Articles tagged with Microbial Infections
A newly-developed AI-powered tool, CAMPER, helps identify peptides that target antibiotic-resistant bacteria by breaking down their outer defenses. The study found that CAMPER is effective in developing treatments against MRSA and other difficult-to-treat pathogens.
A pre-Columbian Bolivian mummy has been found to harbor the ancient Streptococcus pyogenes bacterium, a pathogen responsible for scarlet fever. The genome of this centuries-old bacterium was reconstructed from its DNA, revealing genetic variants that may no longer exist today.
Dr. James Earnest's research focuses on how the immune system responds to mosquito-borne viruses, aiming to create better preventative measures for dengue and Zika infections. He is collaborating with institutions in Mexico and Uganda to study immune responses over time, shedding light on effective memory B cells and antibodies.
Researchers found that Vibrio cholerae can efficiently acquire new sedentary chromosomal integron (SCI) gene cassettes from extracellular DNA. This process allows the bacteria to diversify its antiviral defenses and potentially expand its protection against viruses in different environments.
A retrospective study of 40 immunocompromised ICU patients found associations between low CD4+T-cell counts and specific lung pathogens. Patients with severe CD4 depletion had higher proportions of fungal infections, while moderate immunosuppression was linked to Streptococcus pneumoniae.
Researchers developed an AI tool called PathogenFinder2 that can detect harmful bacteria before they infect humans. The tool uses protein language models and has been shown to significantly improve the detection of bacterial threats.
A new study discovered that a multifaceted infection prevention and control intervention successfully disrupted a large and long-running bacterial outbreak of Klebsiella pneumoniae in a Zambian neonatal intensive care unit. The study found that low-cost measures, including IPC training, enhanced cleaning, and hand hygiene, reduced neon...
The American College of Chest Physicians (CHEST) has certified its first class of critical care advanced practice providers with the CCAPP designation. This achievement recognizes their dedication to high-quality patient care and their role in supporting multidisciplinary critical care teams. The CCAPP certification is designed to vali...
Researchers at the University at Buffalo have developed a new inhalable form of tuberculosis (TB) treatment that delivers rifampin directly to the lungs, reducing liver damage and improving immune activity. The study found that inhaled nanoparticle treatment kept higher levels of the drug in the lungs for up to a week after a single dose.
A Dartmouth study found that plasmids can form tight clusters within bacterial communities, making them resistant to antibiotics and clinical treatments. This phenomenon introduces a new avenue for bacterial infections to become more difficult to treat.
A recent study found significant changes in post-COVID respiratory infections among children, with Mycoplasma pneumoniae experiencing a surge after restrictions were lifted. The study also revealed strong interactions between pathogens, including negative correlations and pathogen interference.
Researchers at NTU Singapore have found that a common bacterium produces reactive oxygen species that impairs wound healing. Neutralizing this process with an antioxidant enzyme restores skin cells' ability to migrate and heal, offering a potential solution to tackle antibiotic-resistant strains.
A comprehensive genomic characterisation of E. coli strains isolated from diabetic foot ulcers reveals high diversity and antibiotic resistance. The study provides valuable insights into the specific pathogens involved in diabetic foot disease and suggests potential targets for improved treatment strategies.
Researchers have made a groundbreaking discovery about how bacteria swim upstream to cause infections, pointing to new designs for biomedical devices that can prevent contamination. The study found that wider channels with faster counterflows are more prone to invasion, but sharp corner designs can inhibit bacterial growth.
Researchers developed a lab-grown model of the prostate gland to study bacterial infections. They found that E. coli targets specific cells and uses a 'lock and key' principle to invade. A sugar molecule called D-mannose blocks this interaction, offering a potential new strategy to prevent and treat prostate infections.
Researchers developed a new method to measure how effectively antibiotics kill bacteria, crucial for treating complex infections. The 'antimicrobial single-cell testing' method predicts treatment success by observing individual bacteria under different conditions.
A high-protein diet rich in casein and wheat gluten can significantly reduce the amount of cholera bacteria able to infect the gut. The study found that these dietary components can suppress a key structure on the surface of cholera bacteria, making it difficult for the pathogen to colonize and cause harm.
Researchers discovered that certain antibodies employ unusual tactics to block bacterial adhesion, including creating molecular wedges and conformational traps. These mechanisms could lead to the development of immune therapies targeting glycan-binding cell-attachment proteins produced by bacteria causing urinary tract infections.
A new study reveals that farmers in the Northeast are facing a growing threat of tick-borne diseases, which can be devastating to their livelihoods. The research found that farmers often experience multiple tick bites per month, with some contracting serious illnesses like Lyme carditis.
The study will select the exact phage that is appropriate for each patient's bacteria, and aims to reduce antibiotic use and healthcare costs. Bacteriophages have been shown to be effective against resistant bacteria causing urinary tract infections.
Researchers at Tulane University have developed the first vaccine able to protect nonhuman primates from melioidosis, a long-neglected and deadly tropical disease on the rise. The vaccine uses outer membrane vesicles to trigger a powerful immune response.
Public Health Alerts provide concise, data-driven information on disease outbreaks and urgent health events. The new series, launched by NEJM Evidence and CIDRAP, offers expert-reviewed reports to support public health evidence-based care.
A team of researchers has identified two proteins critical to the destruction of red blood cells by the Oroya fever pathogen. This discovery paves the way for a potential novel therapy against this deadly neglected tropical disease.
Cholera-causing bacteria show substantial genetic diversity and widespread multi-drug resistance to commonly used antibiotics in Africa. A new study analyzed genomic data from 104 isolates across Cote d'Ivoire, Ghana, Zambia, and South Africa, highlighting the urgent need for antimicrobial stewardship.
The new guideline recommends full-time infection prevention staff, comprehensive training, and support for all staff, as well as partnerships with hospitals and public health agencies. This guidance aims to reduce the risk of infections in nursing homes, saving lives and money.
A new paper outlines a global coalition dedicated to conserving microbial biodiversity, which accounts for 99% of life on Earth. The Microbial Conservation Specialist Group will develop Red List-compatible metrics, pilot restoration projects, and promote public awareness to ensure microbes are recognized as essential to planetary health.
Researchers have developed a new molecular test to identify Lyme disease earlier and more accurately than traditional methods. The test can detect as few as five bacterial cells and has an estimated sensitivity of 90.9%, making it a potential new avenue for testing Lyme disease.
The Phase 3 study demonstrated the safety and non-inferiority of EuTYPH-C Inj.® Multi-dose compared to a World Health Organization (WHO) prequalified comparator TCV, Typbar TCV®. The vaccine was shown to be well-tolerated across all age groups with no serious adverse events.
Researchers from the University of Edinburgh have identified a new mechanism of resistance to common antibiotics, targeting a special repair system possessed by certain bacteria. This discovery could aid efforts to combat antimicrobial resistance, one of the world's most urgent health challenges.
A team led by Professor Jay Hinton will explore how the gut microbiota prevents Salmonella infection in healthy individuals. By analyzing data from a previous human challenge trial, they aim to reveal the microbial mechanisms that confer colonisation resistance.
Researchers at Mount Sinai developed a new technology to track beneficial bacteria after fecal microbiota transplants, providing insights into how donor microbes adapt and persist in the gut. This approach may guide the design of safer and more effective microbiome-based therapies.
The winners of the Applied Microbiology International Horizon Awards 2025 have been recognized for their groundbreaking contributions to global challenges through applied microbiology. The awards celebrate excellence across various domains, including drug discovery and sustainable agriculture.
A new study projects that US funding cuts will result in a catastrophic effect on pediatric TB, with children in Sub-Saharan Africa and Southeast Asia experiencing a significant spike in preventable cases and deaths over the next decade. The loss of US bilateral health aid is projected to result in an additional 2.5 million pediatric T...
Researchers create novel compounds that kill bacteria in a new way, reducing the risk of side effects and environmental harm. The compounds have been shown to be effective in preventing bovine mastitis without affecting milk quality.
A new study reveals rising rates of invasive SDSE infections across Australia, particularly among older Australians and those from remote regions. The research highlights disparities in health outcomes between regions and populations, emphasizing the need for improved surveillance and prevention strategies.
A University of Houston professor has received funding to develop effective treatments for Cryptosporidium infections, which cause severe diarrhea and have no existing cure. The team aims to design drugs that target the parasite's enzyme CDPK1 to minimize systemic exposure and maximize efficacy.
Researchers argue that AI can strengthen pandemic preparedness by detecting emerging diseases earlier. By combining data from humans, animals, and the environment, AI can reveal patterns and provide insights into potential pathogens.
A University of Leicester-led study reveals that around one in three hospital infections involve antimicrobial resistance, independently associated with a higher risk of death. The study found patients with resistant infections had a 58% increased risk of mortality compared to those with susceptible infections.
A new review article highlights the need for effective control and prevention strategies for sexually transmitted gut infections, which can persist longer and be harder to treat. The authors emphasize the importance of prompt diagnosis, appropriate treatment, and community-level education and testing.
A recent study provides insights into the true impact of chikungunya on pediatric health, revealing diagnostic challenges and limited public health responses. Infants are especially susceptible to severe complications, emphasizing the need for improved research, diagnostics, surveillance, and policy.
A study published in PLOS Neglected Tropical Diseases has shown that combining country-level information with individual-level variables can improve the identification of soil-transmitted helminth infections among migrant populations. Researchers found that country-level indicators are stronger predictors than individual-level variable...
Researchers developed a CRISPR-based gene-editing system that changes a single molecule within mosquitoes, halting malaria-parasite transmission. The new system is designed to genetically spread the malaria resistance trait until entire populations of the insects no longer transfer the disease-causing parasites.
A new Korea University study provides the first species-specific health risk estimates for indoor airborne microbes based on animal toxicity data. The research determines that exposure to fungi may be unsafe even at levels below current guidelines, while bacteria are within existing regulatory limits.
Australian scientists used AI to generate a protein that can kill antibiotic-resistant bacteria like E. coli, a major step forward in combating superbugs. The new approach enables efficient de novo design of proteins with specific characteristics and functions.
Dr. Danielle Beckman's research uses animal models to understand how viruses like COVID-19 trigger neurological damage and accelerate Alzheimer's disease. Her work has established critical connections between viral infections and neurodegenerative processes.
Researchers have identified genetic bottlenecks that explain the emergence of pandemic cholera strains. These specific combinations of genes and allelic variants grant an advantage in human intestinal colonization, allowing a small subset of Vibrio cholerae to become deadly pathogens.
Researchers at Tulane University developed a handheld TB test inspired by the bombardier beetle's natural defense mechanism. The ASTRA device requires only a drop of blood and delivers same-day diagnoses without need for laboratory or trained staff, outperforming traditional tests in detection of TB with HIV co-infection.
Researchers from ASU and international collaborators tested a handheld DNA sequencing device at six chicken slaughterhouses in Indonesia. The study found signs of antibiotic-resistant bacteria spreading from wastewater into nearby rivers, highlighting the need for targeted solutions to reduce its spread.
The American College of Chest Physicians (CHEST) has launched a critical care APP education and certification program, covering 11 topic areas including patient-centered care and pharmacology. The CCAPP Certification Exam is now available, with an August 5 deadline to apply for the 2025 exam.
Researchers analyzed trends in healthcare utilization among Japan's oldest-old population aged 75 years and above during the extended COVID-19 pandemic. The analysis revealed a modest drop in medical services and outpatient visits, while healthcare costs remained stable despite decreased patient volumes.
Researchers found that cholera bacteria acquired multiple distinct immune systems protecting them from diverse types of phages. These defense systems, including WonAB, GrwAB, and Vc SduA, contribute to the bacterial population's resistance spectrum.
CoVFit integrates molecular data with large-scale epidemiological data to predict the fitness of SARS-CoV-2 variants. The model was trained on mutations in the spike protein and population-level trends, enabling accurate predictions of variant fitness.
Researchers from Japan evaluate the LC16m8 vaccine, an attenuated vaccinia virus strain, for its efficacy and safety against mpox. The study confirms the vaccine's ability to induce strong immune responses and protect against mpox in mice, monkeys, and humans.
Researchers develop mathematical modeling to predict aflatoxin outbreaks in Texas using remote sensing satellites and soil properties. The model has the potential to save farmers billions of dollars in losses by providing early risk prediction and targeted prevention strategies.
Researchers identify colibactin, a bacterial toxin that alters DNA, as a potential trigger for early-onset colorectal cancer. Exposure to colibactin in childhood may imprint a distinct genetic signature on colon cells, increasing the risk of developing cancer before age 50.
A new study provides a method to estimate sample size required for microbiome studies based on effect sizes and analysis methods. For strong associations, around 500 participants were needed to achieve 80% statistical power, while weaker associations may require thousands of samples.
A Chinese Academy of Sciences research team has identified the first mechanism of citrus resistance to citrus greening disease and developed an AI-assisted therapeutic approach. The discovery addresses the challenge of naturally occurring resistant genes in citrus, offering hope for global agricultural sustainability.
A new class of antibiotic has been shown to be effective in treating MRSA infections, with a daily dose of epidermicin NI01 demonstrating equal efficacy to the current standard of care. The findings justify further pre-clinical development and could lead to new gel-type therapies for skin infections.
The new season of The Last of Us explores the real-life characteristics of cordyceps, including its airborne spore method of infection. Researchers like Dr. Jim Kronstad highlight the warming climate as a potential contributor to the spread of harmful fungi.
The American College of Chest Physicians' CHEST Critical Care and CHEST Pulmonary journals have been indexed in Elsevier's Scopus database. This achievement is a testament to the high-quality research published in these journals, which provide open access content in pulmonary and critical care medicine.