Translational Medicine
Articles tagged with Translational Medicine
OpenBind’s first data and model release marks a milestone for AI enabled drug discovery
The UK-led OpenBind initiative has released its first publicly available dataset and predictive AI model, accelerating the discovery of new medicines using artificial intelligence. The release showcases high-quality, standardized experimental data and a trained predictive model, enabling researchers worldwide to drive the next generati...
New study finds low-dose eye drops successful in managing adult myopia for 24 hours
A new study published in Eye and Vision finds that one drop of low-dose atropine can produce daylong effects in managing myopia. The researchers found that the drop showed clear changes in pupil size and focusing ability, but no short-term structural effects on the eye.
Translational experiments advance efforts to restore vision with transplanted neurons
Researchers at Johns Hopkins Medicine have made progress in transplanting retinal ganglion cells to restore vision in people with optic nerve damage. By disrupting the internal limiting membrane, a thin layer of tissue that blocks the growth and survival of transplanted nerve cells, scientists have seen improved transplantation surviva...
New global consensus establishes blueprint for holistic cardiovascular implantable electronic device lead management and lifelong patient safety
The new consensus statement provides updated guidance on CIED lead management, including extraction and management of traditional devices and newer technologies. The recommendations aim to reduce clinical challenges and morbidity within a rapidly evolving technological landscape, ensuring better quality of life for patients.
Damon Runyon Cancer Research Foundation and St. Jude Children’s Research Hospital award 2026 fellowships
Five fellows will receive funding for four years to study hard-to-treat pediatric cancers, reduce treatment toxicity, and develop innovative therapies. Their research focuses on Ewing sarcoma, leukemia, kidney cancer, and immune system vulnerabilities.
First-in-human trial primes immune system to accept donor livers
A first-in-human trial shows that an infusion of immune cells derived from a donor's blood can prime the recipient's immune system to accept a donor liver, potentially reducing lifelong immunosuppression. Eight out of 13 participants achieved complete withdrawal of immunosuppression and remained off for more than three years.
New AI technology to speed drug development
Scientists at the University of Virginia Health System have developed a suite of AI-powered tools, called YuelDesign, YuelPocket and YuelBond, to transform how new drugs are created. These tools can design drug molecules tailored to fit their protein targets exactly, even accounting for protein flexibility.
Is longevity science stuck? Researchers call for a strategic reset
Aging is redefined as a systems-level failure rather than molecular defects, highlighting the need for coordinated modulation of biological networks. The International Conference on Targeting Longevity 2026 explores new translational strategies and industrial opportunities by focusing on resilience.
New study finds common blood pressure drug boosts cancer treatment
A new study found that the common blood pressure medication telmisartan can significantly enhance the cancer-killing activity of olaparib, potentially expanding its use to many more patients. Telmisartan made tumors more vulnerable to PARP inhibitors, even when they lacked specific DNA repair defects.
The scientist who warned that profit, not science, decides which drugs reach patients
Dr. Gobbi challenges the global drug-development system, stating that promising treatments for mental illness are failing to reach patients due to venture capital and profit motives. Her research focuses on cannabis, melatonin, and psychedelics, with a goal of improving public-health decisions and treatment outcomes.
The ISSCR launches new continuing education course on stem cell therapies for Parkinson’s disease
The ISSCR has launched a new continuing education course on stem cell therapies for Parkinson’s disease, addressing the need for clinicians to provide accurate information on emerging treatments. The course features expert faculty and patient perspectives, and is available through a free and paid pathway.
NRG Oncology/Alliance trial finds immunotherapy did not improve survival when added to chemoradiotherapy for small cell lung cancer
The NRG-LU005 trial found that immunotherapy atezolizumab did not improve survival for patients with limited-stage small cell lung cancer when added to chemoradiation. Twice-daily radiation therapy, however, was associated with improved survival in this population.
Severe COVID-19, flu facilitate lung cancer months or years later, new research shows
Severe COVID-19 and influenza infections can prime the lungs for cancer development, according to new research. Vaccination, however, largely prevents these changes, suggesting a reduced risk of lung cancer.
Alliance for Clinical Trials in Oncology highlights new and open colorectal cancer trials in March
The Alliance for Clinical Trials in Oncology is spotlighting new trials for colorectal cancer in March, focusing on early detection methods and treatments for treatment delays and loss of appetite. The trials aim to improve patient outcomes, with several enrolling patients with newly diagnosed colon or rectal cancer.
Fragile X study uncovers brainwave biomarker bridging humans and mice
Researchers have discovered a novel biomarker for fragile X syndrome in both human patients and mouse models, allowing for the comparison of brain wave patterns between species. This breakthrough enables the development of more effective treatments by enabling non-invasive treatment efficacy readouts across species.
New predictive model to identify complications in the first 2 days following mild or moderate traumatic brain injury
A clinical prediction model called the Goliat score can estimate the risk of acute complications in patients with minor and moderate traumatic brain injuries. The model, developed by researchers at UOC and IRBLleida, uses easily accessible variables to predict neurological or cardiorespiratory complications and mortality within 48 hours.
Pulling the plug on tumors: Varun Venkataramani receives Paul Ehrlich and Ludwig Darmstaedter Early Career Award 2026
Cancer cells tap into the nervous system's power grid by forming synaptic contacts with nerve cells, promoting tumor growth and spread. Venkataramani's research aims to repurpose the drug perampanel for glioblastoma treatment and develop gene therapy approaches to disconnect tumors from the nervous system.
Bioengineered tissue as a revolutionary treatment for secondary lymphedema
Researchers developed bioengineered lymphatic tissue (CeLyT) that restored functional lymph nodes in mice with secondary lymphedema. CeLyTs improved lymphedema symptoms by restoring lymphatic flow, filtration capacity, and immune cell populations.
ISSCR develops roadmap to accelerate pluripotent stem cell-derived therapies to patients
The ISSCR has released a comprehensive roadmap for developing pluripotent stem cell-derived therapies, outlining critical scientific, manufacturing, and regulatory guidance. The Best Practices document provides a risk-based, end-to-end development strategy to support informed decision-making across seven essential areas.
Two-step genome editing enables the creation of full-length humanized mouse models
A two-step genome editing method integrates large human genomic fragments into mice, mimicking human regulatory landscapes. This platform enables the creation of physiologically relevant humanized models for therapeutic targets and disease research.
Discovery reveals how keto diet can prevent seizures when drugs fail
Researchers at the University of Virginia Health System have discovered how the keto diet protects against epilepsy seizures by regulating brain cell activity. The team found that a specific cellular receptor, HCAR2, plays a crucial role in reducing seizures, and may be targeted for new treatments.
Autism research reframed: Why heterogeneity is the data, not the noise
Dr. Noritaka Ichinohe challenges the long-held assumption that averaging away individual differences is necessary in psychiatric research. Instead, biological heterogeneity is seen as a phenomenon demanding explanation. The author's work on primate brain mapping and molecular subtyping has identified convergence points between species ...
Night shifts aren’t just tiring, they can be deadly
A new study from Texas A&M University reveals that circadian disruptions change the structure of mammary glands, weaken immune defenses, and fuel aggressive breast cancer. Disabling an immune checkpoint molecule called LILRB4 helps restore the immune system's ability to fight back.
Tropical disease oroya fever: Elucidation of disease mechanism opens possibility for novel therapy
A team of researchers has identified two proteins critical to the destruction of red blood cells by the Oroya fever pathogen. This discovery paves the way for a potential novel therapy against this deadly neglected tropical disease.
Ahead of ESMO Immuno-Oncology Congress 2025: topics at a glance
The ESMO Immuno-Oncology Congress 2025 will discuss key developments in immuno-oncology, including combined approaches, AI in cancer therapy, and innovative strategies across various cancers. The congress aims to advance the field of immunotherapy and improve patient outcomes.
Research challenges idea that gene PTPN22 boosts production of interferons
A new paper from the University of Kansas overturns the idea that gene PTPN22 boosts production of Type 1 interferon, a key antiviral response. Researchers found no difference in interferon production when PTPN22 was knocked out, but discovered its influence on other immune signaling pathways.
Scientists move closer to better pancreatic cancer treatments
Researchers at UC Riverside and City of Hope have developed a novel Pin1 degrading compound that suppresses pancreatic cancer peritoneal metastases. The treatment targets not only cancer cells but also tumor-supporting cells, potentially overcoming treatment resistance.
UMC Utrecht researchers receive grant to develop predictive model for juvenile dermatomyositis
Researchers at UMC Utrecht are developing a predictive model to accurately predict disease progress in juvenile dermatomyositis. The Interferon Score aims to identify which children can safely reduce medication and which require intensified treatment.
Drug toxicity predicted by differences between preclinical models and humans
A new AI model uses machine learning to predict drug toxicity in humans by identifying biological differences between cells, mice, and humans. The model improved predictive power over existing state-of-the-art models and demonstrated practicality in predicting market withdrawal due to toxicity.
Registration and Abstract Submission Open for “20 Years of iPSC Discovery: A Celebration and Vision for the Future,” 20-22 October 2026, Kyoto, Japan
The International Society for Stem Cell Research invites you to celebrate 20 years of induced pluripotent stem cell (iPSC) discovery and chart its future. The symposium features keynote speakers, featured sessions, and presentations on cutting-edge research.
FDA approves new menopause drug to treat hot flashes, night sweats
The FDA has approved elinzanetant for treating hot flashes and night sweats in postmenopausal women. The drug significantly reduces the frequency and severity of symptoms while improving sleep quality and quality of life.
New Alliance trial studies targeted therapies for rare adrenal cancers
A new Alliance trial is exploring the effectiveness of a combination of targeted therapy and immunotherapy for patients with advanced adrenocortical carcinoma, a rare and aggressive cancer. The study aims to improve disease control and quality of life for patients with limited treatment options.
$6.2M grant will launch UC San Diego REACH Center for Translational Science on Whole Person Health
The UC San Diego REACH Center for Translational Science on Whole Person Health aims to advance research through partnerships with complementary and integrative health institutions. The center will support at least 26 new research scholars and fund pilot grants to drive innovation in translational science.
Richards-Kortum elected to the National Academy of Medicine
Rebecca Richards-Kortum has been elected to the National Academy of Medicine for her major contributions to global health. She created low-cost, lifesaving technologies for underserved communities, transforming health systems worldwide through her innovations in cervical cancer diagnostics and neonatal care technologies.
Eat, explore, rest: a leptin-sensing brain circuit helps overcome anxiety to meet vital needs
A new study has identified a leptin-sensitive brain circuit in the lateral hypothalamus that helps animals overcome anxiety to perform essential behaviors such as eating, exploring, and limiting maladaptive hyperactivity. Boosting the activity of these neurons can restore adaptive choices even under conditions that cause anxiety.
Missing molecule may explain Down syndrome
Scientists found a promising candidate, pleiotrophin, which is essential for brain development and function; restoring it may improve brain circuits in individuals with Down syndrome and other neurological diseases. The study's findings suggest using modified viruses to deliver the protein directly into cells could lead to new treatments.
Personalized breast cancer therapy: A new treatment approach for patients with limited tamoxifen efficacy
Researchers developed TAMENDOX to supplement (Z)-endoxifen in patients with CYP2D6 enzyme deficiency, improving drug concentration and effectiveness. The new therapy was well-tolerated, showing promise as an alternative to aromatase inhibitors for premenopausal women.
UMass Amherst researchers create nanoparticle vaccine that prevents cancer in mice
Researchers at UMass Amherst have developed a nanoparticle-based vaccine that prevents melanoma, pancreatic and triple-negative breast cancer in mice. The vaccine achieved remarkable survival rates, with up to 88% of vaccinated mice remaining tumor-free.
C-Path names Colin Hill to board of directors
Colin Hill joins C-Path's Board of Directors with experience in AI, drug development, and translational acceleration. He aims to bring precision medicine focus to advance treatments worldwide.
First in Asia! Translational Exercise Biomedicine becomes the official partnership journal of FIMS
The International Federation of Sports Medicine (FIMS) has partnered with Translational Exercise Biomedicine (TEB), the first such collaboration in Asia. This partnership aims to enhance research publication, host co-branded events, and advance global advocacy for sports medicine.
Michael Welsh, MD, wins Lasker Award for cystic fibrosis research
Dr. Michael Welsh's research on cystic fibrosis paved the way for a triple-drug combination therapy that has transformed CF from a fatal condition into a manageable one for over 90% of patients. His work also revealed the function and 'broken' nature of the CFTR protein, laying the foundation for targeted therapies.
UCSB-designed soft robot intubation device could save lives
A non-electronic soft robotic device guides a soft tube into the trachea, improving success rates for both expert and non-expert users. The device yields a 100% success rate with highly trained users and an 87% success rate with non-expert providers after just five minutes of training.
Frailty fuels gut imbalance and post-surgery gastrointestinal risks
Researchers found that frail patients with residual intra-abdominal bacteria or fungi are at a higher risk of developing postoperative ileus and infections. The study suggests that incorporating frailty assessment and prehabilitation programs into surgical planning may help reduce complications.
Skin protein found to use physical tension to control tissue growth
The study found that increasing Piezo1 activity leads to a coordinated response, resulting in increased skin surface area and thickness. The findings could ultimately help doctors develop noninvasive therapeutic approaches to create new skin for treating burns and other injuries.
Rare immune cells offer new hope for treating acute respiratory distress syndrome
Researchers at Institute of Science Tokyo found that basophils suppress lung inflammation during ARDS recovery, suggesting potential treatment strategies. Basophils release interleukin-4, which helps immune cells coordinate responses and alleviate lung inflammation.
Longitudinal study unveils promising therapy for treating short bowel syndrome
Researchers discovered that GLP-2 analogs reshape the intestinal environment by expanding villi and crypts, increasing regulatory T cells, and improving nutrient absorption. This breakthrough offers new hope for patients with short bowel syndrome and potentially benefits immunocompromised individuals.
A nonsurgical path to treating pelvic organ prolapse
Researchers at Lehigh University and the Cleveland Clinic are developing a nonsurgical therapy for pelvic organ prolapse using drug-delivering nanoparticles. The treatment aims to delay or reverse matrix degradation, reducing the severity of POP in patients with earlier stages of the disorder.
A wearable robot that learns
A wearable robot has been upgraded to provide personalized assistance to ALS and stroke patients. The device uses machine learning and a physics-based model to adapt to an individual user's movements, offering more nuanced help with daily tasks.
A patient’s own cartilage cells may be the key to help healing after hip surgery
A recent study by researchers at the University of Missouri has made a groundbreaking discovery using patient's own cartilage cells to aid in healing after hip surgery. The research team successfully cultured and expanded cartilage cells, or chondrocytes, in the lab, paving the way for future clinical applications.
Discovering how cells in small intestine of people with coeliac disease communicate with one another
Scientists have created a detailed map of cell behavior in the small intestine of people with coeliac disease using single-cell RNA sequencing. The study found that immune signals from immune system proteins encourage fibroblasts to support changes in the gut lining, suggesting communication between cells plays a key role in the disease.
UVA harnesses AI to improve brain cancer care
Researchers are developing an AI imaging approach to distinguish between tumor progression and treatment effects in glioblastoma patients, promising to improve care and outcomes. The AI approach has already shown accuracy rates of up to 74% in initial testing.
Shortcut to weight loss: No nausea required
Researchers at Syracuse University have identified a new target for treating obesity and diabetes, reducing nausea and vomiting associated with existing treatments. A molecule called tridecaneuropeptide (TDN) produced by brain support cells suppresses appetite and improves glucose processing without adverse effects.
Personalized treatment for peanut allergy
A team of scientists has discovered molecular changes in children's immune systems that determine their response to oral immunotherapy for peanut allergy. Children who respond well have lower levels of inflammatory messengers, while those who don't show increased activation of certain genes.
Beyond the mammogram: Study finds differences between benign and cancerous breast calcifications
Researchers at the University of Illinois found that benign and cancerous breast calcifications have unique structures and formation processes. The study provides a new classification scheme and opens the possibility of treating benign calcifications using certain drugs.
With the second grant to therapy
Researchers at the University of Würzburg are developing a new therapy for KEAP1-mutated lung cancer using a sulfite inhibitor to block tumor cell growth. The team has identified a first-of-its-kind compound, SulfExstatin-1, which accumulates toxic sulfite in cancer cells, initiating their death.
What cats may teach us about Long COVID
Scientists found that mesenchymal stromal cells (MSC) therapy improved immune recovery in cats with FIP, a disease similar to Long COVID. The study showed reduced systemic inflammation and increased regulatory T cells, suggesting potential benefits for human patients.
$50 million raised for UVA's Paul and Diane Manning Institute of Biotechnology
UVA Health received two anonymous $25 million estate gifts to support the Paul and Diane Manning Institute of Biotechnology. The institute will develop new treatments for hard-to-treat diseases with a state-of-the-art biomedical research facility expected to drive economic growth in Central Virginia.
Anti-aging drug Rapamycin extends lifespan as effectively as eating less
A new study reveals that Rapamycin has a comparable life-extending effect to dietary restriction in eight species of vertebrates. The compound, originally developed as an immunosuppressant, offers similar benefits without the need for caloric restriction.
Evaluating infectious disease immune protection using one drop of fingertip blood
Researchers developed a compact diagnostic platform that can evaluate antibody protection against COVID-19 using only a single microliter of fingertip blood. The Tip Optofluidic Immunoassay (TOI) system delivers comprehensive immune profiles in just 40 minutes, enabling rapid and accurate assessment of individual immune protection.