Type 1 Diabetes

New first-in-human study presented at ISSCR 2026 explores immune-engineered cell therapy approach for type 1 diabetes

Researchers evaluate whether hypoimmune cell engineering can help transplanted insulin-producing cells survive without chronic immunosuppression. The study aims to develop a cell replacement approach that can function without chronic immunosuppression, providing a curative therapy for people with type 1 diabetes.

Encellin announces new phase 1 clinical progress at ISSCR 2026 showing early evidence of non-fibrotic engraftment of cell therapy implant for type 1 diabetes

Encellin reports non-fibrotic engraftment and host vascularization in Phase 1 trial participants, building on interim results. The findings support the company's approach to deliver cell therapy safely and durably without immunosuppression.

Newer insulin may reduce dangerous low blood sugar in youth with Type 1 diabetes in low-resource settings

A randomized clinical trial found that long-acting analogue insulin glargine was associated with less time spent in dangerous hypoglycemia and fewer nighttime low blood sugar events. However, benefits only emerged after a year into the trial.

Frontiers in Science Deep Dive webinar series | How ‘peacemakers’ of the immune system could unlock long-term disease remission

Researchers present a roadmap for developing Tregs as adaptable therapies to restore immune balance and support tissue repair. This approach holds promise for treating conditions such as metabolic and cardiovascular disease, as well as neurodegeneration.

How ‘peacemakers’ of the immune system could unlock long-term disease remission

New therapies using regulatory T cells, known as Tregs, could target diseases with inflammation, such as cancer and autoimmune conditions. Early evaluations show good tolerance and safety profiles, but precision is key to tailoring treatments for specific patients.

Physical exercise could help modulate the immune response in type 1 diabetes

A review published in Diabetes Care suggests that physical exercise could play a role in promoting immune regulation, preserving beta-cell function, and reducing inflammation in type 1 diabetes. The evidence highlights the potential benefits of exercise on immune profiles displaying anti-inflammatory characteristics.

Type 1 diabetes diagnoses surge among Puerto Rican teens

The study found a significant increase in type 1 diabetes cases among Hispanic/Latino adolescents in Puerto Rico, from 10.1 per 100,000 in 2009 to 24.1 in 2021, with an average annual increase of 4.1%. This trend has important implications for patient care and public health.

Diabetes is associated with tooth and implant loss

Persons with diabetes are at higher risk of periodontitis, tooth loss, and peri-implantitis. Poor blood sugar control exacerbates these risks, highlighting the importance of close collaboration between healthcare and dental care providers.

Infections are major “health hazard” for people with diabetes

A major study finds people with diabetes are at higher risk of infection, which can lead to hospitalization and death. The researchers argue that infection prevention and management should be embedded in diabetes guidelines to improve patient outcomes.

Retraining the immune system to treat Type 1 Diabetes

A recent study from the University of Missouri-Columbia shows a potential way to protect transplanted islets without immunosuppressive drugs. Researchers engineered islets with thrombomodulin and CD47, which prevented harmful inflammation and allowed cells to respond to glucose naturally.

Pennington Biomedical researchers to present at the ADA’s 2026 Scientific Sessions in New Orleans

Researchers from Pennington Biomedical will showcase their latest findings on prevention, care, and cures for diabetes and obesity at the American Diabetes Association's 2026 Scientific Sessions. The sessions will highlight cutting-edge advancements driving progress in diabetes research and management.

MUSC researchers develop stem cell therapy that shows promise in one day reversing Type 1 diabetes

A new stem cell therapy has been developed by MUSC researchers, which shows promise in reversing Type 1 diabetes in a mouse model. The therapy uses mesenchymal stem/stromal cells genetically modified to produce alpha-1 antitrypsin, shielding surviving insulin-producing cells and stopping the overactive immune response.

Global inequalities in type 1 diabetes are widening among children and adolescents

The global incidence of type 1 diabetes nearly tripled over the past three decades, while health inequalities worsened. Lower-income countries carry a disproportionately large share of T1DM-related deaths and years of life lost due to disparities in access to insulin treatment and healthcare resources.

Whole organ 3D imaging reveals remaining insulin producing cells in type 1 diabetes

Researchers at Umeå University have created the first complete 3D map of an entire pancreas from a donor with late-onset type 1 diabetes. The analysis revealed hundreds of thousands of insulin-producing cells outside traditional islet structures, challenging traditional understanding of β-cell loss in type 1 diabetes.

Early detection of type 1 diabetes in children is broadly feasible

Researchers have found that screening for early-stage type 1 diabetes in children can be implemented sustainably in general pediatric practice, identifying most children who will later develop stage 3 clinical type 1 diabetes. The study suggests that families without a family history of the disease should also be screened.

Diabetes: a protective gel for a future without insulin injections

Researchers developed an innovative hydrogel called Amniogel to support insulin-producing cells after transplantation, achieving normal blood sugar levels in diabetic mice for at least 100 days. This breakthrough opens the door to developing a bioartificial pancreas that could eliminate the need for insulin injections.

The 28th European Congress of Endocrinology (ECE) starts tomorrow

New study finds higher dementia risk in insulin-requiring diabetes

Plant-based diet cuts climate impact by more than half, randomized clinical trial shows

A new study published in Current Developments in Nutrition shows that adopting a low-fat vegan diet can rapidly reduce environmental impact while improving metabolic health. The 12-week randomized clinical trial found dramatic reductions in greenhouse gas emissions and cumulative energy demand.

Predicting genetic risk for Type 1 diabetes just got more accurate thanks to UC San Diego study

The study demonstrates that the T1GRS tool can identify children and adults at high risk for Type 1 diabetes earlier than current methods, enabling preventive measures before the disease develops. The researchers grouped individuals into four sub-types based on genetic features, each with unique clinical profiles and outcomes.

Rice Biotech Launch Pad receives award for research to advance cell-based therapy for Type 1 diabetes

Researchers at Rice Biotech Launch Pad are developing an encapsulation platform to protect transplanted pancreatic islet cells from immune attack. The approach aims to reduce scarring and inflammation, making it possible for people with Type 1 diabetes to manage their condition without long-term immunosuppression.

Metabolic risk factors and clinical presentations of metabolic dysfunction-associated steatotic liver disease using data from the all of US research program

Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately 32% of the US adult population. Obesity was identified as the strongest independent MRF among Asians, Whites, and Hispanics, particularly in individuals younger than 50 years, whereas hypertension was the strongest independent MRF in Blacks.

World Hormone Day 2026

The European Society of Endocrinology organizes World Hormone Day to educate the public about hormone-related health issues. Global endocrine disorders affect millions worldwide, emphasizing the need for proper hormone balance.

Stanford scientists cure diabetes in mice with increasingly gentle pre-transplant treatment

Researchers at Stanford Medicine successfully cured Type 1 diabetes in mice by combining a blood stem cell and pancreatic islet cell transplant with a gentler pre-transplant treatment. The approach resulted in an immune system made up of cells from both the donor and recipient, preventing disease progression and cure.

Progress in stem cell therapy for type 1 diabetes

Scientists at Karolinska Institutet have created a new method to produce insulin-producing cells from human stem cells, effectively regulating blood sugar levels in laboratory tests and reversing diabetes in mice. The optimized production process yields more mature and purer cells, demonstrating their potential for future treatments.

Research spotlight: High‑fat diets linked to rapid decline in protective gut immune cells

A preclinical study found that short-term high-fat diet exposure rapidly depletes critical gut immune cells called ILC3s, leading to intestinal permeability and inflammation. The loss of these cells compromises intestinal barrier function and may contribute to chronic diseases linked to inflammation.

Implantable islet cells could control diabetes without insulin injections

MIT researchers create an implantable device containing insulin-producing cells that survive in the body for at least 90 days, producing enough insulin to regulate blood sugar levels. The device's improved oxygen generator and electronics enable longer cell lifespan and increased insulin production.

Endocrine Society endorses bipartisan bill to address insulin affordability

The Endocrine Society supports the INSULIN Act to address insulin affordability, setting a $35 monthly cap for people with private insurance and creating a program for uninsured individuals. The bill aims to reduce insulin prices by encouraging competition in the market.

Landmark diabetes trial tests new treatments to bring back ‘hypo’ awareness

A landmark trial is underway to test new treatments that restore the body's natural warning signs for low blood glucose in people with type 1 diabetes. The CLEAR trial compares innovative treatments, including an artificial pancreas system and bespoke psychoeducational programs, to find the most effective way to prevent severe episodes.

100,000 participants screened for early-stage type 1 diabetes in the EDENT1FI project

EDENT1FI has screened 100,000 children across Europe for early-stage type 1 diabetes, using standardized screening programs and harmonized data collection. The initiative aims to empower families to manage life with type 1 diabetes effectively and support children and adolescents with early-stage detection.

$3.4 million grant to improve weight-management programs

A $3.4 million NIH grant will fund a semi-automated feedback system to support people tracking diet, exercise, and weight in weight-management programs. The system aims to provide personalized feedback to increase tracking and weight loss success.

Bringing diabetes treatment into focus

Researchers at Kyoto University developed a PET tracer to quantify beta cell mass in type 1 diabetes patients, revealing lower uptake in those with the disease. This measurement was inversely related to hemoglobin A1c and total daily insulin dose, suggesting its potential as a noninvasive readout of residual beta cell mass.

University of Limerick, Ireland, research reveals challenges of living with gestational diabetes

A study from the University of Limerick found that supportive partners play a crucial role in women's experiences of gestational diabetes, with inadequate support increasing the burden of the condition. The research suggests that knowledge, communication, and cultural context are essential factors in determining the effectiveness of pa...

Pennington Biomedical researcher publishes editorial in leading American Heart Association journal

A Pennington Biomedical researcher published an editorial on the benefits of fruit intake for vascular health, citing a study on increasing fruit intake with avocados and mangos. The findings suggest that diets rich in fruits can improve nutrient status and health outcomes, aligning with the goals of the Food Is Medicine initiative.

UCF researcher developing new therapy to treat diabetic neuropathy

A UCF researcher is pursuing innovative approaches to treat diabetic neuropathy without relying on pain pills and anti-depressants. Dr. Jim Nichols is investigating overlooked mechanisms in the body that may show how insulin deficiency affects sensation in limbs.

Syzygium jambolanum extracts show promising protective effects in diabetes management

Syzygium jambolanum extracts demonstrate significant protective and antidiabetic effects, improving glycaemic control and metabolic health. The study reveals a systemic protective effect beyond glucose lowering alone.

ESE and ESPE launch joint transition of care guidance to improve outcomes for young people moving from child to adult endocrine care

The ESE and ESPE have launched a landmark Joint Clinical Practice Guidance to support structured and effective transition of young people with endocrine conditions. The Guidance provides practical, evidence-based recommendations to ensure continuity, safety and quality of care during this critical phase in a patient's life.

A gel for wounds that won’t heal

Researchers developed an oxygen-delivering gel to heal chronic wounds that fail to heal for more than a month. The gel conforms to the wound's shape and provides continuous oxygen levels, helping transform nonhealing wounds into normal injuries.

Physical inactivity drives a significant share of diabetes complications worldwide; new global study finds

A new global study finds that physical inactivity is a significant driver of diabetes complications, with up to 10% of cases potentially preventable. The research emphasizes the need for tailored approaches to promote physical activity among people with diabetes, particularly addressing social and gender inequalities.

Markers at birth may help predict type 1 diabetes

Scientists at the University of Florida and Linköping University discovered protein markers in umbilical cord blood associated with future insulin-dependent diabetes. The study suggests that these markers can be used to predict type 1 diabetes in early childhood, potentially allowing for targeted interventions and lifestyle changes.

Produce prescriptions improve nutrition for medicaid patients with diabetes

A produce prescription program improved nutrition security among Medicaid patients with diabetes, increasing it from 23.2% to 38.7%. The program also improved food security, with 42.9% of participants reporting secure access to healthy foods after completion.

National childhood type 1 diabetes screening is effective and could prevent thousands of emergency diagnoses, UK study shows

A UK-wide childhood screening program for type 1 diabetes has been shown to be effective in detecting early stages of the disease. By identifying children at risk, families can prepare for a potential diagnosis and receive timely treatment, reducing the need for emergency hospitalizations.

Research reveals B cells’ more sinister role in progression of Type 1 diabetes

A groundbreaking study reveals B cells' detrimental role in progressing Type 1 diabetes by interfering with regulatory T cells. The findings suggest targeting B cell-Treg interactions could offer new therapeutic strategies for preserving beta cells and improving patient outcomes.

Pregnancy-related high blood pressure varied among Asian, Pacific Islander subgroups

Research highlights racial-ethnic differences in pregnancy-related high blood pressure risk, with Pacific Islanders and Filipinos more likely to develop a hypertensive disorder. Early identification and treatment can help prevent serious complications for both pregnant individuals and their infants.

Health issues linked to cosmetic jab complications

A study by Anglia Ruskin University found that patients with underlying conditions such as type 1 diabetes are at a significantly higher risk of complications from cosmetic botulinum toxin injections. The researchers recommend restricting administration to medically qualified professionals.

Newly discovered gut microbial molecules in infancy may influence the risk of type 1 diabetes

A study of over 300 stool samples found that gut-microbe-derived bile acids may play a role in shaping the immune system during early childhood. The findings suggest an imbalance in how gut microbes co-produce these compounds, which could link to signs of type 1 diabetes.

Reprogramming immunity to rewrite the story of Type 1 diabetes

Researchers at the Medical University of South Carolina are developing a new therapy for Type 1 diabetes that combines stem cell biology, immunology, and transplantation science. The goal is to restore beta cell function and insulin production in people with T1D without using immunosuppressive drugs.

Predicting who is at risk of developing type 1 diabetes, as new drugs now available

A genetic risk score test can predict who is at highest risk of developing type 1 diabetes and identify adults eligible for new drug teplizumab. The test identifies those in the top ten percent as eight times higher risk, enabling early intervention and treatment.

New UCF mobile health clinic increases access to care

The UCF Health Mobile Health Clinic provides free high-quality healthcare services to underserved communities, serving as a real-world classroom for medical and nursing students. The clinic aims to reduce preventable conditions and improve long-term health through comprehensive screenings, chronic disease monitoring, and education.

People with diabetes face higher risk of sudden cardiac death

A large study found that people with type 1 and type 2 diabetes have a higher risk of sudden cardiac death, particularly in younger adults. The research also showed that sudden cardiac death contributes to shorter life expectancy for those with diabetes.

Individuals with diabetes are more likely to suffer complications after stent surgery

A nationwide observational study from SWEDEHEART reveals that patients with type 1 diabetes have a significantly higher risk of stent complications compared to those without diabetes. The study emphasizes the need for adapted treatment and follow-up strategies for this patient group.

The future of type 1 diabetes: Can stem cells provide a cure?

Researchers explore innovative avenues for regenerating functional β-cells using stem cells and pancreatic progenitor cells. The dual approach of activating endogenous progenitors and transplanting externally differentiated cells represents a powerful, scalable strategy for T1D management.

Possible therapeutic approach to treat diabetic nerve damage discovered

Researchers at University of Cologne identify p35-mediated CDK5 hyperactivity as a central mechanism limiting nerve regeneration in diabetes. Targeted interventions using peptides restore nerve fiber growth, leading to significant motor and sensory improvements.

New report presents recommendations to strengthen primary care for Latino patients with chronic conditions

The report emphasizes the importance of pairing research with policy partners and investing in mentorship and career advancement of Latino scientists and students. It also calls for implementing evidence-based practices, using telemedicine and AI equitably, and designing trauma-informed interventions that fit Latino family life.

Immune cells ‘caught in the act’ could spur earlier detection and prevention of Type 1 Diabetes

A new study has caught immune cells 'in the act' in pancreatic lymph nodes, suggesting an early onset of Type 1 Diabetes. The researchers identified a unique subset of CD4 T cells that ramp up two proteins, NFKB1 and BACH2, turning genes on and off to rev up the immune attack on insulin-making cells.

USC study suggests type 1 diabetes may significantly raise bladder cancer risk

Researchers found a significant link between type 1 diabetes and an increased risk of bladder cancer, with people being 4.29 times more likely to develop the disease. The new analysis controlled for tobacco smoking, a factor that obscured the heightened risk in earlier studies.

Type 1 diabetes cured in mice with gentle blood stem-cell and pancreatic islet transplant

Researchers at Stanford Medicine have successfully transplanted a hybrid immune system into mice with Type 1 diabetes, preventing the disease from progressing. The approach involves adding a drug to the pre-transplant regimen, which resulted in all mice being cured or prevented from developing the disease.

Improving health during pregnancy for those with Type 1 diabetes

A new insulin delivery technology has been found to improve glucose control during pregnancy for women with Type 1 diabetes, reducing the risk of complications for both mother and baby. The study, led by University of Calgary researchers, found that this technology resulted in a three-hour per day improvement in the desired glucose ran...

Sons of mothers with type 1 diabetes show early signs of vascular dysfunction

A new study reveals that sons born to mothers with type 1 diabetes show early signs of vascular dysfunction in their blood vessels, even before metabolic health is affected. The research suggests that this sex-specific effect could help clinicians assess risk and prevent cardiovascular disease earlier in life.

New milestone towards personalized prevention of type 1 diabetes

The POInT trial reveals promising secondary findings: oral insulin delays clinical type 1 diabetes progression, especially in children with high-risk insulin gene variants. This opens doors to targeted, personalized prevention strategies for a genetically defined subgroup of children.