Articles tagged with Metastasis
Researchers at MD Anderson have discovered a previously unknown mechanism that explains how bacteria can drive treatment resistance in patients with oral and colorectal cancer. The study also identifies a new biomarker for improved immunotherapy responses in solid tumors.
Han Xiao, a pioneer in medicinal chemistry, has been awarded the David W. Robertson Award for his contributions to therapeutic discovery. His research focuses on developing chemical tools to probe and manipulate biological systems, with a focus on cancer therapy.
Researchers suggest chemotherapy drugs may be responsible for 'chemo brain' symptoms, citing reduced lymphatic vessel growth and impaired cognitive function. The study highlights the need to consider long-term neurological side effects of cancer treatment on quality of life.
Researchers at UMass Amherst have developed a nanoparticle-based vaccine that prevents melanoma, pancreatic and triple-negative breast cancer in mice. The vaccine achieved remarkable survival rates, with up to 88% of vaccinated mice remaining tumor-free.
Researchers at UCSF have discovered a novel combination of immunotherapies that can reprogram the immune environment of colon cancer tumors in the liver. This therapy often eliminated tumors entirely in preclinical models, showing promise for treating patients with advanced colorectal cancer.
The ASPIRE trial is a Phase III clinical study investigating whether adding chemotherapy to standard treatments can extend survival in men with advanced prostate cancer. The trial aims to determine the effectiveness of combining docetaxel with hormone therapy and apalutamide.
Research presents evidence suggesting that metabolically active visceral fat is associated with more advanced stages of endometrial cancer and lymph node metastases. The study found no strong correlation between visceral fat volume and its metabolic activity.
Researchers discovered that an enzyme called EZH2 drives triple negative breast cancer cells to divide abnormally, enabling them to spread. Inhibiting EZH2 with drugs like tazemetostat restored order to dividing cells and thwarted the spread of TNBC cells.
A Virginia Tech oncologist is championing a precise approach to treating acute myeloid leukemia by tracking subtle molecular changes in patients. His work aims to identify signs of potential relapse and tailor treatment for each individual with this rare blood cancer.
Researchers identify three primary UPR pathways and their downstream cascades, which play a crucial role in the differentiation of osteoblasts and osteoclasts. Targeting these pathways with emerging drugs may alleviate bone-related events and kill tumors localized in bones.
New MSK research explores the importance of tumor location in metastasis, regulatory T cells' role in pain management, and the effectiveness of proton therapy for leptomeningeal metastasis. The study found that different organ sites select for different cell types present in primary tumors, affecting their viability.
Researchers identified NBL1 as a key driver of ovarian cancer metastasis through its activation of the Jak/Stat3 pathway. NBL1 expression levels strongly correlated with advanced clinical stage and poor survival outcomes.
A new algorithm developed by Núria Malats and her team can accurately predict the presence of metastasis in pancreatic cancer using medical images. The PMPD algorithm has shown promising results, classifying 56% of metastases with high accuracy and potentially avoiding unnecessary surgeries.
DDX17 promotes HCC metastasis via the β-catenin/TCF4 pathway, inducing EMT and enhancing migration/invasion. The β-catenin/TCF4/DDX17 feedback loop is essential for HCC dissemination.
Research by Angela Riedel and team identified fibroblastic reticulum cells as main players in reprogramming lymph nodes, corrupting monocytes and blocking T cell activity. Targeted TLR4 blockade combined with PD1 immunotherapy can restore T-cell activity and reduce distant metastasis.
Virginia Tech researchers create method combining MRI, fluid dynamics, and algorithm to identify hidden glioblastoma cells. The technique uses fluid flow patterns to predict tumor re-growth, allowing for more aggressive surgical approaches. This technology has potential to improve cancer treatment outcomes
A new study from Mizzou's College of Veterinary Medicine analyzed the effects of radioactive iodine therapy on thyroid cancer in dogs. The research found that tailoring the dose of radiation more precisely for each dog could improve outcomes and potentially lead to more targeted care.
A new study from Memorial Sloan Kettering Cancer Center shows the Make-an-IMPACT program improves global access to genomic testing for pediatric cancer patients. The program helps develop an experimental antibody that shows promise against metastatic cancer. Researchers also shed light on the origins of ERG-driven prostate cancer and f...
This study reveals that GPNMB modifies the tumor microenvironment by repurposing macrophages into immunosuppressive tumor-associated macrophages. The interaction between GPNMB and Siglec-9 enables this reprogramming, leading to increased cancer cell motility and invasiveness.
Scientists discovered that human melanoma cancer cells behave like stem cells when forced through channels narrower than 10 micrometres, gaining traits to survive, spread, and form new tumours. Researchers created a biomedical device to simulate blood flow through narrow blood vessels, showing the mechanical pressure makes cancer cells...
Researchers at Sanford Burnham Prebys Medical Discovery Institute found that using a drug as a blocker to outcompete the SUMO2 protein may be a winning strategy against synovial sarcoma. This approach aims to reverse aberrant epigenetic rewiring driven by the SS18::SSX fusion oncoproteins and impair sarcomagenesis.
The ASTRO's 2025 Annual Meeting will feature pivotal studies in radiation medicine, highlighting advances in radiopharmaceutical therapy and new indications for low-dose radiation therapy. The meeting will also explore cutting-edge techniques for prostate, breast, lung, and other common cancers.
A study led by Yibin Kang and Yujiao Han reveals that cancer cells hijack a specialized cell to recycle iron, depriving red blood cells of necessary iron and causing anemia. The discovery aims to slow down bone metastasis and alleviate complications.
Researchers identified a core group of 15 bacterial genera in 6 types of GI tumors that predicts prognosis. Microbiome signals inside tumors carry prognostic and therapeutic information that can be measured on routine tissue. The study suggests a microbiota-based risk score to identify high-risk patients and inform treatment decisions.
A recent study published in Nature Communications provides a comprehensive characterization of Large Cell Neuroendocrine Carcinoma (LCNEC), a rare and aggressive type of lung cancer. The research team analyzed data from 590 patients and found that LCNEC shares features with other types of lung cancer, yet has distinct aspects. They ide...
Scientists have developed a monoclonal antibody to combat life-threatening inflammatory diseases like sepsis and ARDS. The antibody shows promise in blocking the immune system's hyperactive response and restoring healthy function without unwanted side effects.
Researchers developed a neoAg mRNA-based vaccine that induces higher frequency of neoAg-specific cytotoxic T cells in mice, leading to tumor regression and eradication. The combination with anti-PD-1 therapy enhances antitumor efficacy, especially against peritoneal metastasis.
The Pew Charitable Trusts has announced the 2025 class of the Pew-Stewart Scholars Program for Cancer Research, supporting five early-career scientists in innovative research projects. The recipients will explore pressing topics such as complex cancer mechanisms and new drug targets.
A team of scientists from the University of Konstanz has identified the PPM1F enzyme as essential for cell migration in both embryonic development and tumor cell invasion. The study found that increased levels of PPM1F enhance the invasive potential of cancer cells, while its absence impairs cell adhesion and migration.
A new case report describes the use of extracorporeal blood filtration to treat stage IV poorly differentiated pancreatic adenocarcinoma. The patient experienced clinical improvement, reduced pain, and no signs of new tumor growth over 12 months of follow-up.
Researchers at Mass General Brigham found that targeted radiation was successful in treating patients with brain metastases, resulting in a lower neurological death rate and reduced need for subsequent whole brain radiation. This study supports personalized treatment approaches to maintain quality of life while managing brain metastases.
Researchers at Memorial Sloan Kettering Cancer Center have gained new insights into how cancer spreads, revealing that metastatic cells can endlessly divide and produce diverse cell types. This flexibility allows them to adapt to various environments and develop resistance to treatments.
Researchers identify tumor-associated macrophages that shield tumors from attack and promote metastasis in advanced prostate cancer. Blocking these cells with anti-SPP1 treatment boosts the immune response, slowing cancer progression.
Researchers at Fujita Health University discovered benzaldehyde's mechanism to halt therapy-resistant pancreatic cancer growth and spread. Benzaldehyde prevents key interactions that enable cancer cells' survival and treatment resistance.
Researchers developed a technique to measure brain tumors' mechanical force, distinguishing between tumors that push against the brain or invade surrounding tissue. This measurement can help clinicians inform patient strategies to alleviate symptoms and predict outcomes of chemotherapy and immunotherapy.
Researchers at MD Anderson have made significant breakthroughs in cancer treatment, including improved outcomes for elderly patients with IDH-mutant AML who are not eligible for intensive chemotherapy. Additionally, new targeted therapies have been approved as frontline treatments, while pre-surgical radiation therapy may offer an alte...
Researchers developed an AI tool called AAnet to characterize cancer cell diversity, identifying five distinct cell groups with different gene expression profiles. This could lead to more targeted therapies and improved patient outcomes.
Researchers developed nanomachines that can efficiently deliver antisense oligonucleotides to sentinel lymph nodes, reducing TGF-β1 levels and reactivating depleted CD8-positive T cells. This enhances cancer treatment outcomes for advanced breast cancers with no effective treatments.
Pernilla Wittung-Stafshede joins Rice University's Department of Chemistry as a professor, bringing expertise in metalloproteins and protein aggregation to enhance cancer research. Her focus is on understanding the role of copper-binding proteins in cancer metastasis and potential future therapies.
Scientists at UC San Francisco discovered how pancreatic cancer cells metastasize to the lungs or liver using the PCSK9 protein. PCSK9 controls cholesterol acquisition, with low levels favoring the liver and high levels supporting lung adaptation.
A recent study published in Nature Genetics sheds light on the genetic changes that occur when cancer spreads from a primary tumor to new sites throughout the body. The research team found that whole-genome duplication is the most common genetic event during metastasis, occurring in nearly one-third of patients.
Researchers at the University of Turku have developed a new fluorescent probe, Illusia, to visualize signaling dynamics in moving cancer cells. This tool has led to a new therapeutic possibility for limiting breast cancer spread, with potential implications beyond breast cancer.
Researchers identified C5aR1 as a novel prognostic biomarker and potential therapeutic target for treating metastatic skin cancer. Elevated C5aR1 presence suggests increased metastasis risk and poor survival in patients with cutaneous squamous cell carcinoma.
Researchers at the University of Maryland Baltimore County have made an important discovery about how cells move through tissues, combining mathematical modeling with advanced imaging to show that physical shape and chemical signals interact. The study's findings could inform new strategies for controlling cell movement via medical tre...
A study published in PNAS reveals that colorectal cancer cells utilize a protein called TBX3, which regulates embryo development, to contribute to their aggressiveness and metastasis. The discovery opens up possibilities for developing targeted therapies to prevent tumor cell spread.
Researchers from City of Hope will present novel cancer treatment approaches and combinations, including innovative combination therapies for breast, genitourinary, and gastrointestinal cancers. Additionally, they'll discuss the safety of readministering trastuzumab-deruxtecan to metastatic breast cancer patients with low-grade lung co...
Researchers at MD Anderson Cancer Center have made significant discoveries in three key areas of cancer care. In a study on sickle cell disease, the team found that the disorder can suppress immunity by altering DNA structure in CD8+ T cells, leading to potential strategies for improving immunotherapy responses. Meanwhile, a biomarker-...
Researchers at MSK uncovered a key signaling molecule involved in the body's immune response against leptomeningeal metastasis. A new grading system to assess thrombocytopenia risk after CAR T cell therapy was also developed. Additionally, a statistical method called UnitedMet estimates metabolic characteristics from challenging clinic...
Researchers at the University of Chicago Medicine discovered a new phenomenon where high doses of radiation cause growth in existing metastatic tumors. The 'badscopal effect' is attributed to increased production of amphiregulin, which weakens the immune system and makes cancer cells more resistant.
A new study uses explainable machine learning to predict metastasis and mortality in children with medulloblastoma, identifying key immune factors driving risk. The model provides a transparent approach to prognostic accuracy and supports personalized clinical decision-making.
The University of Texas at Arlington's nursing and physics team has developed a system to study alpha radiation, improving the effectiveness of radiation therapy. The team's research was recognized with the Best in Physics award at the American Association of Physicists in Medicine's annual meeting.
Researchers from the University of Southampton engineered a new type of super-strong antibody that triggers a stronger response from the immune system compared to naturally produced antibodies. The study confirms that making subtle increases in rigidity stimulates immune activity, creating a powerful immune response against disease.
Researchers at MD Anderson Cancer Center present promising results from clinical trials in three minisymposia abstracts. The studies explore personalized vaccine combination therapy for colorectal cancer, radiotherapy to avoid toxicities of systemic treatments for kidney cancer, and engineered exosomes to silence mutant KRAS in pancrea...
A study led by IGTP identifies an epigenetic signature of 156 altered CpG sites in primary tumours that can help stratify patients according to their risk of developing distant metastases. The findings contribute to a better understanding of the disease and open new avenues for patient stratification and personalised treatment strategies.
Researchers discovered a novel line of communication between metastatic medulloblastoma and leptomeningeal fibroblasts, facilitating recruitment and reprogramming to support tumor growth. Disrupting this communication may offer a potential treatment opportunity for this devastating disease.
A new study reveals the molecular mechanism of lymph node metastasis in gallbladder cancer, identifying eEF1A2 and its K36 trimethylation as prognostic markers. The EEF1AKMT4-eEF1A2K36me3 axis promotes ribosome protein synthesis, enhancing tumor growth and metastasis.
Researchers at Tokyo Metropolitan University have created a novel technique using phase-contrast microscopy to track and analyze the motion of unlabeled cells. This allows for the accurate differentiation of cancerous cells with up to 94% accuracy, opening new avenues for diagnosis and research on cell motility related functions.
Natasha Diba Sheybani, a UVA researcher, has received a $5.5 million grant to develop safer and more precise breast cancer treatments using focused ultrasound technology. Her work aims to overcome key bottlenecks in current treatments and improve patient outcomes.
Researchers found significant disparities in quality of care and outcomes for patients with metastatic pancreatic cancer. Patients with higher social vulnerability indices were less likely to receive guideline-concordant systemic therapy, palliative care, or survive over 12 months.
A Rice University-led team developed an implantable 'cytokine factory' that triggers potent immune responses against hard-to-treat cancers. The IL-12 cytokine factory successfully induces the recruitment of tumor-targeting T cells, eliminating local and distal tumors in preclinical models.