Articles tagged with Lungs
A UK-led clinical trial found that surfactant treatment offers no benefit for infants on life support with severe bronchiolitis. The treatment was designed to improve recovery for critically ill babies, but the evidence does not support this.
A new study reveals that p38 MAPK plays a key role in epigenetic regulation of fibrotic genes in lung fibroblasts, particularly in senescent cells. Pharmacological inhibition of p38 MAPK significantly reduced α-SMA and Col3A1 expression, suggesting a potential therapeutic target for treating age-related fibrotic diseases like IPF.
Researchers found that exposure to microbes induces a lasting immune memory in fibroblasts, protecting lungs from allergic reactions for months. This discovery opens up new possibilities for developing preventive strategies for respiratory allergies.
A new study has confirmed that male and female lungs are wired differently at the molecular level, revealing key gene networks driving sex differences in respiratory health. The research found that male lungs are more reactive to environmental triggers, leading to different disease experiences between sexes.
Inhaled polystyrene nanoparticles induce lung injury by disrupting redox balance and triggering inflammation. Oxidative stress leads to mitochondrial dysfunction, respiration impairment, and apoptosis in lung cells.
A new study from National Jewish Health reveals that exposure to burn pit smoke and desert dust can damage the lungs of military service members. The research found that particles linked to burn pit exposure cause stronger inflammation and stress in lung immune cells, leading to chronic breathing problems.
A study published in EBioMedicine found changes in blood samples from almost 1,000 people hospitalized for COVID-19 may pinpoint patients at risk of long-term lung disease. The study identified elevated levels of certain molecules, which could lead to the development of simple blood tests to detect ongoing lung problems.
Researchers have made a groundbreaking discovery about how bacteria swim upstream to cause infections, pointing to new designs for biomedical devices that can prevent contamination. The study found that wider channels with faster counterflows are more prone to invasion, but sharp corner designs can inhibit bacterial growth.
A study found that lung microbiomes play a significant role in pneumonia, with patients having oral-like pneumotypes more likely to recover. The researchers identified four distinct microbial patterns, or 'pneumotypes,' associated with different types of pneumonia.
Researchers create a simple, automated way of making lung organoids, which could help test early-stage experimental drugs more effectively. The bioreactor produces larger numbers of organoids with fewer manual labor requirements, offering promise for personalized patient treatments.
A European consortium developed a new decision-making framework to predict COPD exacerbation severity and prognostic risk, integrating three key factors: baseline health status, event intensity, and triggers. This framework, known as BAt model, aims to guide treatment strategies and improve consistency across clinical settings.
A cross-sectional survey of 29,268 participants found a significant association between dysfunctional breathing and respiratory conditions, as well as non-respiratory diseases like epilepsy. Tobacco use was also linked to increased prevalence of DB, particularly among those with comorbidities.
A recent study led by Dr. Leah Backhus found that lung cancer patients often receive inadequate posttreatment surveillance, which can lead to a substantial gap in care. The study estimated the true surveillance rates and predictors of guideline-concordant care in patients with early-stage non-small cell lung cancer.
A new study identifies fatty acid elongase ELOVL5 as a key promoter of inflammation resolution in the lungs. The research reveals that ELOVL5 works through a dual mechanism to dampen inflammatory pathways and generate pro-resolving lipid signals.
Researchers found that tubeless anesthesia significantly reduces postoperative complications, promotes enhanced recovery, and lowers costs in selected patients. The study also showed improved respiratory function and reduced intubation times.
The study demonstrated that nebulized HL231 at 261 µg/141 µg dose achieved comparable bronchodilation efficacy, pharmacokinetic profiles, and safety outcomes to Ultibro. HL231 showed a clear dose-response relationship with predominantly mild-to-moderate adverse events.
Researchers at UC Riverside discovered that two toxic chemicals can form when propylene glycol is heated, harming human lung cells. The chemicals, methylglyoxal and acetaldehyde, disrupt cell functions and cause damage even at low levels.
A new Northwestern University study reveals that abnormal cells in transplanted lungs engage in harmful 'conversations' with the immune system, leading to damage and rejection. The findings provide a comprehensive roadmap for treating chronic lung allograft dysfunction and other scarring lung diseases.
UCSF researchers found a key cellular switch driving pulmonary fibrosis and developed a new therapy to block it in mice. The treatment works by preventing healthy lung cells from converting to harmful cell types, reducing scarring and improving lung function.
The American College of Chest Physicians has designated October 19, 2025, as 'Love Your Lungs Day' in recognition of respiratory health. This initiative aims to raise awareness about lung diseases such as asthma and COPD, promoting equity and supporting healthcare providers.
Researchers aim to determine if biomarkers can identify adults at risk of developing interstitial lung disease (ILD), a chronic condition that causes inflammation and scarring in the lung tissue. The approach could lead to the development of new, better treatments with more tolerable side effects.
Denis Evseenko and Toby Maher are developing a regenerative drug to block cells that promote fibrosis in the lungs, aiming to slow or reverse IPF damage. The team plans to test the safety and therapeutic potential of their drug-like molecules in animals and human cells.
A new study from Trinity College Dublin finds that dexamethasone can reduce inflammation in TB patients while enhancing the function of their macrophages to kill Mycobacterium tuberculosis. The research suggests using steroids as an adjunct therapy in conjunction with existing treatments, particularly in cases with excessive inflammation.
A study found that people whose fathers began smoking at age 15 or younger show signs of faster biological aging compared to chronological age. This accelerated aging is linked to a higher risk of diseases such as cancer, arthritis, and dementia. The researchers call for stronger efforts to prevent tobacco use in teenagers.
Research shows that remote monitoring of children's asthma can prevent hospitalizations by around 57%. The system helps keep symptoms under control, leading to better outcomes and lasting self-management skills. This innovative approach could revolutionize healthcare services for patients with asthma.
Research presented at the European Respiratory Society Congress found that a healthy diet rich in fruits and vegetables can partially mitigate the adverse effects of air pollution on lung function. Women who consumed four portions of fruit per day or more appeared to have smaller reductions in lung function associated with air pollution.
Congenital diaphragmatic hernia is a deadly malformation of the lungs and diaphragm that causes underdeveloped lungs, leading to high mortality rates. Researchers discovered increased numbers of inflammatory cells in human lung tissue, both before and after birth, which may influence lung structure development.
A new study found that inhaling marijuana daily is associated with a 44% increased chance of developing asthma. Experts say people should avoid inhaling cannabis to reduce the risk of chronic lung disease. The study's authors emphasize the need for clearer messages about the risks of cannabis use.
Researchers at Tulane University have developed an enhanced CRISPR-based tuberculosis test that works with a simple tongue swab, detecting TB in samples with very low levels of bacteria. The new test shows high sensitivity and accuracy, offering a significant step forward toward effective diagnoses via a variety of samples.
Researchers at UCalgary have found that neurons play a critical role in reducing harmful lung inflammation, which leads to pulmonary fibrosis. The discovery opens up opportunities for using neurological therapies to treat the disease, and preliminary studies suggest that boosting the function of these nerve cells could improve scarring.
A state ban on flavored e-cigarettes may lead to a net negative effect on health for young adults, increasing traditional cigarette use while reducing vaping. The study found that comprehensive bans had no impact on tobacco participation among adults aged 25 and older.
A comprehensive state ban on flavored e-cigarettes leads to a decrease in vaping among young adults aged 18–24 years by about 2–3 percentage points, while increasing traditional cigarette use by a similar amount. For youth under 18, there is suggestive evidence of an increase in cigarette use, undermining broader tobacco control efforts.
A new study will investigate whether low levels of the lung protein CC16 in childhood can predict who will develop early chronic obstructive pulmonary disease (COPD) later in life. The five-year study aims to identify children at risk for early COPD and potentially intervene to prevent lung disease.
The project aims to develop novel, interpretable biomarkers using advanced artificial intelligence to overcome limitations in current diagnostic tools. The team will integrate multi-modal data and biomechanics for better diagnosis and tracking of chronic obstructive pulmonary disease (COPD).
Research shows that the 2025 Los Angeles wildfires resulted in an estimated 440 excess deaths, while the 2023 Maui wildfires led to immediate increases in suicide and overdose deaths. Higher social support was linked to improved mental health outcomes but did not buffer physiological effects.
A new study by Mass General Brigham investigators identified an ancient immune pathway that is activated in patients with acute chest syndrome (ACS) and serves as a key driver of the disease. Blocking this pathway with clinically approved drugs alleviated disease severity in preclinical models.
Researchers discovered that PAR1 triggers a structural transformation in lymphatic vessels, making them more permeable to absorb excess fluid and immune cells. This finding has implications for the treatment of lung diseases and could lead to targeted therapies.
Researchers at Mount Sinai identified Epac1 as a key driver of idiopathic pulmonary fibrosis, a chronic and progressive lung-scarring disease. Blocking Epac1 with a small-molecule drug may slow the progression of the disease, offering new treatment options for patients.
Clinical trials show sutezolid and delpazolid are safer alternatives to linezolid for treating drug-resistant TB, with no cases of nerve damage or blood toxicity reported. The findings suggest these drugs could replace linezolid in treatment regimens.
A study found that exposure to β-glucan reprograms immune cells in the lungs, causing them to overreact and worsen lung damage. The research suggests that trained immunity in the lungs may have negative consequences in certain contexts.
Scientists from Pusan National University discovered a genetic biomarker, FCGBP, that is strongly linked to bronchiolitis obliterans syndrome and poor outcomes following lung transplantation. The finding may help identify high-risk patients and devise timely immunosuppressive treatments.
A team of scientists from Colorado State University and the University of São Paulo have developed a seismological solution to improve the resolution of ultrasound images for lung monitoring. This breakthrough could lead to improved critical care for patients, including continuous lung monitoring at the bedside. The technique uses seis...
Scientists at UC San Francisco discovered how pancreatic cancer cells metastasize to the lungs or liver using the PCSK9 protein. PCSK9 controls cholesterol acquisition, with low levels favoring the liver and high levels supporting lung adaptation.
A computerized decision support tool reduced the time children with lung failure spent on ventilation by shortening weaning time and improving respiratory muscle strength. The intervention group had better functional status at ICU discharge than the control group.
A recent study found that Metagenomic next-generation sequencing (mNGS) can detect pathogens in 86% of cases, outperforming conventional microbiological tests which identified pathogens in only 67% of cases. mNGS guides treatment decisions and improves patient outcomes by detecting rare/atypical pathogens.
A new COPD diagnostic approach integrates respiratory symptoms, quality of life, spirometry, and CT imaging to accurately classify individuals with the disease. This framework reveals increased risks for mortality, exacerbations, and lung function decline among those classified as having COPD.
A study published in The Lancet Respiratory Medicine found that lung capacity develops in two phases: rapid growth during childhood and slower growth until peak lung function. Lung function starts to decline after the peak age, contrary to previous models. Persistent asthma and smoking affect lung function differently than thought.
Researchers found persistent inflammation in heart and lungs of patients with long COVID, even after standard tests return normal results. This study uses advanced PET/MRI imaging to detect abnormal patterns that could serve as early warning signs of future cardiac and pulmonary conditions.
A groundbreaking study from the University of Virginia Health System reveals distinct immune patterns in patients with persistent breathing issues after COVID-19. The research identifies specific T cell changes linked to lung damage and fibrosis, paving the way for personalized treatments.
A new global clinical trial has demonstrated the benefits of an investigational medication called brensocatib, a DPP-1 inhibitor, in improving bronchiectasis patients' quality of life. The study showed that nearly half of patients remained exacerbation-free one year later and experienced significant improvements in lung function.
Researchers from the University of Vienna and EPFL Lausanne found high concentrations of rubber additives in bouldering gym air, similar to car tires. The study suggests that these substances do not belong in the air we breathe, highlighting the need for better ventilation and cleaner climbing shoe materials.
A Phase Ia/Ib trial found that zongertinib demonstrated clinical benefits for patients with advanced HER2-mutant non-small cell lung cancer, particularly those with specific HER2 mutations. The treatment showed a 71% objective response rate and manageable side effects.
Machine perfusion technology significantly extends the time donor hearts can be transported, enabling longer-distance transplants. This innovation has already led to more organs being accepted from regions previously unsuitable due to transportation constraints.
A study on donor lungs preserved outside the body demonstrated that HOPE is a safe and effective method for lung preservation, with no rejections and similar short-term outcomes compared to direct transplantation. The study found that extending perfusion times can optimize donor lungs for future therapies.
Researchers at ISHLT marked the 10-year anniversary of modern DCD heart donation, significantly increasing transplant volumes worldwide. Comparable outcomes have been achieved with DCD hearts compared to traditional DBD hearts, leading to a surge in DCD programs globally.
A day-long conference brought together experts to present ground-breaking outcomes research on CTEPH treatments. The session covered new medications, refined techniques, and innovative approaches to improve diagnosis and treatment outcomes.
Researchers have identified two proteins in birds that compensate for the loss of a key immune component in humans, providing insights into combating respiratory diseases. The study sheds light on how birds maintain lung protection despite their unique respiratory anatomy.
Researchers at Tulane University identified a potential new way to treat idiopathic pulmonary fibrosis (IPF) using an FDA-approved cancer drug. The treatment works by blocking the CTLA4 protein, which blocks overactive T cells, allowing the immune system to clear out damaged cells that cause lung scarring.
Researchers found that using twice-daily tacrolimus resulted in lower rates of chronic lung allograft dysfunction and improved overall survival after lung transplantation compared to cyclosporine. This study provides promising news for lung transplant patients, highlighting the importance of effective treatment strategies to prevent CLAD.
Adding an experimental cancer drug to standard TB treatment reduces lung damage and prevents post-TB lung disease in mice. Researchers found that the drug doubled pulmonary apoptosis and reduced lung scarring by 40% compared to standard treatments.