Scientists at the University of Osaka have developed a method to recreate human B cells with germinal center features using three immune signals, which closely match those found in human tonsils. This breakthrough could help improve vaccine-induced antibody responses and identify targets for autoimmune disease.
Researchers have identified HERC4 as a crucial component of the TNF-induced cell death pathway, linking survival and death signalling. The protein's ubiquitination of RIPK1 initiates the formation of Complex II, triggering cell death through apoptosis or necroptosis.
In vivo CAR-T therapy reduces manufacturing time and cost, enabling more accessible cancer immunotherapy. The strategy also enables superior self-renewal capacity and anti-tumor persistence.
Researchers at Boston Children's Hospital discovered a receptor-free means of signal transduction, identifying a potentially more effective therapeutic target for treating autoimmune diseases. This new method suggests alternative pathways for cell-to-cell communication, which may lead to the development of new therapeutic treatments.
Researchers analyzed blood samples from 114 patients with MS and 21 healthy participants to track immune changes before relapse. They found increased EBV lytic activity in immune cells up to three months before MS relapse and discovered elevated expression of genes linked to MS risk.
Christopher Goodnow's work challenged the concept of complete clonal deletion, revealing self-reactive B cells' ability to acquire self-tolerance and potentially cause autoimmune disease. His research discovered that these cells are essential for immune function and can be converted into functional B cells through 'clonal redemption'.
UCLA researchers are launching a phase 1/2 clinical trial to evaluate the safety and efficacy of JAK inhibitors in preventing immune checkpoint inhibitor-induced type 1 diabetes. The trial aims to test whether these drugs can protect insulin-producing cells in patients who develop diabetes after cancer immunotherapy.
UCF researchers have made a groundbreaking discovery on immune cells, focusing on transfer RNA (tRNA) as a pathway to treatments for cancers, infections, and autoimmune disorders. By modifying tRNA in T cells, the team aims to fine-tune immune responses to multiple diseases.
A study found that a common lupus-associated genetic variant strengthens antiviral immune responses while increasing the risk of autoimmunity. This genetic variant affects the IRF7 transcription factor, which plays a central role in the antiviral immune response.
Researchers at UTHealth Houston developed a treatment that reverses nerve pain in diabetic mice by targeting the MMP-9 enzyme, which breaks down proteins and causes immune response. The new monoclonal antibodies selectively inhibit MMP-9 activity, regenerating nerve fibers and improving wound healing.
A new study identifies high-affinity autoreactive antibodies in atherosclerosis, accelerating disease progression, and provides a potential link to autoimmune diseases such as Multiple Sclerosis and Diabetes Type 1.
The study found that patients taking anifrolumab had lower rates of infections requiring hospitalization compared to those on conventional immunosuppressants. Anifrolumab also reduced the need for systemic antibiotics and increased the likelihood of viral infections, offering distinct benefits over conventional treatments.
A new study reveals striking biological similarities between five major illnesses, including long Covid and PTSD, suggesting common underlying mechanisms. Chronic fatigue syndrome, rheumatoid arthritis, and multiple sclerosis may be driven by shared regulatory networks in immune and metabolic systems.
A new drug patch is being developed to promote the repair of damaged myelin sheaths in multiple sclerosis patients. The patch, which delivers a low dose of theophylline, is being tested in a Phase I clinical trial for its safety and tolerability.
Researchers have identified a subset of B cells known as atypical memory cells as the primary precursors of autoantibody-producing cells during SARS-CoV-2 infection. These cells adopt a markedly different biological program, leading to increased autoantibody production. The study provides new insight into how viral infections can trigg...
A new book by University of Virginia Health System expert Daniel J. Cox outlines a practical alternative to medication for managing pre-diabetes and type 2 diabetes. The GEM program emphasizes smart eating, physical activity, and listening to the body to regulate blood sugar levels.
Scientists create a biomimetic zona pellucida coating called BZP to mimic the natural barrier on egg cells, protecting donor islets from the immune system and reducing blood sugar levels in diabetic mice for 100 days. This approach could lead to a promising commercial cell therapy platform for treating various diseases.
Researchers found specialized astrocytes in mouse brains that can repopulate damaged areas and rebuild cells. These 'regenerative' astrocytes send newly formed cell nuclei to the site of injury, knitting the network back together.
Researchers have uncovered a key mechanism explaining how allergic inflammation in the skin can progress to a body-wide allergic response. IL-13 acts on dendritic cells, enhancing their ability to present allergens and promoting immune responses that produce antibodies.
A recent study found that severe COVID-19 reactivates certain dormant viruses in hospitalized patients, which may contribute to autoimmune disease and chronic conditions. Notably, reactivation of Anelloviridae viruses was associated with long-term physical disability and long COVID.
Researchers engineered a biochemical halo of interleukin 10 to suppress immune rejection of pancreatic beta cells, enabling implanted insulin-producing cells to control blood sugar for over 100 days. The approach could lead to a cure for Type 1 diabetes and improve outcomes for implantable therapies.
Researchers tracked nearly 80,000 adults with type 2 diabetes over ten years, finding those who consistently took their prescribed medication stayed free of serious heart and circulatory complications for over seven extra months. Low adherence was linked to a higher risk of cardiovascular disease, especially in younger adults.
Researchers developed a new method to study long-distance DNA regulation in rare immune cells, uncovering previously hidden connections relevant to autoimmune diseases. The approach prioritized over 100 candidate genes linked to Crohn's disease risk, including CLN3, which was not typically associated with the condition.
Researchers have identified a blood marker that can track the hidden progression of multiple sclerosis (MS), even in the absence of relapses. Elevated levels of glial fibrillary acidic protein (GFAP) are associated with disability progression, while changes in GFAP during treatment predict later risk of progression.
A new online test, MEDWACS, can detect people with prediabetes or undiagnosed type 2 diabetes with high accuracy. The test measures seven parameters, including thigh length, which is linked to a person's risk of developing the condition.
Two studies led by Montserrat Anguera investigate the process of X chromosome inactivation in immune cells and link impaired XCI maintenance to lupus-like disease. Impaired X chromosome inactivation in B cells has been linked to lupus, offering a novel pathogenic mechanism that accounts for the strong female sex bias of SLE.
A 16-week personalized exercise intervention improved glycemic regulation, physical fitness and reduced abdominal fat while increasing skeletal muscle mass. Cognitive impairment also showed significant improvements in working memory, perceptual speed and executive function.
Researchers found type III interferons reduce disease severity in autoimmune uveitis by suppressing Th1/Th17 responses and NLRP1/NLRP3 inflammasome activation. This study identifies IFN-λ as a promising immunomodulatory agent for autoimmune uveitis.
A study by Kumamoto University researchers reveals a hidden communication network between the skin and bone marrow that drives psoriatic inflammation. This pathway highlights a crucial role for neutrophils in fueling psoriatic flare-ups, suggesting a promising new target for future therapies.
The new center at Mount Sinai will join the Colton Consortium for Autoimmunity, expanding research on earlier detection, precision treatment, and disease prevention for people with autoimmune diseases. The Center aims to develop more precise, effective treatments across multiple diseases by understanding shared immune pathways.
A new ultrasensitive blood test can detect Sjögren's disease up to 10 years before symptoms develop by identifying chronically high levels of interferon alpha. This precision medicine approach could help target specific treatments to the right patient, improving management of the condition.
Patients with autoimmune limbic encephalitis experience altered hippocampus size and function, leading to memory loss and apathy. This study reveals a link between hippocampus damage and behavioral changes, shedding light on the condition's effects on cognition and motivation.
Early signs of clinical improvement have been observed in patients with treatment-resistant systemic sclerosis treated with investigational stem cell-derived CAR T-cell therapy, known as FT819. The therapy has demonstrated a reassuring safety profile and has the potential to expand access to patients who might otherwise face barriers t...
A large Swedish study found that certain bacteria in the gut microbiota can be seen in people who develop type 2 diabetes years later. Fluctuations in metabolism and low fibre intake may also contribute to the risk. The discovery paves the way for early identification of at-risk individuals.
Researchers will study blood samples and environmental exposures over 10 years to identify genetic, environmental, and cellular factors contributing to autoimmune diseases. The goal is to develop prevention strategies and treatments by understanding the earliest biological triggers of SARDs.
A new study found that GLP-1 receptor agonists can improve long-term health for people with peripheral artery disease (PAD), managing blood sugar and weight loss while reducing inflammation and improving blood vessel function. The benefits were highest among participants with severe PAD and obesity.
A team of scientists found that a small subset of T cells called stem T cells are responsible for making new T cells and replenishing them in chronic disease. These rare stem T cells express the protein LEF1, which is key to their persistence. Boosting LEF1-positive cells overcame T cell exhaustion in chronic infection, while removing ...
Researchers present a roadmap for developing Tregs as adaptable therapies to restore immune balance and support tissue repair. This approach holds promise for treating conditions such as metabolic and cardiovascular disease, as well as neurodegeneration.
New therapies using regulatory T cells, known as Tregs, could target diseases with inflammation, such as cancer and autoimmune conditions. Early evaluations show good tolerance and safety profiles, but precision is key to tailoring treatments for specific patients.
A study reveals that a cellular interaction between immune cells and fibroblasts drives the progression of Sjögren's disease by promoting chronic inflammation. The CD153+ CD4+ T cell-CD30+ fibroblast axis is identified as a key trigger, and targeting this axis may provide new therapeutic opportunities.
A review published in Diabetes Care suggests that physical exercise could play a role in promoting immune regulation, preserving beta-cell function, and reducing inflammation in type 1 diabetes. The evidence highlights the potential benefits of exercise on immune profiles displaying anti-inflammatory characteristics.
Scientists have identified a unique chimeric RNA called UBA1-CDK16 that plays important roles in women's blood cell development and disease severity. The findings suggest the chimeric RNA may serve as a natural brake to protect women from excessive autoimmune activity.
The Critical Path Institute's Type 1 Diabetes Consortium is strengthening regulatory science and evidence frameworks for disease-modifying therapies. The expanded C-peptide evidence base supports ongoing evaluation of the biomarker as a drug development tool.
Elevated Pim1 expression promotes abnormal Th17 cell differentiation in inflammatory arthritis. Targeting Pim1 with Nilotinib inhibits Th17 cell differentiation and alleviates inflammatory arthritis symptoms.
Scientists discover autoimmune vicious cycle in Sjögren's disease, where CD4+ T cells recognize Ro60 protein and sustain antibody production. This process forms a self-reinforcing loop, contributing to chronic disease, and could lead to targeted therapies with fewer side effects.
A recent study from the University of Missouri-Columbia shows a potential way to protect transplanted islets without immunosuppressive drugs. Researchers engineered islets with thrombomodulin and CD47, which prevented harmful inflammation and allowed cells to respond to glucose naturally.
Researchers have discovered a previously underappreciated mechanism that helps immune cells respond rapidly to infections by altering RNA splicing. This study provides new insights into immune-mediated diseases such as rheumatoid arthritis and lupus, and may lead to more targeted therapies.
Researchers have found a widely available drug combination to be an effective treatment for patients with systemically active Sjögren's disease. The combination of leflunomide and hydroxychloroquine reduced disease activity while maintaining a favorable safety profile.
A study by Radboud University Medical Center found that 75% of patients with stable psoriasis can safely reduce their biologic medication dosage by half, achieving similar symptom control. This reduction in dosage leads to fewer injections and saves up to €8,500 per patient per year.
A study from UC San Francisco researchers reveals that regulatory differences around the world are slowing the development and adoption of biosimilars. The lack of standardization in biosimilar approval processes is a major obstacle for these cheaper alternatives to expensive biologics, which could lower costs for patients.
Researchers found that hydroxychloroquine use was associated with better cardiovascular and cardiometabolic health outcomes in patients with discoid lupus erythematosus. The study also found a lower risk of hypertension, hyperlipidemia, type 2 diabetes, stroke, and coronary artery disease among hydroxychloroquine users.
A study published in Science Advances reveals that neuronal hyperactivity triggered by rogue antibodies is a key driver of the severe autoimmune brain disorder IgLON5 encephalitis. The research also highlights similarities between this condition and Alzheimer's disease, suggesting potential therapeutic targets.
A new study has found that individuals with insulin-requiring type 1 and type 2 diabetes have a significantly higher risk of developing dementia compared to those without diabetes. The study, which examined over 1.3 million adults in South Korea, suggests that dementia risk is not the same for all types of diabetes.
Researchers summarize universal mechanisms of regulatory T cells in solid organ transplantation, enabling durable immune tolerance and reducing rejection. Gene-editing technologies create hypoimmunogenic Tregs for standardized, scalable availability.
Researchers at Garvan Institute of Medical Research discovered key immune cells malfunction in mevalonate kinase deficiency (MKD), a rare but devastating autoinflammatory disorder. Current treatments targeting inflammatory signals produced by macrophages fail in half of patients, but JAK inhibitors may provide relief.
A nationwide Swedish study of 27,789 individuals with confirmed celiac disease found no link between antibiotic use and increased risk of developing the autoimmune disorder. The study also revealed a higher proportion of prior antibiotics used among those with normal mucosa, suggesting other factors may contribute to its development.
A multi-institutional team has discovered a novel immune regulatory mechanism mediated by antibodies that selectively shut down overactive immune responses. The 'immune-induced TCR-like antibody' (iTab) can reduce disease severity and delay its onset in a mouse model of autoimmune disease.
Scientists have identified a gene variant in dogs associated with Addison's disease and multiple autoimmune syndrome. The RESF1 gene, also found in humans, could hold key insights for understanding the human form of the condition.
Research reveals a previously hidden role for somatic mutations — DNA changes acquired throughout life — in diseases beyond cancer. Mutations in key genes were found to contribute to thyroid autoimmunity, potentially providing a path towards precision medicine.
A new study by the Barcelona Supercomputing Center reveals that women's immune systems undergo more pronounced changes with age, leading to a greater susceptibility to autoimmune diseases. In contrast, men experience less extensive immune system changes, but are at higher risk for certain blood cancers.