading to reduced pleasure in eating. Boosting neurotensin levels restores pleasure and promotes weight loss in mice, offering new avenues for addressing obesity.
A new study in The Journal of Immunology reveals how a high-fat diet can impair the immune system's ability to respond to infection. Male mice fed a high-fat diet exhibited impaired neutrophil function, including reduced bacterial killing capacity and abnormal gene expression.
A new study published in Liver International found that a mother's high-fat diet during pregnancy can lead to liver stress and changes in the fetus's bile acid levels. This may be a key factor in the development of metabolic dysfunction-associated steatotic liver disease (MASLD) later in life.
Researchers found that high-fat diets caused significant changes in the brains of aged rats, including inflammatory markers and impaired memory functions, even after only three days. The study suggests that aging and diet-related inflammation may be key factors contributing to age-related memory decline.
Researchers found that CD44-deficient mice stayed lean despite a high-fat diet, while control mice developed obesity. The study suggests CD44 inhibitors could serve as a complementary treatment for obesity and related metabolic disorders.
A large-scale study examined the relationship between nutrients and sleep using data from people who used mobile applications to track their eating and sleeping habits. The results showed that participants with high protein, monounsaturated fatty acid, and polyunsaturated fatty acid intake had improved sleep outcomes.
Researchers found that adolescent rodents fed a high-fat diet showed poor control during motor inhibition tasks and conservative decision-making in adulthood. The study suggests that a high-fat diet in adolescence can provoke long-term changes in impulsive behavior.
Ken Perry, a UTA senior, has been recognized for his research on the connection between high-fat meals and cardiovascular health. He won two awards from the American Physiological Society for his work analyzing data collected from previous studies, which showed a correlation between high-fat consumption and changes in brain blood flow.
Researchers from Salk Institute found that specific dietary fats are incorporated into sphingolipids to drive the development of atherosclerotic cardiovascular disease. The team discovered that trans fats are preferentially metabolized by an enzyme, leading to increased lipoprotein secretion and plaque formation.
A new study suggests that a keto diet rich in ketone bodies may help alleviate symptoms of multiple sclerosis and other autoimmune disorders. The diet promotes the production of indole lactic acid, which blocks the activation of immune cells responsible for these conditions.
A team of scientists from NTU Singapore and HKU found that electro-acupuncture can reverse the effects of obesity in obese individuals and mice on a high fat diet. The treatment targets osteoprotegerin, a protein linked to fat cell formation and obesity development.
A high-fat diet can promote overweight and increase diabetes risk, but fat alone does not change the brain's hypothalamus. Other macronutrients like sugar may have more profound effects on AgRP neurons.
A UC Riverside-led research team found that obesity causes chronic changes in the brain, leading to reduced connections between neurons and lower testosterone levels. The study suggests that the primary site of obesity's effects on reproductive function is the brain, rather than the testes or pituitary gland.
A recent study published by American Society for Nutrition found that paternal fish oil supplementation can lead to lower body weight and improved metabolic health in offspring. Researchers gave male mice a high-fat diet with or without added fish oil, then mated them with female mice on a healthy low-fat diet.
A high-fat diet in adolescent rats disrupts resident gut bacteria, alters behavior, and influences brain chemicals to fuel anxiety. The study also found a link between the high-fat diet and altered expression of genes involved in serotonin production.
A new study found that prenatal exposure to Di (2-ethyhexyl) phthalate in combination with a high-fat diet has a more damaging effect on male mice than each factor alone.
A study of 30 volunteers found that a poor diet can lead to changes in neurotransmitters and grey matter volume, commonly associated with depression and anxiety. Adhering to a Mediterranean-style diet was shown to prevent these changes.
A new study reveals that a cancer drug can improve insulin sensitivity and lower blood glucose levels, but eliminating a specific gene related to fat metabolism worsens insulin resistance. The research highlights the interconnectedness of fat metabolism in organs and the need for simultaneous treatment of obesity and insulin sensitivity.
Researchers are exploring the connection between high-fat diets and Type 2 diabetes, with a focus on the REDD1 protein in heart cells. Insulin resistance in heart cells doubles the risk of heart failure and death, highlighting the need for new treatments for diabetic heart disease.
The study reveals that TM4SF19 protein inhibits a pump in lysosomes, impeding macrophage clearance of dead cells. Macrophages lacking TM4SF19 demonstrate enhanced efficacy in clearing dead adipocytes, reducing weight gain and metabolic dysfunction. The findings may open new avenues for treating obesity and related metabolic disorders.
Rats consuming reheated sesame or sunflower oil showed increased oxidative stress and inflammation in the liver, leading to significant damage in the colon and changes in endotoxins. The study suggests that long-term deep-fried oil consumption may contribute to neurodegeneration and highlight the need for further research on this topic.
Researchers at Ohio State University found that eating fatty food before surgery triggers an inflammatory response in the brain, leading to impaired memory function. The study also showed that taking a DHA omega-3 fatty acid supplement can prevent these effects.
Researchers found that the hedonic overdrive model best explains obesity in male mice fed high-fat diets. The study reveals that dietary protein and carbohydrate, but not fat, drive overconsumption, contradicting the mass balance model of obesity.
A new mouse study reveals that the gut microbiome interacts with the loss of female sex hormones to exacerbate metabolic disease. The research suggests that the gut microbiome contributes to weight gain, fat in the liver, and inflammation, particularly in women after menopause.
A study found that antibiotic use and high-fat diets reduced Clostridia gut microbes, leading to sorbitol intolerance. Restoring the balance with mesalazine may treat the condition.
A new study by University of California Riverside researchers found that high-fat diets affect not only obesity and colon cancer but also the immune system, brain function, and potentially COVID-19 risk. The study, which analyzed genetic changes in mice fed different types of fat, showed that polyunsaturated fatty acids in soybean oil ...
Researchers discovered five types of macrophages in fat tissue, with one subtype promoting inflammation and another quelling it. The findings challenge the long-held assumption that pro-inflammatory macrophages are solely responsible for obesity-related inflammation.
A recent study by Ohio State University researchers found that saturated fats can interfere with the creation of new memories in aged brains. However, omega-3 fatty acids, particularly DHA, may help protect brain cells from fat-related inflammation. The study used cell cultures and brain tissue from aging mice to explore the effects of...
A new study found that 12% of Americans are responsible for eating half of all beef consumed on a given day. The study analyzed data from the CDC's National Health and Nutrition Examination Survey and found that these individuals, mostly men or those between 50-65 years old, eat disproportionately large amounts of beef.
Researchers at the Salk Institute discovered that high-fat diets change gut bacteria and bile acids, leading to inflammation and affecting intestinal stem cell replenishment. The altered bile acids cause inflammation and increase cancer risk in mice.
A recent study led by Dr. Itamar Harel reveals that manipulating AMP biosynthesis can extend lifespan and promote metabolic health in vertebrates. The research used the turquoise killifish as a model organism and found remarkable effects on energy metabolism, including a fasting-like profile and enhanced resistance to high-fat diets.
Researchers investigated hepatic hydrogen sulfide production in a mouse model of Hutchinson-Gilford Progeria Syndrome (HGPS) and found reduced H2S levels in RC-fed mice, with partial rescue on high-fat diet. This study suggests that accelerated aging in HGPS may be partially explained by reduced hepatic H2S levels.
A new study reveals that neurons expressing steroidogenic factor 1 (SF1) influence inflammation in white and brown adipose tissue. SF1 neurons help suppress inflammatory responses in inguinal WAT, but not in epididymal WAT, and activate thermogenic activity in BAT.
Researchers have developed a simple blood test that can diagnose De Vivo disease, a rare and disabling neurological disorder. The test, called METAglut1, has a high sensitivity and specificity, allowing for accurate diagnosis in a short amount of time.
A study published in Scientific Reports found that rats exposed to high-fat diets during pregnancy and early life developed a preference for salty taste. This preference was linked to increased levels of AT1 protein in the taste buds, which can lead to higher sodium intake and potentially contribute to obesity and diet-linked diseases.
A study published in Nature Communications found that removing the SAPS3-inhibiting component frees AMPK to activate, allowing mice to maintain normal weight and avoid obesity. The discovery could lead to a new approach for treating metabolic disorders such as obesity, diabetes, and fatty liver disease.
A study found that time-restricted feeding improves muscle performance in obese fruit flies by upregulating genes related to glycine production and utilization. This approach may provide a natural alternative therapy for managing obesity-related pathologies.
Pregnant women who fast during Ramadan tend to give birth to babies with lower weights. However, this effect is reduced in women consuming a high-fat diet outside of fasting hours, according to new research.
A high-fat diet allows the immune system to eliminate a parasitic worm that causes long-lasting infections in the large intestine. This discovery may lead to new treatments for millions suffering from intestinal parasitic infections worldwide.
Researchers found that clearance of p16Ink4a-positive cells did not impact β-cell mass, but improved β-cell function and proliferative capacity in a subset of HFD mice. The targeted subpopulation of β-cells is non-proliferative and non-SASP producing.
Females with more subcutaneous fat are protected against brain inflammation, a risk factor for dementia and stroke. Removing subcutaneous fat increases brain inflammation in females, even on low-fat diets.
Researchers found that excess fat triggers immune cells to overeat serotonin in the brain of developing male mice, leading to depression-like behavior. Female mice are not affected in the same way, with higher levels of oxytocin linked to social withdrawal.
A new study in mice suggests that a short-term high-fat diet can induce hyperalgesic priming and allodynia, even in the absence of injury or preexisting conditions like obesity or diabetes. Researchers found that palmitic acid, a type of saturated fatty acid, binds to nerve cells, causing inflammation and mimicking injury to neurons.