Articles tagged with Lymphatic System
A Hospital for Special Surgery (HSS) study has identified a previously unknown role for skin immune cells in shaping the development of the lymphatic system. Langerhans cells play a critical role during early life in helping lymphatic vessels grow and develop properly, influencing lifelong immune function.
A large-scale study developed a predictive model for Lymph Node Metastasis (LNM) status in T1b gastric cancer using digital pathology and deep learning. The DL-T1 nomogram achieved an AUC of 0.910, indicating high accuracy in predicting LNM risk.
A new study from the University of Lausanne identifies a specific subset of fibroblasts that produce Ccl19, an 'attractant signal' for cytotoxic T lymphocytes, bringing them into contact with type 1 dendritic cells. This mechanism is essential for proper immune cell organization and function.
A study by the Alliance Foundation Trials shows that combining immunotherapy and chemotherapy before surgery can help more patients with locally advanced non-small cell lung cancer undergo complete cancer resection, improving their long-term health. The treatment also led to high rates of lymph node clearance and successful surgical re...
Researchers at Ohio State University Wexner Medical Center are refining specialized lymphatic microsurgery techniques to treat and prevent lymphedema. The new procedures, including lymphatic bypass and lymph node transfer, offer patients more options and improved quality of life.
Researchers redesigned a key component of lipid nanoparticles to steer particles toward lymph nodes, reducing off-target delivery. This advancement could make mRNA vaccines more efficient, potentially achieving strong immune protection at lower doses.
The LeaN On platform offers a 12-step journey to educate users on lymphoedema signs, actions, and when to seek professional support. It will be tested in a research project to evaluate online lymphoedema support, including nurse-supported and self-directed options.
A team of researchers led by Rice University bioengineer Omid Veiseh is developing a first-of-its-kind regenerative treatment aimed at restoring damaged lymphatic vessels and potentially curing lymphedema. The therapy, called ELIXIR, uses engineered human retinal pigment epithelial cells to rebuild broken lymphatic vessels.
Researchers at WashU Medicine have found that disrupted lymphatic vessels may trigger chronic organ rejection in transplanted lungs and hearts. The study suggests that preventing hyaluronan buildup or restoring lymphatic drainage could prevent fibrosis and long-term damage.
Researchers at Columbia University Irving Medical Center will create genetic tests to diagnose congenital lymphatic disorders, aiming to improve treatments and save lives. The CLARUM project aims to identify new genetic mutations and increase the predictive value of genetic testing for these diseases.
A research team at Tohoku University has made a groundbreaking discovery about the anatomy of lymph nodes, revealing new structures that challenge traditional ideas about immune system function. The findings have significant implications for understanding and treating conditions like lymphedema and cancer.
Researchers will create a new modality called Phase Change Ultrasound Lymphograph to super-resolution map lymphatic structures, providing quantitative information on anatomy and function. The device aims to screen for lymphatic abnormalities and guide treatment decisions.
Researchers developed bioengineered lymphatic tissue (CeLyT) that restored functional lymph nodes in mice with secondary lymphedema. CeLyTs improved lymphedema symptoms by restoring lymphatic flow, filtration capacity, and immune cell populations.
Researchers are developing a comprehensive approach to diagnosing lymphatic disease, which is challenging due to the system's tiny and translucent vessels. The team aims to create a diagnostic toolbox that includes biomarkers, genetic analysis, and advanced detection technologies.
The Rice University's SynthX Center has received a $18 million award from ARPA-H to develop innovative solutions for lymphatic diseases. The project aims to enable early, high-resolution imaging and biomarker-based diagnostics to facilitate accurate diagnoses and improve patient outcomes.
Researchers found that patients with low physical activity levels are at higher risk of developing lymphedema. The study used a lymph scanner to measure tissue water and identified limits for what is considered lymphedema. Regular physical activity may help reduce the risk of lymphedema after head and neck cancer treatment.
Researchers discovered breast cancer modifies lymphatic vessels to facilitate its spread. A specific protein, Matrix Gla protein (MPG), enables cancer cells to bind to lymphatic vessels, supporting metastasis. Understanding this process could lead to targeted therapies and improved patient outcomes.
Researchers at the Medical University of South Carolina have identified a previously unknown hub in the brain's lymphatic drainage system, which helps remove waste from the brain. The study provides evidence of a slow-moving fluid flow through true lymphatic vessels, rather than blood vessels.
Researchers suggest chemotherapy drugs may be responsible for 'chemo brain' symptoms, citing reduced lymphatic vessel growth and impaired cognitive function. The study highlights the need to consider long-term neurological side effects of cancer treatment on quality of life.
A study published in The New England Journal of Medicine found that nearly 4 million children and adolescents were at higher risk of developing blood cancers due to radiation exposure from medical imaging. The researchers estimated that up to 10% of pediatric blood and bone marrow cancers may be attributable to radiation exposure.
Researchers from Weizmann Institute of Science and Sheba Medical Center identified two drugs with the potential to treat KLA, a rare genetic disorder affecting the lymphatic system. The study used transparent zebrafish embryos to decipher the disease mechanism and find effective treatments.
Researchers identified three distinct molecular subtypes of follicular lymphoma, offering insights into personalized treatment plans. The subtypes C1, C2, and C3 differ in their genetic profiles and tumor microenvironments, guiding the use of specific therapies.
Researchers have discovered a new method to enhance brain waste clearance by precisely stimulating the lymphatics under skin on the neck and face. This non-invasive approach may offer a safer alternative to current treatments for age-related neurological disorders, such as Alzheimer's disease.
A new study found that chronic cannabis use, whether smoked or consumed as edibles, is associated with significant cardiovascular risks. People who regularly used marijuana had reduced blood vessel function comparable to tobacco smokers.
A new study reveals the molecular mechanism of lymph node metastasis in gallbladder cancer, identifying eEF1A2 and its K36 trimethylation as prognostic markers. The EEF1AKMT4-eEF1A2K36me3 axis promotes ribosome protein synthesis, enhancing tumor growth and metastasis.
Researchers at WashU Medicine have found that rejuvenating the network of vessels outside the brain can improve memory in old mice. The study lays the groundwork for developing therapies to overcome the challenges faced by conventional medications, which struggle to reach the brain due to the blood-brain barrier.
Researchers have found that the unique shape of lymphatic vessel endothelial cells allows for efficient absorption and transport of fluids while withstanding sudden changes in tissue fluid volume. This distinctive cell shape is also seen in plant leaves, where it helps support structural stability.
Researchers at Tufts University have developed a cancer vaccine that amplifies the visibility of tumor antigens to the immune system, leading to potent responses and lasting immunological memory. The vaccine works against multiple solid tumors in animal models, including melanoma, triple-negative breast cancer, and ovarian cancer.
A team of researchers at USC will receive funding to test a novel approach to slowing age-related cognitive decline, targeting the brain's lymphatic system. The grant aims to delay the onset of Alzheimer's and Parkinson's disease by clearing waste buildup.
Researchers developed a new imaging technique using shortwave-infrared (SWIR) imaging to visualize the lymphatic system, improving resolution and sensitivity compared to traditional near-infrared (NIR) imaging. SWIR imaging with silver sulfide quantum dots offers superior image resolution and outperforms NIR-I imaging techniques.
The underwater endoscopic mucosal resection (UEMR) technique demonstrates promising outcomes in the treatment of gastrointestinal neuroendocrine tumors, particularly in rectal tumors. UEMR achieves complete histological resection at a lower cost with minimal requirement for advanced endoscopic skills.
Researchers successfully restored the brain's waste-clearing process by reviving cervical lymph vessel function in aging mice, utilizing a known drug to boost efficiency. This breakthrough could pave the way for future therapies targeting neurodegenerative diseases.
Patients with mantle cell lymphoma are more vulnerable to other diseases and infections due to intensive chemotherapy and a weakened immune system. A large-scale national study found that MCL patients had twice as many infections as reference subjects, with common causes including influenza and urinary tract infections.
Researchers created a tiny 3D cell culture model that mimics the function of lymphatic vessels to explore how inflammatory substances affect the lymphatic system. They found that certain cytokines cause cells to tighten their junctions, leading to reduced fluid drainage and swelling. Inhibiting a protein called ROCK2 reversed lymphedem...
A new MU study found that APRNs recognize the importance of breast cancer survivorship care and can benefit from standardized education. The findings suggest that formalizing education on breast cancer survivorship could lead to improved healthcare for patients, including symptom management, monitoring, and follow-up appointments.
Researchers develop a new technique to detect circulating tumor cells in blood, overcoming noise issues with existing methods. The dual-ratio approach enhances penetration range and accuracy, paving the way for quicker diagnosis of metastasis.
A team from Osaka University has uncovered the importance of Polydom and Tie1 in cell migration during lymphatic vessel remodeling. The study found that binding between these proteins facilitates lymphatic endothelial cell migration, highlighting a crucial role in lymphangiogenesis.
Researchers at Washington University in St. Louis have found a way to enhance glymphatic transport using focused ultrasound with microbubbles, opening new opportunities for studying brain diseases and function. The non-invasive method shows promise for potentially mitigating neurodegenerative diseases like Alzheimer's and Parkinson's.
Researchers developed a microfluidic model of vascular malformation caused by PIK3CA mutation, allowing them to study disease mechanisms and test treatment efficacy. The model successfully replicated the disease's manifestations and responded to alpelisib, a newly approved PIK3CA inhibitor.
Scientists made a groundbreaking discovery that lymphatic vessels can produce both red and white blood cells, challenging the long-held belief that blood cells come solely from bone marrow. The study suggests that lymphatic vessels may play a role in fighting infection and could be important for treating certain blood cancers.
A study found that resiliency and family support play a crucial role in helping Hispanic breast cancer survivors manage lymphedema. Adaptations such as modifying work tasks and seeking support from family members enable survivors to maintain their quality of life.
Researchers at Washington University School of Medicine have discovered a new pathway that could help prevent Alzheimer's dementia. Increasing the clearance of waste products in the brain by ramping up a genetic quirk known as readthrough may be effective for other neurodegenerative diseases, such as Parkinson's disease.
Researchers developed a new anti-cancer drug LP-182 that simultaneously targets two molecular signaling pathways responsible for cancer growth. The drug is absorbed through the gut's lymphatic system, maintaining optimal therapeutic levels over time.
Researchers created a new device called the lymphangion-chip, which models a section of a lymph vessel and can recreate conditions such as lymphedema. This innovation could lead to better understanding of mechanical forces regulating lymphatic physiology and pathophysiology.
Researchers at MUSC and University of Florida successfully visualize the complete human brain lymphatic system in living humans using a new non-invasive MRI technique. This breakthrough enhances our understanding of brain function and may provide insights into neurodegenerative diseases such as Alzheimer's.
Researchers have developed a way to restore dysfunctional lymphatic networks using hydrogels made from hyaluronic acid. This allows the body to better defend itself against diseases such as cancer, cardiovascular disease, and diabetes. The study's findings have been published in The FASEB Journal.
Researchers at Children's Hospital of Philadelphia (CHOP) resolved a severe lymphatic disorder in a girl with Noonan Syndrome by targeting the SOS1 gene pathway. The treatment, an MEK inhibitor, led to a resolution of symptoms within three months and complete remodeling of her lymphatic system.
A new vasculogenic niche contributes to cardiac lymphatic system development, with cells originating from different tissues. The coronary lymphatic vessels have varied origins and functions.
Researchers found that injections of a novel protein called VEGF-C 152S reduced artery blockage by about 30% and made plaque more stable, potentially reducing strokes. The protein targets the lymphatic system, which is understudied in atherosclerosis.
A new mouse model shows enhancing lymph vessel formation via VEGF-D stimulation in obese adipose tissue has beneficial anti-inflammatory and metabolic effects. This approach may provide a new target for ameliorating the metabolic syndrome associated with obesity.
Researchers will investigate the GI lymphatic system's impact on diabetes reversal after bariatric surgery. The five-year grant aims to shed light on the mechanism involved in reversing diabetes through disruption of lymphatic circulation in an animal model.
Researchers at Lund University discovered a link between a growth factor in the lymphatic system and an increased risk of heart failure. The marker, VEGF-D, affects fluid removal from the body, particularly in women.
A new study reveals that tuna's precise control over their fins is enabled by the hydraulic activity of their lymphatic system. This specialization is also observed in other scombrid species, suggesting an evolutionary adaptation to high-performance swimming needs.
Researchers from CHOP and Penn Medicine found that leakage from the liver's lymphatic system causes protein-losing enteropathy in single-ventricle heart disease patients. A novel intervention to seal off leaks improves symptoms and quality of life for these patients.
A crucial protein called Polydom is essential for developing a functioning lymphatic system. The protein promotes signaling by the Angiopoietin-2-Tie1/Tie2 pathway, which is vital for lymphatic vasculature maturation.
A new biotherapy has been developed to stimulate the creation of new lymphatic vessels in the heart, reducing oedema and inflammation. This innovative approach has shown significant promise in improving cardiac function following a myocardial infarction.
Weizmann Institute researchers resolved the debate on lymphatic system origins, discovering that lymphatic cells grow from a niche within embryonic veins. They also identified a key gene, WNT5B, which prompts stem cells to differentiate into lymphatic cells.
A Cornell University study reports for the first time how arteries form in the embryonic gut and guide the development of the lymphatic system, providing a new avenue to explore treatments for cancer metastasis and gut-specific lymphatic diseases. The research links a master-regulator gene, Pitx2, to artery and lymphatic formation.
Lymphedema is a disease with no cure and little hope for sufferers, where the body fails to circulate lymphatic fluid leading to swelling and permanent tissue remodeling. A new engineering approach may lead to new technologies to test and treat lymphatic disease.
Scientists identify glymphatic system as a potentially powerful tool for treating neurological disorders like Alzheimer's disease. The system is responsible for removing waste from the brain, and its dysfunction may contribute to these conditions.