Articles tagged with Type 1 Diabetes
A European study across eight countries confirms that screening for type 1 diabetes can be effectively implemented in children, with early detection associated with clinical benefits including reduced risk of diabetic ketoacidosis. The study's findings support the integration of screening for early-stage T1D in standard medical care ac...
A nationwide study in Norway found a 11% increase in type 1 diabetes incidence in children aged 0.5-5 years after the introduction of the rotavirus vaccine in September 2014. However, secondary analyses suggest that the vaccine may not be the cause of this increase.
Women are more likely to experience weight loss and improved blood sugar control with GLP-1 RAs, but face higher rates of side effects and unequal access to treatment worldwide. Extensive research is needed to address these disparities and optimize treatment for women in various domains.
A study found that children at high genetic risk of type 1 diabetes whose gut microbiome development plateaued early had three times the risk of developing the disease. The study also identified patterns of microbiome maturation and genetic influences on disease risk.
Researchers assessed glucose levels, carbohydrate intake, and continuous glucose monitoring accuracy during the 2025 Poznań Marathon. Participants with type 1 diabetes completed the race with performance comparable to controls, highlighting the potential for safe marathon participation with proper glucose management.
A small study using continuous glucose monitoring devices found that sex is not associated with an increased risk of hypoglycaemia in adults with type 1 diabetes. The study's results suggest that blood sugar responses are bidirectional and influenced by pre-SI glucose level, BMI, and time of day.
The EASD has published its first evidence-based clinical practice guideline on diabetes distress, emphasizing the importance of assessing and managing emotional burdens in adults with type 1 and type 2 diabetes. The guideline aims to improve clinical care and outcomes by incorporating a person-centered approach to diabetes care.
Researchers at Pennington Biomedical developed GVC-Calc to analyze continuous glucose monitoring data, providing a scalable and transparent approach. The platform supports batch processing, integrates individual-level data with cohort-level results, and offers consensus clinical metrics alongside exploratory measures.
A consensus paper recommends population-wide screening of children for type 1 diabetes, identifying cases before symptoms appear. Screening tests detect islet autoantibodies, which progress at a similar rate regardless of family history, and confirm diagnosis through a step-by-step process.
Researchers at UTHealth Houston developed a treatment that reverses nerve pain in diabetic mice by targeting the MMP-9 enzyme, which breaks down proteins and causes immune response. The new monoclonal antibodies selectively inhibit MMP-9 activity, regenerating nerve fibers and improving wound healing.
A new study by KTU researchers explores whether artificial intelligence can uncover patterns in glucose data to predict changes and assess hypoglycaemia risk. The model achieved high accuracy in forecasting glucose levels and performing well on patients with unseen data.
Researchers discovered a lower risk of subsequent type 1 diabetes development among individuals under 30 who had COVID-19, especially among unvaccinated individuals. The study found a 16% reduced risk across all variants combined and a 42% lower risk 31-180 days post-infection.
A 10-fold increase in new case rate of type 2 diabetes in young people under 20 years old since the turn of century has led to a significant shift in the disease's demographics. The study found an accelerating trend in type 2 diabetes incidence, with a 3.8% annual increase between 2002 and 2023.
Researchers developed a genetic risk score to analyze risk of type 1 diabetes in patients with MODY, identifying 16% with atypical type 1 diabetes. The score, now adopted as part of NHS testing, provides a diagnosis for patients with negative MODY tests.
A cross-sectional study examines state-level type 1 diabetes burden and pediatric endocrinology resource distribution in the US. The study found that type 1 diabetes incidence has increased over time, while pediatric endocrinology resources are not evenly distributed across states.
A new review suggests that continuous glucose monitoring technology offers no scientific evidence of improved health outcomes in people without diabetes. However, it may be beneficial for those with type 2 diabetes by reducing HbA1c levels and minimizing finger-stick tests.
Researchers evaluate whether hypoimmune cell engineering can help transplanted insulin-producing cells survive without chronic immunosuppression. The study aims to develop a cell replacement approach that can function without chronic immunosuppression, providing a curative therapy for people with type 1 diabetes.
Encellin reports non-fibrotic engraftment and host vascularization in Phase 1 trial participants, building on interim results. The findings support the company's approach to deliver cell therapy safely and durably without immunosuppression.
A randomized clinical trial found that long-acting analogue insulin glargine was associated with less time spent in dangerous hypoglycemia and fewer nighttime low blood sugar events. However, benefits only emerged after a year into the trial.
Researchers present a roadmap for developing Tregs as adaptable therapies to restore immune balance and support tissue repair. This approach holds promise for treating conditions such as metabolic and cardiovascular disease, as well as neurodegeneration.
New therapies using regulatory T cells, known as Tregs, could target diseases with inflammation, such as cancer and autoimmune conditions. Early evaluations show good tolerance and safety profiles, but precision is key to tailoring treatments for specific patients.
A review published in Diabetes Care suggests that physical exercise could play a role in promoting immune regulation, preserving beta-cell function, and reducing inflammation in type 1 diabetes. The evidence highlights the potential benefits of exercise on immune profiles displaying anti-inflammatory characteristics.
The Critical Path Institute's Type 1 Diabetes Consortium is strengthening regulatory science and evidence frameworks for disease-modifying therapies. The expanded C-peptide evidence base supports ongoing evaluation of the biomarker as a drug development tool.
The study found a significant increase in type 1 diabetes cases among Hispanic/Latino adolescents in Puerto Rico, from 10.1 per 100,000 in 2009 to 24.1 in 2021, with an average annual increase of 4.1%. This trend has important implications for patient care and public health.
Persons with diabetes are at higher risk of periodontitis, tooth loss, and peri-implantitis. Poor blood sugar control exacerbates these risks, highlighting the importance of close collaboration between healthcare and dental care providers.
A major study finds people with diabetes are at higher risk of infection, which can lead to hospitalization and death. The researchers argue that infection prevention and management should be embedded in diabetes guidelines to improve patient outcomes.
A recent study from the University of Missouri-Columbia shows a potential way to protect transplanted islets without immunosuppressive drugs. Researchers engineered islets with thrombomodulin and CD47, which prevented harmful inflammation and allowed cells to respond to glucose naturally.
Researchers from Pennington Biomedical will showcase their latest findings on prevention, care, and cures for diabetes and obesity at the American Diabetes Association's 2026 Scientific Sessions. The sessions will highlight cutting-edge advancements driving progress in diabetes research and management.
A new stem cell therapy has been developed by MUSC researchers, which shows promise in reversing Type 1 diabetes in a mouse model. The therapy uses mesenchymal stem/stromal cells genetically modified to produce alpha-1 antitrypsin, shielding surviving insulin-producing cells and stopping the overactive immune response.
The global incidence of type 1 diabetes nearly tripled over the past three decades, while health inequalities worsened. Lower-income countries carry a disproportionately large share of T1DM-related deaths and years of life lost due to disparities in access to insulin treatment and healthcare resources.
Researchers at Umeå University have created the first complete 3D map of an entire pancreas from a donor with late-onset type 1 diabetes. The analysis revealed hundreds of thousands of insulin-producing cells outside traditional islet structures, challenging traditional understanding of β-cell loss in type 1 diabetes.
Researchers have found that screening for early-stage type 1 diabetes in children can be implemented sustainably in general pediatric practice, identifying most children who will later develop stage 3 clinical type 1 diabetes. The study suggests that families without a family history of the disease should also be screened.
Researchers developed an innovative hydrogel called Amniogel to support insulin-producing cells after transplantation, achieving normal blood sugar levels in diabetic mice for at least 100 days. This breakthrough opens the door to developing a bioartificial pancreas that could eliminate the need for insulin injections.
A new study has found that individuals with insulin-requiring type 1 and type 2 diabetes have a significantly higher risk of developing dementia compared to those without diabetes. The study, which examined over 1.3 million adults in South Korea, suggests that dementia risk is not the same for all types of diabetes.
The ECE 2026 brings together researchers and clinicians to share the latest endocrine research and developments. Key sessions include Plenaries, Symposia, Awards, Meet the Experts, Debates, and Oral Communications.
A new study published in Current Developments in Nutrition shows that adopting a low-fat vegan diet can rapidly reduce environmental impact while improving metabolic health. The 12-week randomized clinical trial found dramatic reductions in greenhouse gas emissions and cumulative energy demand.
The study demonstrates that the T1GRS tool can identify children and adults at high risk for Type 1 diabetes earlier than current methods, enabling preventive measures before the disease develops. The researchers grouped individuals into four sub-types based on genetic features, each with unique clinical profiles and outcomes.
Researchers at Rice Biotech Launch Pad are developing an encapsulation platform to protect transplanted pancreatic islet cells from immune attack. The approach aims to reduce scarring and inflammation, making it possible for people with Type 1 diabetes to manage their condition without long-term immunosuppression.
The European Society of Endocrinology organizes World Hormone Day to educate the public about hormone-related health issues. Global endocrine disorders affect millions worldwide, emphasizing the need for proper hormone balance.
Researchers at Stanford Medicine successfully cured Type 1 diabetes in mice by combining a blood stem cell and pancreatic islet cell transplant with a gentler pre-transplant treatment. The approach resulted in an immune system made up of cells from both the donor and recipient, preventing disease progression and cure.
Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately 32% of the US adult population. Obesity was identified as the strongest independent MRF among Asians, Whites, and Hispanics, particularly in individuals younger than 50 years, whereas hypertension was the strongest independent MRF in Blacks.
Scientists at Karolinska Institutet have created a new method to produce insulin-producing cells from human stem cells, effectively regulating blood sugar levels in laboratory tests and reversing diabetes in mice. The optimized production process yields more mature and purer cells, demonstrating their potential for future treatments.
A preclinical study found that short-term high-fat diet exposure rapidly depletes critical gut immune cells called ILC3s, leading to intestinal permeability and inflammation. The loss of these cells compromises intestinal barrier function and may contribute to chronic diseases linked to inflammation.
MIT researchers create an implantable device containing insulin-producing cells that survive in the body for at least 90 days, producing enough insulin to regulate blood sugar levels. The device's improved oxygen generator and electronics enable longer cell lifespan and increased insulin production.
The Endocrine Society supports the INSULIN Act to address insulin affordability, setting a $35 monthly cap for people with private insurance and creating a program for uninsured individuals. The bill aims to reduce insulin prices by encouraging competition in the market.
A landmark trial is underway to test new treatments that restore the body's natural warning signs for low blood glucose in people with type 1 diabetes. The CLEAR trial compares innovative treatments, including an artificial pancreas system and bespoke psychoeducational programs, to find the most effective way to prevent severe episodes.
EDENT1FI has screened 100,000 children across Europe for early-stage type 1 diabetes, using standardized screening programs and harmonized data collection. The initiative aims to empower families to manage life with type 1 diabetes effectively and support children and adolescents with early-stage detection.
A $3.4 million NIH grant will fund a semi-automated feedback system to support people tracking diet, exercise, and weight in weight-management programs. The system aims to provide personalized feedback to increase tracking and weight loss success.
Researchers at Kyoto University developed a PET tracer to quantify beta cell mass in type 1 diabetes patients, revealing lower uptake in those with the disease. This measurement was inversely related to hemoglobin A1c and total daily insulin dose, suggesting its potential as a noninvasive readout of residual beta cell mass.
A study from the University of Limerick found that supportive partners play a crucial role in women's experiences of gestational diabetes, with inadequate support increasing the burden of the condition. The research suggests that knowledge, communication, and cultural context are essential factors in determining the effectiveness of pa...
A Pennington Biomedical researcher published an editorial on the benefits of fruit intake for vascular health, citing a study on increasing fruit intake with avocados and mangos. The findings suggest that diets rich in fruits can improve nutrient status and health outcomes, aligning with the goals of the Food Is Medicine initiative.
A UCF researcher is pursuing innovative approaches to treat diabetic neuropathy without relying on pain pills and anti-depressants. Dr. Jim Nichols is investigating overlooked mechanisms in the body that may show how insulin deficiency affects sensation in limbs.
Syzygium jambolanum extracts demonstrate significant protective and antidiabetic effects, improving glycaemic control and metabolic health. The study reveals a systemic protective effect beyond glucose lowering alone.
The ESE and ESPE have launched a landmark Joint Clinical Practice Guidance to support structured and effective transition of young people with endocrine conditions. The Guidance provides practical, evidence-based recommendations to ensure continuity, safety and quality of care during this critical phase in a patient's life.
Researchers developed an oxygen-delivering gel to heal chronic wounds that fail to heal for more than a month. The gel conforms to the wound's shape and provides continuous oxygen levels, helping transform nonhealing wounds into normal injuries.
A new global study finds that physical inactivity is a significant driver of diabetes complications, with up to 10% of cases potentially preventable. The research emphasizes the need for tailored approaches to promote physical activity among people with diabetes, particularly addressing social and gender inequalities.
Scientists at the University of Florida and Linköping University discovered protein markers in umbilical cord blood associated with future insulin-dependent diabetes. The study suggests that these markers can be used to predict type 1 diabetes in early childhood, potentially allowing for targeted interventions and lifestyle changes.
A produce prescription program improved nutrition security among Medicaid patients with diabetes, increasing it from 23.2% to 38.7%. The program also improved food security, with 42.9% of participants reporting secure access to healthy foods after completion.
A UK-wide childhood screening program for type 1 diabetes has been shown to be effective in detecting early stages of the disease. By identifying children at risk, families can prepare for a potential diagnosis and receive timely treatment, reducing the need for emergency hospitalizations.
A groundbreaking study reveals B cells' detrimental role in progressing Type 1 diabetes by interfering with regulatory T cells. The findings suggest targeting B cell-Treg interactions could offer new therapeutic strategies for preserving beta cells and improving patient outcomes.