Articles tagged with Premature Birth
Researchers have identified alpha-1 antitrypsin as a potential target for preventing spontaneous preterm birth. A recent study found that mothers carrying a specific variant of the SERPINA1 gene had shorter pregnancies, and treatment with human alpha-1 antitrypsin prevented preterm birth in mice.
A randomized clinical trial found that dexamethasone eye drops reduced the progression of retinopathy of prematurity to severe disease requiring invasive treatment in preterm infants. However, no differences in adverse events were observed.
Researchers tested cortisone eye drops to slow ROP progression in 100 premature babies. The intervention reduced treatment-requiring ROP by 47% compared to placebo.
Researchers will examine whether online support strengthens brain development linked to emotional and mental health in prematurely born infants. The scalable intervention could transform how families receive support after discharge from the neonatal intensive care unit, bringing evidence-based support into the home.
A new study has found that exposure to glyphosate, a widely used herbicide, may increase the chance of giving birth too early. Women with higher levels of glyphosate in their urine samples were more likely to go into spontaneous labor before 37 weeks.
Exposure to even moderate levels of multiple air pollutants during critical stages of pregnancy may increase the risk of preterm birth. The study found that a mixture of ozone and fine particulate matter posed the strongest relationship to early preterm birth.
Researchers analyzed data from 2,201,446 women and found associations between adverse pregnancy outcomes and an increased long-term risk of developing peripheral artery disease. Women who experience gestational diabetes, preeclampsia, or preterm delivery have a significantly increased risk of PAD later in life.
A landmark study tracks preterm babies from birth to middle adulthood, identifying early cognitive development as the strongest predictor of who flourishes and struggles. Childhood IQ at age 8 is linked to adult outcomes, with a 15-point increase associated with a 79% reduction in poor economic and social functioning.
A study found that nearly half of preterm children did not meet expected attainment levels in writing and maths by age 6-7, while social deprivation and maternal smoking during pregnancy are linked to lower attainment. Strategies to address social inequalities and support preterm children are vital to improve outcomes.
A new wearable monitoring system called OMEGA aims to replace outdated fetal heart rate monitoring technology with a unified real-time assessment of fetal oxygen delivery and adaptive capacity. The system could potentially reduce C-section rates and improve maternal and fetal health outcomes, saving millions in healthcare costs.
A new study by Emory University researchers has uncovered molecular differences between pregnancies that ended in preterm birth and those that reached full term. The findings provide valuable biological insights into the causes of early birth and may lead to improved tools for identifying risk and guiding prevention strategies.
A Norwegian University of Science and Technology study found that doctors in hospitals treating the most premature babies were more likely to diagnose eye disease requiring treatment. This contradicts expectations that these doctors would be over-diagnosing. The researchers are now investigating possible reasons for this difference, in...
A randomized trial investigated the effect of early paracetamol treatment on preterm infants' ductus arteriosus. The study found that paracetamol accelerated closure in 75% of infants compared to 35% in the placebo group.
Researchers are developing innovative approaches to identify markers of autism in children born before 37 weeks of gestation. The project aims to create an AI-enabled digital twin for autism diagnosis, providing personalized support and treatment plans for affected children.
A new Cochrane review finds planned early birth for pregnant women with high blood pressure cuts maternal complications by nearly half and reduces the risk of stillbirth. The practice is found to be safe across both high- and low-income settings, without increasing the likelihood of caesarean section.
A study by the University of Cambridge found that racism and socioeconomic stress can alter key physiological processes in the body during pregnancy, leading to higher rates of preeclampsia and preterm birth in black women. These changes are not due to genetic differences but rather persistent socio-environmental stressors.
A new analysis estimates that exposure to di-2-ethylhexylphthalate (DEHP) contributed to 1.97 million preterm births in 2018, equivalent to 8% of global total. The study also linked DEHP to 74,000 newborn deaths and found a significant health burden across regions with rapidly growing plastics industries.
Researchers found that early pregnancy probiotics containing Clostridium butyricum significantly reduced the recurrence rate of spontaneous preterm delivery, a major cause of neonatal illness and death. The study suggests that probiotic therapy may offer a simple strategy to prevent premature births in women at high risk.
Researchers discovered that mild hypoxia shortly after birth hinders learning and memory into adulthood through altered neuron-to-neuron communication in the hippocampus. The study also found a second protein involved in hypoxia's effects on this channel's functioning, which was restored when targeted.
A global analysis of two antenatal treatments reveals significant international variation in implementation, with higher-income countries showing better uptake. The study highlights the need for further research to understand the reasons behind these disparities and improve global equity in essential antenatal treatments.
New research shows that Rytvela, an anti-inflammatory drug candidate, decreases premature birth and infant mortality when administered after the onset of preterm labor in a preclinical mouse model. The treatment prolongs gestation and fetal growth while allowing newborn organs to develop in utero.
A Swedish study of prematurely born adults found increased morbidity in physical and mental health, yet they reported a high quality of life. The study, which followed participants from birth to age 26-29, suggests that premature birth does not necessarily limit daily life.
A Stanford Medicine-led study develops an AI tool that predicts prematurity complications by analyzing blood samples collected at birth. The algorithm correlates molecular patterns with health outcomes, offering a new understanding of prematurity as multiple distinct conditions.
The study reveals parental quality of life is compromised during the premature infant's hospitalization period. A family-centered approach with tailored support from the neonatal intensive care unit and postdischarge period can protect and promote parental well-being.
Playing soothing live music in NICUs helps babies lower heart rate and respiratory rate while increasing feeding volume. Music sessions also provide a moment's respite for parents, allowing them to bond with their baby.
This study found that vaccination before and during COVID-19 diagnosis in pregnancy significantly lowers the risk of severe maternal illness and premature birth. The results suggest that COVID-19 vaccination plays a crucial role in protecting pregnant individuals from serious health complications associated with the virus.
A new study from the University of Oklahoma suggests that small genetic differences in two proteins may influence how their eyes develop, affecting the risk of retinopathy of prematurity (ROP). Researchers found four genetic variants specific to eye disease, with two protective and two increasing the risk. Early genetic testing could h...
A recent study published in JAMA found that initiating resuscitation of preterm infants with fraction of inspired oxygen levels of 0.6 versus 0.3 did not affect the risk of death or brain injury by 36 weeks' corrected gestational age.
UC San Diego Health has been recognized as a Best Hospital for Maternity Care by U.S. News & World Report for the fourth year in a row. The hospital provides world-class care for parents and newborns, with a focus on compassion, expertise, and dedication.
A study published in JAMA found that expectant management resulted in higher survival rates compared to active treatment for patent ductus arteriosus in extremely preterm infants. The protocol-defined study showed no significant difference in mortality or bronchopulmonary dysplasia between the two groups.
A study found that pregnant women who discontinued GLP-1 medications before or early in their pregnancy experienced higher risks of weight gain, diabetes, hypertensive disorders, and preterm delivery. Those who stopped taking the medications gained an average of 7.2 pounds more weight during pregnancy.
Researchers found that exposure to hotter weather during pregnancy disrupts key amino acids and vitamins, increasing the risk of preterm delivery. The study provides new insights into the biological mechanisms behind preterm birth and may lead to the development of early biomarkers for identification and prevention strategies.
Researchers developed a novel tool, the Preterm Birth Actionable Risk Index (PTB-ARIx), to assess risk for premature births. The index identifies 18 specific risk factors during pregnancy that can be treated with evidence-based interventions.
Researchers developed a first-of-its-kind prenatal brain model to study cerebral hemorrhages on stem cells in preterm birth. An antidote reduced brain damage, and the study identified how neural stem cells are damaged by elevated interleukin-1 levels.
A new study led by the University of Washington analyzed data from over 20,000 births and found that pregnant people exposed to wildfire smoke were more likely to give birth prematurely. The risk was highest in mid-pregnancy and peak exposure levels above 10 micrograms per cubic meter were associated with elevated risks.
A Northwestern University study found that Chicago parents have low intake of omega-3 fatty acids, specifically EPA and DHA, with women consuming even lower amounts. This deficiency may have direct negative effects on children's health, including preterm birth risk.
A new study led by Stanford Medicine found that premature babies who heard recordings of their mothers reading to them showed improved language pathways in their brains. The researchers played the recordings for a total of 2 hours and 40 minutes a day, and saw measurable differences in brain development.
Researchers found that women who had Caesareans during advanced labor are eight times more likely to develop scars near or within the cervix, increasing the risk of premature births. The study also discovered that scars lower down the womb heal less well than those higher up.
In a first-of-its-kind study, researchers found that unplanned, premature births outside hospitals in Austria posed significant challenges for emergency teams. The study identified key findings on how to improve outcomes for mothers and newborns, including the importance of standardised protocols, training, and equipment availability.
A new study from the Medical University of South Carolina reveals that shorter storage durations of donor human milk are linked to reduced gastrointestinal complications in premature infants. The findings suggest minimizing milk storage time may help preserve protective properties crucial for preterm gut health.
Prostacyclin has been found to promote fetal membrane repair through the proliferation and migration of amnion mesenchymal cells. This discovery provides new insight into the mechanisms of fetal membrane healing, which could lead to new therapeutic strategies for managing preterm birth and infant mortality.
A study led by Dr. Eliza McElwee finds that inflammation triggered by infection can lead to fetal brain inflammation and preterm birth. By administering a complement inhibitor, pregnant mice showed reduced inflammation and increased viability of offspring, suggesting a potential new therapeutic approach.
Researchers have identified a strong link between preterm birth and increased risks of chronic health issues later in life, including high blood pressure, depression, and anxiety. The study's findings highlight the importance of including birth history in adult medical records to optimize health outcomes.
A cohort study reveals preterm individuals face increased mental health disorders and cardiometabolic issues compared to full-term peers. At age 35, these risks persist despite strong evidence linking preterm birth to long-term health consequences.
Researchers have identified seven family and social actors linked to better mental health outcomes for preterm children, including self-regulation, strong parent-child relationships, and protection from bullying. These modifiable factors can be altered with interventions, suggesting a broader path to improving outcomes beyond medical i...
Research found that premature babies who had early skin-to-skin contact with their mother were more likely to be breastfed at discharge and for up to one year. Early contact also promotes bonding, reduces stress, and supports long-term development.
Children of older mothers are more likely to be born prematurely or with complications. The study found that babies born to mothers 45 years and older had the highest risks of stillbirth, premature birth, and low birth weight compared to younger mothers.
Researchers found an increased risk of stroke in women who experienced diabetes, high blood pressure, preterm delivery, or low birth weight during pregnancy. These complications could act as early signals for cardiovascular problems, enabling women to receive help and reduce their risk.
A new study has identified specific proteins in umbilical cord blood that signal acute systemic inflammation, providing a non-invasive means to diagnose early onset sepsis in preterm newborns. This discovery could lead to the development of a diagnostic test to avoid prolonged antibiotic exposure for infants at risk.
A daily dose of trimethoprim-sulfamethoxazole reduced the proportion of preterm births by 40% in pregnant women with HIV. The antibiotic also increased birth weight by 177 grams, improving health outcomes for babies. Researchers hope to confirm these findings in future trials.
A new study uses preserved plants and animals from natural history museums to track pollution trends over two centuries. Researchers found significant changes in pollutant levels between specimens collected in the 19th and 20th centuries, highlighting the impact of industrial activity on human health.
A new Emory University study found that air pollution particles can disrupt maternal metabolisms, increasing the risk of premature and early term births. The research, which analyzed blood samples from pregnant women in Atlanta, highlights the need for better understanding and strategies to address this issue.
The USPSTF recommends early, universal screening for syphilis infection during pregnancy to prevent congenital syphilis. Untreated syphilis can cause premature birth, low birth weight, and stillbirth in the fetus.
Pregnant women with fatty liver disease are at an increased risk of giving birth prematurely, with a threefold higher risk compared to the general population. The study also found that women with fatty liver disease had a 63% higher risk of caesarean section.
A new study published in the Journal of Perinatology has found that optimizing darbepoetin dosage can reduce the need for blood transfusions in premature babies. The research, led by Intermountain Health, tested two different dosing schedules and found that both resulted in similar overall health outcomes.
A cross-sectional study found that moderately preterm birth was associated with long-term cognitive problems. The study highlights the need for continued follow-up of all preterm children, particularly those born before 34 weeks' gestational age.
Severe RSV disease among children is more likely those aged 2 or older with pulmonary or neurologic conditions. Younger children under 6 months and prematurity are high-risk factors for severe RSV in younger kids.
A study published in The Lancet found that tocolytic drugs after 30 weeks of pregnancy do not improve the baby's health. Premature birth often has a medical cause and delaying childbirth may actually be harmful.
Three UK researchers will receive a £100,000 (US$126,000) prize at the 2025 awards, honouring their work in Life Sciences, Chemical Sciences, and Physical Sciences & Engineering. The winners were selected from 94 nominees representing 45 academic institutions.
A new study led by Penn State researchers found that low vitamin D levels during the first trimester of pregnancy are associated with higher rates of preterm birth and decreased fetal length. Pregnant women with low vitamin D concentrations were four times more likely to experience a preterm birth compared to those with sufficient levels.