Articles tagged with Wound Healing
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A new hydrogel gel, inspired by nature's NETs, uses near-infrared light to kill bacteria and calm the immune system, promoting wound healing. Trials in mice and pigs show significant reduction in bacterial load and accelerated healing.
Researchers have developed a breakthrough light-responsive Janus dural patch using photocurable hyaluronic acid, providing strong wet adhesion and preventing unwanted tissue adhesion. The patch seals wounds within five seconds with minimal swelling and high biocompatibility.
Researchers at PolyU have developed an acid-resistant, ultra-stable mucus-inspired hydrogel that significantly improves gastrointestinal wound healing in animals and outperforms a clinically approved mucosal protectant. The hydrogel's potential for commercialization is high due to its low cost, ease of production, and established safet...
A study by University of Arizona researchers reveals a previously unknown population of circulating immune cells that play a critical role in fibrosis, the buildup of scar tissue. Blocking signals from these cells during wound healing can reduce scar tissue formation and promote normal healing.
Dr. Johnson V. John has been appointed as a standing member of the NIH's Musculoskeletal Tissue Engineering (MTE) Study Section, ensuring innovative research receives support. His expertise in biomaterials and tissue engineering will contribute to national research priorities.
Researchers developed a composite hydrogel that integrates antibacterial, immunomodulatory, and regenerative functions to promote faster wound closure. The hydrogel demonstrated over 98% antibacterial efficacy and improved fibroblast and endothelial cell growth.
Chronic wounds like diabetic foot ulcers and pressure ulcers are driven by persistent inflammation and immune dysregulation. Emerging immunomodulatory strategies aim to restore immune balance and promote healing.
A new small molecule drug, RAGE406R, has been developed to disrupt a key cellular pathway responsible for chronic inflammation and associated complications in patients with diabetes. The breakthrough could offer a new therapeutic option for stopping the harmful effects of both type 1 and type 2 diabetes at the source.
Researchers at University of California San Diego School of Medicine discovered that quorum sensing in S. aureus delays wound healing and found targeting the agr system could disarm bacteria without antibiotics, preserving healthy skin bacteria to enhance recovery.
Researchers developed a composite bioabsorbable hemostatic sponge inspired by mussels and extracellular matrix. The sponge quickly absorbs blood and firmly adheres to tissues, enhancing hemostatic performance. It promotes wound stabilization, accelerates blood clotting, and reduces inflammation and tissue damage.
A wearable device called a-Heal optimizes each stage of the wound healing process using AI and bioelectronics, delivering medication or an electric field for personalized treatment. Initial preclinical results show the device speeds up the healing process by 25% compared to standard care.
Researchers at University of Bergen found that adding nanoparticles made from carbon and cobalt to weak vinegar solutions kills several dangerous bacterial species, including Staphylococcus aureus. The treatment is non-toxic to human cells and can remove bacterial infections from wounds without affecting healing.
Researchers developed an acid-resistant hydrogel called ultrastable mucus-inspired hydrogel (UMIH) that improved gastrointestinal wound healing in animal models and outperformed a clinically approved mucosal protectant. UMIH showed 15 times stronger adhesive abilities and remained stable for 7 days in acidic conditions.
A new study reveals that body cells change their shape to close gaps such as wounds, using a combination of crawling movements and 'purse-string' contractions. The researchers discovered that the endoplasmic reticulum's ability to reorganize in response to edge curvature plays a crucial role in epithelial cell movement.
Researchers have created a wearable system that combines drug delivery, electrical stimulation, and continuous monitoring to treat diabetic foot ulcers. The microneedle platform anchors securely into the skin and adjusts therapy in real-time to prevent severe tissue damage.
Researchers at the University of Oklahoma are conducting a first-of-its-kind study to investigate the effect of cannabis use on facial wound healing in head and neck cancer patients. The study aims to determine whether cannabis smoking negatively affects wound healing, with potential implications for other types of surgery and conditions.
Researchers have created 'skin in a syringe' by mixing cells with gelatine beads, allowing for 3D printing of functional dermis. This technology could lead to new ways to heal burns and severe wounds with minimal scarring.
This study identifies ANXA2+ migratory hepatocytes as crucial for liver regeneration, highlighting their role in promoting wound closure and treating acute liver failure. The research also explores the therapeutic potential of targeting these cells, offering new avenues for regenerative medicine approaches in hepatology.
Researchers found that low levels of serine trigger a process that turns hair follicle stem cells into skin repair specialists, potentially accelerating wound healing. By manipulating serine levels through diet or medications, it may be possible to speed up the healing process.
A preclinical study has identified a signaling pathway involving GAS6 and AXL proteins that enables rapid healing of oral mucosa wounds. The findings suggest that manipulating this pathway could help reduce skin scars.
A new study identifies critical barriers and promising strategies to scale up low-barrier wound care services for PWUD. The research highlights the urgent need for accessible and empathetic approach to wound care, proposing practical steps to reach those who need it most.
Researchers developed a new approach to identify healed diabetic foot ulcers at risk of reopening based on trans-epidermal water loss measurements. High TEWL values were linked to increased wound recurrence and shorter time to recurrence, suggesting functional skin barrier defects are a critical factor in wound healing.
The international conference will focus on translating phage research into clinical reality, exploring key sessions and major speakers. Companies from various sectors are attending the event, highlighting the growing interest in phage therapy.
A smart bandage called iCares has been developed to monitor chronic wounds in human patients, detecting biomarkers of inflammation and infection. The bandage can provide real-time data and deliver treatment, accelerating the healing process.
A new version of Caltech's smart bandage, iCares, has been shown to continually sample fluid from human patients with chronic wounds, providing real-time data on biomarkers present. The bandage can detect molecules such as nitric oxide and hydrogen peroxide, potentially up to three days before symptoms appear.
A new class of antibiotic has been shown to be effective in treating MRSA infections, with a daily dose of epidermicin NI01 demonstrating equal efficacy to the current standard of care. The findings justify further pre-clinical development and could lead to new gel-type therapies for skin infections.
Researchers developed a first-of-its-kind wearable device that tracks gas emissions from the skin to monitor health, detect wounds and infections, and track hydration levels. The device offers a new way to assess skin health without contacting delicate tissues.
Researchers have discovered that planarians can regenerate body parts and even grow new heads, reversing signs of aging such as lost neurons and muscle mass. This finding has implications for understanding age-related decline in mammals, including humans.
Researchers from UMass Amherst have discovered that epithelial cells communicate with slow electrical signals, 1,000 times slower than nerve impulses. This finding could enable new applications in wearable sensors, wound healing and more.
A team of researchers from Aalto University developed a hydrogel with a unique structure that combines high stiffness with flexibility and self-healing capabilities. The material uses exceptionally large and ultra-thin specific clay nanosheets, allowing it to self-heal via entanglement.
Researchers investigated the wound healing efficacy and macrophage polarization potential of electrospun PCL scaffolds loaded with BMSC-ABs. The study found that the BMSC-AB-loaded PCL scaffolds drive macrophage polarization to the M2 phenotype, promoting anti-inflammatory and angiogenic effects.
A recent study in Nature Communications reveals that white blood cells employ a novel mechanism to dislodge bacteria from human tissues using brute force and integrin-based adhesion rings. The research, led by Xuefeng Wang, has significant implications for understanding the role of macrophages in cleaning up environmental pollutants.
A University of Cincinnati researcher has been awarded a $2.1 million grant to investigate postoperative pain at the molecular and cellular levels. The goal is to develop new, safer non-addictive treatments for chronic pain conditions, including lower back pain and pain associated with diabetes or chemotherapy treatments.
Scientists develop self-assembling nanoflowers from natural building blocks that can inactivate a broad spectrum of bacteria and scavenging reactive oxygen species. The nanoflower-coated bandages show promise as a natural, cost-effective solution for combating infections and accelerating wound healing.
Researchers have made significant advancements in cellulose-based sutures, showcasing their potential as sustainable alternatives for wound closure and healing. The new materials demonstrate non-toxicity, biocompatibility, and mechanical strength, with nanocellulose showing particular promise due to its high strength and flexibility.
A new study published in Aging found that pioglitazone reduced the frequency of skin ulcers in Werner syndrome patients. The research suggests that pioglitazone's anti-inflammatory properties may help wounds heal faster and prevent ulcers from forming.
A large study found that patients with diabetes taking GLP-1 receptor agonist drugs had lower rates of hospital readmission, wound re-opening, and hematoma after surgery. Improved blood sugar control was not the likely mediator, suggesting other mechanisms may be at play.
A study published in JAMA Network Open found that hospital-acquired pressure ulcers are associated with poorer neurological outcomes and reduced motor function in patients with acute cervical spinal cord injury. The findings suggest that preventing pressure ulcers can help protect these patients and lead to improved medical care.
Researchers have developed a 3D artificial skin model with all three layers, simulating diseases and injuries more accurately. The model can replace animals in toxicological studies of medicines and cosmetics, enabling the development of new treatments without animal testing.
Researchers found pandrug-resistant Klebsiella pneumoniae in Ukrainian war victims, showing high virulence and rapid spread. The bacteria's ability to cause disease remains despite antibiotic resistance.
FetTech and Novex Innovations partner to expand regenerative medicine, creating jobs and stimulating local economic growth. The collaboration is part of the NSF-funded Piedmont Triad Regenerative Medicine Engine's ecosystem.
The study presents a lignin-based hydrogel that combines mechanical strength with bioactivity, promoting wound healing and sustained drug release. The hydrogel's controlled-release properties make it an ideal candidate for treating complex wounds and reducing medication side effects.
Researchers developed porous dermal fillers that accelerate tissue healing and regeneration for diabetic wounds. The novel approach combining electrospinning and electrospraying technologies creates biocompatible microspheres that promote cell migration, granulation tissue formation, and neovascularization.
Collymer is a regenerative collagen polymeric biomaterial designed for various medical applications. It can be engineered into materials with different shapes and properties to address unmet clinical needs in wound care, tissue reconstruction, aesthetics, orthopedics, and therapeutic cell delivery.
Researchers used genomic technology to study Marjolin's ulcer, a rare and highly aggressive skin cancer that grows on chronic burn wounds. The study reveals insights into how keratinocytes switch their function to become cancerous, creating a fertile environment for tumor cells to grow and spread.
Researchers designed a skin patch that uses imperceptible electric currents to control microbes, stopping 99% of biofilm formation in bacteria. The device, called Bioelectronic Localized Antimicrobial Stimulation Therapy, could lead to a wearable patch with a wireless circuit to control infections without drugs.
GeniPhys secures $500k NSF grant to support regulatory and commercial readiness of Collymer SAS for soft tissue restoration in advanced wound care. The technology promotes regenerative remodeling without inflammatory response, facilitating faster healing and tissue repair.
A new hemostatic sponge developed by UCF researchers can stop severe bleeding in under a minute, while also acting as an antibacterial agent. The liquid gel transforms into a spongelike foam upon exposure to the wound, applying pressure to restrict hemorrhage and promoting natural clotting.
Researchers found that At2-MMP is essential for suppressing abnormal cell division and preventing excessive proliferation in wounded Arabidopsis stems. Overexpression of At2-MMP restored normal wound healing processes.
Researchers create a new type of artificial spider silk by modifying protein sequences to produce a strong, yet stable material. The resulting silk is woven into bandages that boost wound healing in mice with osteoarthritis and diabetic skin lesions.
A new technology uses autofluorescence imaging to detect bacteria in wounds, allowing for early detection and removal of harmful microorganisms. The study reveals that this method can identify bacteria in approximately 9 out of 10 patients that traditional assessments miss.
Researchers discovered a parasite protein that enhances wound healing in mice by stimulating immune cells to promote tissue regeneration and inhibit scarring. The protein, TGM, accelerates wound closure and improves skin regeneration.
Research finds that people who use illicit opioids are at risk of developing severe xylazine-related wounds, often due to lack of access to proper wound care. The study highlights the need for comprehensive, low-barrier wound care services and compassionate care without judgment.
Researchers at Technical University of Denmark developed a new biopolymer, PAMA, derived from bacteria to heal tissue. The PAMA bactogel shows significant muscle regeneration properties and nearly 100% mechanical recovery in rats.
A $1.9 million NIH grant will support research on closing cellular gaps, with implications for wound healing and cellular regeneration therapies. The goal is to develop a theoretical understanding of the process, enabling control over individual factors and potential applications in regenerating heart cells.
Researchers developed an inexpensive, water-powered electric bandage that accelerates wound healing in chronic wounds. The bandage produces an electric field that promotes healing and reduces inflammation, with animals treated with the bandage showing a 30% faster rate of wound closure.
A research team at DGIST developed an electronic suture that can monitor wound inflammation levels in real-time. This innovation allows for more effective wound care and personalized medicine by detecting infections early.
Research found higher bacterial concentrations in keloid tissue, especially in deep layers, leading to increased inflammation and fibroblast production. Antibiotics and phage treatments may help reduce bacteria and improve treatment outcomes for keloids.
Researchers developed a poly(L-lactic acid) nanofibrous membrane enhanced with curcumin and silver nanoparticles to address the challenges of diabetic wounds. The study's results show promising therapeutic strategy that could revolutionize care for diabetes-related wounds, promoting angiogenesis and collagen deposition.
Researchers have developed nanovesicles derived from activated neutrophils, which effectively combat deep tissue pathogens and promote rapid debridement, collagen deposition, and healing. This innovation has the potential to revolutionize the management of complex infectious wounds and boost treatment efficacy.