Articles tagged with Central Nervous System
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
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Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
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Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
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Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers have uncovered a new understanding of how cardiac events are interconnected with the brain and nervous/immune systems. They found that sensory neurons in the vagus nerve detect injury and transfer signals to dedicated brain structures, leading to activation of the immune system.
Researchers developed miniature 3D tumor organoid models that closely mimic the human brain, revealing how glioblastoma interacts with surrounding brain cells and immune system. The models identified PTPRZ1 as a key regulator of tumor behavior, which helps determine its aggressiveness.
Research finds that nearly one in four Medicare beneficiaries with dementia are prescribed potentially harmful medications linked to falls, confusion, and hospitalization. Despite declines in prescribing rates, high levels of inappropriate prescribing persist among older adults with cognitive impairment.
A study found that older adults are prescribed potentially inappropriate central nervous system-active medications despite guidelines. Patients with cognitive impairment were more likely to receive these medications than those with normal cognition. The study highlights the need for better medication management in older adults.
Dr. Maria Margarita Behrens' work deciphers the molecular signatures defining every human brain cell type, shedding light on neural development and psychiatric disorders. Her single-cell epigenomic atlases will enable researchers to target specific cell types with unprecedented precision.
Researchers tested Spatial Computing theory by examining neural activity and brain wave patterns in animals performing working memory and categorization tasks. The findings support the theory's predictions, including that alpha/beta waves represent task controls and rules, while spiking activity carries sensory information.
A newly discovered neural pathway connects the amygdala with arousal centers in mice, revealing a key mechanism for emotional regulation of sleep-wake cycles. This finding highlights potential therapeutic targets for stress-related insomnia and mood disorders.
Research from Colorado State University sheds light on the regulation of chemical balance in the brain, focusing on GABA, a neurotransmitter that helps calm brain activity. The study provides insights into how neurons maintain effective communication with each other, even when GABA is produced far from synapses.
A study published in JAMA Network Open found that older adults with chronic kidney disease or cerebrovascular disease are at double the risk for developing neuroinvasive West Nile virus infection, which can lead to paralysis and death. The study identified several risk factors, including male sex, immune suppressants, and multiple scle...
Researchers found that increased activity of a specific protein in the brain can alter learning processes associated with rewards. This discovery may lead to better treatments for conditions like addiction and depression.
Researchers at Pitt and UPMC Children's Hospital discovered a biomarker of complicated pediatric traumatic brain injury, which may serve as dynamic indicators of post-injury recovery. The study found that children with TBI had a different epigenetic profile compared to those with orthopaedic injuries.
Researchers found that the prefrontal cortex sends customized signals to visual and motor regions, influencing their activity based on arousal levels and movement. The study reveals distinct roles of prefrontal subregions in shaping visual processing, with one region enhancing stimuli detection and another dampening irrelevant stimuli.
Researchers at Tulane University discovered a new nerve cell signaling mechanism that can turn on pain signaling after injury, potentially leading to safer treatments. The discovery of enzyme vertebrate lonesome kinase (VLK) offers a new way to influence cell behavior and could simplify drug development.
According to Miller, brain waves sculpt the flow of information in the cortex, enabling volitional control of thought. The cortex organizes itself through analog computation, leading to consciousness as a unified awareness of thought and experience.
A recent study found that multilingual individuals experience slower biobehavioral aging compared to monolinguals. The study analyzed data from 86,149 participants across Europe and showed that multilingualism is associated with a lower risk of accelerated aging.
Researchers have demonstrated that doxycycline can improve survival rates and neurological outcomes in children with Central Nervous System Tuberculosis. The study found that treating CNS-TB laboratory models with doxycycline alongside standard TB drugs suppressed inflammation, preserved brain tissue, and improved vascular integrity.
Researchers found that a rotating brain wave helps the cortex recover its computational path after a distraction, improving performance in visual working memory tasks. Longer time intervals between distractions also aid recovery.
A multidisciplinary research team discovered that liver alterations associated with metabolic dysfunction can cause cognitive and neurological impairments. The effects were reversed by a therapy targeting the liver, establishing a 'liver-brain axis'. This finding opens up new therapeutic avenues for treating metabolic liver disease.
A groundbreaking study in The American Journal of Pathology reveals a perineural pathway that enables HIV-infected immune cells to redistribute throughout the body, sustaining inflammation. The findings highlight the importance of the connection between the central nervous system and peripheral nervous system in immunity.
The researchers are studying how brief, playful social interactions affect brain function and cognitive performance in older adults using advanced brain imaging techniques. They aim to develop simple and inexpensive interventions that can be implemented in clinical settings and in the community.
Graz University of Technology and the University of Regensburg are conducting research on the interaction of cell types at the blood-brain barrier, with a particular focus on sex-specific differences in depression. The study aims to identify mechanisms contributing to depression and develop targeted therapies.
A large-scale international study found that creative experiences slow brain aging and promote healthier brain function. Creative activities such as music, dance, and video games were linked to 'younger' brain profiles, particularly in regions vulnerable to neurodegeneration.
The brain divides vision between its two hemispheres to enable seamless perception. Researchers at the Picower Institute found that different frequencies of brain waves are encoded and transferred information from one hemisphere to the other before an object crosses the middle of the field of view.
A study published in Science Advances reveals that an autism-linked mutation disrupts brain circuits responsible for erasing fear memories, leading to PTSD-like symptoms. By reactivating specific neurons, researchers were able to reverse the behavioral and physiological abnormalities.
Research found that cumulative exposure to factors like low education, childhood trauma, and financial stress negatively impacts brain structure and function. This has long-lasting effects on mental and brain health, even in healthy aging and dementia prevention.
The Mount Sinai Hospital has relocated its inpatient services to a newly renovated space at Mount Sinai Morningside, featuring lifts, larger rooms, and state-of-the-art equipment. The new facility aims to enhance care for patients with various rehabilitative needs, including brain and spinal cord injuries.
A team of researchers has developed a mathematical model that integrates sensory feedback to enable eel-like robots to swim and crawl on land. The study shows how multisensory feedback enables eels to adapt their movement patterns after spinal cord injury, providing insights into the evolutionary transition of vertebrates from water to...
A new exosome-based therapeutic agent has been developed to treat traumatic CNS injuries, alleviating neuronal apoptosis and restoring glial homeostasis. The treatment, SeNExo, promotes neuronal repair and reduces oxidative damage, showing potent therapeutic benefits in mouse models.
Researchers evaluated clinical outcomes of endoscopic resection in sellar chondrosarcomas, revealing common symptoms like blurring of vision and headaches. The study also provides recommendations for accurate diagnosis using imaging data and clinical features.
Researchers at Beijing Tiantan Hospital developed a one-stage hybrid operation to treat hypervascular CNS tumors, achieving high rates of gross-total removal and improved neurological function. The technique combines embolization and resection in a single procedure, reducing intraoperative bleeding risk and operative time.
The new book Spinal Surgery Biomechanics: Principles for Residents offers a comprehensive exploration of core biomechanical concepts essential for mastering spinal surgical procedures. It bridges the gap between theory and practice, providing a biomechanical framework that supports surgical planning and patient safety.
Researchers found that astrocytes maintain optimal levels of GABA to enable neural groups to process visual information efficiently. Knocking out Gat3 in mice impaired neuron coordination and reduced ensemble activity, highlighting the importance of astrocytic regulation.
A research team led by Virginia Tech's Fralin Biomedical Research Institute is working on a technique that uses focused ultrasound to deliver creatine directly to the brain. This method aims to restore normal brain mass in models of creatine deficiency, which can impair brain development and lead to severe cognitive challenges.
Hideyuki Okano has been elected President of the International Society for Stem Cell Research (ISSCR), an organization dedicated to promoting excellence in stem cell science. He will champion inclusive excellence, advance discovery, and ensure that the transformative promise of stem cell science benefits the world.
Dr. Danielle Beckman's research uses animal models to understand how viruses like COVID-19 trigger neurological damage and accelerate Alzheimer's disease. Her work has established critical connections between viral infections and neurodegenerative processes.
A new study published in PLOS Biology found that non-invasive brain stimulation can improve maths learning outcomes for individuals with weaker brain connectivity between the dorsolateral prefrontal cortex and the posterior parietal cortex. The treatment also showed positive effects on GABA levels, a brain chemical involved in learning.
Scientists have developed a new multiscale modeling approach that can simulate how microscopic changes affect macroscale brain activity. The framework successfully predicted the effects of anesthesia on synaptic receptors, bridging the gap between molecular and whole-brain levels.
A recent study has discovered a connection between brain damage and an increased likelihood of committing crimes. The research, led by Harvard Medical School and the University of Colorado Anschutz Medical Campus, found that damage to the right uncinate fasciculus was linked to criminal behavior.
A brain age gap refers to the difference between predicted age and actual chronological age. The study found that higher cognitive impairment risk factor scores were consistently associated with poorer cognitive performance, especially in areas like executive function and language. Researchers developed a brain age prediction model to ...
The new edition of Mark Bear's neuroscience textbook emphasizes accessibility and excitement, presenting the hard science without making it hard. The book features over 100 'Path of Discovery' essays by prominent neuroscientists, including several Nobel prize winners.
Dr. Sophia Shi's groundbreaking research reveals that the glycocalyx deteriorates with age, leading to blood-brain barrier dysfunction and cognitive decline. Her work provides concrete molecular targets for drug development and may lead to treatments that address the root causes of neurodegeneration.
Researchers have discovered a novel cell-clearance pathway linked to diseases such as Chediak-Higashi Syndrome, which affects immune system function. The study used CRISPR/Cas9 gene-editing technology and live imaging to characterize this pathway and identify key genes involved.
Researchers discovered that the brain's retrosplenial cortex (RSC) encodes competing navigation hypotheses in distinct neural activity patterns. These patterns allow animals to choose the correct path despite ambiguity, and can be used to compute how to reach a reward.
Researchers have discovered a new method to enhance brain waste clearance by precisely stimulating the lymphatics under skin on the neck and face. This non-invasive approach may offer a safer alternative to current treatments for age-related neurological disorders, such as Alzheimer's disease.
The study reveals that white matter microstructure in infants' brains between 3-9 months predicts their emotional development. Infants with certain brain patterns are more likely to exhibit negative emotions or improved self-soothing abilities.
Research highlights potential link between microplastics in ultra-processed foods and brain health, with possible connections to depression and dementia. The studies propose a novel hypothesis connecting ultra-processed food consumption, microplastic exposure, and mental health outcomes.
Researchers from Mass General Brigham have identified a key predictor of stroke risk among women: brain health scores. Women with higher McCance Brain Care Scores (BCS) had a reduced risk of experiencing a cerebrovascular event, with those with a five-point higher baseline score being 37% less likely to experience an event.
A new technique using focused sound waves and microbubbles has shown great promise in treating debilitating brain lesions called cerebral cavernous malformations. The approach has halted the growth of lesions almost entirely, offering a potential paradigm shift in treatment.
Researchers discovered that the brain suppresses the current action without using another mechanism to inhibit it, enabling seamless transitions between actions. This finding could lead to the development of biologically-inspired robotic systems and improve clinical treatments for Parkinson's patients.
A new AI model developed by Uppsala University accurately diagnoses multiple sclerosis (MS) with an overall accuracy of 90%, identifying the transition from relapsing-remitting to secondary progressive MS in almost 87% of cases. This enables earlier diagnosis, reducing the risk of patients receiving ineffective medicines.
Scientists at St. Jude Children's Research Hospital discovered FOXR2 activation in multiple pediatric CNS tumor types, including high-grade gliomas and pineoblastomas, with significantly different clinical outcomes. The study highlights the importance of combining molecular findings with other diagnostic approaches to improve treatment...
A review article reveals CD2AP's crucial role in amyloid metabolism, tau pathology, synaptic function, and neuroinflammation in Alzheimer's disease. CD2AP deficiency accelerates plaque formation, while its loss in neurons leads to reduced spine density and impaired synaptic plasticity.
A recent SFU study reveals how indirect brain damage affects thalamus function after a stroke, potentially leading to new treatments. Researchers found that the amount of damage to the thalamus correlates with the level of impairment in patients.
Researchers investigated neural mechanisms of stress-induced cardiovascular responses by activating lateral habenula in rats. Activation caused changes in blood pressure and heart rate, which were suppressed by pharmacological blockade of dopamine neurotransmission.
The InteReg project aims to create interactive biomaterials that instruct cells to regenerate after brain or spinal cord injuries, potentially treating MS and other neurological disorders. The project, funded by the Carl Zeiss Foundation, brings together experts in biology, chemistry, medicine, and polymer research.
The Deutsche Forschungsgemeinschaft is establishing seven new Collaborative Research Centres (CRC) with a total funding of €92 million. The CRCs focus on innovative research projects in sustainable construction, electronic systems, and ecosystem services. Seven new Transregios are also being funded to tackle long-term challenges.
Researchers at the University of Arizona Health Sciences have identified a potential new drug, PNA5, that targets cognitive symptoms in Parkinson's disease. The study found that PNA5 dials back inflammation in brain cells, which may prevent further degeneration and alleviate cognitive decline.
Research finds that adults outperform children in learning new motor skills, with older individuals improving faster and retaining skills longer. Better sleep appears to benefit children's learning and memory more, but other factors like sleep deprivation may also play a role.
A comprehensive evidence review on tethered spinal cord found that while surgery can benefit symptomatic patients, data for asymptomatic patients is lacking. The study also highlights the need for more research into conservative management and potential risks of surgical complications.
Scientists have identified a key driver of brain inflammation in neurological diseases, proposing a new treatment approach by neutralizing fibrin. This protein, involved in blood coagulation, triggers neurologic diseases by hijacking the immune system, resulting in damaged neurons.